目的:探讨妊娠期肝内胆汁淤积症实验室指标的生物参考区间及临床意义。方法:筛选506例正常妊娠者及358例妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)患者,分别测定妊娠期肝内胆汁淤积症实验室指标TBA、TB、DB、CG...目的:探讨妊娠期肝内胆汁淤积症实验室指标的生物参考区间及临床意义。方法:筛选506例正常妊娠者及358例妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)患者,分别测定妊娠期肝内胆汁淤积症实验室指标TBA、TB、DB、CG,并将506例正常妊娠者按孕龄,358例ICP患者按疾病轻重度分组进行比较。结果:506例正常妊娠者TBA、TB、DB、CG含量与孕龄无关,其生物参考区间分别为TBA:0～15.29μmol/L,TB3.86～17.90μmol/L,DB0.61～4.81μmol/L,CG0～5.46mg/L。ICP患者TBA、TB、DB、CG含量与正常妊娠比较有显著差异(P<0.05),轻度组与重度组比较也有显著差异(P<0.05)。结论:妊娠期肝内胆汁淤积症实验室指标的生物参考区间的确立对临床辅助诊断ICP具有重要意义,而ICP患者TBA、TB、DB、CG含量测定可作为ICP临床分度诊断的依据,有助于疾病病情判断。展开更多
BACKGROUND: Although pneumonia severity index(PSI) is widely used to evaluate the severity of community-acquired pneumonia(CAP), the calculation of PSI is very complicated. The present study aimed to evaluate the role...BACKGROUND: Although pneumonia severity index(PSI) is widely used to evaluate the severity of community-acquired pneumonia(CAP), the calculation of PSI is very complicated. The present study aimed to evaluate the role of B-type natriuretic peptide(BNP) in predicting the severity of CAP.METHODS: For 202 patients with CAP admitted to the emergency department, BNP levels, cardiac load indexes, inf lammatory indexes including C-reactive protein(CRP), white blood cell count(WBC), and PSI were detected. The correlation between the indexes and PSI was investigated. BNP levels for survivor and non-survivor groups were compared, and a receiver operating characteristic(ROC) curve analysis was performed on the BNP levels versus PSI.RESULTS: The BNP levels increased with CAP severity(r=0.782, P<0.001). The BNP levels of the high-risk group(PSI classes IV and V) were signifi cantly higher than those of the low-risk group(PSI classes I–III)(P<0.001). The BNP levels were signifi cantly higher in the non-survivor group than in the survivor group(P<0.001). In addition, there were positive correlations between BNP levels and PSI scores(r=0.782, P<0.001). The BNP level was highly accurate in predicting the severity of CAP(AUC=0.952). The optimal cut-off point of BNP level for distinguishing high-risk patients from low-risk ones was 125.0 pg/m L, with a sensitivity of 0.891 and a specifi city of 0.946. Moreover, BNP level was accurate in predicting mortality(AUC=0.823). Its optimal cut-off point for predicting death was 299.0 pg/m L, with a sensitivity of 0.675 and a specifi city of 0.816. Its negative predictive cut-off value was 0.926, and the positive predictive cut-off value was 0.426.CONCLUSION: BNP level is positively correlated with the severity of CAP, and may be used as a biomarker for evaluating the severity of CAP.展开更多
文摘目的:探讨妊娠期肝内胆汁淤积症实验室指标的生物参考区间及临床意义。方法:筛选506例正常妊娠者及358例妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)患者,分别测定妊娠期肝内胆汁淤积症实验室指标TBA、TB、DB、CG,并将506例正常妊娠者按孕龄,358例ICP患者按疾病轻重度分组进行比较。结果:506例正常妊娠者TBA、TB、DB、CG含量与孕龄无关,其生物参考区间分别为TBA:0～15.29μmol/L,TB3.86～17.90μmol/L,DB0.61～4.81μmol/L,CG0～5.46mg/L。ICP患者TBA、TB、DB、CG含量与正常妊娠比较有显著差异(P<0.05),轻度组与重度组比较也有显著差异(P<0.05)。结论:妊娠期肝内胆汁淤积症实验室指标的生物参考区间的确立对临床辅助诊断ICP具有重要意义,而ICP患者TBA、TB、DB、CG含量测定可作为ICP临床分度诊断的依据,有助于疾病病情判断。
基金supported by a grant from the Excellent Talent Training Special Fund,Xicheng District of Beijing(20110046)
文摘BACKGROUND: Although pneumonia severity index(PSI) is widely used to evaluate the severity of community-acquired pneumonia(CAP), the calculation of PSI is very complicated. The present study aimed to evaluate the role of B-type natriuretic peptide(BNP) in predicting the severity of CAP.METHODS: For 202 patients with CAP admitted to the emergency department, BNP levels, cardiac load indexes, inf lammatory indexes including C-reactive protein(CRP), white blood cell count(WBC), and PSI were detected. The correlation between the indexes and PSI was investigated. BNP levels for survivor and non-survivor groups were compared, and a receiver operating characteristic(ROC) curve analysis was performed on the BNP levels versus PSI.RESULTS: The BNP levels increased with CAP severity(r=0.782, P<0.001). The BNP levels of the high-risk group(PSI classes IV and V) were signifi cantly higher than those of the low-risk group(PSI classes I–III)(P<0.001). The BNP levels were signifi cantly higher in the non-survivor group than in the survivor group(P<0.001). In addition, there were positive correlations between BNP levels and PSI scores(r=0.782, P<0.001). The BNP level was highly accurate in predicting the severity of CAP(AUC=0.952). The optimal cut-off point of BNP level for distinguishing high-risk patients from low-risk ones was 125.0 pg/m L, with a sensitivity of 0.891 and a specifi city of 0.946. Moreover, BNP level was accurate in predicting mortality(AUC=0.823). Its optimal cut-off point for predicting death was 299.0 pg/m L, with a sensitivity of 0.675 and a specifi city of 0.816. Its negative predictive cut-off value was 0.926, and the positive predictive cut-off value was 0.426.CONCLUSION: BNP level is positively correlated with the severity of CAP, and may be used as a biomarker for evaluating the severity of CAP.
