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肝癌祖细胞在肝细胞癌发生中作用的研究进展 被引量:2
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作者 张杨倩雯(综述) 王红阳(审阅) 陈磊(审阅) 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2021年第1期74-81,共8页
肝细胞癌(hepatocellular carcinoma,HCC)是世界范围内最常见的原发性肝恶性肿瘤。当HCC患者出现明显症状时,肿瘤往往已经是中晚期,极大地影响了患者的生存质量。肝癌祖细胞(hepatocellular carcinoma progenitor cell,HcPC)是一种癌前... 肝细胞癌(hepatocellular carcinoma,HCC)是世界范围内最常见的原发性肝恶性肿瘤。当HCC患者出现明显症状时,肿瘤往往已经是中晚期,极大地影响了患者的生存质量。肝癌祖细胞(hepatocellular carcinoma progenitor cell,HcPC)是一种癌前病变中所含有的肿瘤起始细胞,对HcPC的发生机制以及生物学功能进行系统阐述,可能对HCC的早期诊断和干预治疗具有潜在的重要意义。近年来已有大量文献报道HcPC的生物标志物,如CD44、EpCAM、SOX9、OV6以及CK19等在HCC发生中所发挥重要作用,它们表达水平的升高对肝细胞的恶性转化、HcPC干性的维持以及肿瘤细胞的迁移和侵袭均具有一定的促进作用。针对HcPC的研究有望为HCC早期诊断提供新的思路,而通过阻止HcPC向HCC的恶性转化也有望成为一种治疗HCC的新方法。本文尝试对HcPC的发现过程、HcPC的主要来源、现有HcPC相关生物标志物等进行较为系统的综述,期望有助于今后HcPC相关研究的深入开展。 展开更多
关键词 肝细胞癌(HCC) 肿瘤发生 肝癌祖细胞(hcpc)
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羟基喜树碱联合治疗中晚期非小细胞肺癌28例 被引量:8
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作者 甘志勇 刘衍平 《肿瘤防治杂志》 2000年第6期657-658,共2页
关键词 药物疗法 hcpc DDP CTX 非小细胞肺癌 治疗
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The Evaluation of Child Capacity by Machine Learning According to the Region
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作者 Jamyandorj Narantuya Tsend Ganbat 《Journal of Computer and Communications》 2022年第6期90-98,共9页
Mongolian territory is 1.5 million square kilometers, there are 1.439 kindergartens that include 263.333 children. Mongolia has 5 regional zones. The research was made on selected provinces such as Sukhbaatar district... Mongolian territory is 1.5 million square kilometers, there are 1.439 kindergartens that include 263.333 children. Mongolia has 5 regional zones. The research was made on selected provinces such as Sukhbaatar district from Ulaanbaatar region, Huvsgul aimag from Khangai region, Umnugobi from Central region, Dornod aimag from Eastern region and Bayan-Ulgii from Western region. Total 450 preschool children at age of 3 - 5 years old (30 children at every 3, 4 and 5 years old) were selected randomly, they performed 5 tasks of Math according to the curriculum. The classification of age, sex and region was made under cluster analyses of children’s mathematical ability using research method. The purpose of the research is classification of province zone, determination of inequality and difference between rural and urban areas. It is made support for developer’s policy and decision makers of education under the base of financing and sharing kindergarten budget, specialization, retraining of teachers and children, developing, elaboration and planning curriculum. 展开更多
关键词 Data Mining Machine Learning Clustering hcpc R Programming
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