Effect of extended nursing based on self-efficacy theory on the anxiety of patients with intertrochanteric fracture

BACKGROUND Extended care based on self-efficacy theory to elderly patients with intertrochanteric fractures will provide data reference to optimize the care plan of these patients,reduce patients’concurrent mental diseases,and improve prognosis.AIM To analyze the value of extended nursing based on the self-efficacy theory in older patients with intertrochanteric fractures.METHODS Older patients with intertrochanteric fractures(n=88)admitted to our hospital between January 2021 and December 2024 were randomly divided into two groups-the control group(n=44,routine nursing)and the observation group(n=44,extended nursing)-via balloting and treated for 12 weeks.The mental state,pain severity,limb function,and self-nursing ability of all patients before and after nursing were analyzed.RESULTS After nursing,the Hamilton Anxiety Scale and General Self-Efficacy Scale scores of patients in the two groups improved.Notably,Hamilton Anxiety Scale and General Self-Efficacy Scale scores in the observation group were lower and higher,respectively,than those in the control group(P<0.05).The pain severity in the observation group(2.64±0.22)was lower than that in the control group(2.85±0.41)(P<0.05).The recovery rate of limb function was higher in the observation group than in the control group(P<0.05).In addition,the self-nursing ability scores of the patients in both groups increased,with a significantly higher score in the observation group(P<0.05).CONCLUSION Extended nursing based on the self-efficacy theory can significantly improve mental state,relieve pain,and promote the recovery of limb function and self-nursing ability in older patients with intertrochanteric fractures.

Nursing interventions based on Snyder’s hope theory for depression following percutaneous coronary interventions:A clinical study

BACKGROUND Patients with depression following coronary heart disease often exhibit insufficient psychological resilience and self-care abilities;therefore,emphasis must be placed on nursing interventions.AIM To analyze the application value of problem-oriented education combined with nursing interventions based on the Snyder hope theory model in depressed patients after percutaneous coronary intervention(PCI).METHODS This study included 150 patients diagnosed with PCI postoperative depression because of coronary heart disease between February 2022 and February 2024.Participants were divided into two groups:A control group(n=75)receiving problem-oriented education and an observation group(n=75)receiving combined nursing interventions based on the Snyder hope theory model.Depression status,psychological resilience,self-care ability,and quality of life were compared between the two groups.RESULTS Before nursing interventions,there were no significant differences between the two groups(P>0.05).After the interventions,depression scores decreased while psychological resilience,self-care ability,and quality of life scores increased significantly in the observation group compared to that in the control group,with statistically significant differences noted(P<0.05).This combined approach can enhance psychological resilience,improve self-care abilities,and elevate the overall quality of life,warranting further promotion in clinical practice.CONCLUSION Combination of problem-oriented education and nursing interventions based on the Snyder hope theory model effectively alleviates depression in patients following PCI for coronary heart disease.

入ICU 12h内相关指标构建危重症患者预后预测模型

目的:探讨危重症患者28d死亡的影响因子,以入ICU 12h内指标构建危重症患者预后预测模型。方法:回顾性分析2021年1月—2022年6月我院ICU接收的危重症患者资料,经多因素二元logistic回归模型筛选影响因子,构建预测模型,并采用Nomogram模型展示影响因子对预后影响可视化。结果:共纳入259例危重症患者,入ICU 28d存活180例,死亡79例。多因素logistic回归分析显示年龄(OR=1.021,95%CI:1.002~1.040)、收缩压(OR=0.990,95%CI:0.981~0.999)、血清肌酐(OR=1.142,95%CI:1.018~1.281)、氧合指数(OR=0.998,95%CI:0.996~1.000)、格拉斯哥昏迷评分(OR=0.992,95%CI:0.868~0.981)是危重症患者28d死亡的影响因子(P<0.05);建立危重症患者28d死亡的预测模型为P=1/(1^(+)e^(-z)),Z=0.021×年龄-0.010×SBP^(+)0.133×SCr-0.002×OI-0.081×GCS,该模型对危重症患者预后预测AUC为0.752(95%CI:0.685~0.819,P<0.001),敏感度为0.658,特异度为0.767。结论:入ICU 12h内的年龄、收缩压、血清肌酐、氧合指数、格拉斯哥昏迷评分是本组危重症患者28d死亡的影响因子,依托入ICU 12h内建立的预测模型在早期预测危重症患者有良好的价值。

Comparing Three of the Leadership Theories: Leader-Member Exchange Theory,transformational Leadership and Team Leadership

Leadership is a complex process.It is one of the most researched areas around the world.It has gained importance in every walk of life from politics to business and from education to social organizations.According to the study of"Leadership in Adult Education Venues",here has a much more clear recognition of leadership:leadership is a process whereby an individual influences a group of individuals to achieve a common goal.There are many approaches of leadership throughout the study of this class,the three theories of leadership I choose to describe in this paper are:Leader-Member Exchange(LMX)Theory,Transformational Leadership,and Team Leadership.

表面织构对H13模具钢激光熔覆残余应力影响分析

在H13模具钢多层激光熔覆过程中,通过预置表面织构以降低激光熔覆后模具钢熔覆层的残余应力,减少其裂纹的产生。首先,对待加工表面进行预处理,预置正方形表面织构,并利用Ansys软件APDL语言模拟激光熔覆过程,对熔覆过程中的温度场和应力场进行了耦合分析研究;其次,结合正交实验模拟结果研究预置织构对激光熔覆层温度场和残余应力的影响;最后,进行实验测定。研究结果表明,对正交仿真实验结果进行均值化分析可知,最优熔覆参数为激光功率P=400 W,扫描速率v=20 mm/s,激光光斑半径R=0.8 mm,影响熔覆层残余应力的影响程度顺序依次为激光功率>激光光斑半径>扫描速率。将最优参数下有、无织构的仿真及实际加工结果进行对比,仿真结果中有织构激光熔覆后工件表面的残余应力降低了25.96%,实际熔覆后有织构工件表面的残余应力18.55%。因此通过在H13模具钢基体表面预置织构的方法,可以降低熔覆层残余应力,从而减少或消除裂纹的产生,在利用激光熔覆进行模具再制造过程中可以起到积极有效的作用。

Combining stochastic density functional theory with deep potential molecular dynamics to study warm dense matter

In traditional finite-temperature Kohn–Sham density functional theory(KSDFT),the partial occupation of a large number of high-energy KS eigenstates restricts the use of first-principles molecular dynamics methods at extremely high temperatures.However,stochastic density functional theory(SDFT)can overcome this limitation.Recently,SDFT and the related mixed stochastic–deterministic density functional theory,based on a plane-wave basis set,have been implemented in the first-principles electronic structure software ABACUS[Q.Liu and M.Chen,Phys.Rev.B 106,125132(2022)].In this study,we combine SDFT with the Born–Oppenheimer molecular dynamics method to investigate systems with temperatures ranging from a few tens of eV to 1000 eV.Importantly,we train machine-learning-based interatomic models using the SDFT data and employ these deep potential models to simulate large-scale systems with long trajectories.Subsequently,we compute and analyze the structural properties,dynamic properties,and transport coefficients of warm dense matter.

包覆型MCM-41和Hβ分子筛负载的Pd催化剂双功能催化性能

采用水热合成法制备了一种MCM-41分子筛介孔孔道沿Hβ沸石内核向外生长的包覆型MCM-41和Hβ复合分子筛(Mβ)。以PdCl 2的盐酸溶液做浸渍液,用常规等体积浸渍法制备了Pd/Mβ催化剂。另外,还以预先硅烷化的Mβ作载体,以Pd(OAc)_(2)的甲苯溶液作浸渍液,用等体积浸渍法制备了Pd/S-Mβ催化剂。采用X射线衍射、N_(2)物理吸附、透射电镜(TEM)和吡啶吸附红外等手段对催化剂进行了表征,并以十氢萘的开环反应和二苯并噻吩的加氢脱硫反应评价了催化剂的性能,认识了金属中心和酸中心沿颗粒内部径向分布对双功催化剂能性能的影响。TEM结果表明,在Pd/Mβ催化剂中,Pd金属颗粒填充于MCM-41介孔相孔道中;而在Pd/S-Mβ催化剂中,Pd金属颗粒分布于催化剂表面。在十氢萘的开环和二苯并噻吩的加氢脱硫反应中,Pd/Mβ表现出双功能特性,是潜在的性能良好的加氢脱硫催化剂。尽管Pd/Mβ和Pd/S-Mβ酸性质基本一致,但是空间上将表面Pd金属组分与内核Hβ沸石酸组分用不具有酸性的MCM-41介孔相分隔后,会导致Pd/S-Mβ催化剂酸中心不能发挥作用。

基于KY3H中医体质辨识-评估-干预系统辨证治疗先兆流产临床研究

目的:观察在常规治疗基础上基于KY3H中医体质辨识-评估-干预系统辨证治疗先兆流产的临床疗效。方法:选取2022年7月—2023年6月在浙江中医药大学附属温州市中医院治疗的600例先兆流产患者,以随机数字表法分为对照组与观察组各300例。对照组予以常规治疗,观察组在对照组基础上根据体质类型针对性给予中药汤剂治疗。2组均治疗2周。比较2组临床疗效、性激素水平及保胎成功率。结果:治疗2周后,总有效率观察组93.00%(279/300),高于对照组87.67%(263/300),差异有统计学意义(P<0.05)。2组血清孕酮(P)、雌二醇(E2)、人绒毛膜促性腺激素(HCG)水平均较治疗前升高,观察组血清P、E2、HCG水平均高于对照组,差异均有统计学意义(P<0.05)。保胎成功率观察组90.67%(272/300),高于对照组83.67%(251/300),差异有统计学意义(P<0.05)。结论:在常规治疗基础上基于KY3H中医体质辨识-评估-干预系统辨证治疗先兆流产能提高P、E2、HCG水平,改善妊娠结局。

丙泊酚对脂多糖诱导的MHCC97H细胞黏附、迁移、侵袭和炎症因子的影响及与核转录因子-κB信号通路的关系

目的探究丙泊酚与脂多糖(LPS)刺激下MHCC97H细胞功能、炎症水平及核转录因子-κB(NF-κB)表达的关联。方法该研究起止时间为2021年12月至2022年12月。体外培养人MHCC97H细胞系,分为对照组(等量的溶剂),LPS组(1 mg/L LPS),实验组(LPS+6.25组、LPS+12.5组、LPS+25组,LPS组基础上分别加入6.25、12.5和25μmol/L丙泊酚),用酶联免疫吸附试验、细胞计数试剂盒检测炎症因子白细胞介素6(IL-6)的表达水平和细胞活力筛选出丙泊酚的最适浓度进行后续实验,后将细胞分为对照组、LPS组、LPS+25组和LPS+25+抑制剂组(LPS+25组基础上联合10μmol/L BAY 11-7082),干预24 h。细胞黏附实验测定黏附细胞数;Transwell小室法检测细胞迁移与侵袭水平;蛋白质印迹法测定上皮间质转化(EMT)及NF-κB通路相关蛋白表达水平。结果根据细胞活力和炎症因子IL-6表达选择LPS+25组进行后续实验,与对照组相比,LPS组细胞黏附数、迁移数、侵袭数、N-钙黏蛋白(N-cadherin)、波形蛋白(Vimentin)、纤连蛋白(FN)、IκB激酶α(IKKα)和p-NF-κB p65蛋白水平分别为(152.00±9.01)个、(84.01±10.44)个、(65.67±3.06)个、0.46±0.02、0.47±0.03、0.99±0.02、1.03±0.02、0.95±0.05上调,E-钙黏蛋白(E-cadherin)表达0.42±0.02下调(P<0.05);与LPS组相比,LPS+25组显著扭转了上述指标的变化(P<0.05);与LPS+25组相比,LPS+25+抑制剂组加入NF-κB通路抑制剂后,上述指标变化扭转得更为显著(P<0.05)。结论丙泊酚对LPS刺激下MHCC97H细胞炎症因子表达、黏附、迁移、侵袭能力及EMT进程具有抑制作用,可能与NF-κB通路活性受到抑制有关。

见光诱导催化合成3,4-二氢异喹啉-1(2H)-酮及其衍生物

建立了一种在温和条件下,用可见光催化合成一系列3,4-二氢异喹啉-1(2H)-酮及其衍生物的方法。该方法在室温条件下,以2-烯丙基-N-甲氧基苯甲酰胺为模板底物,以碘化钾作为光催化剂,25 W 460 nm的蓝色LED灯照射下,合成一系列3,4-二氢异喹啉-1(2H)-酮衍生物,最高产率可达到83%。该合成路径具有底物适用范围广、经济实用等特点,为3,4-二氢异喹啉-1(2H)-酮衍生物合成提供了一种经济简便的方法。

Timing theory integrated nursing combined behavior change integrated theory of nursing on primiparous influence

BACKGROUND The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for primipara.This has the potential to enhance the psychological well-being and overall quality of life for primipara,while also furnishing healthcare providers with efficacious interventions to tackle the psychological and physiological obstacles encountered during the stages of pregnancy and postpartum.AIM To explore the effect of timing theory combined with behavior change on selfefficacy,negative emotions and quality of life in patients with primipara.METHODS A total of 80 primipara cases were selected and admitted to our hospital between August 2020 and May 2022.These cases were divided into two groups,namely the observation group and the control group,with 40 cases in each group.The nursing interventions differed between the two groups,with the control group receiving routine nursing and the observation group receiving integrated nursing based on the timing theory and behavior change.The study aimed to compare the pre-and post-nursing scores of Chinese Perceived Stress Scale(CPSS),Edinburgh Postpartum Depression Scale(EPDS),Self-rating Anxiety Scale(SAS),breast milk knowledge,self-efficacy,and SF-36 quality of life in both groups.RESULTS After nursing,the CPSS,EPDS,and SAS scores of the two groups was significantly lower than that before nursing,and the CPSS,EPDS,and SAS scores of the observation group was significantly lower than that of the control group(P=0.002,P=0.011,and P=0.001 respectively).After nursing,the breastfeeding knowledge mastery,selfefficacy,and SF-36 quality of life scores was significantly higher than that before nursing,and the breastfeeding knowledge mastery(P=0.013),self-efficacy(P=0.008),and SF-36 quality of life(P=0.011)scores of the observation group was significantly higher than that of the control group.CONCLUSION The integration of timing theory and behavior change integrated theory has been found to be an effective approach in alleviating negative mood and stress experienced by primipara individuals,while also enhancing their selfefficacy and overall quality of life.This study focuses on the key concepts of timing theory,behavior change,primipara individuals,negative mood,and quality of life.

Systems Theory-Driven Framework for AI Integration into the Holistic Material Basis Research of Traditional Chinese Medicine

This paper introduces a systems theory-driven framework to integration artificial intelligence(AI)into traditional Chinese medicine(TCM)research,enhancing the understanding of TCM’s holistic material basis while adhering to evidence-based principles.Utilizing the System Function Decoding Model(SFDM),the research progresses through define,quantify,infer,and validate phases to systematically explore TCM’s material basis.It employs a dual analytical approach that combines top-down,systems theory-guided perspectives with bottom-up,elements-structure-function methodologies,provides comprehensive insights into TCM’s holistic material basis.Moreover,the research examines AI’s role in quantitative assessment and predictive analysis of TCM’s material components,proposing two specific AIdriven technical applications.This interdisciplinary effort underscores AI’s potential to enhance our understanding of TCM’s holistic material basis and establishes a foundation for future research at the intersection of traditional wisdom and modern technology.

Transient response of doubly-curved bio-inspired composite shells resting on viscoelastic foundation subject to blast load using improved first-order shear theory and isogeometric approach

Investigating natural-inspired applications is a perennially appealing subject for scientists. The current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties and environmental resilience. Biological composite structures with helicoidal schemes and designs have remarkable capacities to absorb impact energy and withstand damage. However, there is a dearth of extensive study on the influence of fiber redirection and reorientation inside the matrix of a helicoid structure on its mechanical performance and reactivity. The present study aimed to explore the static and transient responses of a bio-inspired helicoid laminated composite(B-iHLC) shell under the influence of an explosive load using an isomorphic method. The structural integrity of the shell is maintained by a viscoelastic basis known as the Pasternak foundation, which encompasses two coefficients of stiffness and one coefficient of damping. The equilibrium equations governing shell dynamics are obtained by using Hamilton's principle and including the modified first-order shear theory,therefore obviating the need to employ a shear correction factor. The paper's model and approach are validated by doing numerical comparisons with respected publications. The findings of this study may be used in the construction of military and civilian infrastructure in situations when the structure is subjected to severe stresses that might potentially result in catastrophic collapse. The findings of this paper serve as the foundation for several other issues, including geometric optimization and the dynamic response of similar mechanical structures.

A Data Intrusion Tolerance Model Based on an Improved Evolutionary Game Theory for the Energy Internet

Malicious attacks against data are unavoidable in the interconnected,open and shared Energy Internet(EI),Intrusion tolerant techniques are critical to the data security of EI.Existing intrusion tolerant techniques suffered from problems such as low adaptability,policy lag,and difficulty in determining the degree of tolerance.To address these issues,we propose a novel adaptive intrusion tolerance model based on game theory that enjoys two-fold ideas:(1)it constructs an improved replica of the intrusion tolerance model of the dynamic equation evolution game to induce incentive weights;and (2)it combines a tournament competition model with incentive weights to obtain optimal strategies for each stage of the game process.Extensive experiments are conducted in the IEEE 39-bus system,whose results demonstrate the feasibility of the incentive weights,confirm the proposed strategy strengthens the system’s ability to tolerate aggression,and improves the dynamic adaptability and response efficiency of the aggression-tolerant system in the case of limited resources.

SHARP MORREY REGULARITY THEORY FOR A FOURTH ORDER GEOMETRICAL EQUATION

This paper is a continuation of recent work by Guo-Xiang-Zheng[10].We deduce the sharp Morrey regularity theory for weak solutions to the fourth order nonhomogeneous Lamm-Rivière equation △^{2}u=△(V▽u)+div(w▽u)+(▽ω+F)·▽u+f in B^(4),under the smallest regularity assumptions of V,ω,ω,F,where f belongs to some Morrey spaces.This work was motivated by many geometrical problems such as the flow of biharmonic mappings.Our results deepens the Lp type regularity theory of[10],and generalizes the work of Du,Kang and Wang[4]on a second order problem to our fourth order problems.

Sensitivity impacts owing to the variations in the type of zero-range pairing forces on the fission properties using the density functional theory

Using the Skyrme density functional theory,potential energy surfaces of^(240)Pu with constraints on the axial quadrupole and octupole deformations(q_(20)and q_(30))were calculated.The volume-like and surface-like pairing forces,as well as a combination of these two forces,were used for the Hartree–Fock–Bogoliubov approximation.Variations in the least-energy fission path,fission barrier,pairing energy,total kinetic energy,scission line,and mass distribution of the fission fragments based on the different forms of the pairing forces were analyzed and discussed.The fission dynamics were studied based on the timedependent generator coordinate method plus the Gaussian overlap approximation.The results demonstrated a sensitivity of the mass and charge distributions of the fission fragments on the form of the pairing force.Based on the investigation of the neutron-induced fission of^(239)Pu,among the volume,mixed,and surface pairing forces,the mixed pairing force presented a good reproduction of the experimental data.

Enhancing the resolution of sparse rock property measurements using machine learning and random field theory

The travel time of rock compressional waves is an essential parameter used for estimating important rock properties,such as porosity,permeability,and lithology.Current methods,like wireline logging tests,provide broad measurements but lack finer resolution.Laboratory-based rock core measurements offer higher resolution but are resource-intensive.Conventionally,wireline logging and rock core measurements have been used independently.This study introduces a novel approach that integrates both data sources.The method leverages the detailed features from limited core data to enhance the resolution of wireline logging data.By combining machine learning with random field theory,the method allows for probabilistic predictions in regions with sparse data sampling.In this framework,12 parameters from wireline tests are used to predict trends in rock core data.The residuals are modeled using random field theory.The outcomes are high-resolution predictions that combine both the predicted trend and the probabilistic realizations of the residual.By utilizing unconditional and conditional random field theories,this method enables unconditional and conditional simulations of the underlying high-resolution rock compressional wave travel time profile and provides uncertainty estimates.This integrated approach optimizes the use of existing core and logging data.Its applicability is confirmed in an oil project in West China.

问题与回答——Theorizing A New Agenda for Architecture,An Anthology of Architectural Theory,1965～1995一书引起的思考

内斯比特(KateNesbitt)在她的Theorizing A New Agenda for Architecture,An Anthology of Architectural Theory,1965～1995一书中较为全面地介绍了当代西方建筑理论界所关心的主要问题及其相关的思考。对于这些问题,国内建筑理论界也有自己的认识。该文通过对两者的比较,试图理清建筑理论的基本意义,那就是提出问题并引起思考。

抗纤维化与促“H”型血管核壳结构生物支架修复临界骨缺损

背景:在骨组织愈合过程中,促进新生骨的血管化是加速骨组织修复的常用策略,然而骨缺损修复过程中过快的纤维化进程常常被忽略。目的:设计并制备一种具有调节新生骨痂内纤维化及血管化进程的核壳结构仿生支架,表征其物理学特征,验证其体内外抗纤维化与促成骨性能。方法:制备具有调节新生骨痂内纤维化及血管化进程的核壳结构仿生支架,外层壳结构由聚己内酯静电纺丝纳米纤维负载成纤维细胞活化蛋白抑制剂组成,内层核结构由甲基丙烯酸酐明胶水凝胶负载去铁胺组成,表征静电纺丝和水凝胶的物理学特征,利用活死染色与CCK-8实验验证材料的生物相容性。通过成纤维细胞体外实验分析支架壳结构的抗纤维化作用,通过MC3T3-E1细胞体外实验分析支架壳结构中成纤维细胞活化蛋白抑制剂的促成骨作用,通过人脐静脉内皮细胞分析支架核结构中去铁胺的促血管形成作用。通过大鼠临界骨缺损实验评估核壳结构仿生支架的骨修复作用。结果与结论:①核壳结构仿生支架具有良好的生物相容性,静电纺丝技术制备的聚己内酯电纺纤维具有疏水性,在物理层面上有效阻隔外源性纤维组织长入,电纺纤维膜在2周内可有效释放抗纤维化药物成纤维细胞活化蛋白抑制剂,释放的抗纤维化药物可以抑制骨缺损周围成纤维细胞的生长、黏附,有效降低成纤维相关蛋白的表达,同时可促进MC3T3-E1细胞成骨蛋白的表达,加快其矿化速度;支架核结构中的去铁胺可促进人脐静脉内皮细胞的迁移、成管能力,并促进其强烈表达“H”血管特征性蛋白。②在SD大鼠的股骨制造临界骨缺损模型中,相较于聚己内酯膜,核壳结构仿生支架实现了骨缺损的有效修复。③结果表明,核壳结构仿生支架在预防骨痂过度纤维化的同时促进新生骨痂内“H”血管形成,能有效避免骨不连的发生,加速临界骨缺损修复进程。

温肾通络止痛方对小鼠H型骨微血管内皮细胞/骨髓间充质干细胞共培养体系的影响

背景:骨骼依赖血管与骨细胞之间的密切连接来维持完整性,骨骼处在生理低氧环境中,因此在低氧环境下研究血管生成与骨生成具有重要意义。目的:探究在低氧环境下温肾通络止痛方对H型骨微血管内皮细胞/骨髓间充质干细胞共培养体系的影响及相关机制。方法:运用酶消化法及流式分选技术,分选小鼠H型血管特异型骨微血管内皮细胞;应用骨髓贴壁法分离获取小鼠骨髓间充质干细胞;采用Transwell小室以及缺氧培养工作站建立两种细胞低氧共培养体系,使用50,100μg/m L质量浓度温肾通络止痛方冻干粉进行干预;通过划痕迁移实验与管形成实验评估共培养体系内H型骨微血管内皮细胞的成血管功能;通过碱性磷酸酶染色与茜素红染色评估共培养体系内骨髓间充质干细胞的成骨分化能力;使用Western Blotting与q-PCR检测共培养体系内H型骨微血管内皮细胞中PDGF/PI3K/AKT信号轴相关分子的蛋白表达及mRNA表达。结果与结论:(1)与常氧组相比,低氧组H型骨微血管内皮细胞划痕迁移率及新生血管长度均显著升高(P<0.05),骨髓间充质干细胞成骨分化能力增强(P<0.05);PDGF/PI3K/AKT信号轴相关分子的蛋白、mRNA表达升高(P<0.05);(2)与低氧组相比,经不同质量浓度温肾通络止痛方干预后H型骨微血管内皮细胞划痕迁移率及新生血管长度进一步提高(P<0.05),骨髓间充质干细胞成骨分化能力更强(P<0.05),PDGF/PI3K/AKT信号轴相关分子的蛋白、mRNA表达也进一步升高(P<0.05)。结果表明:低氧条件下H型血管生成及骨生成可能与PDGF/PI3K/AKT信号轴有关,而温肾通络止痛方可能通过激活PDGF/PI3K/AKT信号轴促进“H型血管生成-骨生成”作用从而防治骨质疏松症。