肿瘤是危害人类健康的重要杀手,大约5%~10%的肿瘤由遗传性肿瘤综合征引起。遗传性肿瘤包括孟德尔遗传模式的单基因遗传性肿瘤以及由多基因与环境互相作用的多基因遗传性肿瘤。遗传性肿瘤综合征中与妇科肿瘤相关的有:遗传性乳腺癌-卵巢...肿瘤是危害人类健康的重要杀手,大约5%~10%的肿瘤由遗传性肿瘤综合征引起。遗传性肿瘤包括孟德尔遗传模式的单基因遗传性肿瘤以及由多基因与环境互相作用的多基因遗传性肿瘤。遗传性肿瘤综合征中与妇科肿瘤相关的有:遗传性乳腺癌-卵巢癌综合征(hereditary breast and ovarian cancer,HBOC).展开更多
One of the difficulties in creating a blood substitute on the basis of human haemoglobin(Hb) is the toxic nature of Hb when it is outside the safe environment of the red blood cells.The plasma protein haptoglobin(Hp) ...One of the difficulties in creating a blood substitute on the basis of human haemoglobin(Hb) is the toxic nature of Hb when it is outside the safe environment of the red blood cells.The plasma protein haptoglobin(Hp) takes care of the Hb physiologically leaked into the plasma-it binds Hb and makes it much less toxic while retaining the Hb’s high oxygen transporting capacity.We used Electron Paramagnetic Resonance(EPR) spectroscopy to show that the protein bound radical induced by H2O2 in Hb and Hp-Hb complex is formed on the same tyrosine residue(s),but,in the complex,the radical is found in a more hydrophobic environment and decays slower than in unbound Hb,thus mitigating its oxidative capacity.The data obtained in this study might set new directions in engineering blood substitutes for transfusion that would have the oxygen transporting efficiency typical of Hb,but which would be non-toxic.展开更多
文摘肿瘤是危害人类健康的重要杀手,大约5%~10%的肿瘤由遗传性肿瘤综合征引起。遗传性肿瘤包括孟德尔遗传模式的单基因遗传性肿瘤以及由多基因与环境互相作用的多基因遗传性肿瘤。遗传性肿瘤综合征中与妇科肿瘤相关的有:遗传性乳腺癌-卵巢癌综合征(hereditary breast and ovarian cancer,HBOC).
基金supported by the Biomedical EPR Facility of the University of Essexgranted by the EPSRC funded UK National Service for Computational Chemistry Software(NSCCS,1996-2017)Imperial College London。
文摘One of the difficulties in creating a blood substitute on the basis of human haemoglobin(Hb) is the toxic nature of Hb when it is outside the safe environment of the red blood cells.The plasma protein haptoglobin(Hp) takes care of the Hb physiologically leaked into the plasma-it binds Hb and makes it much less toxic while retaining the Hb’s high oxygen transporting capacity.We used Electron Paramagnetic Resonance(EPR) spectroscopy to show that the protein bound radical induced by H2O2 in Hb and Hp-Hb complex is formed on the same tyrosine residue(s),but,in the complex,the radical is found in a more hydrophobic environment and decays slower than in unbound Hb,thus mitigating its oxidative capacity.The data obtained in this study might set new directions in engineering blood substitutes for transfusion that would have the oxygen transporting efficiency typical of Hb,but which would be non-toxic.
