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蒲金口服液对宫内感染/炎症致早产脑损伤大鼠脑组织OL、OPC细胞凋亡和Nogo-A、OMgp表达的影响
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作者 陈恬恬 谢克功 +2 位作者 马丙祥 张晰 张建奎 《辽宁中医杂志》 CAS 北大核心 2024年第2期193-198,I0006,F0003,共8页
目的探讨蒲金口服液对宫内感染/炎症致早产脑损伤大鼠神经保护作用的机制。方法将80只胎龄<22 d的早产仔鼠随机分为8组(每组10只):早期药物干预组(蒲金口服液高剂量组、蒲金口服液低剂量组、银杏叶提取物组、模型组)和晚期药物干预... 目的探讨蒲金口服液对宫内感染/炎症致早产脑损伤大鼠神经保护作用的机制。方法将80只胎龄<22 d的早产仔鼠随机分为8组(每组10只):早期药物干预组(蒲金口服液高剂量组、蒲金口服液低剂量组、银杏叶提取物组、模型组)和晚期药物干预组。生后21 d龄进行神经行为学检测,并采用qRT-PCR和Western blot方法检测勿动蛋白-A(Nogo-A)和少突胶质细胞髓磷脂糖蛋白(OMgp)的表达,TUNEL法和A2B5、CNPase双标免疫荧光染色法检测少突胶质细胞(OL)、前体细胞(OPC)凋亡情况。结果LPS组早产仔鼠脑组织Nogo-A和OMgpmRNA和蛋白的表达均明显高于正常对照组(P<0.05),蒲金口服液高剂量、低剂量和银杏叶提取物干预组大鼠的神经行为学评分均优于模型组(P<0.05),且早期干预组高于晚期干预组(P<0.05)。蒲金口服液高剂量、低剂量和银杏叶提取物均能降低早产脑损伤大鼠脑组织Nogo-A、OMgp mRNA和蛋白的表达,减少OL和OPC的凋亡(P<0.05),其中蒲金口服液高剂量早期干预效果更显著(P<0.05)。结论蒲金口服液可以改善早产脑损伤大鼠的神经行为学表现,减少脑组织Nogo-A、OMgp的表达和OL、OPC的凋亡,具有神经保护的作用。 展开更多
关键词 宫内感染 早产儿脑损伤 蒲金口服液 nogo-A OMgp OL OPC
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Nogo-A在神经系统疾病中的研究进展
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作者 曲姜昆 姜俊杰 《数理医药学杂志》 CAS 2024年第3期222-227,共6页
神经生长抑制因子A(neurite outgrowth inhibitor A,Nogo-A)在哺乳动物中是一种能够抑制轴突生长的蛋白质。研究发现Nogo-A在神经系统中对轴突生长和突触可塑性起到调节作用,并与阿尔兹海默症、肌萎缩性侧索硬化症、多发性硬化症、脊髓... 神经生长抑制因子A(neurite outgrowth inhibitor A,Nogo-A)在哺乳动物中是一种能够抑制轴突生长的蛋白质。研究发现Nogo-A在神经系统中对轴突生长和突触可塑性起到调节作用,并与阿尔兹海默症、肌萎缩性侧索硬化症、多发性硬化症、脊髓损伤等密切相关。本文综述了Nogo-A及其受体NgR的基本结构、功能以及在神经系统疾病等方面的研究进展。 展开更多
关键词 nogo-A 神经系统疾病 神经退行性病变 脊髓损伤
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Nogo-A蛋白及调控轴突再生作用研究进展
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作者 孟瑶 王颖 《神经损伤与功能重建》 2024年第3期151-156,共6页
中枢神经系统损伤产生的抑制性微环境是神经再生困难的重要原因,其中Nogo-A蛋白是抑制轴突再生的关键因子,其结构域以片段形式通过不同途径释放到细胞外,与受体NgR1、PirB、S1PR2或HSPG相结合,激活多种信号通路调控细胞凋亡、运动以及... 中枢神经系统损伤产生的抑制性微环境是神经再生困难的重要原因,其中Nogo-A蛋白是抑制轴突再生的关键因子,其结构域以片段形式通过不同途径释放到细胞外,与受体NgR1、PirB、S1PR2或HSPG相结合,激活多种信号通路调控细胞凋亡、运动以及细胞骨架蛋白聚合,引起细胞骨架解聚、生长锥塌陷,抑制神经元轴突生长。本文对Nogo-A蛋白的结构、受体和抑制轴突再生作用机制的研究进展进行综述。 展开更多
关键词 nogo-A蛋白 受体 信号通路 轴突再生
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Nogo-B敲除NAFLD小鼠的肠道微生物群和血清代谢组学变化研究
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作者 董旭 郑从洋 +1 位作者 柏兆方 高利利 《解放军医学院学报》 CAS 2024年第6期697-704,F0003,共9页
背景非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是目前全球范围内最常见的慢性肝病,Nogo-B作为其潜在治疗靶点,需确定是否会对肠道微生物群及代谢途径产生影响。目的探讨Nogo-B敲除对NAFLD的保护作用,明确Nogo-B敲除... 背景非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是目前全球范围内最常见的慢性肝病,Nogo-B作为其潜在治疗靶点,需确定是否会对肠道微生物群及代谢途径产生影响。目的探讨Nogo-B敲除对NAFLD的保护作用,明确Nogo-B敲除对NAFLD小鼠肠道微生物群和血清代谢产物的影响。方法12只8周龄野生型小鼠随机分为野生正常饮食组(WT-NCD组)和野生高脂饮食组(WT-HFD组)。12只8周龄Nogo-B敲除(Nogo-B^(-/-))小鼠随机分为Nogo-B敲除正常饮食组(Nogo-B^(-/-)-NCD组)和Nogo-B敲除高脂饮食组(Nogo-B^(-/-)-HFD组)。WT-HFD组和Nogo-B^(-/-)-HFD组小鼠通过喂食12周60 kal%的高脂饮食构建NAFLD小鼠模型,WT-NCD组和Nogo-B^(-/-)-NCD组小鼠则同时喂食正常饮食。4组小鼠均测量体质量;酶联免疫吸附测定检测4组小鼠的肝三酰甘油(triglyceride,TG)和总胆固醇(total cholesterol,TC)水平;苏木精-伊红染色评估4组小鼠的肝病理学特征;对WT-HFD组和Nogo-B^(-/-)-HFD组小鼠进行肠道微生物群和血清代谢物检测。结果12周造模结束后,与WT-NCD组小鼠相比,WT-HFD组小鼠的体质量及肝组织中TC、TG水平升高(P<0.01);与Nogo-B^(-/-)-NCD组小鼠相比,Nogo-B^(-/-)-HFD组小鼠的体质量及肝组织中TC、TG水平升高(P<0.01);而当Nogo-B敲除后,与WT-HFD组小鼠相比,Nogo-B^(-/-)-HFD组小鼠的体质量及肝组织中TC、TG水平下降(P<0.01);肠道微生物组学显示Nogo-B敲除后丁酸球菌科成为其肠道微生物中的优势物种;血清代谢组学显示两组间(WT-HFD组、Nogo-B^(-/-)-HFD组)筛选到差异代谢物159种(上调79,下调80种),极其显著富集(P<0.001)的代谢通路为柠檬酸循环/三羧酸循环(tricarboxylic acid cycle,TCA cycle)等,主要富集到的代谢物为柠檬酸、琥珀酸、异柠檬酸盐和苹果酸。结论Nogo-B敲除后的NAFLD小鼠肝脂质积累情况减轻,肠道有益微生物群增加,一定程度上改善代谢紊乱。Nogo-B可能是NAFLD治疗的潜在靶点。 展开更多
关键词 非酒精性脂肪性肝病 高脂饮食 nogo-B 肠道微生物群 代谢组学
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Dynamic Offloading and Scheduling Strategy for Telematics Tasks Based on Latency Minimization
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作者 Yu Zhou Yun Zhang +4 位作者 Guowei Li Hang Yang Wei Zhang Ting Lyu Yueqiang Xu 《Computers, Materials & Continua》 SCIE EI 2024年第8期1809-1829,共21页
In current research on task offloading and resource scheduling in vehicular networks,vehicles are commonly assumed to maintain constant speed or relatively stationary states,and the impact of speed variations on task ... In current research on task offloading and resource scheduling in vehicular networks,vehicles are commonly assumed to maintain constant speed or relatively stationary states,and the impact of speed variations on task offloading is often overlooked.It is frequently assumed that vehicles can be accurately modeled during actual motion processes.However,in vehicular dynamic environments,both the tasks generated by the vehicles and the vehicles’surroundings are constantly changing,making it difficult to achieve real-time modeling for actual dynamic vehicular network scenarios.Taking into account the actual dynamic vehicular scenarios,this paper considers the real-time non-uniform movement of vehicles and proposes a vehicular task dynamic offloading and scheduling algorithm for single-task multi-vehicle vehicular network scenarios,attempting to solve the dynamic decision-making problem in task offloading process.The optimization objective is to minimize the average task completion time,which is formulated as a multi-constrained non-linear programming problem.Due to the mobility of vehicles,a constraint model is applied in the decision-making process to dynamically determine whether the communication range is sufficient for task offloading and transmission.Finally,the proposed vehicular task dynamic offloading and scheduling algorithm based on muti-agent deep deterministic policy gradient(MADDPG)is applied to solve the optimal solution of the optimization problem.Simulation results show that the algorithm proposed in this paper is able to achieve lower latency task computation offloading.Meanwhile,the average task completion time of the proposed algorithm in this paper can be improved by 7.6%compared to the performance of the MADDPG scheme and 51.1%compared to the performance of deep deterministic policy gradient(DDPG). 展开更多
关键词 Component vehicular DYNAMIC task offloading resource scheduling
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Joint Task Allocation and Resource Optimization for Blockchain Enabled Collaborative Edge Computing
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作者 Xu Wenjing Wang Wei +2 位作者 Li Zuguang Wu Qihui Wang Xianbin 《China Communications》 SCIE CSCD 2024年第4期218-229,共12页
Collaborative edge computing is a promising direction to handle the computation intensive tasks in B5G wireless networks.However,edge computing servers(ECSs)from different operators may not trust each other,and thus t... Collaborative edge computing is a promising direction to handle the computation intensive tasks in B5G wireless networks.However,edge computing servers(ECSs)from different operators may not trust each other,and thus the incentives for collaboration cannot be guaranteed.In this paper,we propose a consortium blockchain enabled collaborative edge computing framework,where users can offload computing tasks to ECSs from different operators.To minimize the total delay of users,we formulate a joint task offloading and resource optimization problem,under the constraint of the computing capability of each ECS.We apply the Tammer decomposition method and heuristic optimization algorithms to obtain the optimal solution.Finally,we propose a reputation based node selection approach to facilitate the consensus process,and also consider a completion time based primary node selection to avoid monopolization of certain edge node and enhance the security of the blockchain.Simulation results validate the effectiveness of the proposed algorithm,and the total delay can be reduced by up to 40%compared with the non-cooperative case. 展开更多
关键词 blockchain collaborative edge computing resource optimization task allocation
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Task Offloading and Resource Allocation in NOMA-VEC:A Multi-Agent Deep Graph Reinforcement Learning Algorithm
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作者 Hu Yonghui Jin Zuodong +1 位作者 Qi Peng Tao Dan 《China Communications》 SCIE CSCD 2024年第8期79-88,共10页
Vehicular edge computing(VEC)is emerging as a promising solution paradigm to meet the requirements of compute-intensive applications in internet of vehicle(IoV).Non-orthogonal multiple access(NOMA)has advantages in im... Vehicular edge computing(VEC)is emerging as a promising solution paradigm to meet the requirements of compute-intensive applications in internet of vehicle(IoV).Non-orthogonal multiple access(NOMA)has advantages in improving spectrum efficiency and dealing with bandwidth scarcity and cost.It is an encouraging progress combining VEC and NOMA.In this paper,we jointly optimize task offloading decision and resource allocation to maximize the service utility of the NOMA-VEC system.To solve the optimization problem,we propose a multiagent deep graph reinforcement learning algorithm.The algorithm extracts the topological features and relationship information between agents from the system state as observations,outputs task offloading decision and resource allocation simultaneously with local policy network,which is updated by a local learner.Simulation results demonstrate that the proposed method achieves a 1.52%∼5.80%improvement compared with the benchmark algorithms in system service utility. 展开更多
关键词 edge computing graph convolutional network reinforcement learning task offloading
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Task Offloading in Edge Computing Using GNNs and DQN
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作者 Asier Garmendia-Orbegozo Jose David Nunez-Gonzalez Miguel Angel Anton 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期2649-2671,共23页
In a network environment composed of different types of computing centers that can be divided into different layers(clod,edge layer,and others),the interconnection between them offers the possibility of peer-to-peer t... In a network environment composed of different types of computing centers that can be divided into different layers(clod,edge layer,and others),the interconnection between them offers the possibility of peer-to-peer task offloading.For many resource-constrained devices,the computation of many types of tasks is not feasible because they cannot support such computations as they do not have enough available memory and processing capacity.In this scenario,it is worth considering transferring these tasks to resource-rich platforms,such as Edge Data Centers or remote cloud servers.For different reasons,it is more exciting and appropriate to download various tasks to specific download destinations depending on the properties and state of the environment and the nature of the functions.At the same time,establishing an optimal offloading policy,which ensures that all tasks are executed within the required latency and avoids excessive workload on specific computing centers is not easy.This study presents two alternatives to solve the offloading decision paradigm by introducing two well-known algorithms,Graph Neural Networks(GNN)and Deep Q-Network(DQN).It applies the alternatives on a well-known Edge Computing simulator called PureEdgeSimand compares them with the two defaultmethods,Trade-Off and Round Robin.Experiments showed that variants offer a slight improvement in task success rate and workload distribution.In terms of energy efficiency,they provided similar results.Finally,the success rates of different computing centers are tested,and the lack of capacity of remote cloud servers to respond to applications in real-time is demonstrated.These novel ways of finding a download strategy in a local networking environment are unique as they emulate the state and structure of the environment innovatively,considering the quality of its connections and constant updates.The download score defined in this research is a crucial feature for determining the quality of a download path in the GNN training process and has not previously been proposed.Simultaneously,the suitability of Reinforcement Learning(RL)techniques is demonstrated due to the dynamism of the network environment,considering all the key factors that affect the decision to offload a given task,including the actual state of all devices. 展开更多
关键词 Edge computing edge offloading fog computing task offloading
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Mobile Crowdsourcing Task Allocation Based on Dynamic Self-Attention GANs
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作者 Kai Wei Song Yu Qingxian Pan 《Computers, Materials & Continua》 SCIE EI 2024年第4期607-622,共16页
Crowdsourcing technology is widely recognized for its effectiveness in task scheduling and resource allocation.While traditional methods for task allocation can help reduce costs and improve efficiency,they may encoun... Crowdsourcing technology is widely recognized for its effectiveness in task scheduling and resource allocation.While traditional methods for task allocation can help reduce costs and improve efficiency,they may encounter challenges when dealing with abnormal data flow nodes,leading to decreased allocation accuracy and efficiency.To address these issues,this study proposes a novel two-part invalid detection task allocation framework.In the first step,an anomaly detection model is developed using a dynamic self-attentive GAN to identify anomalous data.Compared to the baseline method,the model achieves an approximately 4%increase in the F1 value on the public dataset.In the second step of the framework,task allocation modeling is performed using a twopart graph matching method.This phase introduces a P-queue KM algorithm that implements a more efficient optimization strategy.The allocation efficiency is improved by approximately 23.83%compared to the baseline method.Empirical results confirm the effectiveness of the proposed framework in detecting abnormal data nodes,enhancing allocation precision,and achieving efficient allocation. 展开更多
关键词 Mobile crowdsourcing task allocation anomaly detection GAN attention mechanisms
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Heterogeneous Task Allocation Model and Algorithm for Intelligent Connected Vehicles
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作者 Neng Wan Guangping Zeng Xianwei Zhou 《Computers, Materials & Continua》 SCIE EI 2024年第9期4281-4302,共22页
With the development of vehicles towards intelligence and connectivity,vehicular data is diversifying and growing dramatically.A task allocation model and algorithm for heterogeneous Intelligent Connected Vehicle(ICV)... With the development of vehicles towards intelligence and connectivity,vehicular data is diversifying and growing dramatically.A task allocation model and algorithm for heterogeneous Intelligent Connected Vehicle(ICV)applications are proposed for the dispersed computing network composed of heterogeneous task vehicles and Network Computing Points(NCPs).Considering the amount of task data and the idle resources of NCPs,a computing resource scheduling model for NCPs is established.Taking the heterogeneous task execution delay threshold as a constraint,the optimization problem is described as the problem of maximizing the utilization of computing resources by NCPs.The proposed problem is proven to be NP-hard by using the method of reduction to a 0-1 knapsack problem.A many-to-many matching algorithm based on resource preferences is proposed.The algorithm first establishes the mutual preference lists based on the adaptability of the task requirements and the resources provided by NCPs.This enables the filtering out of un-schedulable NCPs in the initial stage of matching,reducing the solution space dimension.To solve the matching problem between ICVs and NCPs,a new manyto-many matching algorithm is proposed to obtain a unique and stable optimal matching result.The simulation results demonstrate that the proposed scheme can improve the resource utilization of NCPs by an average of 9.6%compared to the reference scheme,and the total performance can be improved by up to 15.9%. 展开更多
关键词 task allocation intelligent connected vehicles dispersed computing matching algorithm
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Prevalence and Tasks Associated with Respiratory Symptoms among Waste Electrical and Electronic Equipment Handlers in Ouagadougou, Burkina Faso in 2019
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作者 Marthe Sandrine Sanon Lompo Sombenewindé Bienvenu Alexandre Nikiéma +3 位作者 Issa Traoré Marius Kédoté Jules Owona Manga Nicolas Méda 《Occupational Diseases and Environmental Medicine》 2024年第3期199-210,共12页
Introduction: The uncontrolled management of waste electrical and electronic equipment (W3E) causes respiratory problems in the handlers of this waste. The objective was to study the stains associated with respiratory... Introduction: The uncontrolled management of waste electrical and electronic equipment (W3E) causes respiratory problems in the handlers of this waste. The objective was to study the stains associated with respiratory symptoms in W3E handlers. Methods: The study was cross-sectional with an analytical focus on W3E handlers in the informal sector in Ouagadougou. A peer-validated questionnaire collected data on a sample of 161 manipulators. Results: the most common W3E processing tasks were the purchase or sale of W3E (67.70%), its repair (39.75%) and its collection (31.06%). The prevalence of cough was 21.74%, that of wheezing 14.91%, phlegm 12.50% and dyspnea at rest 10.56%. In bivariate analysis, there were significant associations at the 5% level between W3E repair and phlegm (p-value = 0.044), between W3E burning and wheezing (p-value = 0.011) and between W3E and cough (p-value = 0.01). The final logistic regression models suggested that the burning of W3E and the melting of lead batteries represented risk factors for the occurrence of cough with respective prevalence ratios of 4.57 and 4.63. Conclusion: raising awareness on the wearing of personal protective equipment, in particular masks adapted by W3E handlers, favoring those who are dedicated to the burning of electronic waste and the melting of lead could make it possible to reduce the risk of occurrence of respiratory symptoms. 展开更多
关键词 Respiratory Symptoms W3E Associated tasks OUAGADOUGOU
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MADDPG-D2: An Intelligent Dynamic Task Allocation Algorithm Based on Multi-Agent Architecture Driven by Prior Knowledge
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作者 Tengda Li Gang Wang Qiang Fu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第9期2559-2586,共28页
Aiming at the problems of low solution accuracy and high decision pressure when facing large-scale dynamic task allocation(DTA)and high-dimensional decision space with single agent,this paper combines the deep reinfor... Aiming at the problems of low solution accuracy and high decision pressure when facing large-scale dynamic task allocation(DTA)and high-dimensional decision space with single agent,this paper combines the deep reinforce-ment learning(DRL)theory and an improved Multi-Agent Deep Deterministic Policy Gradient(MADDPG-D2)algorithm with a dual experience replay pool and a dual noise based on multi-agent architecture is proposed to improve the efficiency of DTA.The algorithm is based on the traditional Multi-Agent Deep Deterministic Policy Gradient(MADDPG)algorithm,and considers the introduction of a double noise mechanism to increase the action exploration space in the early stage of the algorithm,and the introduction of a double experience pool to improve the data utilization rate;at the same time,in order to accelerate the training speed and efficiency of the agents,and to solve the cold-start problem of the training,the a priori knowledge technology is applied to the training of the algorithm.Finally,the MADDPG-D2 algorithm is compared and analyzed based on the digital battlefield of ground and air confrontation.The experimental results show that the agents trained by the MADDPG-D2 algorithm have higher win rates and average rewards,can utilize the resources more reasonably,and better solve the problem of the traditional single agent algorithms facing the difficulty of solving the problem in the high-dimensional decision space.The MADDPG-D2 algorithm based on multi-agent architecture proposed in this paper has certain superiority and rationality in DTA. 展开更多
关键词 Deep reinforcement learning dynamic task allocation intelligent decision-making multi-agent system MADDPG-D2 algorithm
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Effects of pooling,specialization,and discretionary task completion on queueing performance
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作者 JIANG Houyuan 《运筹学学报(中英文)》 CSCD 北大核心 2024年第3期81-96,共16页
Pooling,unpooling/specialization,and discretionary task completion are typical operational strategies in queueing systems that arise in healthcare,call centers,and online sales.These strategies may have advantages and... Pooling,unpooling/specialization,and discretionary task completion are typical operational strategies in queueing systems that arise in healthcare,call centers,and online sales.These strategies may have advantages and disadvantages in different operational environments.This paper uses the M/M/1 and M/M/2 queues to study the impact of pooling,specialization,and discretionary task completion on the average queue length.Closed-form solutions for the average M/M/2 queue length are derived.Computational examples illustrate how the average queue length changes with the strength of pooling,specialization,and discretionary task completion.Finally,several conjectures are made in the paper. 展开更多
关键词 queuing systems pooling SPECIALIZATION discretionary task completion average queue length
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Generating Factual Text via Entailment Recognition Task
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作者 Jinqiao Dai Pengsen Cheng Jiayong Liu 《Computers, Materials & Continua》 SCIE EI 2024年第7期547-565,共19页
Generating diverse and factual text is challenging and is receiving increasing attention.By sampling from the latent space,variational autoencoder-based models have recently enhanced the diversity of generated text.Ho... Generating diverse and factual text is challenging and is receiving increasing attention.By sampling from the latent space,variational autoencoder-based models have recently enhanced the diversity of generated text.However,existing research predominantly depends on summarizationmodels to offer paragraph-level semantic information for enhancing factual correctness.The challenge lies in effectively generating factual text using sentence-level variational autoencoder-based models.In this paper,a novel model called fact-aware conditional variational autoencoder is proposed to balance the factual correctness and diversity of generated text.Specifically,our model encodes the input sentences and uses them as facts to build a conditional variational autoencoder network.By training a conditional variational autoencoder network,the model is enabled to generate text based on input facts.Building upon this foundation,the input text is passed to the discriminator along with the generated text.By employing adversarial training,the model is encouraged to generate text that is indistinguishable to the discriminator,thereby enhancing the quality of the generated text.To further improve the factual correctness,inspired by the natural language inference system,the entailment recognition task is introduced to be trained together with the discriminator via multi-task learning.Moreover,based on the entailment recognition results,a penalty term is further proposed to reconstruct the loss of our model,forcing the generator to generate text consistent with the facts.Experimental results demonstrate that compared with competitivemodels,ourmodel has achieved substantial improvements in both the quality and factual correctness of the text,despite only sacrificing a small amount of diversity.Furthermore,when considering a comprehensive evaluation of diversity and quality metrics,our model has also demonstrated the best performance. 展开更多
关键词 Text generation entailment recognition task natural language processing artificial intelligence
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Online task planning method of anti-ship missile based on rolling optimization
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作者 LU Faxing DAI Qiuyang +1 位作者 YANG Guang JIA Zhengrong 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期720-731,共12页
Based on the wave attack task planning method in static complex environment and the rolling optimization framework, an online task planning method in dynamic complex environment based on rolling optimization is propos... Based on the wave attack task planning method in static complex environment and the rolling optimization framework, an online task planning method in dynamic complex environment based on rolling optimization is proposed. In the process of online task planning in dynamic complex environment,online task planning is based on event triggering including target information update event, new target addition event, target failure event, weapon failure event, etc., and the methods include defense area reanalysis, parameter space update, and mission re-planning. Simulation is conducted for different events and the result shows that the index value of the attack scenario after re-planning is better than that before re-planning and according to the probability distribution of statistical simulation method, the index value distribution after re-planning is obviously in the region of high index value, and the index value gap before and after re-planning is related to the degree of posture change. 展开更多
关键词 target allocation of anti-ship missile defense area rolling optimization task re-planning
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Multi-Agent Collaborative Task Planning with Uncertain Task Requirements
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作者 Jia Zhang Zexuan Jin Qichen Dong 《Journal of Beijing Institute of Technology》 EI CAS 2024年第5期361-373,共13页
In response to the uncertainty of information of the injured in post disaster situations,considering constraints such as random chance and the quantity of rescue resource,the split deliv-ery vehicle routing problem wi... In response to the uncertainty of information of the injured in post disaster situations,considering constraints such as random chance and the quantity of rescue resource,the split deliv-ery vehicle routing problem with stochastic demands(SDVRPSD)model and the multi-depot split delivery heterogeneous vehicle routing problem with stochastic demands(MDSDHVRPSD)model are established.A two-stage hybrid variable neighborhood tabu search algorithm is designed for unmanned vehicle task planning to minimize the path cost of rescue plans.Simulation experiments show that the solution obtained by the algorithm can effectively reduce the rescue vehicle path cost and the rescue task completion time,with high optimization quality and certain portability. 展开更多
关键词 multi-agent collaboration task planning vehicle routing problem stochastic demands
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Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites
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作者 Kirsty Goncalves Stefan Przyborski 《Neural Regeneration Research》 SCIE CAS 2025年第9期2645-2654,共10页
Neuronal cell death and the loss of connectivity are two of the primary pathological mechanisms underlying Alzheimer's disease.The accumulation of amyloid-βpeptides,a key hallmark of Alzheimer's disease,is be... Neuronal cell death and the loss of connectivity are two of the primary pathological mechanisms underlying Alzheimer's disease.The accumulation of amyloid-βpeptides,a key hallmark of Alzheimer's disease,is believed to induce neuritic abnormalities,including reduced growth,extension,and abnormal growth cone morphology,all of which contribute to decreased connectivity.However,the precise cellular and molecular mechanisms governing this response remain unknown.In this study,we used an innovative approach to demonstrate the effect of amyloid-βon neurite dynamics in both two-dimensional and three-dimensional cultu re systems,in order to provide more physiologically relevant culture geometry.We utilized various methodologies,including the addition of exogenous amyloid-βpeptides to the culture medium,growth substrate coating,and the utilization of human-induced pluripotent stem cell technology,to investigate the effect of endogenous amyloid-βsecretion on neurite outgrowth,thus paving the way for potential future applications in personalized medicine.Additionally,we also explore the involvement of the Nogo signaling cascade in amyloid-β-induced neurite inhibition.We demonstrate that inhibition of downstream ROCK and RhoA components of the Nogo signaling pathway,achieved through modulation with Y-27632(a ROCK inhibitor)and Ibuprofen(a Rho A inhibitor),respectively,can restore and even enhance neuronal connectivity in the presence of amyloid-β.In summary,this study not only presents a novel culture approach that offers insights into the biological process of neurite growth and inhibition,but also proposes a specific mechanism for reduced neural connectivity in the presence of amyloid-βpeptides,along with potential intervention points to restore neurite growth.Thereby,we aim to establish a culture system that has the potential to serve as an assay for measuring preclinical,predictive outcomes of drugs and their ability to promote neurite outgrowth,both generally and in a patient-specific manner. 展开更多
关键词 Alzheimer's disease induced pluripotent stem cell neurite outgrowth neuron nogo Rho A ROCK stem cell three-dimensional culture
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Policy Network-Based Dual-Agent Deep Reinforcement Learning for Multi-Resource Task Offloading in Multi-Access Edge Cloud Networks
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作者 Feng Chuan Zhang Xu +2 位作者 Han Pengchao Ma Tianchun Gong Xiaoxue 《China Communications》 SCIE CSCD 2024年第4期53-73,共21页
The Multi-access Edge Cloud(MEC) networks extend cloud computing services and capabilities to the edge of the networks. By bringing computation and storage capabilities closer to end-users and connected devices, MEC n... The Multi-access Edge Cloud(MEC) networks extend cloud computing services and capabilities to the edge of the networks. By bringing computation and storage capabilities closer to end-users and connected devices, MEC networks can support a wide range of applications. MEC networks can also leverage various types of resources, including computation resources, network resources, radio resources,and location-based resources, to provide multidimensional resources for intelligent applications in 5/6G.However, tasks generated by users often consist of multiple subtasks that require different types of resources. It is a challenging problem to offload multiresource task requests to the edge cloud aiming at maximizing benefits due to the heterogeneity of resources provided by devices. To address this issue,we mathematically model the task requests with multiple subtasks. Then, the problem of task offloading of multi-resource task requests is proved to be NP-hard. Furthermore, we propose a novel Dual-Agent Deep Reinforcement Learning algorithm with Node First and Link features(NF_L_DA_DRL) based on the policy network, to optimize the benefits generated by offloading multi-resource task requests in MEC networks. Finally, simulation results show that the proposed algorithm can effectively improve the benefit of task offloading with higher resource utilization compared with baseline algorithms. 展开更多
关键词 benefit maximization deep reinforcement learning multi-access edge cloud task offloading
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Two-Stage IoT Computational Task Offloading Decision-Making in MEC with Request Holding and Dynamic Eviction
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作者 Dayong Wang Kamalrulnizam Bin Abu Bakar Babangida Isyaku 《Computers, Materials & Continua》 SCIE EI 2024年第8期2065-2080,共16页
The rapid development of Internet of Things(IoT)technology has led to a significant increase in the computational task load of Terminal Devices(TDs).TDs reduce response latency and energy consumption with the support ... The rapid development of Internet of Things(IoT)technology has led to a significant increase in the computational task load of Terminal Devices(TDs).TDs reduce response latency and energy consumption with the support of task-offloading in Multi-access Edge Computing(MEC).However,existing task-offloading optimization methods typically assume that MEC’s computing resources are unlimited,and there is a lack of research on the optimization of task-offloading when MEC resources are exhausted.In addition,existing solutions only decide whether to accept the offloaded task request based on the single decision result of the current time slot,but lack support for multiple retry in subsequent time slots.It is resulting in TD missing potential offloading opportunities in the future.To fill this gap,we propose a Two-Stage Offloading Decision-making Framework(TSODF)with request holding and dynamic eviction.Long Short-Term Memory(LSTM)-based task-offloading request prediction and MEC resource release estimation are integrated to infer the probability of a request being accepted in the subsequent time slot.The framework learns optimized decision-making experiences continuously to increase the success rate of task offloading based on deep learning technology.Simulation results show that TSODF reduces total TD’s energy consumption and delay for task execution and improves task offloading rate and system resource utilization compared to the benchmark method. 展开更多
关键词 Decision making internet of things load prediction task offloading multi-access edge computing
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A Survey on Task Scheduling of CPU-GPU Heterogeneous Cluster
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作者 ZHOU Yiheng ZENG Wei +2 位作者 ZHENG Qingfang LIU Zhilong CHEN Jianping 《ZTE Communications》 2024年第3期83-90,共8页
This paper reviews task scheduling frameworks,methods,and evaluation metrics of central processing unit-graphics processing unit(CPU-GPU)heterogeneous clusters.Task scheduling of CPU-GPU heterogeneous clusters can be ... This paper reviews task scheduling frameworks,methods,and evaluation metrics of central processing unit-graphics processing unit(CPU-GPU)heterogeneous clusters.Task scheduling of CPU-GPU heterogeneous clusters can be carried out on the system level,nodelevel,and device level.Most task-scheduling technologies are heuristic based on the experts’experience,while some technologies are based on statistic methods using machine learning,deep learning,or reinforcement learning.Many metrics have been adopted to evaluate and compare different task scheduling technologies that try to optimize different goals of task scheduling.Although statistic task scheduling has reached fewer research achievements than heuristic task scheduling,the statistic task scheduling still has significant research potential. 展开更多
关键词 CPU-GPU heterogeneous cluster task scheduling heuristic task scheduling statistic task scheduling PARALLELIZATION
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