Identification of Graves’ophthalmology by laser-induced breakdown spectroscopy combined with machine learning method

Diagnosis of the Graves’ophthalmology remains a significant challenge.We identified between Graves’ophthalmology tissues and healthy controls by using laser-induced breakdown spectroscopy(LIBS)combined with machine learning method.In this work,the paraffin-embedded samples of the Graves’ophthalmology were prepared for LIBS spectra acquisition.The metallic elements(Na,K,Al,Ca),non-metallic element(O)and molecular bands((C-N),(C-O))were selected for diagnosing Graves’ophthalmology.The selected spectral lines were inputted into the supervised classification methods including linear discriminant analysis(LDA),support vector machine(SVM),k-nearest neighbor(ANN),and generalized regression neural network(GRNN),respectively.The results showed that the predicted accuracy rates of LDA,SVM,ANN,GRNN were 76.33%,96.28%,96.56%,and 96.33%,respectively.The sensitivity of four models were 75.89%,93.78%,96.78%,and 96.67%,respectively.The specificity of four models were 76.78%,98.78%,96.33%,and 96.00%,respectively.This demonstrated that LIBS assisted with a nonlinear model can be used to identify Graves’ophthalmopathy with a higher rate of accuracy.The ANN had the best performance by comparing the three nonlinear models.Therefore,LIBS combined with machine learning method can be an effective way to discriminate Graves’ophthalmology.