Objective:To evaluate the therapeutic effect of recombinant bovine basic fibroblast growth factor(rbFGF)eye gel combined with tobramycin-dexamethasone(TOB-Dex)eye drops on dry eye syndrome(DES)after cataract surgery.M...Objective:To evaluate the therapeutic effect of recombinant bovine basic fibroblast growth factor(rbFGF)eye gel combined with tobramycin-dexamethasone(TOB-Dex)eye drops on dry eye syndrome(DES)after cataract surgery.Methods:86 patients with DES after cataract surgery,admitted from November 2021 to November 2023,were randomly divided into groups.The observation group included 43 patients treated with rbFGF eye gel combined with TOB-Dex eye drops.The reference group included 43 patients treated with TOB-Dex eye drops alone.Multiple indicators,including total effective rate and clinical symptom scores,were compared between the two groups.Results:The total effective rate in the observation group was higher than in the reference group(P<0.05).Before treatment,there were no differences in clinical symptom scores,serum factors,or disease severity scores between the two groups(P>0.05).Three weeks after treatment,the observation group had lower clinical symptom scores,serum factors,and disease severity scores compared to the reference group(P<0.05).The adverse reaction rate in the observation group was lower than in the reference group(P<0.05).Conclusion:rbFGF eye gel combined with TOB-Dex eye drops can improve the clinical efficacy for patients with DES after cataract surgery,alleviate disease symptoms,reduce inflammatory responses,and have fewer adverse reactions.展开更多
目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患...目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患者作为研究对象,按随机数字表法分为观察组(APG结合VSD治疗)和对照组(VSD治疗),各41例。比较两组患者的疗效、创面愈合时间、肉芽生长面积、创面愈合率、住院时间、并发症,比较两组患者治疗前后的EGF、bFGF、C反应蛋白(CRP)、白细胞介素6(IL-6)、白细胞计数(WBC)、疼痛视觉模拟评分(VAS)的差值及治疗后1个月、2个月的温哥华瘢痕量表(VSS)评分的差值。结果观察组总有效率高于对照组(P<0.05)。观察组创面愈合时间、住院时间少于对照组,肉芽生长面积大于对照组,创面愈合率高于对照组(P<0.05)。观察组治疗前后EGF、bFGF、CRP、IL-6、WBC的差值高于对照组(P<0.05)。观察组治疗前与治疗后14 d VAS评分及治疗后1个月与2个月VSS评分的差值高于对照组(P<0.05)。两组患者并发症总发生率比较,差异无统计学意义(P>0.05)。结论APG结合VSD治疗深Ⅱ度烧伤可加快患者创面愈合进程,提高EGF、bFGF水平,减轻炎症反应和疼痛,减少瘢痕增生,且并发症少。展开更多
目的探讨贝复新联合肛门袋负压引流冲洗装置在重症监护室(ICU)失禁相关性皮炎(IAD)患者护理中的应用效果。方法本研究为随机对照试验。选取2021年7月至2023年3月在揭阳市人民医院ICU住院的60例IAD患者作为研究对象,采用随机数字表法将...目的探讨贝复新联合肛门袋负压引流冲洗装置在重症监护室(ICU)失禁相关性皮炎(IAD)患者护理中的应用效果。方法本研究为随机对照试验。选取2021年7月至2023年3月在揭阳市人民医院ICU住院的60例IAD患者作为研究对象,采用随机数字表法将研究对象分为对照组和观察组,各30例。研究过程中3例患者退出本研究,最终对照组纳入28例,观察组纳入29例。对照组男18例,女10例,年龄(62.43±13.63)岁,在常规操作基础上应用肛门袋负压引流冲洗装置;观察组男16例,女13例,年龄(63.62±14.11)岁,在常规操作基础上联合应用贝复新和肛门袋负压引流冲洗装置。对比两组患者IAD严重程度、中文版IAD严重程度分级评估工具(Incontinence-Associated Dermatitis and Its Severity Instrument,IADS)减分率、IAD愈合时间。采用t检验、非参数检验、χ^(2)检验。结果干预前两组患者IAD严重程度差异无统计学意义(Z=-0.154,P=0.878)。干预后第3天和第6天,对照组患者IAD严重程度分别降低至2.0(3.0)分、0(0)分,观察组降低至3.0(2.0)分、0(3.0)分,差异均有统计学意义(均P<0.05);对照组患者IADS减分率分别为33.33%(19.92%)、100.00%(42.71%),观察组分别为57.14%(63.33%)、100.00%(0),差异均有统计学意义(均P<0.05)。对照组IAD愈合时间为(8.04±4.97)d,观察组为(6.10±3.89)d,差异无统计学意义(t=1.638,P=0.107)。结论ICU IAD患者应用贝复新联合肛门袋负压引流冲洗装置,能有效缓解IAD严重程度,促进IAD愈合,值得临床推广应用。展开更多
文摘Objective:To evaluate the therapeutic effect of recombinant bovine basic fibroblast growth factor(rbFGF)eye gel combined with tobramycin-dexamethasone(TOB-Dex)eye drops on dry eye syndrome(DES)after cataract surgery.Methods:86 patients with DES after cataract surgery,admitted from November 2021 to November 2023,were randomly divided into groups.The observation group included 43 patients treated with rbFGF eye gel combined with TOB-Dex eye drops.The reference group included 43 patients treated with TOB-Dex eye drops alone.Multiple indicators,including total effective rate and clinical symptom scores,were compared between the two groups.Results:The total effective rate in the observation group was higher than in the reference group(P<0.05).Before treatment,there were no differences in clinical symptom scores,serum factors,or disease severity scores between the two groups(P>0.05).Three weeks after treatment,the observation group had lower clinical symptom scores,serum factors,and disease severity scores compared to the reference group(P<0.05).The adverse reaction rate in the observation group was lower than in the reference group(P<0.05).Conclusion:rbFGF eye gel combined with TOB-Dex eye drops can improve the clinical efficacy for patients with DES after cataract surgery,alleviate disease symptoms,reduce inflammatory responses,and have fewer adverse reactions.
文摘目的探讨自体富血小板凝胶(APG)结合封闭负压引流(VSD)对深Ⅱ度烧伤患者创面愈合进程及表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法选取2018年7月—2021年7月在南通大学附属南通第三医院就诊的82例深Ⅱ度烧伤患者作为研究对象,按随机数字表法分为观察组(APG结合VSD治疗)和对照组(VSD治疗),各41例。比较两组患者的疗效、创面愈合时间、肉芽生长面积、创面愈合率、住院时间、并发症,比较两组患者治疗前后的EGF、bFGF、C反应蛋白(CRP)、白细胞介素6(IL-6)、白细胞计数(WBC)、疼痛视觉模拟评分(VAS)的差值及治疗后1个月、2个月的温哥华瘢痕量表(VSS)评分的差值。结果观察组总有效率高于对照组(P<0.05)。观察组创面愈合时间、住院时间少于对照组,肉芽生长面积大于对照组,创面愈合率高于对照组(P<0.05)。观察组治疗前后EGF、bFGF、CRP、IL-6、WBC的差值高于对照组(P<0.05)。观察组治疗前与治疗后14 d VAS评分及治疗后1个月与2个月VSS评分的差值高于对照组(P<0.05)。两组患者并发症总发生率比较,差异无统计学意义(P>0.05)。结论APG结合VSD治疗深Ⅱ度烧伤可加快患者创面愈合进程,提高EGF、bFGF水平,减轻炎症反应和疼痛,减少瘢痕增生,且并发症少。
文摘目的探讨贝复新联合肛门袋负压引流冲洗装置在重症监护室(ICU)失禁相关性皮炎(IAD)患者护理中的应用效果。方法本研究为随机对照试验。选取2021年7月至2023年3月在揭阳市人民医院ICU住院的60例IAD患者作为研究对象,采用随机数字表法将研究对象分为对照组和观察组,各30例。研究过程中3例患者退出本研究,最终对照组纳入28例,观察组纳入29例。对照组男18例,女10例,年龄(62.43±13.63)岁,在常规操作基础上应用肛门袋负压引流冲洗装置;观察组男16例,女13例,年龄(63.62±14.11)岁,在常规操作基础上联合应用贝复新和肛门袋负压引流冲洗装置。对比两组患者IAD严重程度、中文版IAD严重程度分级评估工具(Incontinence-Associated Dermatitis and Its Severity Instrument,IADS)减分率、IAD愈合时间。采用t检验、非参数检验、χ^(2)检验。结果干预前两组患者IAD严重程度差异无统计学意义(Z=-0.154,P=0.878)。干预后第3天和第6天,对照组患者IAD严重程度分别降低至2.0(3.0)分、0(0)分,观察组降低至3.0(2.0)分、0(3.0)分,差异均有统计学意义(均P<0.05);对照组患者IADS减分率分别为33.33%(19.92%)、100.00%(42.71%),观察组分别为57.14%(63.33%)、100.00%(0),差异均有统计学意义(均P<0.05)。对照组IAD愈合时间为(8.04±4.97)d,观察组为(6.10±3.89)d,差异无统计学意义(t=1.638,P=0.107)。结论ICU IAD患者应用贝复新联合肛门袋负压引流冲洗装置,能有效缓解IAD严重程度,促进IAD愈合,值得临床推广应用。
