目的ATP结合盒B亚家族成员1(ATP binding cassette subfamily B member 1,ABCB1)的异常表达在多种癌症的发生发展中发挥关键作用。然而,G蛋白偶联受体C家族5组A型(G protein coupled receptor family C group5 type A,GPRC5A)调控的ABCB...目的ATP结合盒B亚家族成员1(ATP binding cassette subfamily B member 1,ABCB1)的异常表达在多种癌症的发生发展中发挥关键作用。然而,G蛋白偶联受体C家族5组A型(G protein coupled receptor family C group5 type A,GPRC5A)调控的ABCB1表达对肺腺癌增殖的影响仍不清楚。本研究探讨了GPRC5A调控的ABCB1表达对肺腺癌增殖的影响。方法我们采用RT-PCR、Western-blot或免疫组化实验,分析ABCB1在肺腺癌细胞系、人肺腺癌组织以及GPRC5A基因敲除小鼠和野生型小鼠的气管上皮细胞和肺组织中的表达。采用细胞计数试剂盒-8(CCK-8)分析GPRC5A基因敲除小鼠气管上皮细胞对化疗药物的敏感性。采用皮下肿瘤形成实验探讨下调ABCB1表达是否可抑制体内肺腺癌增殖。采用免疫荧光和免疫沉淀实验研究GPRC5A和ABCB1之间潜在的调控关系。结果ABCB1在肺腺癌细胞系和人类肺腺癌组织中表达上调。GPRC5A基因敲除小鼠的气管上皮细胞及肺组织的ABCB1表达高于野生型小鼠。与GPRC5A野生型小鼠的气管上皮细胞相比,GPRC5A基因敲除小鼠的气管上皮细胞对塔立奇达和多柔比星更敏感。注射移植细胞28天后,接受ABCB1基因敲除细胞移植的GPRC5A-/-C57BL/6小鼠的肺肿瘤的体积和重量均明显低于野生型细胞移植小鼠(P=0.0043,P=0.0060)。此外,免疫荧光和免疫沉淀实验表明,GPRC5A通过直接结合方式调控ABCB1的表达。结论GPRC5A通过抑制ABCB1表达降低肺腺癌增殖。GPRC5A调节ABCB1表达的途径有待研究。展开更多
Let G be a homogeneous group. The author considers the boundedness of commutators generated by the generalized Hardy operators and CMO（G） functions on Herz spaces in the setting of homogeneous group. This article ex...Let G be a homogeneous group. The author considers the boundedness of commutators generated by the generalized Hardy operators and CMO（G） functions on Herz spaces in the setting of homogeneous group. This article extends some known results.展开更多
is the disjoint union of for all , where is the set of all roots of primitive second degree equations , with reduced discriminant equal to k2m. We study the action of two Hecke groups—the full modular group and the g...is the disjoint union of for all , where is the set of all roots of primitive second degree equations , with reduced discriminant equal to k2m. We study the action of two Hecke groups—the full modular group and the group of linear-fractional transformations on . In particular, we investigate the action of on for finding different orbits.展开更多
An iterative transmit power allocation (PA) algorithm was proposed for group-wise space-time block coding (G-STBC) systems with group-wise successive interference cancellation (GSIC) receivers. Group-wise interference...An iterative transmit power allocation (PA) algorithm was proposed for group-wise space-time block coding (G-STBC) systems with group-wise successive interference cancellation (GSIC) receivers. Group-wise interference suppression (GIS) filters are employed to separate each group's transmit signals from other interferences and noise. While the total power on all transmit symbols is constrained, all transmit PA coefficients are updated jointly according to the channel information at each iteration. Through PA, each detection symbol has the same post-detection signal to interference-and-noise ratio (SINR). The simulation results verify that the proposed PA algorithm converges at the equilibrium quickly after few iterations, and it achieves much lower bit error rates than the previous single symbol SIC PA and the fixed ratio PA algorithms for G-STBC systems with GSIC receivers .展开更多
Background: With the inflation of economic constraints on health care and demand to increase care quality, there is an increasing need to develop a clear understanding of what actions by health professionals are perce...Background: With the inflation of economic constraints on health care and demand to increase care quality, there is an increasing need to develop a clear understanding of what actions by health professionals are perceived as threatening quality care. Objective: To explore graduate nursing and pastoral care student’s perceptions of missed care in Norway. Research design: A qualitative study was employed with the formation of six focus groups. Data was analyzed via a thematic content of the discussions. Participants and research context: Thirty-one students attending a University College in Oslo participated. Findings: Five major themes and thirty subthemes were identified. Major themes included labor constraints, organizational contraints, professional constraints, communication constaints and emotional strain. Discussion: Findings of this study resonate with other research as well as with studies on missed nursing care. Findings also lend support to the definition of missed nursing care actions as required care that is omitted, either in part or whole, or delayed. Conclusion: The findings from this study extend understanding of what barriers health professionals perceive as inhibiting them from offering quality care. The focus groups provided a valuable flora for discussion regarding what participants perceived as missed.展开更多
As recounted in this paper, the idea of groups is one that has evolved from some very intuitive concepts. We can do binary operations like adding or multiplying two elements and also binary operations like taking the ...As recounted in this paper, the idea of groups is one that has evolved from some very intuitive concepts. We can do binary operations like adding or multiplying two elements and also binary operations like taking the square root of an element (in this case the result is not always in the set). In this paper, we aim to find the operations and actions of Lie groups on manifolds. These actions can be applied to the matrix group and Bi-invariant forms of Lie groups and to generalize the eigenvalues and eigenfunctions of differential operators on R<sup>n</sup>. A Lie group is a group as well as differentiable manifold, with the property that the group operations are compatible with the smooth structure on which group manipulations, product and inverse, are distinct. It plays an extremely important role in the theory of fiber bundles and also finds vast applications in physics. It represents the best-developed theory of continuous symmetry of mathematical objects and structures, which makes them indispensable tools for many parts of contemporary mathematics, as well as for modern theoretical physics. Here we did work flat out to represent the mathematical aspects of Lie groups on manifolds.展开更多
In this paper, the variable-coefficient diffusion-advection （DA） equation, which arises in modeling various physical phenomena, is studied by the Lie symmetry approach. The similarity reductions are derived by deter...In this paper, the variable-coefficient diffusion-advection （DA） equation, which arises in modeling various physical phenomena, is studied by the Lie symmetry approach. The similarity reductions are derived by determining the complete sets of point symmetries of this equation, and then exact and numerical solutions are reported for the reduced second-order nonlinear ordinary differential equations. Further, an extended （Gl/G）-expansion method is applied to the DA equation to construct some new non-traveling wave solutions.展开更多
Let （K, O, k） be a p-modular system and G be a finite group. We prove that block A of RG and block B of RH are nalurally Morita equivalent of degree n if and only if A≌B＋…＋B}→n^2 as right R[H×H]-modules an...Let （K, O, k） be a p-modular system and G be a finite group. We prove that block A of RG and block B of RH are nalurally Morita equivalent of degree n if and only if A≌B＋…＋B}→n^2 as right R[H×H]-modules and A and B have the same defect（where R∈{k,O}）, which is a generalization of the result of Külshammer Burkhard in a p-modular system for an arbitrary subgroup H of G. It is proved that naturally Morita equivalent blocks are equivalent blocks and Morita equivalent via a bimodule with trivial source.展开更多
In this article, we introduce the notion of fuzzy G-module by defining the group action of G on a fuzzy set of a Z-module M. We establish the cases in which fuzzy submodules also become fuzzy G-submodules. Notions of ...In this article, we introduce the notion of fuzzy G-module by defining the group action of G on a fuzzy set of a Z-module M. We establish the cases in which fuzzy submodules also become fuzzy G-submodules. Notions of a fuzzy prime submodule, fuzzy prime G-submodule, fuzzy semi prime submodule, fuzzy G-semi prime submodule, G-invariant fuzzy submodule and G-invariant fuzzy prime submodule of M are introduced and their properties are described. The homomorphic image and pre-image of fuzzy G-submodules, G-invariant fuzzy submodules and G-invariant fuzzy prime submodules of M are also established.展开更多
目的 探讨着色性干皮病G组（xeroderma pigmentosum group G,XPG）基因在不同年龄段健康汉族人群中的表达情况,分析XPG m RNA和蛋白表达量与年龄之间的相关性,以期为法医学年龄推断提供新的分子生物学指标。方法 收集150名不同年龄段健...目的 探讨着色性干皮病G组（xeroderma pigmentosum group G,XPG）基因在不同年龄段健康汉族人群中的表达情况,分析XPG m RNA和蛋白表达量与年龄之间的相关性,以期为法医学年龄推断提供新的分子生物学指标。方法 收集150名不同年龄段健康汉族人的外周血样,采用TRIzol法提取外周血单个核细胞（peripheral blood mononuclear cell,PBMC）总RNA,通过实时荧光定量PCR检测XPG m RNA在PBMC的相对表达量,酶联免疫吸附试验检测XPG蛋白在血浆中的表达量。结果 XPG m RNA及其蛋白表达量在≤18岁组与19~45岁组之间、≤18岁组与≥46岁组之间的差异均有统计学意义（P〈0.05）,但19~45岁组与≥46岁组之间的差异无统计学意义（P〉0.05）。XPG m RNA和蛋白表达量均无性别差异（P〉0.05）。结论 XPG m RNA在PBMC的相对表达量在低龄段内随年龄增加而下降,其血浆中蛋白随年龄增加而升高;XPG基因有望成为法医学年龄推断的新型指标之一。展开更多
文摘目的ATP结合盒B亚家族成员1(ATP binding cassette subfamily B member 1,ABCB1)的异常表达在多种癌症的发生发展中发挥关键作用。然而,G蛋白偶联受体C家族5组A型(G protein coupled receptor family C group5 type A,GPRC5A)调控的ABCB1表达对肺腺癌增殖的影响仍不清楚。本研究探讨了GPRC5A调控的ABCB1表达对肺腺癌增殖的影响。方法我们采用RT-PCR、Western-blot或免疫组化实验,分析ABCB1在肺腺癌细胞系、人肺腺癌组织以及GPRC5A基因敲除小鼠和野生型小鼠的气管上皮细胞和肺组织中的表达。采用细胞计数试剂盒-8(CCK-8)分析GPRC5A基因敲除小鼠气管上皮细胞对化疗药物的敏感性。采用皮下肿瘤形成实验探讨下调ABCB1表达是否可抑制体内肺腺癌增殖。采用免疫荧光和免疫沉淀实验研究GPRC5A和ABCB1之间潜在的调控关系。结果ABCB1在肺腺癌细胞系和人类肺腺癌组织中表达上调。GPRC5A基因敲除小鼠的气管上皮细胞及肺组织的ABCB1表达高于野生型小鼠。与GPRC5A野生型小鼠的气管上皮细胞相比,GPRC5A基因敲除小鼠的气管上皮细胞对塔立奇达和多柔比星更敏感。注射移植细胞28天后,接受ABCB1基因敲除细胞移植的GPRC5A-/-C57BL/6小鼠的肺肿瘤的体积和重量均明显低于野生型细胞移植小鼠(P=0.0043,P=0.0060)。此外,免疫荧光和免疫沉淀实验表明,GPRC5A通过直接结合方式调控ABCB1的表达。结论GPRC5A通过抑制ABCB1表达降低肺腺癌增殖。GPRC5A调节ABCB1表达的途径有待研究。
基金Supported by Chinese Universities Scientific Fund(2009RC0703 of BUPT)the NNSF of China (10871024)
文摘Let G be a homogeneous group. The author considers the boundedness of commutators generated by the generalized Hardy operators and CMO（G） functions on Herz spaces in the setting of homogeneous group. This article extends some known results.
文摘is the disjoint union of for all , where is the set of all roots of primitive second degree equations , with reduced discriminant equal to k2m. We study the action of two Hecke groups—the full modular group and the group of linear-fractional transformations on . In particular, we investigate the action of on for finding different orbits.
基金The National High Technology ResearchDevelopment Program of China (863 Pro-gram) (No003aa12331007)National Nat-ural Science Foudation of China ( No60572157,60332030)
文摘An iterative transmit power allocation (PA) algorithm was proposed for group-wise space-time block coding (G-STBC) systems with group-wise successive interference cancellation (GSIC) receivers. Group-wise interference suppression (GIS) filters are employed to separate each group's transmit signals from other interferences and noise. While the total power on all transmit symbols is constrained, all transmit PA coefficients are updated jointly according to the channel information at each iteration. Through PA, each detection symbol has the same post-detection signal to interference-and-noise ratio (SINR). The simulation results verify that the proposed PA algorithm converges at the equilibrium quickly after few iterations, and it achieves much lower bit error rates than the previous single symbol SIC PA and the fixed ratio PA algorithms for G-STBC systems with GSIC receivers .
文摘Background: With the inflation of economic constraints on health care and demand to increase care quality, there is an increasing need to develop a clear understanding of what actions by health professionals are perceived as threatening quality care. Objective: To explore graduate nursing and pastoral care student’s perceptions of missed care in Norway. Research design: A qualitative study was employed with the formation of six focus groups. Data was analyzed via a thematic content of the discussions. Participants and research context: Thirty-one students attending a University College in Oslo participated. Findings: Five major themes and thirty subthemes were identified. Major themes included labor constraints, organizational contraints, professional constraints, communication constaints and emotional strain. Discussion: Findings of this study resonate with other research as well as with studies on missed nursing care. Findings also lend support to the definition of missed nursing care actions as required care that is omitted, either in part or whole, or delayed. Conclusion: The findings from this study extend understanding of what barriers health professionals perceive as inhibiting them from offering quality care. The focus groups provided a valuable flora for discussion regarding what participants perceived as missed.
文摘As recounted in this paper, the idea of groups is one that has evolved from some very intuitive concepts. We can do binary operations like adding or multiplying two elements and also binary operations like taking the square root of an element (in this case the result is not always in the set). In this paper, we aim to find the operations and actions of Lie groups on manifolds. These actions can be applied to the matrix group and Bi-invariant forms of Lie groups and to generalize the eigenvalues and eigenfunctions of differential operators on R<sup>n</sup>. A Lie group is a group as well as differentiable manifold, with the property that the group operations are compatible with the smooth structure on which group manipulations, product and inverse, are distinct. It plays an extremely important role in the theory of fiber bundles and also finds vast applications in physics. It represents the best-developed theory of continuous symmetry of mathematical objects and structures, which makes them indispensable tools for many parts of contemporary mathematics, as well as for modern theoretical physics. Here we did work flat out to represent the mathematical aspects of Lie groups on manifolds.
文摘In this paper, the variable-coefficient diffusion-advection （DA） equation, which arises in modeling various physical phenomena, is studied by the Lie symmetry approach. The similarity reductions are derived by determining the complete sets of point symmetries of this equation, and then exact and numerical solutions are reported for the reduced second-order nonlinear ordinary differential equations. Further, an extended （Gl/G）-expansion method is applied to the DA equation to construct some new non-traveling wave solutions.
基金Supported by the National Programfor the BasicScience Researches of China(G19990751)
文摘Let （K, O, k） be a p-modular system and G be a finite group. We prove that block A of RG and block B of RH are nalurally Morita equivalent of degree n if and only if A≌B＋…＋B}→n^2 as right R[H×H]-modules and A and B have the same defect（where R∈{k,O}）, which is a generalization of the result of Külshammer Burkhard in a p-modular system for an arbitrary subgroup H of G. It is proved that naturally Morita equivalent blocks are equivalent blocks and Morita equivalent via a bimodule with trivial source.
文摘In this article, we introduce the notion of fuzzy G-module by defining the group action of G on a fuzzy set of a Z-module M. We establish the cases in which fuzzy submodules also become fuzzy G-submodules. Notions of a fuzzy prime submodule, fuzzy prime G-submodule, fuzzy semi prime submodule, fuzzy G-semi prime submodule, G-invariant fuzzy submodule and G-invariant fuzzy prime submodule of M are introduced and their properties are described. The homomorphic image and pre-image of fuzzy G-submodules, G-invariant fuzzy submodules and G-invariant fuzzy prime submodules of M are also established.
文摘目的 探讨着色性干皮病G组（xeroderma pigmentosum group G,XPG）基因在不同年龄段健康汉族人群中的表达情况,分析XPG m RNA和蛋白表达量与年龄之间的相关性,以期为法医学年龄推断提供新的分子生物学指标。方法 收集150名不同年龄段健康汉族人的外周血样,采用TRIzol法提取外周血单个核细胞（peripheral blood mononuclear cell,PBMC）总RNA,通过实时荧光定量PCR检测XPG m RNA在PBMC的相对表达量,酶联免疫吸附试验检测XPG蛋白在血浆中的表达量。结果 XPG m RNA及其蛋白表达量在≤18岁组与19~45岁组之间、≤18岁组与≥46岁组之间的差异均有统计学意义（P〈0.05）,但19~45岁组与≥46岁组之间的差异无统计学意义（P〉0.05）。XPG m RNA和蛋白表达量均无性别差异（P〉0.05）。结论 XPG m RNA在PBMC的相对表达量在低龄段内随年龄增加而下降,其血浆中蛋白随年龄增加而升高;XPG基因有望成为法医学年龄推断的新型指标之一。
