Objective： To explore the therapeutic effect of Yishen Qufeng Shengshi Recipe （益肾祛风胜湿方, YQSR） in patients with glomerular proteinuria. Methods： A total of 145 patients with glomerular proteinuria were selec...Objective： To explore the therapeutic effect of Yishen Qufeng Shengshi Recipe （益肾祛风胜湿方, YQSR） in patients with glomerular proteinuria. Methods： A total of 145 patients with glomerular proteinuria were selected and randomly assigned to the treatment group （108 cases） and the control group （37 cases） according to a random number table in a ratio of 3：1. All patients received conventional and symptomatic treatment. In addition, patients in the treatment and control groups were given YQSR （200 mL, twice per day, orally） and losartan （50 mg/d orally）, respectively for 6 months. The 24-h urine protein quantity, blood urea nitrogen, and serum creatinine in the two groups were measured at multiple time points before and after treatment. Results： At the end of the study, 5 cases were lost to follow-up in the treatment group and 1 in the control group. Finally, the statistical data included 103 cases in the treatment group and 36 cases in the control group. The total effectiveness after 2, 4, and 6 months was 81.6% （84/103）, 87.4% （90/103）, and 92.2% （95/103）, respectively, in the treatment group and 47.2% （17/36）, 55.6% （20/36）, and 61.1% （22/36）, respectively, in the control group, with significant difference between the two groups （P〈0.01 at all observation points）. In the treatment group, the curative effect after 6 months was better than that after 2 months （P〈0.05）. The 24-h urine protein quantity was significantly lower in the treatment group at 3, 4, 5, and 6 months than that in the control group （P〈0.05 or P〈0.01, respectively）. Conclusion： YQSR could significantly reduce the amount of glomerular proteinuria in the early stage.展开更多
A study was made to analyse.the relationship between serum total cholesterol(STC) and the other three parameters,urinary albumin excretion quantity(UAEQ), serum β2-microglobulin(Sβ2-MG), serum albumin(SA)in a group ...A study was made to analyse.the relationship between serum total cholesterol(STC) and the other three parameters,urinary albumin excretion quantity(UAEQ), serum β2-microglobulin(Sβ2-MG), serum albumin(SA)in a group of 38 patients with primary glomerular disease. The patients were classified into two groups according to proteinuria and serum albumin:Nephr it is group: proteinuria<3.5 g/d,serum albumin>30 g/L;Nephrosis group:proteinuria≥3.5 g/d,serum albumin≤30g/L. STC showed higher correlation with UAEQ(P< 0. 05￣0. 01),but did not have any significant correlation with Sβ2-MG berore and after the treatment or the two groups.STC had negative correlation with SA berore the treat ment of nephrosis group(P<0.01),but STC had no significant correlation with SA in nephritis group and after the treatment of nephrosis group. These data suggest that the decrease of SA is not the sole cause of hypercholestcrolemia. The presence of an association between STC and UAEQ indicates that the kidneys play a certain role in cholesterol metabolism.展开更多
目的了解老年原发性高血压(EH)住院患者慢性肾病(CKD)检出率,分析相关影响因素。方法选择确诊的977例EH患者,分为老年EH组575例和非老年EH组402例,同期选择健康体检者4610例为老年对照组,回顾分析CKD的影响因素。结果老年EH组尿蛋白和...目的了解老年原发性高血压(EH)住院患者慢性肾病(CKD)检出率,分析相关影响因素。方法选择确诊的977例EH患者,分为老年EH组575例和非老年EH组402例,同期选择健康体检者4610例为老年对照组,回顾分析CKD的影响因素。结果老年EH组尿蛋白和估算肾小球滤过率(eGFR)下降比例高于非老年EH组(28.5%vs 11.4%、18.3%vs 4.5%,P<0.05);老年EH组CKD检出率高于非老年EH组和老年对照组(33.7%vs12.4%和3.9%,P<0.05,P<0.01);收缩压每升高20 mm Hg(1 mm Hg=0.133kPa),CKD检出率明显增加(P<0.05)。老年EH组合并CKD的危险因素为糖尿病、年龄、血尿酸、收缩压水平(OR=1.702、1.056、1.013、1.007,P<0.01)。结论住院老年EH患者CKD检出率高于非老年,其发病与血糖、血尿酸及血压水平有关。展开更多
文摘Objective： To explore the therapeutic effect of Yishen Qufeng Shengshi Recipe （益肾祛风胜湿方, YQSR） in patients with glomerular proteinuria. Methods： A total of 145 patients with glomerular proteinuria were selected and randomly assigned to the treatment group （108 cases） and the control group （37 cases） according to a random number table in a ratio of 3：1. All patients received conventional and symptomatic treatment. In addition, patients in the treatment and control groups were given YQSR （200 mL, twice per day, orally） and losartan （50 mg/d orally）, respectively for 6 months. The 24-h urine protein quantity, blood urea nitrogen, and serum creatinine in the two groups were measured at multiple time points before and after treatment. Results： At the end of the study, 5 cases were lost to follow-up in the treatment group and 1 in the control group. Finally, the statistical data included 103 cases in the treatment group and 36 cases in the control group. The total effectiveness after 2, 4, and 6 months was 81.6% （84/103）, 87.4% （90/103）, and 92.2% （95/103）, respectively, in the treatment group and 47.2% （17/36）, 55.6% （20/36）, and 61.1% （22/36）, respectively, in the control group, with significant difference between the two groups （P〈0.01 at all observation points）. In the treatment group, the curative effect after 6 months was better than that after 2 months （P〈0.05）. The 24-h urine protein quantity was significantly lower in the treatment group at 3, 4, 5, and 6 months than that in the control group （P〈0.05 or P〈0.01, respectively）. Conclusion： YQSR could significantly reduce the amount of glomerular proteinuria in the early stage.
文摘A study was made to analyse.the relationship between serum total cholesterol(STC) and the other three parameters,urinary albumin excretion quantity(UAEQ), serum β2-microglobulin(Sβ2-MG), serum albumin(SA)in a group of 38 patients with primary glomerular disease. The patients were classified into two groups according to proteinuria and serum albumin:Nephr it is group: proteinuria<3.5 g/d,serum albumin>30 g/L;Nephrosis group:proteinuria≥3.5 g/d,serum albumin≤30g/L. STC showed higher correlation with UAEQ(P< 0. 05￣0. 01),but did not have any significant correlation with Sβ2-MG berore and after the treatment or the two groups.STC had negative correlation with SA berore the treat ment of nephrosis group(P<0.01),but STC had no significant correlation with SA in nephritis group and after the treatment of nephrosis group. These data suggest that the decrease of SA is not the sole cause of hypercholestcrolemia. The presence of an association between STC and UAEQ indicates that the kidneys play a certain role in cholesterol metabolism.
文摘目的了解老年原发性高血压(EH)住院患者慢性肾病(CKD)检出率,分析相关影响因素。方法选择确诊的977例EH患者,分为老年EH组575例和非老年EH组402例,同期选择健康体检者4610例为老年对照组,回顾分析CKD的影响因素。结果老年EH组尿蛋白和估算肾小球滤过率(eGFR)下降比例高于非老年EH组(28.5%vs 11.4%、18.3%vs 4.5%,P<0.05);老年EH组CKD检出率高于非老年EH组和老年对照组(33.7%vs12.4%和3.9%,P<0.05,P<0.01);收缩压每升高20 mm Hg(1 mm Hg=0.133kPa),CKD检出率明显增加(P<0.05)。老年EH组合并CKD的危险因素为糖尿病、年龄、血尿酸、收缩压水平(OR=1.702、1.056、1.013、1.007,P<0.01)。结论住院老年EH患者CKD检出率高于非老年,其发病与血糖、血尿酸及血压水平有关。
