Purpose: To describe the baseline data of a large cohort of patients included for follow-up with perimetry using the frequency doubling technique (FDT) and w ith quantification of the retinal nerve fibre layer as asse...Purpose: To describe the baseline data of a large cohort of patients included for follow-up with perimetry using the frequency doubling technique (FDT) and w ith quantification of the retinal nerve fibre layer as assessed by GDx, and to c alculate the sensitivity and specificity of both devices from these baseline dat a. Methods: Regular visitors to our glaucoma service were included. All subjects were followed for at least 4 years with FDT in full-threshold mode, GDx and co nventional perimetry. Patients were classified as having either glaucoma or susp ect glaucoma, according to baseline perimetry results. In addition, a group of h ealthy subjects was recruited outside the hospital. Results: A total of 452 glau coma patients, 423 glaucoma suspects and 237 healthy subjects were incorporated into the analyses. Sensitivities for both FDT and GDx were fixed at 0.90. For th e group as a whole, the specificity was 0.81 for FDT, using number of depressed test-points p <0.01 in the total deviation probability plot with a cut-off poi nt >1, and 0.78 for GDx, using the Number, with a cut-off point >29. The area u nder the receiver operating characteristic (ROC)curve was 0.92 for FDT and 0.94 for GDx. Of the subjects with suspect glaucoma, 75%showed normal FDT test resul ts and 52%showed normal GDx results. Unlike FDT, GDx failed to detect some mode rate/severe glaucoma cases. Conclusions: The performances of FDT and GDx are app roximately equivalent in terms of sensitivity, specificity and area under the RO C curve. In glaucoma suspects, GDx in particular yielded a rather high percentag e of positive test results. The majority of these positive test results are pres umably false-positive results rather than results indicating preperimetric glau coma.展开更多
Carbon nanotubes（CNTs） have received wide application and investigation because of their unique electronic, chemical and mechanical properties. But the self-aggregation of CNTs limits their practical application and...Carbon nanotubes（CNTs） have received wide application and investigation because of their unique electronic, chemical and mechanical properties. But the self-aggregation of CNTs limits their practical application and study. In order to disperse CNTs effectively, polymers, such as polyglycerol and its derivatives, are adopted as dispersants in view of their strong interaction with CNTs. In order to understand the interaction between CNTs and glycerol in water in detail, a series of simulations has been conducted to investigate the interaction between them and analyze the influences of CNTs diameter and temperature. All the analyses indicate that the glycerol molecules are prone to aggregate around CNTs with the addition of CNTs. This is mainly due to hydrophobic interaction. It is confirmed that this aggregation is influenced by CNTs diameter and the temperature to some degree. This work will establish the basis for the exploration of polyglycerol and its derivatives interacting with CNTs and provide an invaluable guide to seek for emergent dispersants for CNTs.展开更多
文摘Purpose: To describe the baseline data of a large cohort of patients included for follow-up with perimetry using the frequency doubling technique (FDT) and w ith quantification of the retinal nerve fibre layer as assessed by GDx, and to c alculate the sensitivity and specificity of both devices from these baseline dat a. Methods: Regular visitors to our glaucoma service were included. All subjects were followed for at least 4 years with FDT in full-threshold mode, GDx and co nventional perimetry. Patients were classified as having either glaucoma or susp ect glaucoma, according to baseline perimetry results. In addition, a group of h ealthy subjects was recruited outside the hospital. Results: A total of 452 glau coma patients, 423 glaucoma suspects and 237 healthy subjects were incorporated into the analyses. Sensitivities for both FDT and GDx were fixed at 0.90. For th e group as a whole, the specificity was 0.81 for FDT, using number of depressed test-points p <0.01 in the total deviation probability plot with a cut-off poi nt >1, and 0.78 for GDx, using the Number, with a cut-off point >29. The area u nder the receiver operating characteristic (ROC)curve was 0.92 for FDT and 0.94 for GDx. Of the subjects with suspect glaucoma, 75%showed normal FDT test resul ts and 52%showed normal GDx results. Unlike FDT, GDx failed to detect some mode rate/severe glaucoma cases. Conclusions: The performances of FDT and GDx are app roximately equivalent in terms of sensitivity, specificity and area under the RO C curve. In glaucoma suspects, GDx in particular yielded a rather high percentag e of positive test results. The majority of these positive test results are pres umably false-positive results rather than results indicating preperimetric glau coma.
基金Supported by the National Natural Science Foundation of China（Nos.21133005, 21073080）, the Program for Liaoning Excellent Talents in University（LNET）, China（No.LJQ2013111） and the Natural Science Foundation of Liaoning Province, China （No.2014020150）.
文摘Carbon nanotubes（CNTs） have received wide application and investigation because of their unique electronic, chemical and mechanical properties. But the self-aggregation of CNTs limits their practical application and study. In order to disperse CNTs effectively, polymers, such as polyglycerol and its derivatives, are adopted as dispersants in view of their strong interaction with CNTs. In order to understand the interaction between CNTs and glycerol in water in detail, a series of simulations has been conducted to investigate the interaction between them and analyze the influences of CNTs diameter and temperature. All the analyses indicate that the glycerol molecules are prone to aggregate around CNTs with the addition of CNTs. This is mainly due to hydrophobic interaction. It is confirmed that this aggregation is influenced by CNTs diameter and the temperature to some degree. This work will establish the basis for the exploration of polyglycerol and its derivatives interacting with CNTs and provide an invaluable guide to seek for emergent dispersants for CNTs.
