Discreet investors exert greater influence on cooperation in the public goods game

This paper studies the evolutionary process of cooperative behavior in a public goods game model with heterogeneous investment strategies in square lattices.In the proposed model,players are divided into defectors,cooperators and discreet investors.Among these,defectors do not participate in investing,discreet investors make heterogeneous investments based on the investment behavior and cooperation value of their neighbors,and cooperators invest equally in each neighbor.In real life,heterogeneous investment is often accompanied by time or economic costs.The discreet investors in this paper pay a certain price to obtain their neighbors'investment behavior and cooperation value,which quantifies the time and economic costs of the heterogeneous investment process.The results of Monte Carlo simulation experiments in this study show that discreet investors can effectively resist the invasion of the defectors,form a stable cooperative group and expand the cooperative advantage in evolution.However,when discreet investors pay too high a price,they lose their strategic advantage.The results in this paper help us understand the role of heterogeneous investment in promoting and maintaining human social cooperation.

Multi-strategy hybrid whale optimization algorithms for complex constrained optimization problems

A multi-strategy hybrid whale optimization algorithm(MSHWOA)for complex constrained optimization problems is proposed to overcome the drawbacks of easily trapping into local optimum,slow convergence speed and low optimization precision.Firstly,the population is initialized by introducing the theory of good point set,which increases the randomness and diversity of the population and lays the foundation for the global optimization of the algorithm.Then,a novel linearly update equation of convergence factor is designed to coordinate the abilities of exploration and exploitation.At the same time,the global exploration and local exploitation capabilities are improved through the siege mechanism of Harris Hawks optimization algorithm.Finally,the simulation experiments are conducted on the 6 benchmark functions and Wilcoxon rank sum test to evaluate the optimization performance of the improved algorithm.The experimental results show that the proposed algorithm has more significant improvement in optimization accuracy,convergence speed and robustness than the comparison algorithm.

Relationship between nutritional therapy and beneficial bacteria ratio in severe disease

Objective:To evaluate relationship between changes in the beneficial bacteria in intensive care unit(ICU)patients and nutritional therapy type.Methods:Ten patients aged≥18 years admitted to the ICU between January and December 2020,were included.Good enteral nutrition was defined as early achievement of target calorie intake through enteral feeding.The ratio of beneficial bacteria at the first and second bowel movements after each patient’s admission was calculated and the patients were classified into the increase or decrease group.Among all patients,five each were in the increase and decrease groups.We investigated patient background,changes in sequential organ failure assessment(SOFA)and acute physiology and chronic health evaluation(APACHE)Ⅱscores,nutritional doses or methods,and clinical outcomes.Results:No relationship was found between changes in the ratio of beneficial bacteria and changes in SOFA/APACHEⅡscores at the time of admission.The rate of good enteral nutrition was significantly higher in the increase group than in the decrease group(4/5 vs.0/5,P=0.01).Conclusions:An increase in beneficial bacteria may be significantly related to the early establishment of enteral nutrition.In the future,accumulating cases may make it possible to establish a new nutritional strategy for critically ill patients from an intestinal microbiota perspective.

“Overseas Warehouse” Make Chinese Sellers Become More “Intimate” with Overseas Buyers

With the deepening of Internet technology in international trade,cross-border e-commerce has become the main incremental contributor in the import and export trade of goods,and its transaction volume has gradually increased from 16%of China’s total import and export of goods in 2014 to 42%in 2023.

Hsa-miR-483-5p/mRNA network that regulates chemotherapy resistance in locally advanced rectal cancer identified through plasma exosome transcriptomics

BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of chemoresistance.METHODS In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA sequencing.RESULTS Exosome hsa-miR-483-5p was up-regulated in good responders post-nCRT.Bioinformatics analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling pathway.Further analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor stage.In addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 values.Accordingly,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was constructed.CONCLUSION This study provides insights into the mechanism of chemoresistance in terms of exosomal miRNAs.However,further research is required within the framework of our established miRNA-mRNA network.

Buoyed Confidence Underscores China’s Robust Economy

Recently released economic data reflecting China’s brisk economic activities and vibrant foreign trade attest to a steady acceleration in the country’s economic growth.The National Bureau of Statistics(NBS)reported 5.5 percent year-on-year growth during the first two months of 2024 for retail sales of consumer goods,4.2 percent for fixed-asset investment,and 7 percent for value-added of the industrial enterprises above the designated size.The country’s total import and export of goods,meanwhile,expanded 8.7 percent year-on-year,and its volume for this period achieved a historical high of RMB 6.61 trillion.

The Violent Redemption Theme in A Good Man is Hard to Find

Flannery O’Connor is one of the representative figures of American Southern writers.Being recognized as the most outstanding writer of the American South after Faulkner,she has great influence in the literary world.Her works are always shrouded in a strange and grotesque atmosphere and full of death as well as religious metaphors.The protagonists are a series of American Southern freaks struggling with the crisis of spiritual belief.The protagonists of her novel A Good Man is Hard to Find are a hypocritical believer in the world of sinners and a lost man suffering in the midst of real sin,thus O’Connor uses the highest form of violence-death to bring ultimate redemption to them.In people’s conception,violence and redemption are often opposite to each other,but O’Connor uses bloody and violent plots to explore the theme of religious salvation,integrating and unifying the two contrary concepts to form her unique and profound violent redemption writing.

Convenience on Three Wheels China-made motor tricycles are transforming the way goods and people are transported in Uganda

In most cities,towns and villages in Uganda,Chinamade motor tricycles have become a game-changer for commuters and entrepreneurs alike.

Changes in the Supply of Public Intermediate Goods,Fixed Wage,and the Relative Price in the Harris-Todaro Model

Since the Harris-Todaro model was proposed in 1970,it has played a crucial role in analyzing various environmental and trade issues in developing countries.This paper analyzes the effects of the amount of public intermediate goods provided by the government,the increase in the fixed wage rate in the urban sector,and the changes in the relative international prices of agricultural and manufacturing goods on labor employment,unemployment,and the economic welfare in the context of a small open economy.It also proposes relevant policies to reduce the unemployment rate while improving national welfare.

An Overview of Quality Management of Therapeutic Vaccines in Clinical Trials in China

Objective To provide suggestions and a reference for improving the quality management system of clinical trials of therapeutic vaccines and promoting the development of therapeutic vaccines in China.Methods Literature research,case study and comparative study were used to analyze the quality management system of clinical trials of therapeutic vaccines.Results and Conclusion From the perspective of the sponsor,investigators and the thirdparty technical service company,the problems such as the low efficiency of clinical trial sample preparation and the lax implementation of the protocol by hospital departments in the quality management of clinical trials of therapeutic vaccines in China were found.Then,the optimization plan for the quality management of clinical trials of therapeutic vaccines is proposed,including optimizing the preparation process of therapeutic vaccines and strengthening the training of hospital department personnel.

曹伟云教授治疗Good’s综合征合并支气管扩张验案1例

Good’s综合征是一种免疫缺陷性疾病,属于少见病,关于本病的报道并不多,尤其是采用中药治疗的报道少之又少。Good’s综合征患者因免疫力欠佳,易合并感染,尤以合并支气管扩张伴感染偏多。目前,西医治疗多为对症治疗,急性期予抗生素控制感染,但患者病情易反复。本文主要从曹伟云教授对Good’s综合征合并支气管扩张病的中医病因病机和辨证论治等方面展开论述,认为Good’s综合征合并支气管扩张或因初感外邪、侵犯肺系,或因痰热日久、消耗阴液,或因久病体虚、伤及阴阳引起,在治疗上或予以清热散邪,或予以养阴清热、化痰排脓,或予以补阳养阴,同时根据伴随症进行药物加减,通过整体观念辨证论治,扶正与祛邪动态调整,尤以扶正为要,增强患者的免疫力,改善患者体质,迅速缓解患者临床症状,减少病情发作次数和患者住院次数。

Research on Construction of Pharmacovigilance System for Marketing Authorization Holders in China

Objective To provide suggestions for helping marketing authorization holders(MAHs)to develop an effective and compliant pharmacovigilance system.Methods The construction strategies of pharmacovigilance system of the multinational pharmaceutical companies were analyzed based on the requirements of regulations and laws.Results and Conclusion There are some gaps between local and multinational pharmaceutical companies in the construction of pharmacovigilance system.We can learn from the experience of multinational pharmaceutical companies to improve the pharmacovigilance system,which includes building a sound pharmacovigilance organizational structure,establishing a series of operational system files and cultivating professional talents.MAHs of China should improve the structure of enterprise pharmacovigilance system.Besides,members of Drug Safety Committee should be department managers with higher position so that they can fulfil the responsibilities of risk assessment.If MAHs possess a large variety and quantity of products,a Drug Safety Committee should be established to ensure the timely discovery of risks.In addition,MAHs should pay attention to the implementation of related regulations and laws on pharmacovigilance and establish compliant,effective and operatable files combing with the actual operation of pharmacovigilance system.Finally,MAHs should introduce and train pharmacovigilance talents,and hire pharmacovigilance experts as consultants to solve the problem of talent shortage.

DISTRIBUTION MODEL OF FATIGUE LIFEAND ITS GOODNESS-OF-FIT TEST

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Study on Variation of Fitting Goodness of Relation Between Earthquake Frequency and Magnitude before Moderately Strong Earthquakes (Ms≥5.0)

In this paper,characteristics of spatial and temporal variation of linear fitting goodness before some moderately strong earthquakes(Ms≥5.0)in the eastern part of China(east of longitude 180)are studied according to the famous Gutenberg-Richter’s relation expressed as lgN=a-bM,by using the moderate and small events that occurred in and around the source area.The results show that the linear goodness of fitting varies abnormally prior to these moderately strong earthquakes.In the early stage of the earthquake preparatory process,distribution of the energy released through small events in and around the source area is isostatic and the fitting goodness approximates 1,while the distribution of the energy turns to be isostatic before moderately strong earthquakes,leading to the obvious decrease of the linear goodness of fitting.This phenomenon could be a medium term anomaly and a medium term criterion for moderately strong earthquake prediction.

Appreciation and Analysis of the“Truth,Goodness and Beauty”in Primary School Mathematics Class

Focus on cultivating students’mathematical thinking and ability to solve problems in life,guide students to form a scientific attitude of seeking truth from facts,and make students feel the charm of mathematics.

Frequency Domain Goodness of Fit Test Based Spectrum Sensing Method with Dynamically Varying Noise

In cognitive radio networks,spectrum sensing under circumstances of dynamically varying noise and lacking prior information is a key challenge to the conventional spectrum sensing algorithms.Since the necessary information is rather difficult to obtain practically,most existing spectrum sensing methods are fettered in applications.Motivated by these,in this paper,a Frequency domain Goodness of Fit Test(FGoF)based spectrum sensing method is proposed.The FGoF makes full use of underlying information in Guard-Bands and the advantages of GoF test works for any distribution.Analytical and simulated results show that the FGoF is a robust spectrum sensing method in cognitive radio with the inherent advantages of invulnerability to dynamically varying noise.

Generalized Kumaraswamy Generalized Power Gompertz Distribution: Statistical Properties, Application, and Validation Using a Modified Chi-Squared Goodness of Fit Test

A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function and cumulative distribution function is presented. The statistical features of the Generalized Kumaraswamy Generalized Power Gompertz distribution are systematically derived and adequately studied. The estimation of the model parameters in the absence of censoring and under-right censoring is performed using the method of maximum likelihood. The test statistic for right-censored data, criteria test for GKGPG distribution, estimated matrix Ŵ, Ĉ, and Ĝ, criteria test Y2n, alongside the quadratic form of the test statistic is derived. Mean simulated values of maximum likelihood estimates and their corresponding square mean errors are presented and confirmed to agree closely with the true parameter values. Simulated levels of significance for Y2n (γ) test for the GKGPG model against their theoretical values were recorded. We conclude that the null hypothesis for which simulated samples are fitted by GKGPG distribution is widely validated for the different levels of significance considered. From the summary of the results of the strength of a specific type of braided cord dataset on the GKGPG model, it is observed that the proposed GKGPG model fits the data set for a significance level ε = 0.05.

Goodness of Fit Test Based on BLUS Residuals for Error Distribution of Regression Model

The error distribution testing plays an important role in linear regression as distribution misspecification seriously affects the validity and efficiency of regression analysis. The least squares (OLS) residuals are often used to construct test statistics;in order to overcome the non-independent and identically residuals, the best linear unbiased scale (BLUS) residuals are applied in this paper, which, unlike OLS residuals, the residuals vector is identically and independently distributed. Based on the BLUS residuals, a new test statistic is constructed by using the sample random distance between sample quantile and quasi sample quantile derived from the null distribution, and the goodness-of-fit test of error distribution in the linear model is studied. The powers of the new tests under certain alternatives are examined. They are more powerful tests for the hypotheses concerned.

ZENG Xu-bai and the Journal Truth, Beauty, and Goodness

The journal Truth, Beauty, and Goodness was the main field where ZENG Xu-bai published his literature works; in response to the miscellaneous ＂revolutionary literature＂ at that time, he put forward the idea that literature should be a combination of unity and artistry, and emphasized self-expression of literature on the basis of popularization of literature. With these literature views, his works also had shown his pursuit for the specialty and artistry of literature, as well as a transition from technique-oriented writing to a balance of emotion expression and technique usage. Anyway, during his translation of French literature and creative practice, the rich literature nutrition he received led to his unclear and complex thoughts which he neutralized with carefulness, and hence his unique literature views.

An Analysis of the Literature’s Truth, Goodness and Beauty

Literary works are an important medium for the exploration of truth,goodness and beauty,of which human beings have never stopped the discussion and pursuit.First of all,this paper gives an overview of what are truth,goodness and beauty.Then it summarizes what has been the focus of the unity of truth,goodness and beauty between China and the West.Finally,this paper values the analysis of the truth,goodness and beauty of literary works:the facts of literature should be true,the purpose should be good,and the form should be beautiful.Based on this,the author puts forward the relationship between the three harmonies with the unity of truth,goodness and beauty in literary works,which the author believes is the ultimate pursuit of literature.