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STUDIES ON THE SAPONIN CONSTITUENTS OF GYNOSTEMMA LONGIPES
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作者 Xiao Li ZHANG Heng Li ZHANG +1 位作者 Wen Ji SUN Zhen Fang SHAN National North-West Center of Metrology,Xl'AN,710048 SHAANXI Provincial Institute for Drug Control,Xl'AN,710061 《Chinese Chemical Letters》 SCIE CAS CSCD 1991年第3期221-222,共2页
Two new cornpounds,saponin I and saponin II,were isolated from Gynostemma longipes f.Y.Wu. The struetures have been characterized on the basis of cbenical and speetroseopie evidence. ^-~.
关键词 CHO IR STUDIES ON THE SAPONIN CONSTITUENTS OF gynostemma longipes
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Dammarane-type triterpenoids from Gynostemma longipes and their protective activities on hypoxia-induced injury in PC12 cells
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作者 LIANG Haizhen CHEN Xiaojuan +7 位作者 LI Qi ZHANG Mengmeng LU Pengxin ZHANG Jie SONG Juan ZHANG Tao GUO Baolin MA Baiping 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2024年第5期466-480,共15页
Sixteen new dammarane-type triterpenoid saponins(1-16)featuring diverse structural variations in the side chain at C-17,along with twenty-one known analogues(17-37),have been isolated from the rhizomes of Gynostemma l... Sixteen new dammarane-type triterpenoid saponins(1-16)featuring diverse structural variations in the side chain at C-17,along with twenty-one known analogues(17-37),have been isolated from the rhizomes of Gynostemma longipes C.Y.Wu,a plant renowned for its medicinal and edible properties.The structural elucidation of these compounds was accomplished through comprehensive analyses of 1D and 2D NMR and HRMS spectroscopic data,supplemented by comparison with previously reported data.Subsequent assays on the isolates for their protective effects against hypoxia-induced damage in pheochromocytoma cells(PC12 cells)revealed that nine saponins exhibited significant anti-hypoxic activities.Further investigation into the anti-hypoxia mechanisms of the representative saponins demonstrated that compounds 22 and 36 markedly reduced the levels of hypoxia-induced apoptosis.Additionally,these compounds were found to decrease the release of lactate dehydrogenase(LDH)and malondialdehyde(MDA),while increasing the activity of superoxide dismutase(SOD),thereby indicating that the saponins could mitigate hypoxia-induced injuries by ameliorating apoptosis and oxidative stress.These findings offer substantial evidence for the future utilization and development of G.longipes,identifying dammarane-type triterpenoid saponins as its active anti-hypoxic constituents. 展开更多
关键词 gynostemma longipes Dammarane-type saponins Anti-hypoxia effect Apoptosis
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