Objective To determine the prognostic significance of MIBl proliferation marker expression on ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) of the breast. Methods By means of histological and imm...Objective To determine the prognostic significance of MIBl proliferation marker expression on ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) of the breast. Methods By means of histological and immunohis tochemical techniques, MIB1 labelling index (LI) was determined in 31 pathologic specimens (DIal 6, IDC 22 and 3 benign breast lesions as control ). Results Significantly higher (P< 0. 05) MIB1 expression wus noted in breast carcinomas in contrast with benign breast lesions. MIBl LI increased with increasing tumor invasion from DCIS to IDC (P< 0. 05). Increased tendency of MIB1 LI had been also noted in according with the increased nuclear grabing (NG) of IDC. Conclusion MIBI ex- pression can faithfully reflect the proliferative activity of the breast lesions, where the breast cancers with both high MIBl LI and NG seem to have a poor prognosis.展开更多
文摘Objective To determine the prognostic significance of MIBl proliferation marker expression on ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) of the breast. Methods By means of histological and immunohis tochemical techniques, MIB1 labelling index (LI) was determined in 31 pathologic specimens (DIal 6, IDC 22 and 3 benign breast lesions as control ). Results Significantly higher (P< 0. 05) MIB1 expression wus noted in breast carcinomas in contrast with benign breast lesions. MIBl LI increased with increasing tumor invasion from DCIS to IDC (P< 0. 05). Increased tendency of MIB1 LI had been also noted in according with the increased nuclear grabing (NG) of IDC. Conclusion MIBI ex- pression can faithfully reflect the proliferative activity of the breast lesions, where the breast cancers with both high MIBl LI and NG seem to have a poor prognosis.
