During hepatitis B virus(HBV)infection,the host immune response,including the presence of functional HBV-specific T cells and HBV-specific antibody-producing B cells,ultimately determines the HBV infection outcome:eit...During hepatitis B virus(HBV)infection,the host immune response,including the presence of functional HBV-specific T cells and HBV-specific antibody-producing B cells,ultimately determines the HBV infection outcome:either the virus is cleared,or infection persists.Functional exhaustion of HBV-specific CD8^(+) cytotoxic T cells is the most important immune feature in chronic HBV infection.However,chronic HBV infection also re-writes humoral immunity,whereby B cells are the leading participants.In this review,we highlight HBV-specific B cell responses and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.展开更多
基金This work was supported in part by the sub-subject of the major projects of national science and technology(2018ZX10302206-001-007 to Y.Wang,2017ZX10203202-002-012 to Y.Wang).
文摘During hepatitis B virus(HBV)infection,the host immune response,including the presence of functional HBV-specific T cells and HBV-specific antibody-producing B cells,ultimately determines the HBV infection outcome:either the virus is cleared,or infection persists.Functional exhaustion of HBV-specific CD8^(+) cytotoxic T cells is the most important immune feature in chronic HBV infection.However,chronic HBV infection also re-writes humoral immunity,whereby B cells are the leading participants.In this review,we highlight HBV-specific B cell responses and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.
