Norepinephrine(NA),a stress hormone,can accelerate hair graying by binding toβ2 adrenergic receptors(β_(2)AR)on melanocyte stem cells(McSCs).From this,NA-β_(2)AR axis could be a potential target for preventing the ...Norepinephrine(NA),a stress hormone,can accelerate hair graying by binding toβ2 adrenergic receptors(β_(2)AR)on melanocyte stem cells(McSCs).From this,NA-β_(2)AR axis could be a potential target for preventing the stress effect.However,identifying selective blockers forβ_(2)AR has been a key challenge.Therefore,in this study,advanced computer-aided drug design(CADD)techniques were harnessed to screen natural molecules,leading to the discovery of rhynchophylline as a promising compound.Rhynchophylline exhibited strong and stable binding within the active site ofβ_(2)AR,as verified by molecular docking and dynamic simulation assays.When administered to cells,rhyncho-phylline effectively inhibited NA-β_(2)AR signaling.This intervention resulted in a significant reduction of hair graying in a stress-induced mouse model,from 28.5%to 8.2%.To gain a deeper understanding of the underlying mechanisms,transcriptome sequencing was employed,which revealed that NA might disrupt melanogenesis by affecting intracellular calcium balance and promoting cell apoptosis.Importantly,rhynchophylline acted as a potent inhibitor of these downstream pathways.In conclusion,the study demonstrated that rhynchophylline has the potential to mitigate the negative impact of NA on melanogenesis by targetingβ_(2)AR,thus offering a promising solution for preventing stress-induced hair graying.展开更多
The rail surface status image is affected by the noise in the shooting environment and contains a large amount of interference information, which increases the difficulty of rail surface status identification. In orde...The rail surface status image is affected by the noise in the shooting environment and contains a large amount of interference information, which increases the difficulty of rail surface status identification. In order to solve this problem, a preprocessing method for the rail surface state image is proposed. The preprocessing process mainly includes image graying, image denoising, image geometric correction, image extraction, data amplification, and finally building the rail surface image database. The experimental results show that this method can efficiently complete image processing, facilitate feature extraction of rail surface status images, and improve rail surface status recognition accuracy.展开更多
On the basis of summarizing theories related to public goods,with the aid of trend curve of China's annual grain yield from 1978 to 2010,in combination with grain policies at that time,empirical analysis is carrie...On the basis of summarizing theories related to public goods,with the aid of trend curve of China's annual grain yield from 1978 to 2010,in combination with grain policies at that time,empirical analysis is carried out on institution as key factor influencing the farmers' enthusiasm,showing that there is highly positive correlation between institutional change and grain production.In order to raise farmers' production enthusiasm and ensure the national grain security,this paper puts forward appropriate countermeasure systems from the point of view of innovating grain production policies.The countermeasure systems include:firstly,innovate agricultural operation institution;secondly,improve agricultural personnel cultivation mechanism;thirdly,complete financial investment system;fourthly,set up grain security protection system;and finally,build risk support system.展开更多
制造活动的发展已从原始的手工制造发展成为机器制造(单机)、流水线制造进而进入了柔性制造系统时期并开始向高度自动化的未来工厂发展。自动制造系统是一个典型的分级递阶的智能控制系统。我们可以从系统的功能或从管理学的角度对系统...制造活动的发展已从原始的手工制造发展成为机器制造(单机)、流水线制造进而进入了柔性制造系统时期并开始向高度自动化的未来工厂发展。自动制造系统是一个典型的分级递阶的智能控制系统。我们可以从系统的功能或从管理学的角度对系统进行不同的划分。Pun和Dougmeingts把系统划分为物理系统、信息系统与决策系统。Pun据此提出了GRAI(Graphs with Results and Activities Interrelated,结果与活动相关的图)。GRAI是适合于对制造系统进行管理、决策控制的概念模型方法。它已被ESPRIT—CIM小组采纳,并在许多国家的小型系统中应用并取得成功。 事实上,决策与控制是有相差别的一面的。我们可以把自动制造系统划分为决策系统、控制系统、信息系统与物理系统(如图1所示)。展开更多
基金the Shenzhen Science and Technology Innovation Committee(grant numbers JCYJ20200109142444449,JCYJ20210324120007021)the National Natural Science Foundation of China(grant numbers 31801196)Basic and Applied Basic Research Foundation of Guangdong Province(grant numbers 2022A1515110645).
文摘Norepinephrine(NA),a stress hormone,can accelerate hair graying by binding toβ2 adrenergic receptors(β_(2)AR)on melanocyte stem cells(McSCs).From this,NA-β_(2)AR axis could be a potential target for preventing the stress effect.However,identifying selective blockers forβ_(2)AR has been a key challenge.Therefore,in this study,advanced computer-aided drug design(CADD)techniques were harnessed to screen natural molecules,leading to the discovery of rhynchophylline as a promising compound.Rhynchophylline exhibited strong and stable binding within the active site ofβ_(2)AR,as verified by molecular docking and dynamic simulation assays.When administered to cells,rhyncho-phylline effectively inhibited NA-β_(2)AR signaling.This intervention resulted in a significant reduction of hair graying in a stress-induced mouse model,from 28.5%to 8.2%.To gain a deeper understanding of the underlying mechanisms,transcriptome sequencing was employed,which revealed that NA might disrupt melanogenesis by affecting intracellular calcium balance and promoting cell apoptosis.Importantly,rhynchophylline acted as a potent inhibitor of these downstream pathways.In conclusion,the study demonstrated that rhynchophylline has the potential to mitigate the negative impact of NA on melanogenesis by targetingβ_(2)AR,thus offering a promising solution for preventing stress-induced hair graying.
文摘The rail surface status image is affected by the noise in the shooting environment and contains a large amount of interference information, which increases the difficulty of rail surface status identification. In order to solve this problem, a preprocessing method for the rail surface state image is proposed. The preprocessing process mainly includes image graying, image denoising, image geometric correction, image extraction, data amplification, and finally building the rail surface image database. The experimental results show that this method can efficiently complete image processing, facilitate feature extraction of rail surface status images, and improve rail surface status recognition accuracy.
基金Supported by Sichuan Provincial Department of Education Youth Foundation(09SB071)
文摘On the basis of summarizing theories related to public goods,with the aid of trend curve of China's annual grain yield from 1978 to 2010,in combination with grain policies at that time,empirical analysis is carried out on institution as key factor influencing the farmers' enthusiasm,showing that there is highly positive correlation between institutional change and grain production.In order to raise farmers' production enthusiasm and ensure the national grain security,this paper puts forward appropriate countermeasure systems from the point of view of innovating grain production policies.The countermeasure systems include:firstly,innovate agricultural operation institution;secondly,improve agricultural personnel cultivation mechanism;thirdly,complete financial investment system;fourthly,set up grain security protection system;and finally,build risk support system.
文摘制造活动的发展已从原始的手工制造发展成为机器制造(单机)、流水线制造进而进入了柔性制造系统时期并开始向高度自动化的未来工厂发展。自动制造系统是一个典型的分级递阶的智能控制系统。我们可以从系统的功能或从管理学的角度对系统进行不同的划分。Pun和Dougmeingts把系统划分为物理系统、信息系统与决策系统。Pun据此提出了GRAI(Graphs with Results and Activities Interrelated,结果与活动相关的图)。GRAI是适合于对制造系统进行管理、决策控制的概念模型方法。它已被ESPRIT—CIM小组采纳,并在许多国家的小型系统中应用并取得成功。 事实上,决策与控制是有相差别的一面的。我们可以把自动制造系统划分为决策系统、控制系统、信息系统与物理系统(如图1所示)。
