AIM:To assess the effects of partially hydrolyzed guar gum(PHGG) diet supplement in pediatric chronic abdominal pain(CAP) and irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed i...AIM:To assess the effects of partially hydrolyzed guar gum(PHGG) diet supplement in pediatric chronic abdominal pain(CAP) and irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in sixty children(8-16 years) with functional bowel disorders,such as CAP or IBS,diagnosed according to Rome Ⅲ criteria.All patients underwent ultrasound,blood and stool examinations to rule out any organic disease.Patients were allocated to receive PHGG at dosage of 5 g/d(n = 30) or placebo(fruitjuice n = 30) for 4 wk.The evaluation of the efficacy of fiber supplement included IBS symptom severity score(Birmingham IBS Questionnaire),severity of abdominal pain(Wong-Baker Face Pain Rating Score) and bowel habit(Bristol Stool Scale).Symptom scores were completed at 2,4,and 8 wk.The change from baseline in the symptom severity scale at the end of treatment and at 4 wk follow-up after treatment was the primary endpoint.The secondary endpoint was to evaluate compliance to supplementation with the PHGG in the pediatric population.Differences within groups during the treatment period and follow-up were evaluated by the Wilcoxon signed-rank test.RESULTS:The results of the study were assessed considering some variables,such as frequency and intensity of symptoms with modifications of the bowel habit.Both groups were balanced for baseline characteristics and all patients completed the study.Group A(PHGG group) presented a higher level of efficacy compared to group B(control group),(43% vs 5%,P = 0.025) in reducing clinical symptoms with modification of Birmingham IBS score(median 0 ± 1 vs 4 ± 1,P = 0.025),in intensity of CAP assessed with the Wong-Baker Face Pain Rating Score and in normalization of bowel habit evaluated with the Bristol Stool Scale(40% vs 13.3%,P = 0.025).In IBS subgroups,statistical analysis shown a tendency toward normalization of bowel movements,but there was no difference in the prevalence of improvement in two bowel habit subsets.PHGG was therefore better tolerated without any adverse effects.CONCLUSION:Although the cause of pediatric functional gastrointestinal disorders is not known,the results show that complementary therapy with PHGG may have beneficial effects on symptom control.展开更多
目的观察咀嚼口香糖对喉罩全麻患者宫腔镜手术后咽喉痛的影响。方法将90例喉罩全麻下宫腔镜手术患者随机分成实验组(G组)和对照组(C组),每组各45例。手术结束后,对所有患者进行Ramsay镇静评分,当患者清醒、Ramsay评分2~3分时,记录此时(...目的观察咀嚼口香糖对喉罩全麻患者宫腔镜手术后咽喉痛的影响。方法将90例喉罩全麻下宫腔镜手术患者随机分成实验组(G组)和对照组(C组),每组各45例。手术结束后,对所有患者进行Ramsay镇静评分,当患者清醒、Ramsay评分2~3分时,记录此时(T0)咽喉痛视觉模拟评估法(visual analogue scale,VAS)评分,然后予实验组患者咀嚼口香糖10 min,对照组不予咀嚼口香糖。随访记录术后2 h (T2)、6 h (T6)、24 h (T24)吞咽和不吞咽时的咽喉痛VAS评分。结果术后24 h内咽喉痛VAS评分>3的总体发生率:实验组(15.56%,7/45)显著低于对照组(35.56%,16/45)( P =0.026)。除T0时点外,术后其余各时点无论吞咽与否,实验组咽喉痛评分均显著低于对照组( P <0.05);术后24 h患者的麻醉满意度评分实验组(8.87±1.08)明显高于对照组(7.16±1.15)( P <0.001)。结论妇科短小手术术后咀嚼口香糖能够减轻喉罩全麻引起的咽喉痛。展开更多
文摘AIM:To assess the effects of partially hydrolyzed guar gum(PHGG) diet supplement in pediatric chronic abdominal pain(CAP) and irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in sixty children(8-16 years) with functional bowel disorders,such as CAP or IBS,diagnosed according to Rome Ⅲ criteria.All patients underwent ultrasound,blood and stool examinations to rule out any organic disease.Patients were allocated to receive PHGG at dosage of 5 g/d(n = 30) or placebo(fruitjuice n = 30) for 4 wk.The evaluation of the efficacy of fiber supplement included IBS symptom severity score(Birmingham IBS Questionnaire),severity of abdominal pain(Wong-Baker Face Pain Rating Score) and bowel habit(Bristol Stool Scale).Symptom scores were completed at 2,4,and 8 wk.The change from baseline in the symptom severity scale at the end of treatment and at 4 wk follow-up after treatment was the primary endpoint.The secondary endpoint was to evaluate compliance to supplementation with the PHGG in the pediatric population.Differences within groups during the treatment period and follow-up were evaluated by the Wilcoxon signed-rank test.RESULTS:The results of the study were assessed considering some variables,such as frequency and intensity of symptoms with modifications of the bowel habit.Both groups were balanced for baseline characteristics and all patients completed the study.Group A(PHGG group) presented a higher level of efficacy compared to group B(control group),(43% vs 5%,P = 0.025) in reducing clinical symptoms with modification of Birmingham IBS score(median 0 ± 1 vs 4 ± 1,P = 0.025),in intensity of CAP assessed with the Wong-Baker Face Pain Rating Score and in normalization of bowel habit evaluated with the Bristol Stool Scale(40% vs 13.3%,P = 0.025).In IBS subgroups,statistical analysis shown a tendency toward normalization of bowel movements,but there was no difference in the prevalence of improvement in two bowel habit subsets.PHGG was therefore better tolerated without any adverse effects.CONCLUSION:Although the cause of pediatric functional gastrointestinal disorders is not known,the results show that complementary therapy with PHGG may have beneficial effects on symptom control.
文摘目的观察咀嚼口香糖对喉罩全麻患者宫腔镜手术后咽喉痛的影响。方法将90例喉罩全麻下宫腔镜手术患者随机分成实验组(G组)和对照组(C组),每组各45例。手术结束后,对所有患者进行Ramsay镇静评分,当患者清醒、Ramsay评分2~3分时,记录此时(T0)咽喉痛视觉模拟评估法(visual analogue scale,VAS)评分,然后予实验组患者咀嚼口香糖10 min,对照组不予咀嚼口香糖。随访记录术后2 h (T2)、6 h (T6)、24 h (T24)吞咽和不吞咽时的咽喉痛VAS评分。结果术后24 h内咽喉痛VAS评分>3的总体发生率:实验组(15.56%,7/45)显著低于对照组(35.56%,16/45)( P =0.026)。除T0时点外,术后其余各时点无论吞咽与否,实验组咽喉痛评分均显著低于对照组( P <0.05);术后24 h患者的麻醉满意度评分实验组(8.87±1.08)明显高于对照组(7.16±1.15)( P <0.001)。结论妇科短小手术术后咀嚼口香糖能够减轻喉罩全麻引起的咽喉痛。
