Thyroid stimulating hormone receptor（TSHR） is thought to be a significant candidate for genetic susceptibility to Graves＇ disease（GD）.However,the association between TSHR gene polymorphism and the risk of GD rema...Thyroid stimulating hormone receptor（TSHR） is thought to be a significant candidate for genetic susceptibility to Graves＇ disease（GD）.However,the association between TSHR gene polymorphism and the risk of GD remains controversial.In this study,we investigated the relationship between the two conditions by meta-analysis.We searched all relevant case-control studies in PubMed,Web of Science,CNKI and Wanfang for literature available until May2015,and chose studies on two single nucleotide polymorphisms（SNPs）：rs 179247 and rsl2101255,within TSHR intron-1.Bias of heterogeneity test among studies was determined by the fixed or random effect pooled measure,and publication bias was examined by modified Begg＇s and Egger＇s test.Eight eligible studies with 15 outcomes were involved in this meta-analysis,including 6,976 GD cases and 7,089 controls from China,Japan,Poland,UK and Brazil.Pooled odds ratios（ORs） for allelic comparisons showed that both TSHR rsl79247A/G and rsl2101255T/C polymorphism had significant association with GD（OR=1.422,95%CI=1.353—1.495,P〈0.001,P_（heterogeneity）=0.448;OR= 1.502,95%CI：1.410-1.600,P〈0.001,P_（heterogeneity）=0.642）,and the associations were the same under dominant,recessive and co-dominant models.In subgroup analyses,the conclusions are also consistent with all those in Asian,European and South America subgroups（P〈0.001）.Our meta-analysis revealed a significant association between TSHR rsl79247A/G and rsl2101255T/C polymorphism with GD in five different populations from Asia,Europe and South America.Further studies are needed in other ethnic backgrounds to independently confirm our findings.展开更多
目的探讨初诊断Graves病患者白细胞或中性粒细胞减少的相关因素及其与TRAb水平的相关性。方法选取初诊断Graves病患者336例,根据白细胞及中性粒细胞水平分组,238例白细胞和中性粒细胞正常者为对照组（A组）,98例白细胞或中性粒细胞减少...目的探讨初诊断Graves病患者白细胞或中性粒细胞减少的相关因素及其与TRAb水平的相关性。方法选取初诊断Graves病患者336例,根据白细胞及中性粒细胞水平分组,238例白细胞和中性粒细胞正常者为对照组（A组）,98例白细胞或中性粒细胞减少者为研究组（B组）。比较并分析2组患者的一般情况及实验室检查特征。结果 B组TRAb水平显著高于A组（18.09±13.29 vs 13.75±12.9,P〈0.05）,而甲功、TGAb、TPOAb无统计学差异。回归分析表明,Graves病甲亢患者合并白细胞或中性粒细胞减少的风险女性大于男性（P〈0.05）。Graves病甲亢患者TRAb水平越高,合并白细胞或中性粒细胞减少的风险越大（OR=1.025,95%CI=1.005～1.046,P=0.014）。Graves病甲亢患者白细胞计数（r=-0.024,P=0.001）、中性粒细胞计数（r=-0.018,P=0.003）与TRAb水平呈负相关。结论初诊断Graves病患者白细胞或中性粒细胞减少与TRAb水平相关。展开更多
INTRODUCTION Autoimmunity is defined as, a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body＇s own tissues （autoantigens）. In numerous autoimmune di...INTRODUCTION Autoimmunity is defined as, a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body＇s own tissues （autoantigens）. In numerous autoimmune diseases, such an immune response is well recognized that causes damage to the self-constituents of body tissues by the products of the immune system. Graves＇ hyperthyroidism occurs after the loss of tolerance to the thyroid stimulating hormone receptor （TSHR） and the generation of thyroid stimulatory antibodies that mimic the action of thyroid-stimulating hormone （TSH）.展开更多
基金supported by grants from the National Natural Science Foundation of China(Grant No.81102032)
文摘Thyroid stimulating hormone receptor（TSHR） is thought to be a significant candidate for genetic susceptibility to Graves＇ disease（GD）.However,the association between TSHR gene polymorphism and the risk of GD remains controversial.In this study,we investigated the relationship between the two conditions by meta-analysis.We searched all relevant case-control studies in PubMed,Web of Science,CNKI and Wanfang for literature available until May2015,and chose studies on two single nucleotide polymorphisms（SNPs）：rs 179247 and rsl2101255,within TSHR intron-1.Bias of heterogeneity test among studies was determined by the fixed or random effect pooled measure,and publication bias was examined by modified Begg＇s and Egger＇s test.Eight eligible studies with 15 outcomes were involved in this meta-analysis,including 6,976 GD cases and 7,089 controls from China,Japan,Poland,UK and Brazil.Pooled odds ratios（ORs） for allelic comparisons showed that both TSHR rsl79247A/G and rsl2101255T/C polymorphism had significant association with GD（OR=1.422,95%CI=1.353—1.495,P〈0.001,P_（heterogeneity）=0.448;OR= 1.502,95%CI：1.410-1.600,P〈0.001,P_（heterogeneity）=0.642）,and the associations were the same under dominant,recessive and co-dominant models.In subgroup analyses,the conclusions are also consistent with all those in Asian,European and South America subgroups（P〈0.001）.Our meta-analysis revealed a significant association between TSHR rsl79247A/G and rsl2101255T/C polymorphism with GD in five different populations from Asia,Europe and South America.Further studies are needed in other ethnic backgrounds to independently confirm our findings.
文摘目的探讨初诊断Graves病患者白细胞或中性粒细胞减少的相关因素及其与TRAb水平的相关性。方法选取初诊断Graves病患者336例,根据白细胞及中性粒细胞水平分组,238例白细胞和中性粒细胞正常者为对照组（A组）,98例白细胞或中性粒细胞减少者为研究组（B组）。比较并分析2组患者的一般情况及实验室检查特征。结果 B组TRAb水平显著高于A组（18.09±13.29 vs 13.75±12.9,P〈0.05）,而甲功、TGAb、TPOAb无统计学差异。回归分析表明,Graves病甲亢患者合并白细胞或中性粒细胞减少的风险女性大于男性（P〈0.05）。Graves病甲亢患者TRAb水平越高,合并白细胞或中性粒细胞减少的风险越大（OR=1.025,95%CI=1.005～1.046,P=0.014）。Graves病甲亢患者白细胞计数（r=-0.024,P=0.001）、中性粒细胞计数（r=-0.018,P=0.003）与TRAb水平呈负相关。结论初诊断Graves病患者白细胞或中性粒细胞减少与TRAb水平相关。
基金Financial support and sponsorship This study was supported by the grants from National Natural Science Foundation of China （No. 81170729 and No. 81200574）.
文摘INTRODUCTION Autoimmunity is defined as, a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body＇s own tissues （autoantigens）. In numerous autoimmune diseases, such an immune response is well recognized that causes damage to the self-constituents of body tissues by the products of the immune system. Graves＇ hyperthyroidism occurs after the loss of tolerance to the thyroid stimulating hormone receptor （TSHR） and the generation of thyroid stimulatory antibodies that mimic the action of thyroid-stimulating hormone （TSH）.
