HBsAg positive families including 375 indiduals were investigated in genetic epidemiology.The results showed the HBsAg carrier rate of the blood relatives was significantly higherthan that of the non-blood relatives(P...HBsAg positive families including 375 indiduals were investigated in genetic epidemiology.The results showed the HBsAg carrier rate of the blood relatives was significantly higherthan that of the non-blood relatives(P<0.01).The HBsAg carrier rate decreased with the degreeof relatives,that is,the HBsAg carrier rate of the lst degree relatives was higher than that of the 2nddegree relatives and the HBsAg carrier rate or the 2nd degree relatives wus higher than that of the3rd degree relatives(P<0.01).The HBsAg carrier rate of the individuals living together with theprobands was higher than that of those living apart (P<0.01).But the other two marker of HBVinfectivity,anti-HBs and anti-HBc didn't show significant difference mentioned above.The resultsanalysed by means of Logistic Regression model showed blood relationship played an important rolein HBsAg carrier state.In addition,the history of common environment was associated with HBsAgcarrier state.The average of heritability in the 1st,2nd,3rd degree relatives was 88.80%.Analysis.of genetic model showed HBsAg carrier saute corresponded to the ckaracteristic of multifactorial genetic disease,excluding the possibility of single gene genetic disease.展开更多
A serological survey conducted among 196 pregnant women resident in and around Maiduguri, an urban town in north eastern Nigeria showed that 33 (16.8%) were asymptomatic carriers of hepatitis B virus surface antigen (...A serological survey conducted among 196 pregnant women resident in and around Maiduguri, an urban town in north eastern Nigeria showed that 33 (16.8%) were asymptomatic carriers of hepatitis B virus surface antigen (HBsAg). They are within the age range of 14-40 years with mean (± SD) age of 24.7 (± 6.3). The women attend antenatal clinic at the State Specialist Hospital, a secondary health facility in Maiduguri, Borno state. The women are all heterosexuals. The distribution of HBsAg carrier rate according to age of women studied showed a significant (p = 0.0061) increase of the prevalence of HBsAg from 4 (8.7%) in the lower age group (39 years). According to the number of pregnancies, the prevalence of HBsAg infection increased significantly from 6 (9.2%) among primiparous to 13 (13.7%) and 14 (38.9%) among multiparous and grand multiparous respectively. The carrier rate of HBsAg infection among the pregnant women studied based on their duration of pregnancies and their social class showed no significant differences. However, according to the factors known to be commonly associated with the highest risk of transmission of HBV such as history of blood transfusion, Tribal marks/tattooing, use of sharps, sharing of articles, history of jaundice in the women and husbands, history of sexually transmitted infections (STIs) of the women and husbands and the type of marriage (monogamous or polygamous), number of sexual relationships per week, only the history of blood transfusion was significantly associated with HBsAg carrier rate (RR = 3.71., 95% Confidence Interval (C.I.), 1.89-7.30, p = 0.0078). The study confirms that pregnant women who attend antenatal clinic in this secondary health facility are at higher risk of being infected with the HBV, which could lead to both prenatal and post natal transmission to their newborns.展开更多
文摘HBsAg positive families including 375 indiduals were investigated in genetic epidemiology.The results showed the HBsAg carrier rate of the blood relatives was significantly higherthan that of the non-blood relatives(P<0.01).The HBsAg carrier rate decreased with the degreeof relatives,that is,the HBsAg carrier rate of the lst degree relatives was higher than that of the 2nddegree relatives and the HBsAg carrier rate or the 2nd degree relatives wus higher than that of the3rd degree relatives(P<0.01).The HBsAg carrier rate of the individuals living together with theprobands was higher than that of those living apart (P<0.01).But the other two marker of HBVinfectivity,anti-HBs and anti-HBc didn't show significant difference mentioned above.The resultsanalysed by means of Logistic Regression model showed blood relationship played an important rolein HBsAg carrier state.In addition,the history of common environment was associated with HBsAgcarrier state.The average of heritability in the 1st,2nd,3rd degree relatives was 88.80%.Analysis.of genetic model showed HBsAg carrier saute corresponded to the ckaracteristic of multifactorial genetic disease,excluding the possibility of single gene genetic disease.
文摘A serological survey conducted among 196 pregnant women resident in and around Maiduguri, an urban town in north eastern Nigeria showed that 33 (16.8%) were asymptomatic carriers of hepatitis B virus surface antigen (HBsAg). They are within the age range of 14-40 years with mean (± SD) age of 24.7 (± 6.3). The women attend antenatal clinic at the State Specialist Hospital, a secondary health facility in Maiduguri, Borno state. The women are all heterosexuals. The distribution of HBsAg carrier rate according to age of women studied showed a significant (p = 0.0061) increase of the prevalence of HBsAg from 4 (8.7%) in the lower age group (39 years). According to the number of pregnancies, the prevalence of HBsAg infection increased significantly from 6 (9.2%) among primiparous to 13 (13.7%) and 14 (38.9%) among multiparous and grand multiparous respectively. The carrier rate of HBsAg infection among the pregnant women studied based on their duration of pregnancies and their social class showed no significant differences. However, according to the factors known to be commonly associated with the highest risk of transmission of HBV such as history of blood transfusion, Tribal marks/tattooing, use of sharps, sharing of articles, history of jaundice in the women and husbands, history of sexually transmitted infections (STIs) of the women and husbands and the type of marriage (monogamous or polygamous), number of sexual relationships per week, only the history of blood transfusion was significantly associated with HBsAg carrier rate (RR = 3.71., 95% Confidence Interval (C.I.), 1.89-7.30, p = 0.0078). The study confirms that pregnant women who attend antenatal clinic in this secondary health facility are at higher risk of being infected with the HBV, which could lead to both prenatal and post natal transmission to their newborns.
