Glycosmis longipetala F. J. Mou ＆ D. X. Zhang is described from Guangxi and Yunnan provinces in southwestern China. The new species is similar to G. cochinchinensis （Lour.） Pierre ex Engl. by its simple leaves, but...Glycosmis longipetala F. J. Mou ＆ D. X. Zhang is described from Guangxi and Yunnan provinces in southwestern China. The new species is similar to G. cochinchinensis （Lour.） Pierre ex Engl. by its simple leaves, but distinguishable in having long-elliptic or oblanceolate （vs. ovate） leaves, long-ovoid to ellipsoid （vs. ovoid） floral buds, ovaries with many tubercles （vs. smooth） and glabrous （vs. pubescent） stamens. The pollen grains of the new species are 23.9±3.09 （20.8-27.0）×22.0±1.80 （20.4-24.4）μm in size with reticulate exine ornamentation in equatorial area and foveolate in polar area. The chromosome number of the new species is 2n=72.展开更多
A new C-glycosyl flavone 7,4＇-dihydroxy-5-methoxyflavone-6-C-β-D-glucopyranoside 1 has been isolated and characterized form ethanolic extract of leaves part of Glycosmis arborea.The structure of compound was verifie...A new C-glycosyl flavone 7,4＇-dihydroxy-5-methoxyflavone-6-C-β-D-glucopyranoside 1 has been isolated and characterized form ethanolic extract of leaves part of Glycosmis arborea.The structure of compound was verified by means of high field 1D and 2D NMR（DEFT,COSY,DQF-HSQC,HMBC） and HRMS spectral analysis,respectively.展开更多
Three quinolinone alkaloids, two acridone alkaloids and a flavones glycoside were isolated from the aerial parts of Glycosmis mauritiana. These compounds were characterized as 7, 8-Dimethoxy-2,2,6-trimethyl-pyrano qui...Three quinolinone alkaloids, two acridone alkaloids and a flavones glycoside were isolated from the aerial parts of Glycosmis mauritiana. These compounds were characterized as 7, 8-Dimethoxy-2,2,6-trimethyl-pyrano quinolin-5-one, 4-Methoxy 1-methyl quinolin-2-one, 6-Hydroxy N-methyl 2,3-furo-quinolin-4-one, 1-Hydroxy-10-methyl acridone, 1- Hydroxy-2, 3-dimethoxy-10-methylacridin-9-one and Luteolin-4'-O-[α-L-rhamnopyranosyl-(1→2)-{α-L-rhamnopyra- nosyl-(1→6)}-β-D-glycopyranoside]. The isolated compounds were characterized by UV, IR and N. M. R (1H, 13C) studies.展开更多
Six novel compounds,comprising three quinolones(1a,1b,and 2)and three flavanones(3-5),along with seven known analogs(6-13),were isolated from the 95%EtOH extract of the stems and leaves of Glycosmis craibii var.glabra...Six novel compounds,comprising three quinolones(1a,1b,and 2)and three flavanones(3-5),along with seven known analogs(6-13),were isolated from the 95%EtOH extract of the stems and leaves of Glycosmis craibii var.glabra.The structures of the new compounds were elucidated using HR-ESI-MS,UV,and 1D and 2D nuclear magnetic resonance(NMR)data analysis.The ab-solute configurations were determined through Mosher ester and electronic circular dichroism(ECD)spectral analysis.Compounds 2,6,9,and 10 demonstrated inhibition of nitric oxide(NO)production stimulated by lipopolysaccharide in BV-2 microglial cells,with IC50 values ranging from 13.5 to 20.1 μmol·L^(-1),comparable to the positive control,dexamethasone.展开更多
Four unprecedented macrocyclic nonapeptides,orberryamides A–D(1–4),were isolated from Glycosmis pentaphylla(orangeberry)and structurally characterized by obtaining solid data from numerous analytical measurements.Co...Four unprecedented macrocyclic nonapeptides,orberryamides A–D(1–4),were isolated from Glycosmis pentaphylla(orangeberry)and structurally characterized by obtaining solid data from numerous analytical measurements.Compound 1 incorporated a new amino acid residue,named orangeberrine(Orgb),compounds 2 and 3 integrated the rare,nonproteinogenic amino acid residues(Kyn and Dioia,respectively),and compound 4 existed as two major conformational isomers in solution at ambient temperature.The biosynthetic pathways proposed for compounds 1–4 are of considerable biological significance for the modification and metabolism of tryptophan(Trp)and/or Trp containing proteins in nature.Besides,compounds 1–4 suppressed Th17 differentiation significantly,and the effects of 1–3 was achieved through targeting the ligand-binding domain(LBD)of the retinoic acid-related orphan receptor gamma t(RORγt).展开更多
基金supported by National Natural Science Foundation of China (30370107).
文摘Glycosmis longipetala F. J. Mou ＆ D. X. Zhang is described from Guangxi and Yunnan provinces in southwestern China. The new species is similar to G. cochinchinensis （Lour.） Pierre ex Engl. by its simple leaves, but distinguishable in having long-elliptic or oblanceolate （vs. ovate） leaves, long-ovoid to ellipsoid （vs. ovoid） floral buds, ovaries with many tubercles （vs. smooth） and glabrous （vs. pubescent） stamens. The pollen grains of the new species are 23.9±3.09 （20.8-27.0）×22.0±1.80 （20.4-24.4）μm in size with reticulate exine ornamentation in equatorial area and foveolate in polar area. The chromosome number of the new species is 2n=72.
文摘A new C-glycosyl flavone 7,4＇-dihydroxy-5-methoxyflavone-6-C-β-D-glucopyranoside 1 has been isolated and characterized form ethanolic extract of leaves part of Glycosmis arborea.The structure of compound was verified by means of high field 1D and 2D NMR（DEFT,COSY,DQF-HSQC,HMBC） and HRMS spectral analysis,respectively.
文摘Three quinolinone alkaloids, two acridone alkaloids and a flavones glycoside were isolated from the aerial parts of Glycosmis mauritiana. These compounds were characterized as 7, 8-Dimethoxy-2,2,6-trimethyl-pyrano quinolin-5-one, 4-Methoxy 1-methyl quinolin-2-one, 6-Hydroxy N-methyl 2,3-furo-quinolin-4-one, 1-Hydroxy-10-methyl acridone, 1- Hydroxy-2, 3-dimethoxy-10-methylacridin-9-one and Luteolin-4'-O-[α-L-rhamnopyranosyl-(1→2)-{α-L-rhamnopyra- nosyl-(1→6)}-β-D-glycopyranoside]. The isolated compounds were characterized by UV, IR and N. M. R (1H, 13C) studies.
基金supported by National Natural Science Foundation of China(Nos.81973199,82173949,and 81773864)the Key Research and Development Project of Shandong Province(No.2021CXGC010507)。
文摘Six novel compounds,comprising three quinolones(1a,1b,and 2)and three flavanones(3-5),along with seven known analogs(6-13),were isolated from the 95%EtOH extract of the stems and leaves of Glycosmis craibii var.glabra.The structures of the new compounds were elucidated using HR-ESI-MS,UV,and 1D and 2D nuclear magnetic resonance(NMR)data analysis.The ab-solute configurations were determined through Mosher ester and electronic circular dichroism(ECD)spectral analysis.Compounds 2,6,9,and 10 demonstrated inhibition of nitric oxide(NO)production stimulated by lipopolysaccharide in BV-2 microglial cells,with IC50 values ranging from 13.5 to 20.1 μmol·L^(-1),comparable to the positive control,dexamethasone.
基金supported financially by the grants(nos.21532007 and 21772213)from the National Natural Science Foundation of the People’s Republic of China.
文摘Four unprecedented macrocyclic nonapeptides,orberryamides A–D(1–4),were isolated from Glycosmis pentaphylla(orangeberry)and structurally characterized by obtaining solid data from numerous analytical measurements.Compound 1 incorporated a new amino acid residue,named orangeberrine(Orgb),compounds 2 and 3 integrated the rare,nonproteinogenic amino acid residues(Kyn and Dioia,respectively),and compound 4 existed as two major conformational isomers in solution at ambient temperature.The biosynthetic pathways proposed for compounds 1–4 are of considerable biological significance for the modification and metabolism of tryptophan(Trp)and/or Trp containing proteins in nature.Besides,compounds 1–4 suppressed Th17 differentiation significantly,and the effects of 1–3 was achieved through targeting the ligand-binding domain(LBD)of the retinoic acid-related orphan receptor gamma t(RORγt).
