AIM： To suspect laryngopharyngeal reflux（LPR） in patients with ocular surface disease（OSD）. METHODS： The present study evaluated a group of subjects with OSD assessing the Ocular Surface Disease Index（OSDI） an...AIM： To suspect laryngopharyngeal reflux（LPR） in patients with ocular surface disease（OSD）. METHODS： The present study evaluated a group of subjects with OSD assessing the Ocular Surface Disease Index（OSDI） and the Reflux Symptom Index（RSI） to detect patients with suspected LPR and define a possible relationship between tests.RESULTS： Two hundred and ninety subjects（175 females, mean age： 60.41±15.68y） were consecutively visited at ophthalmologist offices. One hundred and one（34%） patients had pathological RSI（〉13） and consequently a suspected LPR.CONCLUSION： The current study shows that suspected LPR may be common（34%） in patients with OSD and a suspected LPR may be considered in OSD patients when RSI score is 〉13 and OSDI score is 〉42.展开更多
Background: Cyclosporine A (CsA) is an inhibitor of calcineurin that prevents T-cell production of inflammatory cytokines and disrupts the immune-mediated inflammatory response that plays a crucial mechanism in puncta...Background: Cyclosporine A (CsA) is an inhibitor of calcineurin that prevents T-cell production of inflammatory cytokines and disrupts the immune-mediated inflammatory response that plays a crucial mechanism in punctal stenosis. Purpose: To evaluate the clinical outcomes and tolerances of CsA in treating epiphora in eyes with punctal stenosis. Study Design: Prospective study. Methods: The study included patients who presented with symptomatic epiphora associated with lower punctal stenosis during the period between July 2019 and December 2020. Patients were treated with topical 0.05% CsA on twice daily dose with topical preservative-free artificial tears Q.I. D. Patients were followed up monthly for at least 3 months by Munk epiphora grading, Fluorescein dye disappearance test (FDT) and evaluation of the patient satisfaction. Results: A total of 26 patients with 47 eyes were included in the study with a mean age of 55.1 ± 10.24 years. All the eyes had grade 0 lower punctal stenosis with grade 4 on Munk grading and grade 3 in FDT. There was a statistically significant difference in the Munk grading and FDT along the follow-up period compared to the baseline values (p Conclusion: CsA can control the inflammation of the conjunctival sac and restore the integrity of the ocular surface with subsequent symptomatic relief of the epiphora in eyes with punctal stenosis.展开更多
目的:应用颞侧球结膜眼红指数(TCHI)、眼部症状评分(OSS)及视觉模拟量表(VAS)研究翼状胬肉切除联合自体结膜移植术后患者眼表炎症反应变化情况,并将上述指标应用于抗炎治疗效果评价中,判断其应用有效性。方法:以100例翼状胬肉患者为研...目的:应用颞侧球结膜眼红指数(TCHI)、眼部症状评分(OSS)及视觉模拟量表(VAS)研究翼状胬肉切除联合自体结膜移植术后患者眼表炎症反应变化情况,并将上述指标应用于抗炎治疗效果评价中,判断其应用有效性。方法:以100例翼状胬肉患者为研究对象,均采取翼状胬肉切除联合自体结膜移植术治疗,术后对眼表炎症进行治疗。评估术前,术后1、3、7、10 d,术后1、2个月眼表炎症,应用眼表综合分析仪对TCHI做出评估,观察OSS、VAS评分等主观量化指标的动态变化,采用荧光素钠染色法对角膜上皮愈合情况进行观察,并测量最佳矫正视力(BCVA)。结果:患者术后2个月BCVA明显较术前低(P<0.05)。术后10 d患者角膜无荧光素染色出现,提示角膜上皮缺损愈合完全。术后1 d OSS评分及TCHI值高于术前(均P<0.05);随着抗炎治疗的开展,患者术后7 d OSS评分及TCHI值均降至术前水平(均P>0.05);患者术后1、2个月上述指标均较术前低(均P<0.05)。患者术后1 d VAS评分高于术前(P<0.05);随着抗炎治疗的开展,患者术后7 d VAS评分降至术前水平(P>0.05);术后2个月VAS评分较术前低(P<0.05)。结论:OSS、VAS评分及TCHI可对行翼状胬肉切除联合自体结膜移植术治疗患者的炎症状态做出有效评估,并可作为抗炎治疗有效性的评价指标。展开更多
文摘AIM： To suspect laryngopharyngeal reflux（LPR） in patients with ocular surface disease（OSD）. METHODS： The present study evaluated a group of subjects with OSD assessing the Ocular Surface Disease Index（OSDI） and the Reflux Symptom Index（RSI） to detect patients with suspected LPR and define a possible relationship between tests.RESULTS： Two hundred and ninety subjects（175 females, mean age： 60.41±15.68y） were consecutively visited at ophthalmologist offices. One hundred and one（34%） patients had pathological RSI（〉13） and consequently a suspected LPR.CONCLUSION： The current study shows that suspected LPR may be common（34%） in patients with OSD and a suspected LPR may be considered in OSD patients when RSI score is 〉13 and OSDI score is 〉42.
文摘Background: Cyclosporine A (CsA) is an inhibitor of calcineurin that prevents T-cell production of inflammatory cytokines and disrupts the immune-mediated inflammatory response that plays a crucial mechanism in punctal stenosis. Purpose: To evaluate the clinical outcomes and tolerances of CsA in treating epiphora in eyes with punctal stenosis. Study Design: Prospective study. Methods: The study included patients who presented with symptomatic epiphora associated with lower punctal stenosis during the period between July 2019 and December 2020. Patients were treated with topical 0.05% CsA on twice daily dose with topical preservative-free artificial tears Q.I. D. Patients were followed up monthly for at least 3 months by Munk epiphora grading, Fluorescein dye disappearance test (FDT) and evaluation of the patient satisfaction. Results: A total of 26 patients with 47 eyes were included in the study with a mean age of 55.1 ± 10.24 years. All the eyes had grade 0 lower punctal stenosis with grade 4 on Munk grading and grade 3 in FDT. There was a statistically significant difference in the Munk grading and FDT along the follow-up period compared to the baseline values (p Conclusion: CsA can control the inflammation of the conjunctival sac and restore the integrity of the ocular surface with subsequent symptomatic relief of the epiphora in eyes with punctal stenosis.
文摘目的:应用颞侧球结膜眼红指数(TCHI)、眼部症状评分(OSS)及视觉模拟量表(VAS)研究翼状胬肉切除联合自体结膜移植术后患者眼表炎症反应变化情况,并将上述指标应用于抗炎治疗效果评价中,判断其应用有效性。方法:以100例翼状胬肉患者为研究对象,均采取翼状胬肉切除联合自体结膜移植术治疗,术后对眼表炎症进行治疗。评估术前,术后1、3、7、10 d,术后1、2个月眼表炎症,应用眼表综合分析仪对TCHI做出评估,观察OSS、VAS评分等主观量化指标的动态变化,采用荧光素钠染色法对角膜上皮愈合情况进行观察,并测量最佳矫正视力(BCVA)。结果:患者术后2个月BCVA明显较术前低(P<0.05)。术后10 d患者角膜无荧光素染色出现,提示角膜上皮缺损愈合完全。术后1 d OSS评分及TCHI值高于术前(均P<0.05);随着抗炎治疗的开展,患者术后7 d OSS评分及TCHI值均降至术前水平(均P>0.05);患者术后1、2个月上述指标均较术前低(均P<0.05)。患者术后1 d VAS评分高于术前(P<0.05);随着抗炎治疗的开展,患者术后7 d VAS评分降至术前水平(P>0.05);术后2个月VAS评分较术前低(P<0.05)。结论:OSS、VAS评分及TCHI可对行翼状胬肉切除联合自体结膜移植术治疗患者的炎症状态做出有效评估,并可作为抗炎治疗有效性的评价指标。
