Gouania longipetala Hemsl. (Rhamnaceae) is a medicinal plant from Côte d’Ivoire used to treat many diseases like malaria, gastrointestinal infections and gout. Scientific research of aerial part revealed the pre...Gouania longipetala Hemsl. (Rhamnaceae) is a medicinal plant from Côte d’Ivoire used to treat many diseases like malaria, gastrointestinal infections and gout. Scientific research of aerial part revealed the presence of triterpenoid compounds, saponins, phenolic compounds and flavonoids and also mentioned antibacterial, antioxydant and anti-inflammatory activities. Despite the various therapeutic uses of the plant, no scientific research mentions the chemical content of the root. So, this phytochemical investigation is made to identify secondary metabolites present in the hydromethanolic extract of its roots. And the research led to the isolation and characterization of three lupane-type triterpenoid compounds: a novel compound derived from gouanic acid, lupeol (1) and betulin (2), which had been previously reported in the literature. The newly discovered lupane-triterpenoid was identified as 1α-hydroxy-lup-20(29)-en-3-oxo-27,28-dioic acid (3). The structures of these compounds were determined based on analyses of spectroscopic data, including 1D-NMR, 2D-NMR and HR-ESI-MS techniques.展开更多
Two new benzopyran derivatives,1-[（rel 2S,3R）-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]ethanone（1）,and 1-[（rel 25,35）-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]ethanone（2）,along with four known flavonoi...Two new benzopyran derivatives,1-[（rel 2S,3R）-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]ethanone（1）,and 1-[（rel 25,35）-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]ethanone（2）,along with four known flavonoids,prodelphinidin C,prodelphinidin B3,（-）-epi-gallocatechin and（＋）-gallocatechin,were isolated from the stems of Gouania leptostachya DC.var. tonkinensis Pitard.Their structures were determined on the basis of spectroscopic methods including HR-ESI-MS,1D and 2D NMR.Prodelphinidin C exhibited significant inhibitory activity forα-glucosidase.展开更多
文摘Gouania longipetala Hemsl. (Rhamnaceae) is a medicinal plant from Côte d’Ivoire used to treat many diseases like malaria, gastrointestinal infections and gout. Scientific research of aerial part revealed the presence of triterpenoid compounds, saponins, phenolic compounds and flavonoids and also mentioned antibacterial, antioxydant and anti-inflammatory activities. Despite the various therapeutic uses of the plant, no scientific research mentions the chemical content of the root. So, this phytochemical investigation is made to identify secondary metabolites present in the hydromethanolic extract of its roots. And the research led to the isolation and characterization of three lupane-type triterpenoid compounds: a novel compound derived from gouanic acid, lupeol (1) and betulin (2), which had been previously reported in the literature. The newly discovered lupane-triterpenoid was identified as 1α-hydroxy-lup-20(29)-en-3-oxo-27,28-dioic acid (3). The structures of these compounds were determined based on analyses of spectroscopic data, including 1D-NMR, 2D-NMR and HR-ESI-MS techniques.
基金the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program",China(No.2009ZX09301-001)
文摘Two new benzopyran derivatives,1-[（rel 2S,3R）-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]ethanone（1）,and 1-[（rel 25,35）-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]ethanone（2）,along with four known flavonoids,prodelphinidin C,prodelphinidin B3,（-）-epi-gallocatechin and（＋）-gallocatechin,were isolated from the stems of Gouania leptostachya DC.var. tonkinensis Pitard.Their structures were determined on the basis of spectroscopic methods including HR-ESI-MS,1D and 2D NMR.Prodelphinidin C exhibited significant inhibitory activity forα-glucosidase.
