Objective Malignant gliomas display over-expression of the receptor tyrosine kinase EphA2. However,expression levels of the EphA2 ligand,EphrinA1,have not been fully elucidated. This study aims to determine the expres...Objective Malignant gliomas display over-expression of the receptor tyrosine kinase EphA2. However,expression levels of the EphA2 ligand,EphrinA1,have not been fully elucidated. This study aims to determine the expression of EphA2 / EphrinA1 in detail,and further detect the predictive展开更多
BACKGROUND The sleep quality of patients with postoperative glioma at home has not been reported worldwide.In this study,the sleep quality of postoperative glioma patients at home was explored through telephone interv...BACKGROUND The sleep quality of patients with postoperative glioma at home has not been reported worldwide.In this study,the sleep quality of postoperative glioma patients at home was explored through telephone interviews.AIM To investigate the sleep quality of patients with postoperative glioma.METHODS Glioma patients who were treated and operated on at Nanjing Brain Hospital from May 2012 to August 2019 were selected as participants via convenience sampling.A total of 549 patients were recruited by telephone,and 358 of those patients responded to the Pittsburgh Sleep Quality Index(PSQI).RESULTS The total PSQI score was 5.19±3.39 in all patients with postoperative glioma,which was higher than that of the normal group.There were 135 patients with poor sleep quality(PSQI>7),which accounted for 37.7%of all respondents.The scores of the seven dimensions of the PSQI were sleep latency(1.22±1.05),sleep disturbance(1.12±0.98),subjective sleep quality(1.03±0.92),habitual sleep efficiency(1.02±0.91),daytime dysfunction(0.95±0.43),sleep persistence(0.83±0.76),and use of sleeping medication(0.25±0.24).The results showed that the subjective sleep quality of the patients who underwent an operation 1-2 years ago was worse than that of the patients who underwent an operation more than 2 years ago(P<0.05).Older patients had worse sleep latency and sleep duration scores than younger patients(P<0.05).Sleep disturbance and daytime dysfunction were worse in patients who received postoperative radiotherapy/chemotherapy(P<0.05).CONCLUSION The sleep quality of patients with postoperative glioma at home is worse than that of normal adults.Moreover,difficulty falling asleep and sleep disorders are common complications among these patients,and age,postoperative duration,and postoperative chemoradiotherapy could affect sleep quality.展开更多
Objective This study is to evaluate the efficacy and toxicity of temozolomide (TMZ) chemotherapy based on O 6 -methylguanine-DNA methyltransferase (MGMT) protein expression in patients with malignant gliomas. Methods ...Objective This study is to evaluate the efficacy and toxicity of temozolomide (TMZ) chemotherapy based on O 6 -methylguanine-DNA methyltransferase (MGMT) protein expression in patients with malignant gliomas. Methods A total of 40 patients with pathologically confirmed malignant gliomas were enrolled. All patients had pretreated with radiotherapy and had assessable lesions.展开更多
文摘Objective Malignant gliomas display over-expression of the receptor tyrosine kinase EphA2. However,expression levels of the EphA2 ligand,EphrinA1,have not been fully elucidated. This study aims to determine the expression of EphA2 / EphrinA1 in detail,and further detect the predictive
基金Nanjing Medical Science and Technique Development FoundationNo.QRX17087。
文摘BACKGROUND The sleep quality of patients with postoperative glioma at home has not been reported worldwide.In this study,the sleep quality of postoperative glioma patients at home was explored through telephone interviews.AIM To investigate the sleep quality of patients with postoperative glioma.METHODS Glioma patients who were treated and operated on at Nanjing Brain Hospital from May 2012 to August 2019 were selected as participants via convenience sampling.A total of 549 patients were recruited by telephone,and 358 of those patients responded to the Pittsburgh Sleep Quality Index(PSQI).RESULTS The total PSQI score was 5.19±3.39 in all patients with postoperative glioma,which was higher than that of the normal group.There were 135 patients with poor sleep quality(PSQI>7),which accounted for 37.7%of all respondents.The scores of the seven dimensions of the PSQI were sleep latency(1.22±1.05),sleep disturbance(1.12±0.98),subjective sleep quality(1.03±0.92),habitual sleep efficiency(1.02±0.91),daytime dysfunction(0.95±0.43),sleep persistence(0.83±0.76),and use of sleeping medication(0.25±0.24).The results showed that the subjective sleep quality of the patients who underwent an operation 1-2 years ago was worse than that of the patients who underwent an operation more than 2 years ago(P<0.05).Older patients had worse sleep latency and sleep duration scores than younger patients(P<0.05).Sleep disturbance and daytime dysfunction were worse in patients who received postoperative radiotherapy/chemotherapy(P<0.05).CONCLUSION The sleep quality of patients with postoperative glioma at home is worse than that of normal adults.Moreover,difficulty falling asleep and sleep disorders are common complications among these patients,and age,postoperative duration,and postoperative chemoradiotherapy could affect sleep quality.
文摘Objective This study is to evaluate the efficacy and toxicity of temozolomide (TMZ) chemotherapy based on O 6 -methylguanine-DNA methyltransferase (MGMT) protein expression in patients with malignant gliomas. Methods A total of 40 patients with pathologically confirmed malignant gliomas were enrolled. All patients had pretreated with radiotherapy and had assessable lesions.
