Gnidimacrin, a diterpene compound, isolated from the methanol extract of Stellera, chamaejasme L., showed significant antitumor activities against mouse leukemia P-388 and L-1210 in vivo, such as Lewis lung carcinoma,...Gnidimacrin, a diterpene compound, isolated from the methanol extract of Stellera, chamaejasme L., showed significant antitumor activities against mouse leukemia P-388 and L-1210 in vivo, such as Lewis lung carcinoma, B-16 melanoma and Colon cancer 26. It showed ILSs of 40%.49% and 41% at the dosages of 0.01-0.02 mg/kg ip,respectively. Gnidimacrin strongly inhibited cell Proliferation of human cancer cell lines such as leukemia K562, stomach cancers Kato-III, MKN-28, MKN-45, and mouse leukemia L-1210 by the MTT assay and colony forming assay in vitro. The IC50 of gnidimacrin was 0.007-0.00012 μg/ml. It is concluded that gnidimacrin is the principal antitumor element in Stellera chemaejasme L. with strong antitumor activities.展开更多
Methanol extract of Stellera chamaejasme L wasassessed for antitumor activity by an antitumor activebioassay against murine leukemia P388 in vivo. Thebioassay-directed separation of the extract furnishedseven diterpen...Methanol extract of Stellera chamaejasme L wasassessed for antitumor activity by an antitumor activebioassay against murine leukemia P388 in vivo. Thebioassay-directed separation of the extract furnishedseven diterpene compounds (stellerarin, stelleramacrin,gnidimacrin, pimelea factor P2, subtoxin, huratoxin,simplexin ) and two biflavanone compounds (neochemae-jasmin A and B). Among them, gnidimacrin, stellerarinand stelleramacrin (a novel compound) were found tohave high antitumor and cytotoxic activities against P388,L1210 and K562 in vivo and in vitro. The results suggestedthat the diterpene compounds were the potent anti-tumor principles of Stellera chamaejame L展开更多
文摘Gnidimacrin, a diterpene compound, isolated from the methanol extract of Stellera, chamaejasme L., showed significant antitumor activities against mouse leukemia P-388 and L-1210 in vivo, such as Lewis lung carcinoma, B-16 melanoma and Colon cancer 26. It showed ILSs of 40%.49% and 41% at the dosages of 0.01-0.02 mg/kg ip,respectively. Gnidimacrin strongly inhibited cell Proliferation of human cancer cell lines such as leukemia K562, stomach cancers Kato-III, MKN-28, MKN-45, and mouse leukemia L-1210 by the MTT assay and colony forming assay in vitro. The IC50 of gnidimacrin was 0.007-0.00012 μg/ml. It is concluded that gnidimacrin is the principal antitumor element in Stellera chemaejasme L. with strong antitumor activities.
文摘Methanol extract of Stellera chamaejasme L wasassessed for antitumor activity by an antitumor activebioassay against murine leukemia P388 in vivo. Thebioassay-directed separation of the extract furnishedseven diterpene compounds (stellerarin, stelleramacrin,gnidimacrin, pimelea factor P2, subtoxin, huratoxin,simplexin ) and two biflavanone compounds (neochemae-jasmin A and B). Among them, gnidimacrin, stellerarinand stelleramacrin (a novel compound) were found tohave high antitumor and cytotoxic activities against P388,L1210 and K562 in vivo and in vitro. The results suggestedthat the diterpene compounds were the potent anti-tumor principles of Stellera chamaejame L
