目的探讨慢性乙型肝炎肝硬化患者血清维生素D水平与乙型肝炎病毒(hepatitis B virus,HBV)复制及肝脏纤维化程度的相关性。方法收集2016年11月-2018年11月在青岛市第六人民医院就诊的乙型肝炎肝硬化患者327例,检测血清25-羟基维生素D(25-...目的探讨慢性乙型肝炎肝硬化患者血清维生素D水平与乙型肝炎病毒(hepatitis B virus,HBV)复制及肝脏纤维化程度的相关性。方法收集2016年11月-2018年11月在青岛市第六人民医院就诊的乙型肝炎肝硬化患者327例,检测血清25-羟基维生素D(25-hydroxyvitamin D,25(OH)D)含量,<30 ng/mL者列为实验组,≥30 ng/mL者列为对照组。检测两组血清病毒水平及肝纤维化指标。结果实验组HBV DNA水平明显高于对照组;实验组肝纤维化指标透明质酸(hyaluronic acid,HA)、Ⅲ型前胶原(typeⅢprocollagen,PC-Ⅲ)、Ⅳ型胶原(typeⅣcollagen,C-Ⅳ)明显高于对照组,两组层粘连蛋白(laminin,LN)无显著性差异。结论维持乙肝肝硬化患者的血清维生素D的正常水平,可有利于抑制乙型肝炎病毒复制,延缓肝脏纤维化进程。展开更多
In this study, discharge at the outlet of Xijiang River, the biggest sub-basin of the Zhujiang River, was simulated and projected from 1961 to 2099 using the hydrological model HBV-D. The model uses precipitation and ...In this study, discharge at the outlet of Xijiang River, the biggest sub-basin of the Zhujiang River, was simulated and projected from 1961 to 2099 using the hydrological model HBV-D. The model uses precipitation and temperature data from CISRO/MK3 5, MPI/ECHAM5, and NCAR/CCSM3 under three greenhouse gas emission scenarios (SRES A2, A1B, B1). The results in water resources and flood frequency suggest that annual precipitation and annual runoff would increase after 2050 relative to the reference period of 1961-1990. In addition, increasing trends have been projected in area averaged monthly precipitation and runoff from May to October, while decreasing trends in those from December to February. More often and larger floods would occur in future. Potential increase in runoff during the low-flow season could ease the pressure of water demand until 2030, but the increase in runoff in the high-flow season, with more often and larger floods, more pressure on flood control after 2050 is expected.展开更多
以4-取代-9-(2′-脱氧-2′-β-氟-β-D-呋喃糖基)吡咯[2,3-d]嘧啶类化合物为原料,与三氯氧磷一锅法合成出具有新型结构的吡咯[2,3-d]嘧啶核苷单磷酸酯类化合物,其化学结构经核磁共振磷谱(31P NMR)、核磁共振氢谱(1 H NMR)、高分辨质谱(H...以4-取代-9-(2′-脱氧-2′-β-氟-β-D-呋喃糖基)吡咯[2,3-d]嘧啶类化合物为原料,与三氯氧磷一锅法合成出具有新型结构的吡咯[2,3-d]嘧啶核苷单磷酸酯类化合物,其化学结构经核磁共振磷谱(31P NMR)、核磁共振氢谱(1 H NMR)、高分辨质谱(HRMS)分析确证;对合成的目标化合物进行了初步的体外抗乙肝病毒药理活性实验,结果显示设计合成的7个化合物对乙型肝炎病毒表面抗原(HBsAg)和乙型肝炎e抗原(HBeAg)都有一定的抑制作用,其中化合物3a,3d,3f对HBsAg和HBeAg的抑制率较高,3a的毒性较低.展开更多
基金supported by the National Basic Research Program of China (No. 2010CB428401)
文摘In this study, discharge at the outlet of Xijiang River, the biggest sub-basin of the Zhujiang River, was simulated and projected from 1961 to 2099 using the hydrological model HBV-D. The model uses precipitation and temperature data from CISRO/MK3 5, MPI/ECHAM5, and NCAR/CCSM3 under three greenhouse gas emission scenarios (SRES A2, A1B, B1). The results in water resources and flood frequency suggest that annual precipitation and annual runoff would increase after 2050 relative to the reference period of 1961-1990. In addition, increasing trends have been projected in area averaged monthly precipitation and runoff from May to October, while decreasing trends in those from December to February. More often and larger floods would occur in future. Potential increase in runoff during the low-flow season could ease the pressure of water demand until 2030, but the increase in runoff in the high-flow season, with more often and larger floods, more pressure on flood control after 2050 is expected.
文摘以4-取代-9-(2′-脱氧-2′-β-氟-β-D-呋喃糖基)吡咯[2,3-d]嘧啶类化合物为原料,与三氯氧磷一锅法合成出具有新型结构的吡咯[2,3-d]嘧啶核苷单磷酸酯类化合物,其化学结构经核磁共振磷谱(31P NMR)、核磁共振氢谱(1 H NMR)、高分辨质谱(HRMS)分析确证;对合成的目标化合物进行了初步的体外抗乙肝病毒药理活性实验,结果显示设计合成的7个化合物对乙型肝炎病毒表面抗原(HBsAg)和乙型肝炎e抗原(HBeAg)都有一定的抑制作用,其中化合物3a,3d,3f对HBsAg和HBeAg的抑制率较高,3a的毒性较低.
