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蒲金口服液对宫内感染/炎症致早产脑损伤大鼠脑组织OL、OPC细胞凋亡和Nogo-A、OMgp表达的影响
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作者 陈恬恬 谢克功 +2 位作者 马丙祥 张晰 张建奎 《辽宁中医杂志》 CAS 北大核心 2024年第2期193-198,I0006,F0003,共8页
目的探讨蒲金口服液对宫内感染/炎症致早产脑损伤大鼠神经保护作用的机制。方法将80只胎龄<22 d的早产仔鼠随机分为8组(每组10只):早期药物干预组(蒲金口服液高剂量组、蒲金口服液低剂量组、银杏叶提取物组、模型组)和晚期药物干预... 目的探讨蒲金口服液对宫内感染/炎症致早产脑损伤大鼠神经保护作用的机制。方法将80只胎龄<22 d的早产仔鼠随机分为8组(每组10只):早期药物干预组(蒲金口服液高剂量组、蒲金口服液低剂量组、银杏叶提取物组、模型组)和晚期药物干预组。生后21 d龄进行神经行为学检测,并采用qRT-PCR和Western blot方法检测勿动蛋白-A(Nogo-A)和少突胶质细胞髓磷脂糖蛋白(OMgp)的表达,TUNEL法和A2B5、CNPase双标免疫荧光染色法检测少突胶质细胞(OL)、前体细胞(OPC)凋亡情况。结果LPS组早产仔鼠脑组织Nogo-A和OMgpmRNA和蛋白的表达均明显高于正常对照组(P<0.05),蒲金口服液高剂量、低剂量和银杏叶提取物干预组大鼠的神经行为学评分均优于模型组(P<0.05),且早期干预组高于晚期干预组(P<0.05)。蒲金口服液高剂量、低剂量和银杏叶提取物均能降低早产脑损伤大鼠脑组织Nogo-A、OMgp mRNA和蛋白的表达,减少OL和OPC的凋亡(P<0.05),其中蒲金口服液高剂量早期干预效果更显著(P<0.05)。结论蒲金口服液可以改善早产脑损伤大鼠的神经行为学表现,减少脑组织Nogo-A、OMgp的表达和OL、OPC的凋亡,具有神经保护的作用。 展开更多
关键词 宫内感染 早产儿脑损伤 蒲金口服液 nogo-A OMgp OL OPC
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Nogo-A在神经系统疾病中的研究进展
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作者 曲姜昆 姜俊杰 《数理医药学杂志》 CAS 2024年第3期222-227,共6页
神经生长抑制因子A(neurite outgrowth inhibitor A,Nogo-A)在哺乳动物中是一种能够抑制轴突生长的蛋白质。研究发现Nogo-A在神经系统中对轴突生长和突触可塑性起到调节作用,并与阿尔兹海默症、肌萎缩性侧索硬化症、多发性硬化症、脊髓... 神经生长抑制因子A(neurite outgrowth inhibitor A,Nogo-A)在哺乳动物中是一种能够抑制轴突生长的蛋白质。研究发现Nogo-A在神经系统中对轴突生长和突触可塑性起到调节作用,并与阿尔兹海默症、肌萎缩性侧索硬化症、多发性硬化症、脊髓损伤等密切相关。本文综述了Nogo-A及其受体NgR的基本结构、功能以及在神经系统疾病等方面的研究进展。 展开更多
关键词 nogo-A 神经系统疾病 神经退行性病变 脊髓损伤
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Nogo-A蛋白及调控轴突再生作用研究进展
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作者 孟瑶 王颖 《神经损伤与功能重建》 2024年第3期151-156,共6页
中枢神经系统损伤产生的抑制性微环境是神经再生困难的重要原因,其中Nogo-A蛋白是抑制轴突再生的关键因子,其结构域以片段形式通过不同途径释放到细胞外,与受体NgR1、PirB、S1PR2或HSPG相结合,激活多种信号通路调控细胞凋亡、运动以及... 中枢神经系统损伤产生的抑制性微环境是神经再生困难的重要原因,其中Nogo-A蛋白是抑制轴突再生的关键因子,其结构域以片段形式通过不同途径释放到细胞外,与受体NgR1、PirB、S1PR2或HSPG相结合,激活多种信号通路调控细胞凋亡、运动以及细胞骨架蛋白聚合,引起细胞骨架解聚、生长锥塌陷,抑制神经元轴突生长。本文对Nogo-A蛋白的结构、受体和抑制轴突再生作用机制的研究进展进行综述。 展开更多
关键词 nogo-A蛋白 受体 信号通路 轴突再生
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Nogo-B敲除NAFLD小鼠的肠道微生物群和血清代谢组学变化研究
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作者 董旭 郑从洋 +1 位作者 柏兆方 高利利 《解放军医学院学报》 CAS 2024年第6期697-704,F0003,共9页
背景非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是目前全球范围内最常见的慢性肝病,Nogo-B作为其潜在治疗靶点,需确定是否会对肠道微生物群及代谢途径产生影响。目的探讨Nogo-B敲除对NAFLD的保护作用,明确Nogo-B敲除... 背景非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是目前全球范围内最常见的慢性肝病,Nogo-B作为其潜在治疗靶点,需确定是否会对肠道微生物群及代谢途径产生影响。目的探讨Nogo-B敲除对NAFLD的保护作用,明确Nogo-B敲除对NAFLD小鼠肠道微生物群和血清代谢产物的影响。方法12只8周龄野生型小鼠随机分为野生正常饮食组(WT-NCD组)和野生高脂饮食组(WT-HFD组)。12只8周龄Nogo-B敲除(Nogo-B^(-/-))小鼠随机分为Nogo-B敲除正常饮食组(Nogo-B^(-/-)-NCD组)和Nogo-B敲除高脂饮食组(Nogo-B^(-/-)-HFD组)。WT-HFD组和Nogo-B^(-/-)-HFD组小鼠通过喂食12周60 kal%的高脂饮食构建NAFLD小鼠模型,WT-NCD组和Nogo-B^(-/-)-NCD组小鼠则同时喂食正常饮食。4组小鼠均测量体质量;酶联免疫吸附测定检测4组小鼠的肝三酰甘油(triglyceride,TG)和总胆固醇(total cholesterol,TC)水平;苏木精-伊红染色评估4组小鼠的肝病理学特征;对WT-HFD组和Nogo-B^(-/-)-HFD组小鼠进行肠道微生物群和血清代谢物检测。结果12周造模结束后,与WT-NCD组小鼠相比,WT-HFD组小鼠的体质量及肝组织中TC、TG水平升高(P<0.01);与Nogo-B^(-/-)-NCD组小鼠相比,Nogo-B^(-/-)-HFD组小鼠的体质量及肝组织中TC、TG水平升高(P<0.01);而当Nogo-B敲除后,与WT-HFD组小鼠相比,Nogo-B^(-/-)-HFD组小鼠的体质量及肝组织中TC、TG水平下降(P<0.01);肠道微生物组学显示Nogo-B敲除后丁酸球菌科成为其肠道微生物中的优势物种;血清代谢组学显示两组间(WT-HFD组、Nogo-B^(-/-)-HFD组)筛选到差异代谢物159种(上调79,下调80种),极其显著富集(P<0.001)的代谢通路为柠檬酸循环/三羧酸循环(tricarboxylic acid cycle,TCA cycle)等,主要富集到的代谢物为柠檬酸、琥珀酸、异柠檬酸盐和苹果酸。结论Nogo-B敲除后的NAFLD小鼠肝脂质积累情况减轻,肠道有益微生物群增加,一定程度上改善代谢紊乱。Nogo-B可能是NAFLD治疗的潜在靶点。 展开更多
关键词 非酒精性脂肪性肝病 高脂饮食 nogo-B 肠道微生物群 代谢组学
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Joint Task Allocation and Resource Optimization for Blockchain Enabled Collaborative Edge Computing
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作者 Xu Wenjing Wang Wei +2 位作者 Li Zuguang Wu Qihui Wang Xianbin 《China Communications》 SCIE CSCD 2024年第4期218-229,共12页
Collaborative edge computing is a promising direction to handle the computation intensive tasks in B5G wireless networks.However,edge computing servers(ECSs)from different operators may not trust each other,and thus t... Collaborative edge computing is a promising direction to handle the computation intensive tasks in B5G wireless networks.However,edge computing servers(ECSs)from different operators may not trust each other,and thus the incentives for collaboration cannot be guaranteed.In this paper,we propose a consortium blockchain enabled collaborative edge computing framework,where users can offload computing tasks to ECSs from different operators.To minimize the total delay of users,we formulate a joint task offloading and resource optimization problem,under the constraint of the computing capability of each ECS.We apply the Tammer decomposition method and heuristic optimization algorithms to obtain the optimal solution.Finally,we propose a reputation based node selection approach to facilitate the consensus process,and also consider a completion time based primary node selection to avoid monopolization of certain edge node and enhance the security of the blockchain.Simulation results validate the effectiveness of the proposed algorithm,and the total delay can be reduced by up to 40%compared with the non-cooperative case. 展开更多
关键词 blockchain collaborative edge computing resource optimization task allocation
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Task Offloading in Edge Computing Using GNNs and DQN
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作者 Asier Garmendia-Orbegozo Jose David Nunez-Gonzalez Miguel Angel Anton 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期2649-2671,共23页
In a network environment composed of different types of computing centers that can be divided into different layers(clod,edge layer,and others),the interconnection between them offers the possibility of peer-to-peer t... In a network environment composed of different types of computing centers that can be divided into different layers(clod,edge layer,and others),the interconnection between them offers the possibility of peer-to-peer task offloading.For many resource-constrained devices,the computation of many types of tasks is not feasible because they cannot support such computations as they do not have enough available memory and processing capacity.In this scenario,it is worth considering transferring these tasks to resource-rich platforms,such as Edge Data Centers or remote cloud servers.For different reasons,it is more exciting and appropriate to download various tasks to specific download destinations depending on the properties and state of the environment and the nature of the functions.At the same time,establishing an optimal offloading policy,which ensures that all tasks are executed within the required latency and avoids excessive workload on specific computing centers is not easy.This study presents two alternatives to solve the offloading decision paradigm by introducing two well-known algorithms,Graph Neural Networks(GNN)and Deep Q-Network(DQN).It applies the alternatives on a well-known Edge Computing simulator called PureEdgeSimand compares them with the two defaultmethods,Trade-Off and Round Robin.Experiments showed that variants offer a slight improvement in task success rate and workload distribution.In terms of energy efficiency,they provided similar results.Finally,the success rates of different computing centers are tested,and the lack of capacity of remote cloud servers to respond to applications in real-time is demonstrated.These novel ways of finding a download strategy in a local networking environment are unique as they emulate the state and structure of the environment innovatively,considering the quality of its connections and constant updates.The download score defined in this research is a crucial feature for determining the quality of a download path in the GNN training process and has not previously been proposed.Simultaneously,the suitability of Reinforcement Learning(RL)techniques is demonstrated due to the dynamism of the network environment,considering all the key factors that affect the decision to offload a given task,including the actual state of all devices. 展开更多
关键词 Edge computing edge offloading fog computing task offloading
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Mobile Crowdsourcing Task Allocation Based on Dynamic Self-Attention GANs
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作者 Kai Wei Song Yu Qingxian Pan 《Computers, Materials & Continua》 SCIE EI 2024年第4期607-622,共16页
Crowdsourcing technology is widely recognized for its effectiveness in task scheduling and resource allocation.While traditional methods for task allocation can help reduce costs and improve efficiency,they may encoun... Crowdsourcing technology is widely recognized for its effectiveness in task scheduling and resource allocation.While traditional methods for task allocation can help reduce costs and improve efficiency,they may encounter challenges when dealing with abnormal data flow nodes,leading to decreased allocation accuracy and efficiency.To address these issues,this study proposes a novel two-part invalid detection task allocation framework.In the first step,an anomaly detection model is developed using a dynamic self-attentive GAN to identify anomalous data.Compared to the baseline method,the model achieves an approximately 4%increase in the F1 value on the public dataset.In the second step of the framework,task allocation modeling is performed using a twopart graph matching method.This phase introduces a P-queue KM algorithm that implements a more efficient optimization strategy.The allocation efficiency is improved by approximately 23.83%compared to the baseline method.Empirical results confirm the effectiveness of the proposed framework in detecting abnormal data nodes,enhancing allocation precision,and achieving efficient allocation. 展开更多
关键词 Mobile crowdsourcing task allocation anomaly detection GAN attention mechanisms
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MADDPG-D2: An Intelligent Dynamic Task Allocation Algorithm Based on Multi-Agent Architecture Driven by Prior Knowledge
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作者 Tengda Li Gang Wang Qiang Fu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第9期2559-2586,共28页
Aiming at the problems of low solution accuracy and high decision pressure when facing large-scale dynamic task allocation(DTA)and high-dimensional decision space with single agent,this paper combines the deep reinfor... Aiming at the problems of low solution accuracy and high decision pressure when facing large-scale dynamic task allocation(DTA)and high-dimensional decision space with single agent,this paper combines the deep reinforce-ment learning(DRL)theory and an improved Multi-Agent Deep Deterministic Policy Gradient(MADDPG-D2)algorithm with a dual experience replay pool and a dual noise based on multi-agent architecture is proposed to improve the efficiency of DTA.The algorithm is based on the traditional Multi-Agent Deep Deterministic Policy Gradient(MADDPG)algorithm,and considers the introduction of a double noise mechanism to increase the action exploration space in the early stage of the algorithm,and the introduction of a double experience pool to improve the data utilization rate;at the same time,in order to accelerate the training speed and efficiency of the agents,and to solve the cold-start problem of the training,the a priori knowledge technology is applied to the training of the algorithm.Finally,the MADDPG-D2 algorithm is compared and analyzed based on the digital battlefield of ground and air confrontation.The experimental results show that the agents trained by the MADDPG-D2 algorithm have higher win rates and average rewards,can utilize the resources more reasonably,and better solve the problem of the traditional single agent algorithms facing the difficulty of solving the problem in the high-dimensional decision space.The MADDPG-D2 algorithm based on multi-agent architecture proposed in this paper has certain superiority and rationality in DTA. 展开更多
关键词 Deep reinforcement learning dynamic task allocation intelligent decision-making multi-agent system MADDPG-D2 algorithm
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Generating Factual Text via Entailment Recognition Task
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作者 Jinqiao Dai Pengsen Cheng Jiayong Liu 《Computers, Materials & Continua》 SCIE EI 2024年第7期547-565,共19页
Generating diverse and factual text is challenging and is receiving increasing attention.By sampling from the latent space,variational autoencoder-based models have recently enhanced the diversity of generated text.Ho... Generating diverse and factual text is challenging and is receiving increasing attention.By sampling from the latent space,variational autoencoder-based models have recently enhanced the diversity of generated text.However,existing research predominantly depends on summarizationmodels to offer paragraph-level semantic information for enhancing factual correctness.The challenge lies in effectively generating factual text using sentence-level variational autoencoder-based models.In this paper,a novel model called fact-aware conditional variational autoencoder is proposed to balance the factual correctness and diversity of generated text.Specifically,our model encodes the input sentences and uses them as facts to build a conditional variational autoencoder network.By training a conditional variational autoencoder network,the model is enabled to generate text based on input facts.Building upon this foundation,the input text is passed to the discriminator along with the generated text.By employing adversarial training,the model is encouraged to generate text that is indistinguishable to the discriminator,thereby enhancing the quality of the generated text.To further improve the factual correctness,inspired by the natural language inference system,the entailment recognition task is introduced to be trained together with the discriminator via multi-task learning.Moreover,based on the entailment recognition results,a penalty term is further proposed to reconstruct the loss of our model,forcing the generator to generate text consistent with the facts.Experimental results demonstrate that compared with competitivemodels,ourmodel has achieved substantial improvements in both the quality and factual correctness of the text,despite only sacrificing a small amount of diversity.Furthermore,when considering a comprehensive evaluation of diversity and quality metrics,our model has also demonstrated the best performance. 展开更多
关键词 Text generation entailment recognition task natural language processing artificial intelligence
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Policy Network-Based Dual-Agent Deep Reinforcement Learning for Multi-Resource Task Offloading in Multi-Access Edge Cloud Networks
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作者 Feng Chuan Zhang Xu +2 位作者 Han Pengchao Ma Tianchun Gong Xiaoxue 《China Communications》 SCIE CSCD 2024年第4期53-73,共21页
The Multi-access Edge Cloud(MEC) networks extend cloud computing services and capabilities to the edge of the networks. By bringing computation and storage capabilities closer to end-users and connected devices, MEC n... The Multi-access Edge Cloud(MEC) networks extend cloud computing services and capabilities to the edge of the networks. By bringing computation and storage capabilities closer to end-users and connected devices, MEC networks can support a wide range of applications. MEC networks can also leverage various types of resources, including computation resources, network resources, radio resources,and location-based resources, to provide multidimensional resources for intelligent applications in 5/6G.However, tasks generated by users often consist of multiple subtasks that require different types of resources. It is a challenging problem to offload multiresource task requests to the edge cloud aiming at maximizing benefits due to the heterogeneity of resources provided by devices. To address this issue,we mathematically model the task requests with multiple subtasks. Then, the problem of task offloading of multi-resource task requests is proved to be NP-hard. Furthermore, we propose a novel Dual-Agent Deep Reinforcement Learning algorithm with Node First and Link features(NF_L_DA_DRL) based on the policy network, to optimize the benefits generated by offloading multi-resource task requests in MEC networks. Finally, simulation results show that the proposed algorithm can effectively improve the benefit of task offloading with higher resource utilization compared with baseline algorithms. 展开更多
关键词 benefit maximization deep reinforcement learning multi-access edge cloud task offloading
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Online task planning method of anti-ship missile based on rolling optimization
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作者 LU Faxing DAI Qiuyang +1 位作者 YANG Guang JIA Zhengrong 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期720-731,共12页
Based on the wave attack task planning method in static complex environment and the rolling optimization framework, an online task planning method in dynamic complex environment based on rolling optimization is propos... Based on the wave attack task planning method in static complex environment and the rolling optimization framework, an online task planning method in dynamic complex environment based on rolling optimization is proposed. In the process of online task planning in dynamic complex environment,online task planning is based on event triggering including target information update event, new target addition event, target failure event, weapon failure event, etc., and the methods include defense area reanalysis, parameter space update, and mission re-planning. Simulation is conducted for different events and the result shows that the index value of the attack scenario after re-planning is better than that before re-planning and according to the probability distribution of statistical simulation method, the index value distribution after re-planning is obviously in the region of high index value, and the index value gap before and after re-planning is related to the degree of posture change. 展开更多
关键词 target allocation of anti-ship missile defense area rolling optimization task re-planning
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A Systematic Literature Review on Task Allocation and Performance Management Techniques in Cloud Data Center
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作者 Nidhika Chauhan Navneet Kaur +5 位作者 Kamaljit Singh Saini Sahil Verma Abdulatif Alabdulatif Ruba Abu Khurma Maribel Garcia-Arenas Pedro A.Castillo 《Computer Systems Science & Engineering》 2024年第3期571-608,共38页
As cloud computing usage grows,cloud data centers play an increasingly important role.To maximize resource utilization,ensure service quality,and enhance system performance,it is crucial to allocate tasks and manage p... As cloud computing usage grows,cloud data centers play an increasingly important role.To maximize resource utilization,ensure service quality,and enhance system performance,it is crucial to allocate tasks and manage performance effectively.The purpose of this study is to provide an extensive analysis of task allocation and performance management techniques employed in cloud data centers.The aim is to systematically categorize and organize previous research by identifying the cloud computing methodologies,categories,and gaps.A literature review was conducted,which included the analysis of 463 task allocations and 480 performance management papers.The review revealed three task allocation research topics and seven performance management methods.Task allocation research areas are resource allocation,load-Balancing,and scheduling.Performance management includes monitoring and control,power and energy management,resource utilization optimization,quality of service management,fault management,virtual machine management,and network management.The study proposes new techniques to enhance cloud computing work allocation and performance management.Short-comings in each approach can guide future research.The research’s findings on cloud data center task allocation and performance management can assist academics,practitioners,and cloud service providers in optimizing their systems for dependability,cost-effectiveness,and scalability.Innovative methodologies can steer future research to fill gaps in the literature. 展开更多
关键词 Cloud computing data centre task allocation performance management resource utilization
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Enhanced Hybrid Equilibrium Strategy in Fog-Cloud Computing Networks with Optimal Task Scheduling
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作者 Muchang Rao Hang Qin 《Computers, Materials & Continua》 SCIE EI 2024年第5期2647-2672,共26页
More devices in the Intelligent Internet of Things(AIoT)result in an increased number of tasks that require low latency and real-time responsiveness,leading to an increased demand for computational resources.Cloud com... More devices in the Intelligent Internet of Things(AIoT)result in an increased number of tasks that require low latency and real-time responsiveness,leading to an increased demand for computational resources.Cloud computing’s low-latency performance issues in AIoT scenarios have led researchers to explore fog computing as a complementary extension.However,the effective allocation of resources for task execution within fog environments,characterized by limitations and heterogeneity in computational resources,remains a formidable challenge.To tackle this challenge,in this study,we integrate fog computing and cloud computing.We begin by establishing a fog-cloud environment framework,followed by the formulation of a mathematical model for task scheduling.Lastly,we introduce an enhanced hybrid Equilibrium Optimizer(EHEO)tailored for AIoT task scheduling.The overarching objective is to decrease both the makespan and energy consumption of the fog-cloud system while accounting for task deadlines.The proposed EHEO method undergoes a thorough evaluation against multiple benchmark algorithms,encompassing metrics likemakespan,total energy consumption,success rate,and average waiting time.Comprehensive experimental results unequivocally demonstrate the superior performance of EHEO across all assessed metrics.Notably,in the most favorable conditions,EHEO significantly diminishes both the makespan and energy consumption by approximately 50%and 35.5%,respectively,compared to the secondbest performing approach,which affirms its efficacy in advancing the efficiency of AIoT task scheduling within fog-cloud networks. 展开更多
关键词 Artificial intelligence of things fog computing task scheduling equilibrium optimizer differential evaluation algorithm local search
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Dynamic access task scheduling of LEO constellation based on space-based distributed computing
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作者 LIU Wei JIN Yifeng +2 位作者 ZHANG Lei GAO Zihe TAO Ying 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第4期842-854,共13页
A dynamic multi-beam resource allocation algorithm for large low Earth orbit(LEO)constellation based on on-board distributed computing is proposed in this paper.The allocation is a combinatorial optimization process u... A dynamic multi-beam resource allocation algorithm for large low Earth orbit(LEO)constellation based on on-board distributed computing is proposed in this paper.The allocation is a combinatorial optimization process under a series of complex constraints,which is important for enhancing the matching between resources and requirements.A complex algorithm is not available because that the LEO on-board resources is limi-ted.The proposed genetic algorithm(GA)based on two-dimen-sional individual model and uncorrelated single paternal inheri-tance method is designed to support distributed computation to enhance the feasibility of on-board application.A distributed system composed of eight embedded devices is built to verify the algorithm.A typical scenario is built in the system to evalu-ate the resource allocation process,algorithm mathematical model,trigger strategy,and distributed computation architec-ture.According to the simulation and measurement results,the proposed algorithm can provide an allocation result for more than 1500 tasks in 14 s and the success rate is more than 91%in a typical scene.The response time is decreased by 40%com-pared with the conditional GA. 展开更多
关键词 beam resource allocation distributed computing low Earth obbit(LEO)constellation spacecraft access task scheduling
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Associative Tasks Computing Offloading Scheme in Internet of Medical Things with Deep Reinforcement Learning
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作者 Jiang Fan Qin Junwei +1 位作者 Liu Lei Tian Hui 《China Communications》 SCIE CSCD 2024年第4期38-52,共15页
The Internet of Medical Things(Io MT) is regarded as a critical technology for intelligent healthcare in the foreseeable 6G era. Nevertheless, due to the limited computing power capability of edge devices and task-rel... The Internet of Medical Things(Io MT) is regarded as a critical technology for intelligent healthcare in the foreseeable 6G era. Nevertheless, due to the limited computing power capability of edge devices and task-related coupling relationships, Io MT faces unprecedented challenges. Considering the associative connections among tasks, this paper proposes a computing offloading policy for multiple-user devices(UDs) considering device-to-device(D2D) communication and a multi-access edge computing(MEC)technique under the scenario of Io MT. Specifically,to minimize the total delay and energy consumption concerning the requirement of Io MT, we first analyze and model the detailed local execution, MEC execution, D2D execution, and associated tasks offloading exchange model. Consequently, the associated tasks’ offloading scheme of multi-UDs is formulated as a mixed-integer nonconvex optimization problem. Considering the advantages of deep reinforcement learning(DRL) in processing tasks related to coupling relationships, a Double DQN based associative tasks computing offloading(DDATO) algorithm is then proposed to obtain the optimal solution, which can make the best offloading decision under the condition that tasks of UDs are associative. Furthermore, to reduce the complexity of the DDATO algorithm, the cacheaided procedure is intentionally introduced before the data training process. This avoids redundant offloading and computing procedures concerning tasks that previously have already been cached by other UDs. In addition, we use a dynamic ε-greedy strategy in the action selection section of the algorithm, thus preventing the algorithm from falling into a locally optimal solution. Simulation results demonstrate that compared with other existing methods for associative task models concerning different structures in the Io MT network, the proposed algorithm can lower the total cost more effectively and efficiently while also providing a tradeoff between delay and energy consumption tolerance. 展开更多
关键词 associative tasks cache-aided procedure double deep Q-network Internet of Medical Things(IoMT) multi-access edge computing(MEC)
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Multi-Agent Deep Deterministic Policy Gradien-Based Task Offloading Resource Allocation Joint Offloading
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作者 Xuan Zhang Xiaohui Hu 《Journal of Computer and Communications》 2024年第6期152-168,共17页
With the advancement of technology and the continuous innovation of applications, low-latency applications such as drones, online games and virtual reality are gradually becoming popular demands in modern society. How... With the advancement of technology and the continuous innovation of applications, low-latency applications such as drones, online games and virtual reality are gradually becoming popular demands in modern society. However, these applications pose a great challenge to the traditional centralized mobile cloud computing paradigm, and it is obvious that the traditional cloud computing model is already struggling to meet such demands. To address the shortcomings of cloud computing, mobile edge computing has emerged. Mobile edge computing provides users with computing and storage resources by offloading computing tasks to servers at the edge of the network. However, most existing work only considers single-objective performance optimization in terms of latency or energy consumption, but not balanced optimization in terms of latency and energy consumption. To reduce task latency and device energy consumption, the problem of joint optimization of computation offloading and resource allocation in multi-cell, multi-user, multi-server MEC environments is investigated. In this paper, a dynamic computation offloading algorithm based on Multi-Agent Deep Deterministic Policy Gradient (MADDPG) is proposed to obtain the optimal policy. The experimental results show that the algorithm proposed in this paper reduces the delay by 5 ms compared to PPO, 1.5 ms compared to DDPG and 10.7 ms compared to DQN, and reduces the energy consumption by 300 compared to PPO, 760 compared to DDPG and 380 compared to DQN. This fully proves that the algorithm proposed in this paper has excellent performance. 展开更多
关键词 Edge Computing task Offloading Deep Reinforcement Learning Resource Allocation MADDPG
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局部应用Nogo-B蛋白促进糖尿病鼠创面愈合的作用研究
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作者 秦晶 马丹丹 吴海斌 《齐齐哈尔医学院学报》 2024年第8期701-705,共5页
目的探究Nogo-B蛋白对糖尿病小鼠创面愈合的影响。方法选择24只糖尿病小鼠制备背部全层皮肤缺损创面模型,随机分为PBS对照组及Nogo-B蛋白处理组两组,每组各12只。Nogo-B蛋白处理组在创面局部注射浓度为250 ng/ml的Nogo-B蛋白溶液,对照... 目的探究Nogo-B蛋白对糖尿病小鼠创面愈合的影响。方法选择24只糖尿病小鼠制备背部全层皮肤缺损创面模型,随机分为PBS对照组及Nogo-B蛋白处理组两组,每组各12只。Nogo-B蛋白处理组在创面局部注射浓度为250 ng/ml的Nogo-B蛋白溶液,对照组注射等量PBS溶液。第0天、3天、7天、14天分别创面拍照比较创面愈合率。第7天、第14天每组各处死3只小鼠并创面取材,采用HE染色评估创面上皮化及组织学形态;免疫组织化学及荧光比较创面炎症细胞浸润、干细胞表达及血管化情况差异。结果造模后第7天、第14天,Nogo-B蛋白处理组创面愈合率均高于对照组(P<0.01);HE染色显示Nogo-B蛋白处理组创面组织上皮化距离显著多于对照组;免疫荧光染色显示愈合后期第14天Nogo-B蛋白组创面内CD45表达较对照组减少,而两个时间点,BrdU和α-SMA阳性表达细胞数目均较对照组显著增多。结论局部应用Nogo-B蛋白能够通过持续加速表皮干细胞增殖、创面血管化以及减轻愈合后期创面炎症反应等作用机理来促进糖尿病小鼠创面愈合。 展开更多
关键词 糖尿病 创面愈合 nogo-B 血管新生 炎症反应
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Optimizing Spatial Crowdsourcing:A Quality-Aware Task Assignment Approach for Mobile Communication
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作者 Jiali Weng Xike Xie 《Journal of Electronic Research and Application》 2024年第3期104-111,共8页
The widespread use of advanced electronic devices has led to the emergence of spatial crowdsourcing,a method that taps into collective efforts to perform real-world tasks like environmental monitoring and traffic surv... The widespread use of advanced electronic devices has led to the emergence of spatial crowdsourcing,a method that taps into collective efforts to perform real-world tasks like environmental monitoring and traffic surveillance.Our research focuses on a specific type of spatial crowdsourcing that involves ongoing,collaborative efforts for continuous spatial data acquisition.However,due to limited budgets and workforce availability,the collected data often lacks completeness,posing a data deficiency problem.To address this,we propose a reciprocal framework to optimize task assignments by leveraging the mutual benefits of spatiotemporal subtask execution.We introduce an entropy-based quality metric to capture the combined effects of incomplete data acquisition and interpolation imprecision.Building on this,we explore a quality-aware task assignment method,corresponding to spatiotemporal assignment strategies.Since the assignment problem is NP-hard,we develop a polynomial-time algorithm with the guaranteed approximation ratio.Novel indexing and pruning techniques are proposed to further enhance performance.Extensive experiments conducted on datasets validate the effectiveness of our methods. 展开更多
关键词 Spatiotemporal crowdsourcing Mobile communication task quality
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QoS-Constrained,Reliable and Energy-Efficient Task Deployment in Cloud Computing
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作者 Zhenghui Zhang Yuqi Fan 《计算机科学与技术汇刊(中英文版)》 2024年第1期22-31,共10页
Reliability,QoS and energy consumption are three important concerns of cloud service providers.Most of the current research on reliable task deployment in cloud computing focuses on only one or two of the three concer... Reliability,QoS and energy consumption are three important concerns of cloud service providers.Most of the current research on reliable task deployment in cloud computing focuses on only one or two of the three concerns.However,these three factors have intrinsic trade-off relationships.The existing studies show that load concentration can reduce the number of servers and hence save energy.In this paper,we deal with the problem of reliable task deployment in data centers,with the goal of minimizing the number of servers used in cloud data centers under the constraint that the job execution deadline can be met upon single server failure.We propose a QoS-Constrained,Reliable and Energy-efficient task replica deployment(QSRE)algorithm for the problem by combining task replication and re-execution.For each task in a job that cannot finish executing by re-execution within deadline,we initiate two replicas for the task:main task and task replica.Each main task runs on an individual server.The associated task replica is deployed on a backup server and completes part of the whole task load before the main task failure.Different from the main tasks,multiple task replicas can be allocated to the same backup server to reduce the energy consumption of cloud data centers by minimizing the number of servers required for running the task replicas.Specifically,QSRE assigns the task replicas with the longest and the shortest execution time to the backup servers in turn,such that the task replicas can meet the QoS-specified job execution deadline under the main task failure.We conduct experiments through simulations.The experimental results show that QSRE can effectively reduce the number of servers used,while ensuring the reliability and QoS of job execution. 展开更多
关键词 Cloud Computing task Deployment RELIABILITY Quality of Service Energy Consumption
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A Multi-Task Deep Learning Framework for Simultaneous Detection of Thoracic Pathology through Image Classification
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作者 Nada Al Zahrani Ramdane Hedjar +4 位作者 Mohamed Mekhtiche Mohamed Bencherif Taha Al Fakih Fattoh Al-Qershi Muna Alrazghan 《Journal of Computer and Communications》 2024年第4期153-170,共18页
Thoracic diseases pose significant risks to an individual's chest health and are among the most perilous medical diseases. They can impact either one or both lungs, which leads to a severe impairment of a person’... Thoracic diseases pose significant risks to an individual's chest health and are among the most perilous medical diseases. They can impact either one or both lungs, which leads to a severe impairment of a person’s ability to breathe normally. Some notable examples of such diseases encompass pneumonia, lung cancer, coronavirus disease 2019 (COVID-19), tuberculosis, and chronic obstructive pulmonary disease (COPD). Consequently, early and precise detection of these diseases is paramount during the diagnostic process. Traditionally, the primary methods employed for the detection involve the use of X-ray imaging or computed tomography (CT) scans. Nevertheless, due to the scarcity of proficient radiologists and the inherent similarities between these diseases, the accuracy of detection can be compromised, leading to imprecise or erroneous results. To address this challenge, scientists have turned to computer-based solutions, aiming for swift and accurate diagnoses. The primary objective of this study is to develop two machine learning models, utilizing single-task and multi-task learning frameworks, to enhance classification accuracy. Within the multi-task learning architecture, two principal approaches exist soft parameter sharing and hard parameter sharing. Consequently, this research adopts a multi-task deep learning approach that leverages CNNs to achieve improved classification performance for the specified tasks. These tasks, focusing on pneumonia and COVID-19, are processed and learned simultaneously within a multi-task model. To assess the effectiveness of the trained model, it is rigorously validated using three different real-world datasets for training and testing. 展开更多
关键词 PNEUMONIA Thoracic Pathology COVID-19 Deep Learning Multi-task Learning
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