Recent collaborative,large-scale genomic profiling of the most common and aggressive brain tumor glioblastoma multiforme(GBM) has significantly advanced our understanding of this disease.The gene encoding platelet-der...Recent collaborative,large-scale genomic profiling of the most common and aggressive brain tumor glioblastoma multiforme(GBM) has significantly advanced our understanding of this disease.The gene encoding platelet-derived growth factor receptor alpha(PDGFR a) was identified as the third of the top 11 amplified genes in clinical GBM specimens.The important roles of PDGFR a signaling during normal brain development also implicate the possible pathologic consequences of PDGFR a over-activation in glioma.Although the initial clinical trials using PDGFR kinase inhibitors have been predominantly disappointing,diagnostic and treatment modalities involving genomic profiling and personalized medicine are expected to improve the therapy targeting PDGFR a signaling.In this review,we discuss the roles of PDGFR a signaling during development of the normal central nervous system(CNS) and in pathologic conditions such as malignant glioma.We further compare various animal models of PDGF-induced gliomagenesis and their potential as a novel platform of pre-clinical drug testing.We then summarize our recent publication and how these findings will likely impact treatments for gliomas driven by PDGFR a overexpression.A better understanding of PDGFR a signaling in glioma and their microenvironment,through the use of human or mouse models,is necessary to design a more effective therapeutic strategy against gliomas harboring the aberrant PDGFR a signaling.展开更多
基金supported in part by grants from NIH CA130966the Pennsylvania Department of Health and Innovative Research Scholar Awards of the Hillman Foundation to Shi-Yuan Cheng and Bo Hua James S McDonnell Foundation Researching Award in Brain Cancers to Bo Hu
文摘Recent collaborative,large-scale genomic profiling of the most common and aggressive brain tumor glioblastoma multiforme(GBM) has significantly advanced our understanding of this disease.The gene encoding platelet-derived growth factor receptor alpha(PDGFR a) was identified as the third of the top 11 amplified genes in clinical GBM specimens.The important roles of PDGFR a signaling during normal brain development also implicate the possible pathologic consequences of PDGFR a over-activation in glioma.Although the initial clinical trials using PDGFR kinase inhibitors have been predominantly disappointing,diagnostic and treatment modalities involving genomic profiling and personalized medicine are expected to improve the therapy targeting PDGFR a signaling.In this review,we discuss the roles of PDGFR a signaling during development of the normal central nervous system(CNS) and in pathologic conditions such as malignant glioma.We further compare various animal models of PDGF-induced gliomagenesis and their potential as a novel platform of pre-clinical drug testing.We then summarize our recent publication and how these findings will likely impact treatments for gliomas driven by PDGFR a overexpression.A better understanding of PDGFR a signaling in glioma and their microenvironment,through the use of human or mouse models,is necessary to design a more effective therapeutic strategy against gliomas harboring the aberrant PDGFR a signaling.
