A tridentate Schiff base ligand, (E)-2-(4-dimethylbenzydimino) glycylglycine (glygly-DAB), derived from the condensation of 4-Dimethylaminobenzaldehyde (DAB) and glycylglycine (glygly) together with its Co(II), Ni(II)...A tridentate Schiff base ligand, (E)-2-(4-dimethylbenzydimino) glycylglycine (glygly-DAB), derived from the condensation of 4-Dimethylaminobenzaldehyde (DAB) and glycylglycine (glygly) together with its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and characterized using various physico-chemical methods including C,H,N elemental analysis, melting point determination, molar conductivity measurement, IR, 1H NMR and UV-Vis. The ligand and metal complexes were screened in vitro for antimicrobial and antifungal activities on four bacterial strains (Staphylococcus aureus, Escherichia coli, Salmonella thyphi and Pseudomonas aeruginosa) and two fungal strains (Candida albicans and Cryptococcus neoformans). glygly-DAB showed remarkable antifungal activities on all the fungal strains and antibacterial activities on one bacterial strain.展开更多
A coordination complex was synthesized from NiCl2 and dipeptide glycylglycine（GG）. It was characterized by element analysis, NMR and TG methods, and then was determined to be Ni（C4HsN2O3）2Cl2. Using an isoperiboli...A coordination complex was synthesized from NiCl2 and dipeptide glycylglycine（GG）. It was characterized by element analysis, NMR and TG methods, and then was determined to be Ni（C4HsN2O3）2Cl2. Using an isoperibolic reaction calorimeter, the standard molar enthalpy of formation of Ni（GG）2Cl2（solid） has been determined to be -（1 674.66±2.02） kJ · mol^-1 at 298.15 K.展开更多
文摘A tridentate Schiff base ligand, (E)-2-(4-dimethylbenzydimino) glycylglycine (glygly-DAB), derived from the condensation of 4-Dimethylaminobenzaldehyde (DAB) and glycylglycine (glygly) together with its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and characterized using various physico-chemical methods including C,H,N elemental analysis, melting point determination, molar conductivity measurement, IR, 1H NMR and UV-Vis. The ligand and metal complexes were screened in vitro for antimicrobial and antifungal activities on four bacterial strains (Staphylococcus aureus, Escherichia coli, Salmonella thyphi and Pseudomonas aeruginosa) and two fungal strains (Candida albicans and Cryptococcus neoformans). glygly-DAB showed remarkable antifungal activities on all the fungal strains and antibacterial activities on one bacterial strain.
基金Supported by the National Natural Science Foundation of China (20373050).
文摘A coordination complex was synthesized from NiCl2 and dipeptide glycylglycine（GG）. It was characterized by element analysis, NMR and TG methods, and then was determined to be Ni（C4HsN2O3）2Cl2. Using an isoperibolic reaction calorimeter, the standard molar enthalpy of formation of Ni（GG）2Cl2（solid） has been determined to be -（1 674.66±2.02） kJ · mol^-1 at 298.15 K.
