Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） ...Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） and Xuanzhong （GB 39）, and at acupoints Baihui （DU 20） and Guanyuan （RN 4）, in D-galactose-induced senile mice. The results revealed that moxa cone moxibustion improved total superoxide dismutase and Cu/Zn-superoxide dismutase activity in the homogenates of the cerebral tissue, as well as ameliorating deficits in neuronal morphology and neuronal density in the cerebral cortex and hippocampal CA3. Moxa cone moxibustion also enhanced learning and memory functions of senile mice. Moxa cone moxibustion at Zusanli, Xuanzhong, Baihuiand Guanyuan acupoints can thus be used to complement free radical scavengers, with efficacy that is equal to that of electroacupuncture at Zusanliand Xuanzhong, and superior to that of nimodipine treatment.展开更多
OBJECTIVE: To systematically evaluate the clinical effects of herb-partitioned moxibustion on patients with primary dysmenorrhea. METHODS: Randomized controlled trials of herb-partitioned moxibustion for primary dysme...OBJECTIVE: To systematically evaluate the clinical effects of herb-partitioned moxibustion on patients with primary dysmenorrhea. METHODS: Randomized controlled trials of herb-partitioned moxibustion for primary dysmenorrhea published from the year the database was established to November, 2017 were searched from CNKI,Wanfang Database, VIP database, CBM, PubMed, Embase, and Cochrane Library. Data extraction and quality evaluation were performed in papers meeting inclusion criteria. The outcomes measurements included clinical effect rate, visual analogue score(VAS), plasma PGF2α, adverse events, recurrence rate, and quality of life. The Rev Man 5.3 software was applied for meta-analysis. RESULTS:(1) A total of 16 studies were eligible and included in the meta-analysis involved1126 patients.(2) A statistically significant increasing in clinical effective rate was found in HMP group compared with control group [OR=3.49, 95%CI(2.25, 5.39), P<0.00001].(3) There was significant difference between two groups in visual analogue score [MD=–7.48, 95%CI(–9.93, –5.02), P<0.00001], which suggested the patients who received HPM had lower VAS scales than those who received no HPM.(4) There was significantly difference in serum PGF2α between the groups receiving HPM and the control group [MD=–4.61, 95%CI(–9.19, –0.03), P=0.05].(5) 2 trials reported followup duration, and all included studies did not mention the recurrence of PD during the follow-up stage, and all included studies did not mention the improvement of quality of life of PD during period of management and follow-up stage.CONCLUSIONS: Herb-partitioned moxibustion is beneficial for primary dysmenorrhea. However, the conclusion is not completely accurate with limitations of the current RCTs. The safety of herb-partitioned moxibustion remains to be defined by future studies. Attention should be paid to long-term effects of herb-partitioned moxibustion in clinical research. High-quality RCTs are required to confirm the effectiveness of herb-partitioned moxibustion for primary dysmenorrhea.展开更多
Objective： TO evaluate the effect of electro-acupuncture on Zusanli （ST 36）, Guanyuan （RN 4） in patients with sepsis, and explore its mechanism in term of immune regulation. Methods： In this prospective randomiz...Objective： TO evaluate the effect of electro-acupuncture on Zusanli （ST 36）, Guanyuan （RN 4） in patients with sepsis, and explore its mechanism in term of immune regulation. Methods： In this prospective randomized controlled trial, 60 patients with sepsis were randomly assigned to the control group and the intervention group equally by block randomization. Patients in the control group received routine treatment and those in the intervention group received electro-acupuncture at bilateral Zusanli and Guanyuan in addition to routine treatment, respectively. The mortality at 28 days, Acute Physiology and Chronic Health Evaluation （APACHE）- II score were compared to evaluate the effect, and the levels of T cell subsets （CD3＋, CD4＋, CD8＋, CD4＋/CD8＋） and monocytes of human leukocyte antigen （HLA）-DR using flow cytometry were compared to explore the mechanism of this combined treatment. ]Results： Fifty-eight patients completed the trial with 29 in each group. There was no significant difference of mortality in the 28th day between the two groups, with 5 death of 29 patients in the intervention group （17.2%） and 9 of 29 in the control group （31.0%）. After treatment, APACHE-11 score of both groups was significantly decreased, however, score of the intervention group was lower than the control group （13.28＋7.07 vs. 17.10＋5.83; P〈0.01）. The levels of CD3＋, CD4＋, CD8＋ and CD4＋/CD8＋ ratio of the intervention group improved after treatment and were higher than the control group （59.71% ± 11.94% vs. 52.54% ±11.86%; 36.46% ± 7.60% vs. 31.58%± 10.23%; 18.40%±8.82% vs. 23.07% ± 7.30%; 2.38± 1.14 vs. 1.54±0.80, respectively; all P〈0.05）. The expression of HLA-DR significantly increased after treatment in the intervention group than that in the control group （7.28% ± 9.26% vs. 1.27% ± 7.00%; P〈0.01）. Conclusion： Electro-acupuncture at Zusanli and Guanyuan could improve clinical curative effect in patients with sepsis, which might be achieved by regulation of the immune system.展开更多
基金Scientific Research Projects of Education Bureau of Guangxi Zhuang Autonomous Region,No.200710LX022the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.0832170
文摘Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） and Xuanzhong （GB 39）, and at acupoints Baihui （DU 20） and Guanyuan （RN 4）, in D-galactose-induced senile mice. The results revealed that moxa cone moxibustion improved total superoxide dismutase and Cu/Zn-superoxide dismutase activity in the homogenates of the cerebral tissue, as well as ameliorating deficits in neuronal morphology and neuronal density in the cerebral cortex and hippocampal CA3. Moxa cone moxibustion also enhanced learning and memory functions of senile mice. Moxa cone moxibustion at Zusanli, Xuanzhong, Baihuiand Guanyuan acupoints can thus be used to complement free radical scavengers, with efficacy that is equal to that of electroacupuncture at Zusanliand Xuanzhong, and superior to that of nimodipine treatment.
文摘OBJECTIVE: To systematically evaluate the clinical effects of herb-partitioned moxibustion on patients with primary dysmenorrhea. METHODS: Randomized controlled trials of herb-partitioned moxibustion for primary dysmenorrhea published from the year the database was established to November, 2017 were searched from CNKI,Wanfang Database, VIP database, CBM, PubMed, Embase, and Cochrane Library. Data extraction and quality evaluation were performed in papers meeting inclusion criteria. The outcomes measurements included clinical effect rate, visual analogue score(VAS), plasma PGF2α, adverse events, recurrence rate, and quality of life. The Rev Man 5.3 software was applied for meta-analysis. RESULTS:(1) A total of 16 studies were eligible and included in the meta-analysis involved1126 patients.(2) A statistically significant increasing in clinical effective rate was found in HMP group compared with control group [OR=3.49, 95%CI(2.25, 5.39), P<0.00001].(3) There was significant difference between two groups in visual analogue score [MD=–7.48, 95%CI(–9.93, –5.02), P<0.00001], which suggested the patients who received HPM had lower VAS scales than those who received no HPM.(4) There was significantly difference in serum PGF2α between the groups receiving HPM and the control group [MD=–4.61, 95%CI(–9.19, –0.03), P=0.05].(5) 2 trials reported followup duration, and all included studies did not mention the recurrence of PD during the follow-up stage, and all included studies did not mention the improvement of quality of life of PD during period of management and follow-up stage.CONCLUSIONS: Herb-partitioned moxibustion is beneficial for primary dysmenorrhea. However, the conclusion is not completely accurate with limitations of the current RCTs. The safety of herb-partitioned moxibustion remains to be defined by future studies. Attention should be paid to long-term effects of herb-partitioned moxibustion in clinical research. High-quality RCTs are required to confirm the effectiveness of herb-partitioned moxibustion for primary dysmenorrhea.
基金Supported by Project of Chinese Medicine Bureau of Guangdong Province(No.20121199)Guangdong Provincial Department of Science and Technology Project(No.2014A020212279)
文摘Objective： TO evaluate the effect of electro-acupuncture on Zusanli （ST 36）, Guanyuan （RN 4） in patients with sepsis, and explore its mechanism in term of immune regulation. Methods： In this prospective randomized controlled trial, 60 patients with sepsis were randomly assigned to the control group and the intervention group equally by block randomization. Patients in the control group received routine treatment and those in the intervention group received electro-acupuncture at bilateral Zusanli and Guanyuan in addition to routine treatment, respectively. The mortality at 28 days, Acute Physiology and Chronic Health Evaluation （APACHE）- II score were compared to evaluate the effect, and the levels of T cell subsets （CD3＋, CD4＋, CD8＋, CD4＋/CD8＋） and monocytes of human leukocyte antigen （HLA）-DR using flow cytometry were compared to explore the mechanism of this combined treatment. ]Results： Fifty-eight patients completed the trial with 29 in each group. There was no significant difference of mortality in the 28th day between the two groups, with 5 death of 29 patients in the intervention group （17.2%） and 9 of 29 in the control group （31.0%）. After treatment, APACHE-11 score of both groups was significantly decreased, however, score of the intervention group was lower than the control group （13.28＋7.07 vs. 17.10＋5.83; P〈0.01）. The levels of CD3＋, CD4＋, CD8＋ and CD4＋/CD8＋ ratio of the intervention group improved after treatment and were higher than the control group （59.71% ± 11.94% vs. 52.54% ±11.86%; 36.46% ± 7.60% vs. 31.58%± 10.23%; 18.40%±8.82% vs. 23.07% ± 7.30%; 2.38± 1.14 vs. 1.54±0.80, respectively; all P〈0.05）. The expression of HLA-DR significantly increased after treatment in the intervention group than that in the control group （7.28% ± 9.26% vs. 1.27% ± 7.00%; P〈0.01）. Conclusion： Electro-acupuncture at Zusanli and Guanyuan could improve clinical curative effect in patients with sepsis, which might be achieved by regulation of the immune system.
