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Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches 被引量:1
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作者 Jielin Chen Mingpan Cheng +4 位作者 Petr Stadlbauer JiříŠponer Jean-Louis Mergny Huangxian Ju Jun Zhou 《CCS Chemistry》 CAS 2022年第9期3036-3050,共15页
As nonclassical nucleic acid structures,G-quadruplexes(G4s)not only play important roles in gene regulation and stability maintenance,but are also widely used in nanotechnology.Structural diversity is one of the main ... As nonclassical nucleic acid structures,G-quadruplexes(G4s)not only play important roles in gene regulation and stability maintenance,but are also widely used in nanotechnology.Structural diversity is one of the main factors explaining the popularity of G4s,but a comprehensive and integrated study of different factors determining G4 structural versatility is currently lacking. 展开更多
关键词 G-QUADRUPLEX G-quadruplex topology gswitch sequence composition structural versatility
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