Objective The current study was designed to find out the effect of Glucosidorum Tripterygii Totorum (GTT) on the serum level of soluble interleukin-2 receptor (sIL-2R) in patient with ankylosing spondylitis (AS). Meth...Objective The current study was designed to find out the effect of Glucosidorum Tripterygii Totorum (GTT) on the serum level of soluble interleukin-2 receptor (sIL-2R) in patient with ankylosing spondylitis (AS). Method 29 patients with active AS were selected to take GTT (1mg per kg) three times a day for one year. After that, its curative effect was evaluated. The serum level of sIL-2R of these patients was measured by sandwich ELISA method and was compared with that of normal subjects. Result The serum level of sIL-2R in active AS patients was obviously higher than that of the non-active AS patients. (P<0.01). The total effective rate of GTT on AS was 89.6%, while clinical relief rate 27.6%, obvious effective rate 44.8%, effective rate 17.2% and non-effective rate 10.4%. The patients’ serum level of sIL-2R after therapy was significantly lower than that before therapy except patients with no effect. (P<0.05). Conclusion GTT has positive curative effect on active AS patients and could cause obvious decrease of the serum level of sIL-2R. The serum level of sIL-2R can be used as an important index of activity of AS and as a guide of therapy.展开更多
This paper reports that Glucosidorurn Tripterygii Totorum(GTT) , 20 mg, three times daily wasused as a substitute for cortical hormone to treat corticosteroid-dependent type of aspirin-inducod asthma.The results showe...This paper reports that Glucosidorurn Tripterygii Totorum(GTT) , 20 mg, three times daily wasused as a substitute for cortical hormone to treat corticosteroid-dependent type of aspirin-inducod asthma.The results showed that the total effective rate was 100 % , with 31 cases of rnarked effectiveness t 86. 11 % )and 5 cases of effectiveness (13. 89% ) . Plasma cortisol was signiticantly elevated to normal level aftertreatment (P< 0. 001 ) . Cushing's syndrome disappeared gradually. The blood glucose in the 9 patients whowere complicated with diabetes mellitus returned to normal and their glucosuria test became negative . Thevalue of peak expiratory flow (PEF) increased to different degreesf P < 0 . 01 for male, P < 0 . 05 for female) .The increment of PEF in the patients complicated with emphysema was not so much as in those patients notcomplicated with emphysema, but compared with premedication value, the elevation of PEF was significant(P< 0. 05) . There were no side-effects during treatment and the side-effects of cortical hormone could beavoided . Thus, the treatment proved valuable.展开更多
文摘Objective The current study was designed to find out the effect of Glucosidorum Tripterygii Totorum (GTT) on the serum level of soluble interleukin-2 receptor (sIL-2R) in patient with ankylosing spondylitis (AS). Method 29 patients with active AS were selected to take GTT (1mg per kg) three times a day for one year. After that, its curative effect was evaluated. The serum level of sIL-2R of these patients was measured by sandwich ELISA method and was compared with that of normal subjects. Result The serum level of sIL-2R in active AS patients was obviously higher than that of the non-active AS patients. (P<0.01). The total effective rate of GTT on AS was 89.6%, while clinical relief rate 27.6%, obvious effective rate 44.8%, effective rate 17.2% and non-effective rate 10.4%. The patients’ serum level of sIL-2R after therapy was significantly lower than that before therapy except patients with no effect. (P<0.05). Conclusion GTT has positive curative effect on active AS patients and could cause obvious decrease of the serum level of sIL-2R. The serum level of sIL-2R can be used as an important index of activity of AS and as a guide of therapy.
文摘This paper reports that Glucosidorurn Tripterygii Totorum(GTT) , 20 mg, three times daily wasused as a substitute for cortical hormone to treat corticosteroid-dependent type of aspirin-inducod asthma.The results showed that the total effective rate was 100 % , with 31 cases of rnarked effectiveness t 86. 11 % )and 5 cases of effectiveness (13. 89% ) . Plasma cortisol was signiticantly elevated to normal level aftertreatment (P< 0. 001 ) . Cushing's syndrome disappeared gradually. The blood glucose in the 9 patients whowere complicated with diabetes mellitus returned to normal and their glucosuria test became negative . Thevalue of peak expiratory flow (PEF) increased to different degreesf P < 0 . 01 for male, P < 0 . 05 for female) .The increment of PEF in the patients complicated with emphysema was not so much as in those patients notcomplicated with emphysema, but compared with premedication value, the elevation of PEF was significant(P< 0. 05) . There were no side-effects during treatment and the side-effects of cortical hormone could beavoided . Thus, the treatment proved valuable.
