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中药三联疗法联合GnRH-a减量法防治保守性手术后卵巢子宫内膜异位症复发的临床研究
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作者 周月娟 张一沛 边庆华 《中国中医药现代远程教育》 2024年第21期98-100,共3页
目的探究中药三联疗法联合促性腺素释放素药物(GnRH-a)减量法防治保守性手术后卵巢子宫内膜异位症复发的临床效果。方法选择2022年7月—2023年12月于南昌市洪都中医院就诊并经腹腔镜手术确诊的卵巢子宫内膜异位症患者100例,按随机数字... 目的探究中药三联疗法联合促性腺素释放素药物(GnRH-a)减量法防治保守性手术后卵巢子宫内膜异位症复发的临床效果。方法选择2022年7月—2023年12月于南昌市洪都中医院就诊并经腹腔镜手术确诊的卵巢子宫内膜异位症患者100例,按随机数字表法分为参照组与研究组,各50例。参照组给予亮丙瑞林常规剂量治疗,研究组给予中药三联疗法联合亮丙瑞林减量法治疗,比较两组血清雌二醇(E_(2))、孕酮(P)、糖化抗原125(CA125)水平,抗子宫内膜抗体(EMAb)阳性率,视觉模拟量表(VAS)疼痛评分及治疗总有效率。结果研究组治疗总有效率为98.00%(49/50),高于参照组的84.00%(42/50)(P<0.05)。治疗后及停药6个月后,研究组VAS评分均低于参照组(P<0.05)。治疗后,研究组血清E_(2)、CA125水平及EMAb阳性率低于参照组,P含量高于参照组(P<0.05)。结论对于保守性手术后的卵巢子宫内膜异位症患者,采用中药三联疗法联合GnRH-a减量法治疗,可有效降低其病情复发率,改善痛经症状,远程疗效较理想。 展开更多
关键词 卵巢子宫内膜异位症 中药三联疗法 gnrh-a减量法 中西医结合疗法
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GnRH-a联合HCG对多囊卵巢综合征疗效
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作者 马单单 岳桂英 范鹏莺 《山西卫生健康职业学院学报》 CAS 2024年第1期20-21,共2页
目的:分析促性腺激素释放激素激动剂(GnRH-a)联合人绒毛膜促性腺激素(HCG)治疗多囊卵巢综合征(PCOS)患者的疗效,并探讨相关机制。方法:将80例PCOS患者分为两组,即观察组和对照组,均接受来曲唑治疗,对照组刺激排卵方案为单用HCG,观察组则... 目的:分析促性腺激素释放激素激动剂(GnRH-a)联合人绒毛膜促性腺激素(HCG)治疗多囊卵巢综合征(PCOS)患者的疗效,并探讨相关机制。方法:将80例PCOS患者分为两组,即观察组和对照组,均接受来曲唑治疗,对照组刺激排卵方案为单用HCG,观察组则为HCG+GnRH-a,观察用药后子宫内膜厚度、获卵数、成熟卵子数、优势卵泡数及血清促卵泡激素(FSH)、黄体生成素(LH)、孕激素(P)水平,比较用药前后尿LH波动情况,并统计排卵人数、单个促排周期妊娠率、未破裂卵泡黄素化(LUFS)发生率、卵巢过度刺激综合征(OHSS)发生率。结果:观察组PCOS患者成熟卵泡数量、优势卵泡数量及血清FSH、LH含量均高于对照组(P<0.05),子宫内膜厚度、获卵数、血孕激素水平比较无统计学意义(P>0.05);观察组排卵率高于对照组,LUFS发生率、OHSS发生率均低于对照组(P<0.05)。结论:GnRH-a联合HCG治疗PCOS是可行的,能显著提高排卵率,且能控制OHSS等并发症发生率。 展开更多
关键词 多囊卵巢综合征 gnrh-a HCG 排卵
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GnRH-a和LNG-IUS,口服孕激素联合治疗子宫腺肌病患者疗效的研究进展
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作者 来艳菲 沙仁高娃 《中国科技期刊数据库 医药》 2024年第6期0005-0008,共4页
子宫腺肌病(adenomyosis,AM)是指子宫内膜腺体及间质侵入子宫肌层的一种妇科良性疾病,具有雌激素依赖性,多发生于育龄期女性。近年来其发病率逐渐上升,年龄也更趋向年轻化。对于育龄期妇女来说,明确诊断子宫腺肌病并选择合适的治疗方案... 子宫腺肌病(adenomyosis,AM)是指子宫内膜腺体及间质侵入子宫肌层的一种妇科良性疾病,具有雌激素依赖性,多发生于育龄期女性。近年来其发病率逐渐上升,年龄也更趋向年轻化。对于育龄期妇女来说,明确诊断子宫腺肌病并选择合适的治疗方案,有助于阻断病程进展,改善生活能力,缓解心理压力,保护生育能力。目前,对于子宫腺肌病的治疗包括内科治疗和外科治疗,由于患病年龄的范围逐渐趋近20-30岁的女性,治疗方式上也发生了很大变化,更多人摒弃了传统的手术治疗方式,选择更新颖的内科治疗。其中,选择左炔诺孕酮宫内缓释节育系统(LNG-IUS)、促性腺激素释放激素激动剂(GnRH-a)及孕激素(DNG)作为治疗方法比较普遍。本文介绍了近年来使用以上方法治疗子宫腺肌病的研究进展。 展开更多
关键词 子宫腺肌病 gnrh-a LNG-IUS 孕激素 研究
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比较hCG联合GnRH-a双扳机和hCG单扳机方案对卵巢高反应人群的影响
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作者 覃慧斯 周红 +5 位作者 舒金辉 蔡君英 邓曦和 甘贤优 林若芸 汪彩珠 《中国性科学》 2024年第2期57-61,共5页
目的分析对比在拮抗剂方案中应用促性腺激素释放激素激动剂(GnRH-a)联合人绒毛膜促性腺激素(hCG)双扳机和hCG单扳机对卵巢高反应人群体外受精助孕周期的影响。方法回顾性收集2019年1月至2022年6月期间在广西壮族自治区妇幼保健院采用体... 目的分析对比在拮抗剂方案中应用促性腺激素释放激素激动剂(GnRH-a)联合人绒毛膜促性腺激素(hCG)双扳机和hCG单扳机对卵巢高反应人群体外受精助孕周期的影响。方法回顾性收集2019年1月至2022年6月期间在广西壮族自治区妇幼保健院采用体外受精/卵胞质内单精子注射(IVF/ICSI)助孕、因卵巢高反应行全胚冷冻的260例患者的临床资料,其中使用双扳机为A组(n=131),使用hCG单扳机为B组(n=129)。比较分析两组新鲜周期内的2PN率、优质胚胎率等临床指标的差异,同时比较两组首次移植周期内的妊娠结局差异。结果两组新鲜周期的2PN率、卵裂率、D3可利用胚胎数、D3优胚数、D5优胚数、总囊胚数、囊胚形成率、卵巢过度刺激综合征(OHSS)发生率比较,差异无统计学意义(P>0.05);但A组冻存胚胎数高于B组,差异具有统计学意义(P=0.023)。A、B两组中重度OHSS发生率分别为1.52%和2.32%,差异无统计学意义(P=0.986),但A组为2例中度OHSS(住院治疗1例),B组为3例重度OHSS(住院治疗3例)。两组首次冻融周期的生化妊娠率、临床妊娠率、胚胎种植率、持续妊娠率、活产率等比较,差异无统计学意义(P>0.05)。结论在GnRH拮抗剂方案中,对卵巢高反应人群使用GnRH-a联合hCG双扳机,可与hCG单扳机同样诱发卵泡成熟及获卵,不影响其助孕结局,同时有利于降低中重度OHSS的发生。 展开更多
关键词 卵巢高反应 促性腺激素释放激素拮抗剂方案 双扳机 体外受精
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Trigger转座子衍生蛋白1对肝癌细胞生长的影响
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作者 高平 叶子坚 +1 位作者 钱晓宇 钟秀颖 《华南理工大学学报(自然科学版)》 EI CAS CSCD 北大核心 2024年第4期1-7,共7页
细胞周期失调是肿瘤重要的标志之一,生物信息学分析结果表明,Trigger转座子衍生蛋白1(TIGD1)在临床肝癌组织中高表达且与细胞周期相关,但相关机制未知。为了探究TIGD1调控肝癌细胞生长的具体机制,首先,利用shRNA质粒构建靶向敲低TIGD1... 细胞周期失调是肿瘤重要的标志之一,生物信息学分析结果表明,Trigger转座子衍生蛋白1(TIGD1)在临床肝癌组织中高表达且与细胞周期相关,但相关机制未知。为了探究TIGD1调控肝癌细胞生长的具体机制,首先,利用shRNA质粒构建靶向敲低TIGD1的肝癌细胞系Hep3B,并分析TIGD1敲低对肝癌细胞生长的影响,结果表明细胞生长受阻;接着,通过细胞流式技术分析TIGD1敲低对肝癌细胞周期进程的影响,结果显示,TIGD1敲低的Hep3B细胞系的细胞周期进程主要阻滞于G2/M期;然后,通过免疫沉淀(IP)实验验证TIGD1可能发生相互结合的蛋白分子,结果表明,TIGD1可能与Aurora激酶相互作用蛋白1(AURKAIP1)存在相互结合,进一步的Co-IP实验证实了TIGD1和AURKAIP1之间的相互作用。已知AURKAIP1可调控Aurora激酶A(AURKA)的蛋白酶体降解途径,AURKA是一种有丝分裂调控蛋白,与细胞周期进程密切相关。文中进一步探究TIGD1对AURKA蛋白水平的影响,实验结果表明,在TIGD1敲低的情况下,AURKA在Hep3B细胞系中的蛋白水平明显下调,mRNA水平没有明显变化。综上所述,TIGD1可能通过调控AURKA在肝癌细胞中的转录后水平来影响细胞周期进程,从而影响肝癌的发生发展。 展开更多
关键词 trigger转座子衍生蛋白1 肝癌 细胞生长 细胞周期
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Byzantine Robust Federated Learning Scheme Based on Backdoor Triggers
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作者 Zheng Yang Ke Gu Yiming Zuo 《Computers, Materials & Continua》 SCIE EI 2024年第5期2813-2831,共19页
Federated learning is widely used to solve the problem of data decentralization and can provide privacy protectionfor data owners. However, since multiple participants are required in federated learning, this allows a... Federated learning is widely used to solve the problem of data decentralization and can provide privacy protectionfor data owners. However, since multiple participants are required in federated learning, this allows attackers tocompromise. Byzantine attacks pose great threats to federated learning. Byzantine attackers upload maliciouslycreated local models to the server to affect the prediction performance and training speed of the global model. Todefend against Byzantine attacks, we propose a Byzantine robust federated learning scheme based on backdoortriggers. In our scheme, backdoor triggers are embedded into benign data samples, and then malicious localmodels can be identified by the server according to its validation dataset. Furthermore, we calculate the adjustmentfactors of local models according to the parameters of their final layers, which are used to defend against datapoisoning-based Byzantine attacks. To further enhance the robustness of our scheme, each localmodel is weightedand aggregated according to the number of times it is identified as malicious. Relevant experimental data showthat our scheme is effective against Byzantine attacks in both independent identically distributed (IID) and nonindependentidentically distributed (non-IID) scenarios. 展开更多
关键词 Federated learning Byzantine attacks backdoor triggers
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Stress triggering effect on the 2022 Honghe M_(S)5.0 earthquake with historical strong earthquakes
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作者 Mingce Wang Zifeng Liu Ruijie Luo 《Geodesy and Geodynamics》 EI CSCD 2024年第2期107-113,共7页
The 2022 Honghe M_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than M_(S)5.0.To elucidate the seismogenic mechani... The 2022 Honghe M_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than M_(S)5.0.To elucidate the seismogenic mechanism and scrutinize stress-triggered interactions,we calculated co-seismic and post-seismic Coulomb stress alterations induced by nine historical seismic events(M≥6.0).The analysis reveals that these substantial seismic events provoked co-seismic stress augmentations of 1.409 bar and postseismic stress increments of 0.159 bar.Noteworthy seismic events,such as the 1833 Songming,1877Shiping,1913 Eshan,and 1970 Tonghai earthquakes,catalyzed the occurrence of the Honghe earthquake.Areas of heightened future seismic risk include the southern region of the Red River Fault and the eastern segments of the Shiping-Jianshui and Qujiang faults.Additionally,we assessed the correlation between the spatial distribution of aftershocks and the Coulomb stress shift triggered by the mainshock,taking into account the influence of calculation parameter settings. 展开更多
关键词 Honghe Ms5.0 earthquake Coulomb failurestress Stress triggering Historical strongearthquakes
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Characteristics and triggering mechanisms of early negative Indian Ocean Dipole
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作者 Yue Fang Shuangwen Sun +2 位作者 Yongcan Zu Jianhu Wang Lin Feng 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第3期59-65,共7页
Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in China.Early nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in... Negative Indian Ocean Dipole(nIOD)can exert great impacts on global climate and can also strongly influence the climate in China.Early nIOD is a major type of nIOD,which can induce more pronounced climate anomalies in summer than La Niña-related nIOD.However,the characteristics and triggering mechanisms of early nIOD are unclear.Our results based on reanalysis datasets indicate that the early nIOD and La Niña-related nIOD are the two major types of nIOD,and the former accounts for over one third of all the nIOD events in the past six decades.These two types of nIODs are similar in their intensities,but are different in their spatial patterns and seasonal cycles.The early nIOD,which develops in spring and peaks in summer,is one season earlier than the La Niña-related nIOD.The spatial pattern of the wind anomaly associated with early nIOD exhibits a winter monsoon-like pattern,with strong westerly anomalies in the equatorial Indian Ocean and eastly anomalies in the northern Indian Ocean.Opposite to the triggering mechanism of early positve IOD,the early nIOD is induced by delayed Indian summer monsoon onset.The results of this study are helpful for improving the prediction skill of IOD and its climate impacts. 展开更多
关键词 Indian Ocean Dipole(IOD) triggering mechanism Indian summer monsoon seasonal cycle negative IOD
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A study of pulsed high voltage driven hollow-cathode electron beam sources through synchronous optical trigger
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作者 霍卫杰 贺伟国 +2 位作者 韩罗峰 朱康武 王锋 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第5期82-90,共9页
In this study,a pulsed,high voltage driven hollow-cathode electron beam sources through an optical trigger is designed with characteristics of simple structure,low cost,and easy triggering.To validate the new design,t... In this study,a pulsed,high voltage driven hollow-cathode electron beam sources through an optical trigger is designed with characteristics of simple structure,low cost,and easy triggering.To validate the new design,the characteristics of hollow-cathode discharge and electron beam characterization under pulsed high voltage drive are studied experimentally and discussed by discharge characteristics and analyses of waveform details,respectively.The validation experiments indicate that the pulsed high voltage supply significantly improves the frequency and stability of the discharge,which provides a new solution for the realization of a high-frequency,high-energy electron beam source.The peak current amplitude in the high-energy electron beam increases from 6.2 A to 79.6 A,which indicates the pulsed power mode significantly improves the electron beam performance.Besides,increasing the capacitance significantly affects the highcurrent,lower-energy electron beam more than the high-energy electron beam. 展开更多
关键词 hollow-cathode nanosecond pulsed electron beam sources optical trigger pulsed high voltage supply beam current distribution
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Mechanisms to explain soil liquefaction triggering,development,and persistence during an earthquake
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作者 Fernando Teixeira 《Earthquake Science》 2024年第6期558-573,共16页
Mechanisms have been proposed to explain the triggering,development,and persistence of soil liquefaction.The mechanism explaining the horizontal failure plane(triggering)and its depth below the phreatic surface is gov... Mechanisms have been proposed to explain the triggering,development,and persistence of soil liquefaction.The mechanism explaining the horizontal failure plane(triggering)and its depth below the phreatic surface is governed by the flux properties and effective stress at that plane.At the failure plane,the pore water pressure was higher than the effective stress,and the volume change was the highest.The pore water pressure is a function of the soil profile features(particularly the phreatic zone width)and bedrock motion(horizontal acceleration).The volume change at the failure plane is a function of the intrinsic permeability of the soil and bedrock displacement.The failure plane was predicted to occur during the oscillation with the highest amplitude,disregarding further bedrock motion,which was consistent with low seismic energy densities.Two mechanisms were proposed to explain the persistence of soil liquefaction.The first is the existence of low-permeability layers in the depth range in which the failure planes are predicted to occur.The other allows for the persistence and development of soil liquefaction;it is consistent with homogeneous soils and requires water inflow from bedrock water springs.The latter explains many of the features of soil liquefaction observed during earthquakes,namely,surficial effects,“instant”liquefaction,and the occurrence of short-and long-term changes in the level of the phreatic surfaces.This model(hypothesis),the relationship between the flux characteristics and loss of soil shear strength,provides self-consistent constraints on the depth below the phreatic surfaces where the failure planes are observed(expected to occur).It requires further experimental and observational evidence.Similar reasoning can be used to explain other saturated soil phenomena. 展开更多
关键词 soil liquefaction triggering soil liquefaction persistence intrinsic soil permeability impervious soil layers bedrock water springs
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Dynamically triggered seismicity on a tectonic scale:A review
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作者 Chengzhi Qi Mingyang Wang +2 位作者 Gevorg Kocharyan Artem Kunitskikh Zefan Wang 《Deep Underground Science and Engineering》 2024年第1期1-24,共24页
Earthquakes triggered by dynamic disturbances have been confirmed by numerous observations and experiments.In the past several decades,earthquake triggering has attracted increasing attention of scholars in relation t... Earthquakes triggered by dynamic disturbances have been confirmed by numerous observations and experiments.In the past several decades,earthquake triggering has attracted increasing attention of scholars in relation to exploring the mechanism of earthquake triggering,earthquake prediction,and the desire to use the mechanism of earthquake triggering to reduce,prevent,or trigger earthquakes.Natural earthquakes and large‐scale explosions are the most common sources of dynamic disturbances that trigger earthquakes.In the past several decades,some models have been developed,including static,dynamic,quasi‐static,and other models.Some reviews have been published,but explosiontriggered seismicity was not included.In recent years,some new results on earthquake triggering have emerged.Therefore,this paper presents a new review to reflect the new results and include the content of explosion‐triggered earthquakes for the reference of scholars in this area.Instead of a complete review of the relevant literature,this paper primarily focuses on the main aspects of dynamic earthquake triggering on a tectonic scale and makes some suggestions on issues that need to be resolved in this area in the future. 展开更多
关键词 dynamic disturbances dynamic models problems for future research quasi‐static models static models triggered seismicity
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腹腔镜手术联合GnRH-a治疗子宫内膜异位症近期疗效及预后复发影响因素分析
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作者 袁婷婷 吴鹤立 +1 位作者 潘学景 卢秋阳 《四川生理科学杂志》 2024年第3期675-677,共3页
目的:分析腹腔镜手术联合促性腺激素释放激素类似物(Gonadotropin releasing hormone analogues,GnRH-a)治疗子宫内膜异位症(Endometriosis,EMS)近期疗效及预后复发情况.方法:回顾性收集2021年3月至2022年4月于本院就诊的EMS患者88例作... 目的:分析腹腔镜手术联合促性腺激素释放激素类似物(Gonadotropin releasing hormone analogues,GnRH-a)治疗子宫内膜异位症(Endometriosis,EMS)近期疗效及预后复发情况.方法:回顾性收集2021年3月至2022年4月于本院就诊的EMS患者88例作为研究对象.按照治疗方案的不同将患者分为对照组(腹腔镜手术治疗,42例)和观察组(腹腔镜手术+GnRH-a治疗,46例).对比两组近期疗效、预后复发率以及影响观察组预后的因素.结果:观察组临床疗效高于对照组,复发率低于对照组(P<0.05).观察组中,经二元Logistic回归分析结果显示,发病年龄、美国生育学会(American fertility society,AFS)的EMS分期、术前痛经史、术前孕次、术前产次、宫腔操作既往史是观察组复发率的影响因素(P<0.05).结论:腹腔镜手术联合GnRH-a治疗EMS近期疗效理想,但仍存在一定复发率,发病年龄、AFS的EMS分期、术前痛经史、术前孕次、术前产次、宫腔操作既往史是影响其复发的因素,临床及时对此给予针对性干预有利于预后改善. 展开更多
关键词 腹腔镜手术 gnrh-a EMS 近期疗效 预后复发
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黄体期添加GnRH-a在拮抗剂方案新鲜胚胎移植中的应用
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作者 郭磊 《医药前沿》 2024年第4期51-53,共3页
目的:探讨黄体期添加促性腺激素释放激素激动剂(GnRH-a)在拮抗剂方案新鲜胚胎移植中的应用效果及对妊娠结局的影响.方法:回顾性分析2021年1—12月在徐州市妇幼保健院接受体外受精胚胎移植术(IVF-ET)助孕的90例患者的临床资料,均采用拮... 目的:探讨黄体期添加促性腺激素释放激素激动剂(GnRH-a)在拮抗剂方案新鲜胚胎移植中的应用效果及对妊娠结局的影响.方法:回顾性分析2021年1—12月在徐州市妇幼保健院接受体外受精胚胎移植术(IVF-ET)助孕的90例患者的临床资料,均采用拮抗剂方案促排卵,根据其黄体期不同支持方案,分为常规组(n=45)与添加组(n=45).常规组在黄体期予以常规支持用药,添加组则在常规组基础上添加GnRH-a,比较两组的临床指标及妊娠结局.结果:添加组患者的种植率、生化妊娠率、临床妊娠率均高于常规组,差异有统计学意义(P<0.05).结论:在对采用拮抗剂方案促排卵的IVF-ET患者黄体期中添加GnRH-a,能够有效提高其胚胎种植率,获得较高的临床妊娠率,能够有效改善其新鲜胚胎移植的妊娠结局. 展开更多
关键词 新鲜胚胎移植 拮抗剂方案 黄体期 gnrh-a 妊娠结局
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腹腔镜双瓣法联合GnRH-a治疗子宫腺肌病的临床疗效分析
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作者 唐金芝 《中文科技期刊数据库(文摘版)医药卫生》 2024年第8期0018-0021,共4页
分析子宫腺肌病采取腹腔镜双瓣法联合GnRH-a进行治疗的临床疗效。方法 根据双盲原则随机收集以往两年来我院就诊的子宫腺肌病病患60例,对其进行分组,对照组采取保守治疗,研究组给予腹腔镜双瓣法联合GnRH-a治疗,比较两组病患的治疗效果... 分析子宫腺肌病采取腹腔镜双瓣法联合GnRH-a进行治疗的临床疗效。方法 根据双盲原则随机收集以往两年来我院就诊的子宫腺肌病病患60例,对其进行分组,对照组采取保守治疗,研究组给予腹腔镜双瓣法联合GnRH-a治疗,比较两组病患的治疗效果和临床治疗改善情况。结果 两组治疗效果对比存在显著统计学差异(P<0.05);研究组患者治疗后3个月、6个月、12个月的痛经得分、子宫体积及血清CA125明显优于对照组,对比具有统计学意义(P<0.05)。结论 临床中为子宫腺肌病患者提供腹腔镜双瓣法联合GnRH-a进行治疗效果确切,能够显著缓解痛经,帮助缩小子宫体积,具有推行价值。 展开更多
关键词 子宫腺肌病 腹腔镜双瓣法 gnrh-a 临床疗效 痛经 子宫体积
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GnRH-a降调节激素替代内膜准备方案在反复种植失败冻融胚胎移植周期中的应用 被引量:2
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作者 蔡婕 张燕茹 +2 位作者 孙亦婷 陈丽萍 周黎明 《现代实用医学》 2023年第9期1140-1142,共3页
目的比较GnRH-a降调节激素替代(GnRH-a-HRT)内膜准备方案和激素替代(HRT)内膜准备两种方案在反复种植失败(RIF)人群中对冻融胚胎移植周期及临床结局的影响。方法回顾性分析2021年1月至2022年6月在宁波市妇女儿童医院生殖医学中心行冻融... 目的比较GnRH-a降调节激素替代(GnRH-a-HRT)内膜准备方案和激素替代(HRT)内膜准备两种方案在反复种植失败(RIF)人群中对冻融胚胎移植周期及临床结局的影响。方法回顾性分析2021年1月至2022年6月在宁波市妇女儿童医院生殖医学中心行冻融胚胎移植的RIF患者194例,分为GnRH-a-HRT内膜准备和单纯HRT内膜准备两组,分析比较两组一般临床资料、移植、实验室资料和妊娠结局。结果两组年龄、不孕年限、不孕病因及移植次数差异均无统计学意义(均P>0.05)。GnRH-a-HRT组移植日内膜(10.21±2.42)mm,高于HRT组的(8.86±1.54)mm(P<0.05);两组促排卵方案、胚胎移植数目、移植胚胎囊胚比例、优质胚胎率差异均无统计学意义(均P>0.05)。GnRH-a-HRT组临床妊娠率(56.82%)和活产率(40.91%)较HRT组(44.67%和34.00%)有轻微提高,胚胎着床率(39.51%vs 40.91%)和流产率(24.00%vs 20.90%)接近,两组差异均无统计学意义(均P>0.05)。结论GnRH-a-HRT方案在RIF人群冻融胚胎移植周期与单纯HRT内膜准备方案相比,移植日内膜厚度明显增加,但临床妊娠率和活产率相似,GnRH-a-HRT可作为RIF患者冻融胚胎移植周期内膜准备的一个选择。 展开更多
关键词 冻融胚胎移植 长效gnrh-a 激素替代周期 妊娠率 活产率
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探讨腹腔镜手术与GnRH-a联合应用在子宫内膜异位症患者中对其术后恢复效果的影响分析
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作者 张磊 张清华 《中国科技期刊数据库 医药》 2023年第11期17-20,共4页
研究子宫内膜异位症患者在腹腔镜手术联合促性腺激素释放激素激动剂治疗后的恢复情况。方法 本文选取了我院2016年2月至2022年12月90例子宫内膜异位症患者,随机分成两组:对照组接受腹腔镜手术,观察组根据对照组接受GnRH-a治疗。记录并... 研究子宫内膜异位症患者在腹腔镜手术联合促性腺激素释放激素激动剂治疗后的恢复情况。方法 本文选取了我院2016年2月至2022年12月90例子宫内膜异位症患者,随机分成两组:对照组接受腹腔镜手术,观察组根据对照组接受GnRH-a治疗。记录并评价疾病复发率(痛经、月经异常、盆腔疼痛)、自然妊娠率、卵巢功能指标。结果 出院6个月后,观察组疾病复发率和妊娠率均显著低于对照组(P<0.05)。根据FSH/E2检查结果的比较,干预前(P>0.05),干预后观察组的FSH(150.80±50.38)U/L显著高于对照组,E2(32.98±14.25)nmol/L显著低于对照组(p<0.05),观察组LXA4水平为(562.81±43.92)ng/L,对照组为(309.92±27.82)ng/L。同时,观察组MMP-9和ALDI水平明显低于对照组,具有统计学意义(P<0.05)。结论 应用GnRH-a联合干预对子宫内膜异位症腹腔镜手术治疗的患者的治疗疗效良好,可明显改善患者的卵巢功能,值得推广。 展开更多
关键词 腹腔镜手术 gnrh-a 子宫内膜异位症 恢复效果 卵巢功能
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GnRH-Agonist Trigger versus Human Chorionic Gonadotrophin (HCG) Trigger in Cases of Controlled Ovarian Stimulation;Randomized Controlled Trial 被引量:2
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作者 Mohamed Elmahdy Suzan Elsharkawy 《Open Journal of Obstetrics and Gynecology》 2021年第11期1452-1460,共9页
Objectives: The aim of the study was to compare the efficacy and safety of GnRH-agonist to the human chorionic gonadotrophin (HCG) trigger in cases of simple ovarian stimulation.</span></span><span>&... Objectives: The aim of the study was to compare the efficacy and safety of GnRH-agonist to the human chorionic gonadotrophin (HCG) trigger in cases of simple ovarian stimulation.</span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Study design: Randomized controlled trial was conducted on 291 women complaining of unexplained infertility visiting Elshatby Maternity University Hospital from February to December 2019. Trial registration unique ID</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> is</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> PACTR202001787868341 (</span></span></span><a href="https://www.pactr.org/"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">https://www.pactr.org/</span></span></span></a><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">). Age included from 20</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">- 43 years. All patients were stimulated by the sequential stimulation protocol using letrozole then FSH injection, when the criteria of ovulation trigger were reached</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">;</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> cases were randomized into two groups using closed envelopes method</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Group A (123 cases) GnRh agonist (triptorelin 0.2 IU) subcutaneous injection and Group B (168 cases) HCG 10,000 IU intramuscular injection w</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ere</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> used for triggering of ovulation then followed by timed intercourse.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Results: Primary outcome was the clinical pregnancy rate while rate of miscarriage and ovarian hyper-stimulation rate were the secondary outcome. Clinical pregnancy rates, in Group A w</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ere</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> (21.1%) while it was (31.5%) in another group (P</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">=</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.049). Miscarriage rate was (4.9%) in the first group and (3.6%) in the second group (P</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">=</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.580). Except for one case of moderate ovarian hyper-stimulation syndrome (OHSS) complicated the HCG group, there were no such cases in GnRH group.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Conclusion: Triggering final oocyte maturation with HCG was superior to GnRH agonists triggers as regards the clinical pregnancy rate. 展开更多
关键词 GnRH Agonist HCG Ovulation trigger OHSS
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Resilient Event-Triggered Model Predictive Control for Adaptive Cruise Control Under Sensor Attacks 被引量:1
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作者 Zhijian Hu Rong Su +2 位作者 Kai Zhang Zeyuan Xu Renjie Ma 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第3期807-809,共3页
Dear Editor,This letter addresses the resilient model predictive control(MPC)problems for adaptive cruise control(ACC)systems under sensor attacks.In the light of vulnerabilities of ACC systems to sensor attacks,an in... Dear Editor,This letter addresses the resilient model predictive control(MPC)problems for adaptive cruise control(ACC)systems under sensor attacks.In the light of vulnerabilities of ACC systems to sensor attacks,an intrusion detection mechanism is proposed at the controller side to distinguish abnormal data.Then,the robust control gains are derived to design the terminal region constraint for MPC. 展开更多
关键词 trigger EVENT CONSTRAINT
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卵巢子宫内膜异位囊肿术后复发患者临床特征及GnRH-a联合腹腔镜手术疗效 被引量:4
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作者 周芮 骆丽娜 李雪岩 《中国计划生育学杂志》 2023年第3期636-640,645,共6页
目的:分析影响卵巢子宫内膜异位囊肿(OMA)患者术后复发的临床特征及促性腺激素释放激素激动剂(GnRH-a)联合腹腔镜治疗效果。方法:选取2019年5月-2021年5月在本院及富阳区中医院接受腹腔镜治疗的OMA患者104例,其中术后复发24例纳入复发组... 目的:分析影响卵巢子宫内膜异位囊肿(OMA)患者术后复发的临床特征及促性腺激素释放激素激动剂(GnRH-a)联合腹腔镜治疗效果。方法:选取2019年5月-2021年5月在本院及富阳区中医院接受腹腔镜治疗的OMA患者104例,其中术后复发24例纳入复发组,未复发80例纳入对照组,观察两组临床特征,分析影响OMA术后复发的相关因素;根据治疗方法将OMA术后复发患者分为腹腔镜组(腹腔镜囊肿剔除术)与联合组(腹腔镜囊肿剔除术联合GnRH-a)各12例,对比两组治疗前后性激素、月经情况及临床疗效。结果:经logistic回归模型分析显示,囊壁侧为双侧、r-AFS分期Ⅲ~Ⅳ期及囊壁厚度较厚是OMA患者术后复发的独立危险因素(P<0.05);治疗后腹腔镜组和联合组雌二醇、卵泡刺激素及黄体生成素水平均下降,但联合组改善程度优于腹腔镜组;联合组经期疼痛程度评分(3.2±0.9分)低于腹腔镜组(5.3±1.3分),临床总有效率(100.0%)高于腹腔镜组(66.7%)(均P<0.05)。结论:囊壁侧别、R-AFS分期及囊壁厚度均影响OMA腹腔镜术后复发,而腹腔镜术后联合GnRH-a治疗能改善患者性激素水平及经期疼痛,提高临床疗效。 展开更多
关键词 卵巢子宫内膜异位囊肿 复发 腹腔镜手术 gnrh-a 临床疗效 影响因素
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A review of tidal triggering of global earthquakes 被引量:1
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作者 Ruyu Yan Xiaodong Chen +2 位作者 Heping Sun Jianqiao Xu Jiangcun Zhou 《Geodesy and Geodynamics》 CSCD 2023年第1期35-42,共8页
Earthquake prediction remains a challenging and difficult task for scientists all over the world.The tidal triggering of earthquakes is being proven by an increasing number of investigations,most of which have shown t... Earthquake prediction remains a challenging and difficult task for scientists all over the world.The tidal triggering of earthquakes is being proven by an increasing number of investigations,most of which have shown that earthquakes are positively correlated with tides,and thus,tides provide a potential tool for earthquake prediction,especially for imminent earthquakes.In this study,publications concerning the tidal triggering of earthquakes were compiled and analyzed with regard to global earthquakes,which were classified into three main types:tectonic,volcanic,and slow earthquakes.The results reveal a high correlation between tectonic earthquakes and tides(mainly for semidiurnal and diurnal tides;14-day tides) before and after the occurrence of significant earthquakes.For volcanic earthquakes,observations of volcanoes on the seafloor and land indicate that volcanic earthquakes in near-shore volcanic areas and mid-ocean ridges have a strong correlation with tidal forces,mostly those with semidiurnal and diurnal periods.For slow earthquakes,the periodicity of the tremor duration is highly correlated with semidiurnal and diurnal tides.In conclusion,the tidal triggering of these three types of earthquakes makes a positive contribution to earthquake preparation and understanding the triggering mechanism,and thus,the prediction of these types of earthquakes should be investigated.However,there are still several inadequacies on this topic that need to be resolved to gain a definitiveanswer regarding the tidal triggering of all earthquakes.The main inadequacies are discussed in this paper from our point of view. 展开更多
关键词 Tidal triggering Tectonic earthquakes Volcanic earthquakes Slow earthquakes Earthquake prediction
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