This paper reports on the installation and observations of a new solar telescope installed on 2014 October 7 at the Kodaikanal Observatory. The telescope is a refractive type equipped with a tunable Lyot Hα filter. A...This paper reports on the installation and observations of a new solar telescope installed on 2014 October 7 at the Kodaikanal Observatory. The telescope is a refractive type equipped with a tunable Lyot Hα filter. A CCD camera with size 2k ×2k acquires images of the Sun and has a pixel size of 1.21″ pixel^-1 and a full field-of-view of 41＇. The telescope is equipped with a guiding system which keeps the image of the Sun within a few pixels throughout the observations. The FWHM of the Lyot filter is 0.4A and the filter is motorized, capable of scanning the Hα line profile at a smaller step size of 0.01 A. Partial-disk imaging covering about 10＇ is also possible with the help of a relay lens kept in front of the CCD camera. In this paper, we report the detailed specifications of the telescope, filter unit, the installation, observations and the procedures we have followed to calibrate and align the data. We also present preliminary results with this new full-disk telescope.展开更多
This paper presents the analytical results of solar MgⅠb_(2)flash spectra,obtained by the prototype Fiber Arrayed Solar Optic Telescope in process of the 2013 Gabon total solar eclipse.The analysis reveals irregular ...This paper presents the analytical results of solar MgⅠb_(2)flash spectra,obtained by the prototype Fiber Arrayed Solar Optic Telescope in process of the 2013 Gabon total solar eclipse.The analysis reveals irregular distributions of the spectral line parameters like ratio of line source function to continuum oneβ,ratio of line emissivity to continuum emissivityζ,ratio of the continuum opacity to the line opacity r_(0),line center optical depthτ_(0)、,the line widthΔλ_(D),and the line-of-sight velocity v_(los),while the approximately spherical symmetry can be found in the maps of integrated line intensity and continuum intensity.These irregular distributions originate from those of line profile features like the maximum intensity,the line width and line center wavelength.It is also found from the recovered line center optical depthτ_(0) that in the middle chromosphere,the optical depth is not small due to nonignorable absorption and the long light path along the line-of-sight.Finally,we show that the excessive broadening of spectral lines can be due to co-existence of multiple radiative sources with different line-of-sight velocities unresolved in one detector pixel.展开更多
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report...Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.展开更多
文摘This paper reports on the installation and observations of a new solar telescope installed on 2014 October 7 at the Kodaikanal Observatory. The telescope is a refractive type equipped with a tunable Lyot Hα filter. A CCD camera with size 2k ×2k acquires images of the Sun and has a pixel size of 1.21″ pixel^-1 and a full field-of-view of 41＇. The telescope is equipped with a guiding system which keeps the image of the Sun within a few pixels throughout the observations. The FWHM of the Lyot filter is 0.4A and the filter is motorized, capable of scanning the Hα line profile at a smaller step size of 0.01 A. Partial-disk imaging covering about 10＇ is also possible with the help of a relay lens kept in front of the CCD camera. In this paper, we report the detailed specifications of the telescope, filter unit, the installation, observations and the procedures we have followed to calibrate and align the data. We also present preliminary results with this new full-disk telescope.
基金the National Natural Science Foundation of China(NSFC,Grant Nos.11527804,U1931206,11373065,11078005,10943002 and 12003066)。
文摘This paper presents the analytical results of solar MgⅠb_(2)flash spectra,obtained by the prototype Fiber Arrayed Solar Optic Telescope in process of the 2013 Gabon total solar eclipse.The analysis reveals irregular distributions of the spectral line parameters like ratio of line source function to continuum oneβ,ratio of line emissivity to continuum emissivityζ,ratio of the continuum opacity to the line opacity r_(0),line center optical depthτ_(0)、,the line widthΔλ_(D),and the line-of-sight velocity v_(los),while the approximately spherical symmetry can be found in the maps of integrated line intensity and continuum intensity.These irregular distributions originate from those of line profile features like the maximum intensity,the line width and line center wavelength.It is also found from the recovered line center optical depthτ_(0) that in the middle chromosphere,the optical depth is not small due to nonignorable absorption and the long light path along the line-of-sight.Finally,we show that the excessive broadening of spectral lines can be due to co-existence of multiple radiative sources with different line-of-sight velocities unresolved in one detector pixel.
基金supported by the National Natural Science Foundation of China,Nos.82171429,81771384a grant from Wuxi Municipal Health Commission,No.1286010241190480(all to YS)。
文摘Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.
