Long-Term Chinese Herbs Decoction Administration for Management of Hot Flashes Associated with Endocrine Therapy in Breast Cancer Patients

Objective：To evaluate the effect of Chinese herbs decoction Shu-Gan-Liang-Xue on endocrine therapy-associated hot flashes symptom in breast cancer patients.Methods：Sixty-six patients with breast cancer receiving adjuvant endocrine therapy were categorized to two groups,the control group received endocrine therapy alone,the other group is administered with Chinese herbs decoction Shu-Gan-Liang-Xue besides the endocrine therapy：Shu-Gan-Liang-Xue decoction was administered above 6 months per year for more than 2 years.Frequency of hot flashes per day was recorded,and the effect of Shu-Gan-Liang-Xue decoction on hot flashes symptom being assessed with Kupperman Scoring Index.Results：Sixty cases were analyzed,32 cases in endocrine therapy combining Chinese herbs decoction group,28 cases in mere endocrine therapy group.For hot flashes symptom,in Chinese herbs decoction administration group,7 cases（21.9%） reported symptom disappeared,22 cases（68.7%） reported symptom alleviated,3 cases（9.4%） reported symptom not changed;in endocrine therapy alone group,5 cases（17.9%） reported symptom disappeared,13 cases（46.4%） reported symptom alleviated,10 cases（10/28,35.7%） reported symptom not changed.The difference between two groups was statistically significant（P=0.013）.For sleeping disorder,in Chinese herbs decoction administration group,27 cases（84.4%） reported symptom improved,5 cases（15.6%） reported no change;in endocrine therapy alone group,16 cases（57.1%） symptom improved,12 cases（42.9%） reported no change in sleeping disorder（P=0.019）,the difference was also of significance statistically.Conclusion：Long-term Chinese herbs decoction administration remarkably improved hot flashes symptom and sleeping disorder associated with endocrine therapy,meanwhile without definite toxicity and influence on the risk of recurrence of tumor.

Echocardiographic Evaluation of Qiangxin Decoction Combined with Cardiac Resynchronization Therapy for Patients with Chronic Heart Failure

OBJECTIVE: To explore the echocardiographic evaluation of patients with chronic heart failure (CHF) after Qiangxin Decoction combined with cardiac resynchronization therapy. METHODS: A total of 140 CHF patients admitted to our hospital were randomly divided into combined group (Qiangxin Decoction and cardiac resynchronization, n = 70) and routine group (cardiac resynchronization, n = 70), and they were treated for 2 courses (16 weeks), with 8 weeks as a course. The improvement of heart function classification (HYHA) was observed before and after treatment, and the therapeutic effects were evaluated according to the improvement of heart function classification (markedly effective, effective, invalid, and worsening). The traditional Chinese medicine (TCM) diagnostic criteria was the main symptoms (0 to 6 points), secondary symptoms (0 to 3 points), tongue picture (0 to 1 point) and pulse condition (0 to 1 point), and the higher the score was, the more obvious the symptoms were. The left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and cardiac output (CO) were observed and recorded according to the heart color ultrasound before and after treatment. And the Minnesota Living with Heart Failure Questionnaire (MLHFQ) was used to evaluate the life quality before and after treatment, and the highest score of the scale was 105 points. The higher the score was, the obvious the symptoms were, and the worse the life quality was. And the adverse reactions were recorded in the 2 groups. RESULTS: After the treatment, the total effective rate in the routine group was significantly lower than that in the combined group (75.71% vs . 94.30%), and there was statistically significant difference (P < 0.05). After the treatment, the TCM syndrome score in the routine group was higher than that in the combined group ((14.37±3.59) points vs.(10.53±3.11) points), and there was statistically significant difference (P < 0.05). After the treatment, the levels of LVEDD and LVESD in the routine group were higher than those in the combined group, and there were statistically significant differences (P < 0.05). The levels of LVEF and CO in the routine group were lower than those in the combined group, and there were statistically significant differences (P < 0.05). After the treatment, the score of MLHFQ scale in the routine group was higher than that in the combined group ((57.38±8.53) points vs.(46.39±7.14) points), and there was statistically significant difference (P < 0.05). CONCLUSION: Qiangxin Decoction combined with cardiac resynchronization therapy has good echocardiographic evaluation in patients with chronic heart failure.

Effects of Chaihu Guizhi Ganjiang Decoction Combined with Standard Triple Therapy on Reducing Serum CagA and Hp-NAP in Patients with H.pylori-Related Gastritis

OBJECTIVE: To explore the effects of Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy on treating H.pylori-related gastritis. METHODS: Eighty-two patients with H. pylori-related gastritis treated in our hospital from January 2016 to December 2017 were selected according to the random number table method and divided into experimental group and control group, with 41 patients in each group. The control group was treated with standard triple therapy, while the experimental group was additionally treated with modified Chaihu Guizhi Ganjiang Decoction. The venous blood of one elbow was taken before and after treatment. The concentrations of serum CagA and Hp-NAP were detected by enzyme-linked immunosorbent assay(ELISA). The symptoms were evaluated according to the change of symptom scores before and after the intervention. The H.pylori eradication rate was calculated. RESULTS: There was no significant difference in CagA and Hp-NAP concentrations between the 2 groups before intervention(P > 0.05). After intervention, CagA and Hp-NAP concentrations in experimental group were(19.21±6.27) ng/L and(24.37±6.10) ng/L respectively which were lower than(25.81±7.14) ng/L and(32.09±5.73) ng/L of control group. The differences were statistically significant(P < 0.05). The total effective rate of major symptoms in experimental group was 39 cases(95.12%), which was significantly higher than that of the control group(31 cases, 75.61%). There was statistically significant difference between the 2 groups(P < 0.05). The eradication rate of H.pylori was 38 cases(92.68%) in the experimental group, which was significantly higher than 31 cases(75.61%) of the control group. The difference between the 2 groups was statistically significant(P < 0.05). CONCLUSION: Chaihu Guizhi Ganjiang Decoction combined with standard triple therapy can effectively reduce CagA, Hp-NAP of serum level in patients with H.pylori-related gastritis, improve efficacy of symptoms and eradication rate of H.pylori, and is worthy of clinical promotion.

Study on effect of Traditional Chinese Medicine Jianpi Chushi decoction and ointment on chronic eczema

Objective:To study the effects of Traditional Chinese Medicine Jianpi Chushi decoction and ointment on chronic eczema.Methods:DNCB acetone solution was used to sensitize the skin of back and ears of 36 rats in order to establish chronic eczema model.A total of 36 rats were divided into four groups of 9 randomly including oral medicine group,external inunctum group,combination therapy group,and model control group respectively.Besides,the blank group of 4 healthy rats were set.The oral medicine group was given Traditional Chinese Medicine Jianpi Chushi decoction [(Poria cocos,Chinese yam,Cortex dictamni,Zaocys dhumnade,Rhizoma atractylodis,Pericarpium citri reticulatae,Scutellaria baicalensis,Radix Sophorae Flavescentis,Raw Radix Paeoniae Alba,Licorice roots(Northwest Origin)] by gastric infusion(1.6 g/m L·5 m L/d); the external inunctum group was given Qingpeng ointment on the skin,the combination therapy group was given Jianpi Chushi decoction by gastric infusion and Qingpeng ointment combination therapy.The model control group was given normal saline(NS) of the same volume by gastric infusion and vaseline on skin.Continuous administration 15 d and stopped for 3 d.The thickness difference and weight difference of left and right ear of every group were measured and the degree of ear swelling were evaluated.The CD4^+ and CD8^+ content and the IL-2,IL-4 level of serum were detected,and the inflammatory cells counts of back skin were recorded.Results:After treatment,the degree of ear swelling of oral medicine group,external inunctum group and combination therapy group significant decreased compared with model control group(P<0.05).The CD4^+,CD8^+ cell content and IL-2 level of oral medicine group,external inunctum group,combination therapy group and model control group significant decreased compared with blank group,and IL-2 level and the inflammatory cells count increased.After 15 d of treatment,the CD4^+,CD8^+ cell content and IL-2 level of serum of oral medicine group,external inunctum group and combination therapy group raised and the IL-4 level and the inflammatory cells count had significant decreased compared with model control group,and the effect of combination therapy group was more obvious(P<0.05).Conclusions:Qral Jianpi Chushi decoction could treat chronic eczema effectively,and oral Chinese medicine combined with ointment could enhance and speed up the efficacy.

Protective Effect of Jiechangning (结肠宁) Decoction in Treating Experimental Ulcerative Colitis in Guinea Pigs

Objective: To study the therapeutic effects and mechanism of Jiechangning (结肠宁, JCN) decoction on carrageenan induced experimental ulcerative colitis (UC). Methods: After sensitizing guinea pigs with carrageenan, we established UC animal models by free drinking water containing 2% acid degraded carrageenan (ADC). JCN decoction was orally administered once a day for 2 weeks after carrageenan treatment. Salicylazosulfapyridine (SASP) and normal saline were given to the other two groups as control. The levels of colon lipid peroxide (LPO), acid phosphatase (ACP)activity and tumor necrosis factor-α (TNF-α) were measured; colitis activity score (CAS) was carried out for assessment of the degree of tissue inflammation and injury; the colonic pathological changes were examined simultaneously with hematoxylin and eosin (HE) and toluidine blue staining used to evaluate the therapeutic effects of JCN decoction and SASP. Results: Experimental colitis models resembling human UC were successfully induced. The levels of tissue LPO, ACP activity and the content of tissue TNF-α were markedly increased in the model group as compared with the normal control group ( P <0.01) and were positively correlated with CAS. JCN decoction could reverse these changes like SASP. HE staining showed that JCN decoction and SASP could reduce CAS and the degree of tissue injury, toluidine blue staining revealed that mucosa and submucosa red metachromasia pellets in JCN group and SASP group were markedly fewer than those in the model group. Conclusion: JCN decoction is effective in treating experimental UC, which provides theoretical basis for its clinical application.

Clinical Comparison and Analysis of Decoction of Traditional Chinese Medicine Combined with Ear Acupoint Application and Simple Artificial Tears in the Treatment of Dry Eye Syndrome

OBJECTIVE: To study the clinical comparison and analysis of decoction of Traditional Chinese Medicine(TCM) combined with ear acupoint application and simple artificial tears in the treatment of dry eye syndrome. METHODS:A total of 62 patients(124 eyes) with dry eye syndrome treated in the Department of Ophthalmology of The 4th People's Hospital of Shenyang from July 2017 to March 2018 were selected and equally divided into 2 groups according to the admission order. The observation group received the combination therapy of TCM decoction and ear acupoint application, while the control group was given the simple artificial tears. The symptom score after 2 weeks, 4 weeks, and 8 weeks as well as the indicators including break-up time(BUT), Schirmer I test(SIT) and fluorescein(FL) were recorded and compared between groups. RESULTS: The symptom scores had no difference before treatment(P > 0.05), and were better in the observation group than those in the control group after treatment(P < 0.05). At 2 weeks, 4 weeks, and 8 weeks after the treatment, the amelioration level of BUT, SIT, and FL indicators in the observation group was better than that of the control group(P < 0.05). CONCLUSION: Compared with the artificial tears treatment method, the TCM decoction combined with ear acupoint application can significantly ameliorate the tear film stability, tear secretion, and reduce ocular surface damage for dry eye patients.

Sishengtang decoction in alleviation of toxic and side effects of transarterial embolization

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Mechanism of Shugan Lidan decoction in treating chronic calculous cholecystitis

Chronic calculous cholecystitis is a common clinical medical disease,which is classified as"hypochondriac pain"in traditional Chinese medicine(TCM).It is caused by liver failure and stagnation of liver qi.Therefore,the method of Soothing the liver and promoting bile flow is often used for regulating and harmonizing qi and blood.This paper discusses its mechanism of action,and points out that Shugan Lidan decoction has great effect on the treatment of chronic calculous cholecystitis,especially in the early treatment of the disease and delaying the progress of the disease,which provides help for the clinical treatment of chronic calculous cholecystitis.

血府逐瘀汤治疗冠心病研究进展

冠心病是临床常见的心血管疾病之一,其发病率和病死率呈上升趋势,严重危害居民健康,加重国家经济负担。血府逐瘀汤有活血化瘀、理气止痛的功效,主治胸中血瘀证。临床上根据其功效常用于治疗血瘀证冠心病,并取得良好疗效。此文旨在对血府逐瘀汤治疗冠心病的临床运用、作用机制及研究进展展开探讨,为深入挖掘血府逐瘀汤临床及实验研究提供新思路。

归脾汤联合琥珀酸亚铁片和输血治疗用于重度缺铁性贫血患者的疗效及对血常规指标、铁代谢和免疫功能的影响

目的:探讨归脾汤联合琥珀酸亚铁片和输血治疗用于重度缺铁性贫血患者的疗效及对血常规指标、铁代谢和免疫功能的影响。方法:选取2018年1月至2023年5月于河北北方学院附属第一医院就诊的重度缺铁性贫血患者130例,以信封抽签法随机分为观察组(65例)和对照组(65例)。两组患者均给予输血治疗,对照组患者口服琥珀酸亚铁片,观察组患者口服琥珀酸亚铁片和归脾汤。治疗4周后,对临床疗效进行评价,观察治疗前后两组患者的血常规指标[血红蛋白(Hb)、红细胞计数(RBC)、平均红细胞血红蛋白量(MCH)和平均红细胞体积(MCV)]、铁代谢指标[血清铁(SI)、血清铁蛋白(SF)和可溶性转铁蛋白受体(sTfR)]及免疫功能指标(CD3^(+)、CD4^(+)和CD8^(+)T淋巴细胞比例)水平,并记录不良反应。结果:与对照组[86.15%(56/65)]比较,观察组患者的总有效率[96.92%(63/65)]更高,差异有统计学意义(P<0.05)。治疗后,两组患者的Hb、RBC、MCH和MCV水平,SI、SF水平,CD3^(+)、CD4^(+)和CD8^(+)T淋巴细胞比例较治疗前明显升高,sTfR水平较治疗前明显降低;且观察组患者的Hb、RBC、MCH和MCV水平,SI、SF水平,CD3^(+)、CD4^(+)和CD8^(+)T淋巴细胞比例较对照组明显升高,sTfR水平较对照组明显降低,差异均有统计学意义(P<0.05)。对照组、观察组患者不良反应发生率比较[3.08%(2/65)vs. 4.62%(3/65)],差异无统计学意义(P>0.05)。结论:归脾汤联合琥珀酸亚铁片和输血治疗用于重度缺铁性贫血患者的疗效较好,可改善血常规指标、铁代谢情况及免疫功能,且安全性好。

八珍汤加减辅助对鼻咽癌鼻内镜下鼻咽扩大切除术后放疗患者临床疗效及免疫指标的影响

目的观察八珍汤加减辅助对鼻咽癌(NPC)鼻内镜下鼻咽扩大切除术后放疗患者临床疗效及免疫指标的影响。方法选取2022年5月至2024年1月行鼻内镜下鼻咽扩大切除术的NPC患者94例作为研究对象,随机数字表法分为对照组和观察组,每组47例。所有患者行术后放疗,对照组给予放疗后常规营养干预和不良反应处理,观察组在对照组的基础上加服八珍汤加减。比较2组临床疗效、唾液分泌功能、疼痛程度、免疫功能及生活质量,并观察不良反应。结果观察组客观缓解率82.89%(39/47)较对照组63.83%(30/47)高(P<0.05)。治疗后,观察组唾液腺分泌指数、鼻咽癌生存质量量表评分、CD3+和CD4+/CD8+水平较对照组高(P<0.05),观察组疼痛视觉模拟评分量表评分、CD8+水平较对照组低(P<0.05)。观察组血小板/白细胞减少、口腔黏膜炎发生率较对照组低(P<0.05)。结论八珍汤加减能改善NPC鼻内镜下鼻咽扩大切除术后放疗患者的放疗效果,缓解疼痛,提高唾液分泌功能,还能够调节免疫功能,减轻不良反应,起到增效减毒的作用。

济复汤内服兼药渣烫熨治疗癌性便秘临床观察

目的观察济复汤内服兼药渣烫熨对癌性便秘的疗效。方法选取2019年1月—2022年1月癌性便秘患者62例,均给予一般干预和整体护理,随机分为对照组30例和观察组32例。对照组予乳果糖口服溶液及双歧杆菌三联活菌胶囊。观察组予济复汤内服兼药渣烫熨。2周后观察2组患者便秘改善情况。结果观察组患者的总有效率为90.62%(29/32),高于对照组的66.67%(20/30),差异有统计学意义(P<0.05),观察组便秘改善情况优于对照组。结论济复汤内服兼药渣烫熨在癌性便秘中的应用效果显著,操作简便,安全节约,值得推广应用。

甘麦大枣汤联合失眠认知行为疗法治疗抑郁共病失眠的疗效观察

目的:探讨甘麦大枣汤联合失眠认知行为疗法(CBT-I)治疗抑郁共病失眠的疗效,为抑郁共病失眠的临床治疗提供新方法。方法:选取某精神卫生中心收治的110例抑郁共病失眠患者,随机分为观察组和对照组各55例,对照组给予常规西医治疗,观察组给予为期6周的甘麦大枣汤联合CBT-I治疗,比较两组患者HAMD-17、PSQI和SERS评分差异。结果:观察组干预结束时和随访时PSQI、SERS得分低于对照组(P<0.01),PSQI得分、HAMD得分、SERS得分均低于干预前(P<0.01);对照组干预结束时PSQI总分、HAMD总分均下降(P<0.01或P<0.05),SERS得分上升(P<0.01)。结论:甘麦大枣汤联合CBT-I对抑郁共病失眠的临床效果显著,可持续缓解抑郁症状,提升睡眠质量,且安全性高,在临床中具有推广价值。

中和思想指导下苇茎汤治疗胸腔积液临床观察

目的 在中和医派思想的指导下探讨苇茎汤治疗胸腔积液的临床疗效。方法 选取2022年1月—2023年1月收治的胸腔积液患者60例,随机分为观察组和试验组,每组30例。观察组采用常规西医治疗,试验组在常规西医治疗的同时,联合应用苇茎汤进行治疗,3个疗程后观察2组临床疗效并对患者肺功能进行评价。结果 治疗后,试验组FVC、FEV1、FEV1/FVC、PEER均高于观察组(P<0.05)。结论 苇茎汤能够提高胸腔积液患者的肺功能,改善肺循环及气道阻塞,提高重症患者治愈率及生活质量。

培元黜浊汤治疗中晚期肝癌临床观察

目的:观察培元黜浊汤治疗中晚期肝癌患者的临床效果。方法:根据纳入和排除标准筛选中晚期肝癌患者60例,将其随机分为两组各30例。对照组予索拉非尼联合苦参注射液治疗,治疗组在对照组基础上联用培元黜浊汤治疗,疗程为3个月。结果:治疗组的胸闷、善太息,情志抑郁,腹胀,大便溏泄,神疲乏力,纳呆中医证候等级改善优于对照组(P<0.05);且淋巴细胞亚群指标水平与生活质量评分的改善均明显优于对照组。治疗组疾病控制率稍高于对照组,AFP指标水平低于对照组,但差异无统计学意义(P﹥0.05);治疗组不良反应发生率36.67%低于对照组的76.67%(P<0.01)。结论:培元黜浊汤联合索拉非尼治疗中晚期肝癌临床疗效显著,可改善患者免疫功能,提高生活质量。

疏肝健脾汤联合刮痧治疗亚健康失眠临床观察

目的 观察疏肝健脾汤联合刮痧治疗亚健康失眠的临床效果。方法 将90例亚健康失眠患者随机分为治疗组和对照组,每组45例。治疗组采用疏肝健脾汤联合刮痧治疗,对照组口服艾司唑仑片。2组均连续治疗3周,观察2组患者的临床疗效。结果 治疗组总有效率92.86%(39/42)高于对照组的78.57%(33/42),差异有显著统计学意义(P<0.01)。治疗后,治疗组匹兹堡睡眠质量指数(PSQI)及中医证候积分均明显低于对照组(P<0.01)。结论 疏肝健脾汤联合刮痧治疗可有效改善亚健康失眠患者的失眠状态,提高其生活质量,值得临床进一步推广。

身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型不宁腿综合征的临床观察

目的观察身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型不宁腿综合征(RLS)患者的临床疗效。方法将50名痰瘀痹阻型RLS患者按照随机数字表法分为2组,对照组25例予盐酸普拉克索片治疗,治疗组25例在对照组基础上联合身痛逐瘀汤加味治疗。2组均治疗1周为1个疗程,治疗2个疗程后统计疗效,比较2组治疗前后国际RLS严重程度评分量表(IRLS)评分、匹兹堡睡眠质量指数量表(PSQI)评分及中医症状评分变化情况。结果治疗组总有效率92.00%(23/25),对照组总有效率60.00%(15/25),治疗组总有效率高于对照组(P<0.05)。与本组治疗前比较,2组治疗后IRLS评分、PSQI评分及中医症状评分均降低(P<0.05),且治疗组治疗后IRLS评分、PSQI评分及中医症状评分均低于对照组(P<0.05)。结论身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型RLS疗效确切,可有效改善患者临床症状及中医症状,改善患者睡眠质量,操作简便,临床疗效显著,安全性良好。

升肝舒郁汤加减联合磁电生物反馈疗法治疗女性压力性尿失禁的临床研究

目的:探究升肝舒郁汤加减联合磁电生物反馈疗法治疗女性压力性尿失禁(SUI)的临床疗效。方法:选取符合纳入标准的108例SUI患者,依据简单随机方法随机分组。最终纳入观察组52例,对照组53例。对照组接受磁电生物反馈疗法治疗,每周2次;观察组在对照组治疗基础上口服升肝舒郁汤加减方治疗,每日1剂,分早晚两次饭后服用。两组患者均连续治疗8周。比较两组治疗前后盆底肌Ⅰ类肌、Ⅱ类肌的纤维肌力及肌电值;采用1 h尿垫试验、改良牛津评分评估SUI改善情况,比较临床疗效;采用尿失禁影响问卷简表(ⅡQ-7)评估患者生活质量;记录治疗期间不良反应发生情况。结果:治疗后,观察组Ⅰ类、Ⅱ类肌纤维肌力和肌电值均高于对照组(P<0.05)。治疗后,观察组1 h漏尿量低于对照组,改良牛津评分高于对照组(P<0.05)。观察组的治疗总有效率为92.31%(48/52),高于对照组的75.47%(40/53)(P<0.05)。治疗后,观察组ⅡQ-7评分低于对照组,治疗前后ⅡQ-7评分差值高于对照组(P<0.05)。两组患者不良反应总发生率比较差异无统计学意义(P>0.05)。结论:升肝舒郁汤加减联合磁电生物反馈疗法治疗女性SUI疗效确切,能减轻患者临床症状,提高盆底肌肌力,改善盆底功能,提高生活质量。

柴芍胃康汤联合四联疗法治疗肝胃气滞证Hp阳性慢性萎缩性胃炎的疗效观察

目的:观察柴芍胃康汤联合四联疗法治疗肝胃气滞证幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)的疗效及对患者胃泌素-17(G-17)、丙二醛(MDA)、胃蛋白酶原(PG)Ⅰ和PGⅡ水平,胃黏膜组织病理和Hp根除的影响。方法:选取2021年6月至2023年5月该院收治的肝胃气滞证Hp阳性CAG患者140例,按随机数字表法分为联合组和对照组(各70例)。对照组患者给予标准四联疗法,联合组患者在对照组的基础上给予柴芍胃康汤治疗。比较两组患者治疗前后血清G-17、MDA、PGⅠ和PGⅡ水平,胃黏膜组织病理评分、Hp根除率,观察安全性和临床疗效。结果:治疗后,两组患者血清G-17、PGⅠ水平明显升高,MDA、PGⅡ水平和胃黏膜组织病理评分明显降低;且联合组患者血清G-17、PGⅠ水平较对照组升高,MDA、PGⅡ水平和胃黏膜组织病理评分较对照组降低,差异均有统计学意义(P<0.05)。联合组患者的Hp根除率、总有效率分别为92.86%(65/70)、92.86%(65/70),明显高于对照组的81.43%(57/70)、81.43%(57/70),差异均有统计学意义(P<0.05)。结论:柴芍胃康汤联合四联疗法治疗肝胃气滞证Hp阳性CAG的疗效较好,可改善患者胃功能、氧化应激和胃黏膜组织病理损伤,并可有效提高Hp根除率。