With the advent of left-handed magnetic materials, it is desirable to develop high-performance wave devices based on their novel properties of wave propagation. This letter reports the special properties of elastic wa...With the advent of left-handed magnetic materials, it is desirable to develop high-performance wave devices based on their novel properties of wave propagation. This letter reports the special properties of elastic wave propagation in magnetoelastic multilayered composites with negative permeability as compared to those in counterpart structures with positive permeability. These novel properties of elastic waves are discerned from the diversified dispersion curves, which represent the propagation and attenuation characteristics of elastic waves. To compute these dispersion curves, the method of reverberation-ray matrix is extended for the analysis of elastic waves in magnetoelastic multilayered composites. Although only the results of a single piezomagnetic and a binary magnetoelastic layers with mechanically free and magnetically short surfaces as well as perfect interface are illustrated in the numerical examples, the analysis is applicable to magnetoelastic multilayered structures with other kinds of boundaries/interfaces.展开更多
Objective:Traditional Chinese medicine plays a significant role in the treatment of the pandemic of coronavirus disease 2019(COVID-19).Tanreqing Capsule(TRQC)was used in the treatment of COVID-19 patients in the Shang...Objective:Traditional Chinese medicine plays a significant role in the treatment of the pandemic of coronavirus disease 2019(COVID-19).Tanreqing Capsule(TRQC)was used in the treatment of COVID-19 patients in the Shanghai Public Health Clinical Center.This study aimed to investigate the clinical efficacy of TRQC in the treatment of COVID-19.Methods:A retrospective cohort study was conducted on 82 patients who had laboratory-confirmed mild and moderate COVID-19;patients were treated with TRQC in one designated hospital.The treatment and control groups consisted of 25 and 57 cases,respectively.The treatment group was given TRQC orally three times a day,three pills each time,in addition to conventional Western medicine treatments which were also administered to the control group.The clinical efficacy indicators,such as the negative conversion time of pharyngeal swab nucleic acid,the negative conversion time of fecal nucleic acid,the duration of negative conversion of pharyngeal-fecal nucleic acid,and the improvement in the level of immune indicators such as T-cell subsets(CD3,CD4 and CD45)were monitored.Results:COVID-19 patients in the treatment group,compared to the control group,had a shorter negative conversion time of fecal nucleic acid(4 vs.9 days,P=0.047)and a shorter interval of negative conversion of pharyngeal-fecal nucleic acid(0 vs.2 days,P=0.042).The level of CD3+T cells increased in the treatment group compared to the control group([317.09±274.39]vs.[175.02±239.95]counts/l L,P=0.030).No statistically significant differences were detected in the median improvement in levels of CD4+T cells(173 vs.107 counts/l L,P=0.208)and CD45+T cells(366 vs.141 counts/l L,P=0.117)between the treatment and control groups.Conclusion:Significant reductions in the negative conversion time of fecal nucleic acid and the duration of negative conversion of pharyngeal-fecal nucleic acid were identified in the treatment group as compared to the control group,illustrating the potential therapeutic benefits of using TRQC as a complement to conventional medicine in patients with mild and moderate COVID-19.The underlying mechanism may be related to the improved levels of the immune indicator CD3+T cells.展开更多
Objective:To explore the effect of entecavir on patients with decompensated chronic hepatitis B cirrhosis.Methods:From October 2007 to December 2019,100 patients with decompensated chronic hepatitis B cirrhosis who we...Objective:To explore the effect of entecavir on patients with decompensated chronic hepatitis B cirrhosis.Methods:From October 2007 to December 2019,100 patients with decompensated chronic hepatitis B cirrhosis who were treated in our hospital were selected to carry out this study.The clinical data of the patients were analyzed.According to whether entecavir treatment was carried out,100 patients were divided into two groups,50 cases in the control group and 50 cases in the observation group.The control group was treated with conventional drugs,and the observation group was treated with entecavir.Liver function indexes,liver fibrosis indexes,HBV-DNA negative conversion rate and incidence of adverse reactions were compared between the two groups.Results:Compared with the control group,the liver function indexes of the observation group were lower,P<0.05;Compared with the control group,the observation group was better,P<0.05;The negative rate of HBV-DNA in the observation group was lower than that in the control group(P<0.05);There was no difference in the incidence of adverse reactions between the two groups,P>0.05.Conclusion:Entecavir can not only improve the liver function,but also enhance the shortterm treatment effect,without increasing adverse reactions,and has high safety,which is worthy of recommendation.展开更多
This paper summarized the pressure control methods used in 16 large-scale production facilities in China for vaccines against foot-and-mouth disease virus and highly pathogenic avian influenza virus.We presented the p...This paper summarized the pressure control methods used in 16 large-scale production facilities in China for vaccines against foot-and-mouth disease virus and highly pathogenic avian influenza virus.We presented the pressure control modes,with their characteristics,of the"constant supply"mode-variable exhaust air volume system and the"constant supply"mode-constant exhaust air volume system.This paper analyzed the influence of common problems(e.g.,pressure reference zero drift,positive pressure reversal and failure to restore the original normal working conditions after working condition conversion)on system stability during pressure control in BSL-3 large-scale production facilities and their solutions,providing references for the design and implementation of similar construction projects under the new situation.展开更多
基金supported by the National Natural Science Foundation of China(11372119)partly by the Fundamental Research Funds for the Central Universities(2016XZZX001-05)
文摘With the advent of left-handed magnetic materials, it is desirable to develop high-performance wave devices based on their novel properties of wave propagation. This letter reports the special properties of elastic wave propagation in magnetoelastic multilayered composites with negative permeability as compared to those in counterpart structures with positive permeability. These novel properties of elastic waves are discerned from the diversified dispersion curves, which represent the propagation and attenuation characteristics of elastic waves. To compute these dispersion curves, the method of reverberation-ray matrix is extended for the analysis of elastic waves in magnetoelastic multilayered composites. Although only the results of a single piezomagnetic and a binary magnetoelastic layers with mechanically free and magnetically short surfaces as well as perfect interface are illustrated in the numerical examples, the analysis is applicable to magnetoelastic multilayered structures with other kinds of boundaries/interfaces.
基金supported by Emergency Scientific Research Project of Shanghai Health Committee and Shanghai Administration of Traditional Chinese Medicine(No.2020YJ01)Shanghai Key Laboratory of Traditional Chinese Clinical Medicine(No.14DZ2273200)Shanghai Key Clinical Specialty(No.SHSLCZDZK05101)。
文摘Objective:Traditional Chinese medicine plays a significant role in the treatment of the pandemic of coronavirus disease 2019(COVID-19).Tanreqing Capsule(TRQC)was used in the treatment of COVID-19 patients in the Shanghai Public Health Clinical Center.This study aimed to investigate the clinical efficacy of TRQC in the treatment of COVID-19.Methods:A retrospective cohort study was conducted on 82 patients who had laboratory-confirmed mild and moderate COVID-19;patients were treated with TRQC in one designated hospital.The treatment and control groups consisted of 25 and 57 cases,respectively.The treatment group was given TRQC orally three times a day,three pills each time,in addition to conventional Western medicine treatments which were also administered to the control group.The clinical efficacy indicators,such as the negative conversion time of pharyngeal swab nucleic acid,the negative conversion time of fecal nucleic acid,the duration of negative conversion of pharyngeal-fecal nucleic acid,and the improvement in the level of immune indicators such as T-cell subsets(CD3,CD4 and CD45)were monitored.Results:COVID-19 patients in the treatment group,compared to the control group,had a shorter negative conversion time of fecal nucleic acid(4 vs.9 days,P=0.047)and a shorter interval of negative conversion of pharyngeal-fecal nucleic acid(0 vs.2 days,P=0.042).The level of CD3+T cells increased in the treatment group compared to the control group([317.09±274.39]vs.[175.02±239.95]counts/l L,P=0.030).No statistically significant differences were detected in the median improvement in levels of CD4+T cells(173 vs.107 counts/l L,P=0.208)and CD45+T cells(366 vs.141 counts/l L,P=0.117)between the treatment and control groups.Conclusion:Significant reductions in the negative conversion time of fecal nucleic acid and the duration of negative conversion of pharyngeal-fecal nucleic acid were identified in the treatment group as compared to the control group,illustrating the potential therapeutic benefits of using TRQC as a complement to conventional medicine in patients with mild and moderate COVID-19.The underlying mechanism may be related to the improved levels of the immune indicator CD3+T cells.
文摘Objective:To explore the effect of entecavir on patients with decompensated chronic hepatitis B cirrhosis.Methods:From October 2007 to December 2019,100 patients with decompensated chronic hepatitis B cirrhosis who were treated in our hospital were selected to carry out this study.The clinical data of the patients were analyzed.According to whether entecavir treatment was carried out,100 patients were divided into two groups,50 cases in the control group and 50 cases in the observation group.The control group was treated with conventional drugs,and the observation group was treated with entecavir.Liver function indexes,liver fibrosis indexes,HBV-DNA negative conversion rate and incidence of adverse reactions were compared between the two groups.Results:Compared with the control group,the liver function indexes of the observation group were lower,P<0.05;Compared with the control group,the observation group was better,P<0.05;The negative rate of HBV-DNA in the observation group was lower than that in the control group(P<0.05);There was no difference in the incidence of adverse reactions between the two groups,P>0.05.Conclusion:Entecavir can not only improve the liver function,but also enhance the shortterm treatment effect,without increasing adverse reactions,and has high safety,which is worthy of recommendation.
基金supported and financially funded by the National Key R&D Program of China:Source identification,monitoring and integrated control of indoor microbial contamination(No.2017YFC0702800).
文摘This paper summarized the pressure control methods used in 16 large-scale production facilities in China for vaccines against foot-and-mouth disease virus and highly pathogenic avian influenza virus.We presented the pressure control modes,with their characteristics,of the"constant supply"mode-variable exhaust air volume system and the"constant supply"mode-constant exhaust air volume system.This paper analyzed the influence of common problems(e.g.,pressure reference zero drift,positive pressure reversal and failure to restore the original normal working conditions after working condition conversion)on system stability during pressure control in BSL-3 large-scale production facilities and their solutions,providing references for the design and implementation of similar construction projects under the new situation.
