AIM: To investigate whether vascular endothelial growth factor (VEGF) was over-expressed in hepatocellular carcinoma (HCC) or in surrounding cirrhotic liver tissues.METHODS: Immunohistochemistry was performed to inves...AIM: To investigate whether vascular endothelial growth factor (VEGF) was over-expressed in hepatocellular carcinoma (HCC) or in surrounding cirrhotic liver tissues.METHODS: Immunohistochemistry was performed to investigate the expression of VEGF proteins in HCC tissues from 105 consecutive patients undergoing curative resection for HCC. The immunostaining results and related clinicopathologic materials were analyzed with statistical methods. Kaplan-Meier method was used to calculate survival curves, and Log-rank test was performed to compare differences in survival rates of the patients with positive HCC staining and negative VEGF.RESULTS: VEGF-positive expression was found in 72 of105 HCC patients (68.6%). Capsular infiltration (P= 0.005),vascular invasion (P = 0.035) and intrahepatic metastasis(P=0.008) were observed more frequently in patients with VEGF-positive expression than in those with VEGFnegative expression. Kaplan-Meier curves showed that VEGF-positive expression was associated with a shorter overall survival (P = 0.014). VEGF-positive expression was found in 47 of tissues 68 HCC (69.1%), and VEGF-positive expression was found in 54 of 68 surrounding cirrhotic liver tissues (79.4%). VEGF-positive expression was significantly higher in surrounding cirrhotic liver tissues than in HCC (P= 0.017).CONCLUSION: VEGF may play an important role in the angiogenesis and prognosis of HCC, as well as in the angiogenesis of liver cirrhosis.展开更多
The amounts of somatostatin and sulfhydryl group were measured in malignant tumors of melanoma S91,Lewis lung cancer, sarcoma S180 and their surrounding tissues. All the tumors had decreased levels of somatostatin com...The amounts of somatostatin and sulfhydryl group were measured in malignant tumors of melanoma S91,Lewis lung cancer, sarcoma S180 and their surrounding tissues. All the tumors had decreased levels of somatostatin compared to their surrounding tissues whereas the amounts of sulfhydryl group in tumors increased evidently. The results suggest that the loss of somatostatin in tumor tissues may be induced by sulfhydryl group, which reduce the intramolecular disulfide bond of somatostatin.展开更多
Objective To explore the invasion of different types of meningeoma to their surrounding tissue. Methods The specimen from 124 patients with meningeomas,who underwent surgery in Southern Hospital from April 2009 to Jun...Objective To explore the invasion of different types of meningeoma to their surrounding tissue. Methods The specimen from 124 patients with meningeomas,who underwent surgery in Southern Hospital from April 2009 to June 2010 were used to analyze the invasion of different types of meningeomas to their surrounding tissue. All the tumors were resected in the standard of Simposon I. We referred to WHO 2007展开更多
目的探讨剪切波弹性成像定量分析乳腺病灶周边硬度对判断病灶良、恶性的诊断价值。方法回顾性分析2018年12月至2020年5月经中国科学技术大学附属第一医院(安徽省立医院)南区诊断为乳腺癌的60例患者临床资料,共60个病灶,其中良性病灶31个...目的探讨剪切波弹性成像定量分析乳腺病灶周边硬度对判断病灶良、恶性的诊断价值。方法回顾性分析2018年12月至2020年5月经中国科学技术大学附属第一医院(安徽省立医院)南区诊断为乳腺癌的60例患者临床资料,共60个病灶,其中良性病灶31个,恶性病灶29个。测量并记录每个病灶弹性模量值[最大值(E_(max))、最小值(E_(min))、平均值(E_(mean))、标准差(E_(sd))]和病灶周围区域(Shell 1.0、2.0、3.0 mm)的弹性模量值,同时比较“硬环征”的表现情况。比较良、恶性病灶及周围组织弹性模量值之间的差异。以病理诊断为金标准,绘制受试者工作特性曲线(ROC),比较各弹性模量的曲线下面积(AUC),获得诊断价值最大的弹性模量。最后比较BI-RADS分类、弹性成像及两者联合的诊断价值。结果良性组患者年龄小于恶性组,差异有统计学意义(P<0.05)。良、恶性组病灶最大径的差异无统计学意义(P>0.05)。恶性组“硬环征”发生率高于良性组,差异有统计学意义(P<0.05)。良、恶性组病灶内部及周围的弹性模量E_(min)比较,差异无统计学意义(P>0.05);恶性组E_(mean)、E_(max)、E_(sd)均高于良性组,差异有统计学意义(P<0.05)。各组弹性模量(E_(mean)、E_(max)、E_(sd))的ROC显示,Shell 2.0 mm E_(max)的AUC为所有弹性模量中最大,为0.843,截断值为97.06,敏感度82.76%,特异度74.19%。BIRADS分类、Shell 2.0 mm E_(max)两者联合获得的ROC曲线,AUC值为0.965,敏感度93.1%,特异度93.5%。结论常规超声BI-RADS分类、剪切波超声弹性成像技术相联合,能明显提高乳腺癌患者良、恶性病灶诊断准确率。展开更多
基金Supported by the China Scholarship Council, No. 98915009
文摘AIM: To investigate whether vascular endothelial growth factor (VEGF) was over-expressed in hepatocellular carcinoma (HCC) or in surrounding cirrhotic liver tissues.METHODS: Immunohistochemistry was performed to investigate the expression of VEGF proteins in HCC tissues from 105 consecutive patients undergoing curative resection for HCC. The immunostaining results and related clinicopathologic materials were analyzed with statistical methods. Kaplan-Meier method was used to calculate survival curves, and Log-rank test was performed to compare differences in survival rates of the patients with positive HCC staining and negative VEGF.RESULTS: VEGF-positive expression was found in 72 of105 HCC patients (68.6%). Capsular infiltration (P= 0.005),vascular invasion (P = 0.035) and intrahepatic metastasis(P=0.008) were observed more frequently in patients with VEGF-positive expression than in those with VEGFnegative expression. Kaplan-Meier curves showed that VEGF-positive expression was associated with a shorter overall survival (P = 0.014). VEGF-positive expression was found in 47 of tissues 68 HCC (69.1%), and VEGF-positive expression was found in 54 of 68 surrounding cirrhotic liver tissues (79.4%). VEGF-positive expression was significantly higher in surrounding cirrhotic liver tissues than in HCC (P= 0.017).CONCLUSION: VEGF may play an important role in the angiogenesis and prognosis of HCC, as well as in the angiogenesis of liver cirrhosis.
文摘The amounts of somatostatin and sulfhydryl group were measured in malignant tumors of melanoma S91,Lewis lung cancer, sarcoma S180 and their surrounding tissues. All the tumors had decreased levels of somatostatin compared to their surrounding tissues whereas the amounts of sulfhydryl group in tumors increased evidently. The results suggest that the loss of somatostatin in tumor tissues may be induced by sulfhydryl group, which reduce the intramolecular disulfide bond of somatostatin.
文摘Objective To explore the invasion of different types of meningeoma to their surrounding tissue. Methods The specimen from 124 patients with meningeomas,who underwent surgery in Southern Hospital from April 2009 to June 2010 were used to analyze the invasion of different types of meningeomas to their surrounding tissue. All the tumors were resected in the standard of Simposon I. We referred to WHO 2007
文摘目的探讨剪切波弹性成像定量分析乳腺病灶周边硬度对判断病灶良、恶性的诊断价值。方法回顾性分析2018年12月至2020年5月经中国科学技术大学附属第一医院(安徽省立医院)南区诊断为乳腺癌的60例患者临床资料,共60个病灶,其中良性病灶31个,恶性病灶29个。测量并记录每个病灶弹性模量值[最大值(E_(max))、最小值(E_(min))、平均值(E_(mean))、标准差(E_(sd))]和病灶周围区域(Shell 1.0、2.0、3.0 mm)的弹性模量值,同时比较“硬环征”的表现情况。比较良、恶性病灶及周围组织弹性模量值之间的差异。以病理诊断为金标准,绘制受试者工作特性曲线(ROC),比较各弹性模量的曲线下面积(AUC),获得诊断价值最大的弹性模量。最后比较BI-RADS分类、弹性成像及两者联合的诊断价值。结果良性组患者年龄小于恶性组,差异有统计学意义(P<0.05)。良、恶性组病灶最大径的差异无统计学意义(P>0.05)。恶性组“硬环征”发生率高于良性组,差异有统计学意义(P<0.05)。良、恶性组病灶内部及周围的弹性模量E_(min)比较,差异无统计学意义(P>0.05);恶性组E_(mean)、E_(max)、E_(sd)均高于良性组,差异有统计学意义(P<0.05)。各组弹性模量(E_(mean)、E_(max)、E_(sd))的ROC显示,Shell 2.0 mm E_(max)的AUC为所有弹性模量中最大,为0.843,截断值为97.06,敏感度82.76%,特异度74.19%。BIRADS分类、Shell 2.0 mm E_(max)两者联合获得的ROC曲线,AUC值为0.965,敏感度93.1%,特异度93.5%。结论常规超声BI-RADS分类、剪切波超声弹性成像技术相联合,能明显提高乳腺癌患者良、恶性病灶诊断准确率。
