The incidence and prevalence of acute gouty arthritis are increasing with the total prevalence ofgout in China. Non-drug therapies are now being increasingly evaluated for its role in acute andchronic gout with less t...The incidence and prevalence of acute gouty arthritis are increasing with the total prevalence ofgout in China. Non-drug therapies are now being increasingly evaluated for its role in acute andchronic gout with less toxic and side effects and better therapeutic effects. This reviewsummarized that activated coarse fiber, inhibited fine fiber, the influence on5-hydroxytryptamine (5-HT), increased K+ and the anti-inflammation factors were the possiblemechanisms of non-drug therapies for the acute gouty arthritis;This review also introduced thetraditional non-drug therapies and modern non-drug therapies;The traditional non-drugtherapies, including acupuncture, puncture cupping can significantly alleviate acuteinflammation of gout joints and prevent joint dysfunction without obvious toxic and side effects;Modern non-drug therapies, such as laser therapy, electrotherapy, magnetic therapy andultrasonic therapy, also could effectively improve swelling and pain symptoms and joint functionof patients with acute gouty arthritis, and reduce the levels of C-reactive protein, serum uricacid and erythrocyte sedimentation rate. To sum up, the non-drug therapies, especially theincreasing varieties of modern physical therapies, have achieved good effects in the treatmentof acute gouty arthritis with the characteristics of less toxicity and side effects, which are worthyof wide use.展开更多
Gout is caused by the deposition of uric acid as monosodium urate（MSU）. Chronic hyperuricemia is the necessary condition for MSU deposition, which arises from over-production and/or under-excretion of uric acid. Ren...Gout is caused by the deposition of uric acid as monosodium urate（MSU）. Chronic hyperuricemia is the necessary condition for MSU deposition, which arises from over-production and/or under-excretion of uric acid. Renal under-excretion of uric acid accounts for greater than 90% of the patients with hyperuricemia, making URAT1 inhibitors, which act through uricosuric effect a promising class of urate-lowering therapy（ULT）. This review aims at the summary and discussion of the latest development of URAT1 inhibitors for the treatment of hyperuricemia and gout and providing an insight into their structure-activity relationship（SAR）, which will be helpful to the design of URAT1 inhibitors for both academic research and pharmaceutical industry. The current development pipeline of URAT1 inhibitors is promising and encouraging.展开更多
Musculoskeletal diseases such as neck, shoulder, back and leg pain are ext remely common in clinic. Diseases of the joints of the ext remi ti es, especially sputum, wr ist spr ains, and periarthritis of the shoulders,...Musculoskeletal diseases such as neck, shoulder, back and leg pain are ext remely common in clinic. Diseases of the joints of the ext remi ti es, especially sputum, wr ist spr ains, and periarthritis of the shoulders, and even lumbar disc herniation, use X-shaped balance acupuncture therapy to relieve pain and improve motor function. The method of obtaining acupoints is simple and easy to operate. Many of clinical comparison shows that this therapy is simple to conventional acupuncture and moxibustion in the treatment of local pain and joint diseases. This review concluded the advantaged about the X-shaped balance acupuncture therapy and it worth to clinical promotion.展开更多
文摘The incidence and prevalence of acute gouty arthritis are increasing with the total prevalence ofgout in China. Non-drug therapies are now being increasingly evaluated for its role in acute andchronic gout with less toxic and side effects and better therapeutic effects. This reviewsummarized that activated coarse fiber, inhibited fine fiber, the influence on5-hydroxytryptamine (5-HT), increased K+ and the anti-inflammation factors were the possiblemechanisms of non-drug therapies for the acute gouty arthritis;This review also introduced thetraditional non-drug therapies and modern non-drug therapies;The traditional non-drugtherapies, including acupuncture, puncture cupping can significantly alleviate acuteinflammation of gout joints and prevent joint dysfunction without obvious toxic and side effects;Modern non-drug therapies, such as laser therapy, electrotherapy, magnetic therapy andultrasonic therapy, also could effectively improve swelling and pain symptoms and joint functionof patients with acute gouty arthritis, and reduce the levels of C-reactive protein, serum uricacid and erythrocyte sedimentation rate. To sum up, the non-drug therapies, especially theincreasing varieties of modern physical therapies, have achieved good effects in the treatmentof acute gouty arthritis with the characteristics of less toxicity and side effects, which are worthyof wide use.
基金Supported by Key Projects of Tianjin Science and Technology Support Plan(16YFZCSY00910)Natural Science Foundation of Shandong Province(ZR2015BM028)
文摘Gout is caused by the deposition of uric acid as monosodium urate（MSU）. Chronic hyperuricemia is the necessary condition for MSU deposition, which arises from over-production and/or under-excretion of uric acid. Renal under-excretion of uric acid accounts for greater than 90% of the patients with hyperuricemia, making URAT1 inhibitors, which act through uricosuric effect a promising class of urate-lowering therapy（ULT）. This review aims at the summary and discussion of the latest development of URAT1 inhibitors for the treatment of hyperuricemia and gout and providing an insight into their structure-activity relationship（SAR）, which will be helpful to the design of URAT1 inhibitors for both academic research and pharmaceutical industry. The current development pipeline of URAT1 inhibitors is promising and encouraging.
文摘Musculoskeletal diseases such as neck, shoulder, back and leg pain are ext remely common in clinic. Diseases of the joints of the ext remi ti es, especially sputum, wr ist spr ains, and periarthritis of the shoulders, and even lumbar disc herniation, use X-shaped balance acupuncture therapy to relieve pain and improve motor function. The method of obtaining acupoints is simple and easy to operate. Many of clinical comparison shows that this therapy is simple to conventional acupuncture and moxibustion in the treatment of local pain and joint diseases. This review concluded the advantaged about the X-shaped balance acupuncture therapy and it worth to clinical promotion.
