AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to...AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) parameters.METHODS: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL parameters discriminated early glaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma patients.CONCLUSION: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere glaucoma). Further, the discriminating performance of GC-IPL thicknesses is comparable to that.展开更多
目的采用Cirrus HD OCT测量近视人群的青光眼诊断参数差异性及近视人群的特征。方法选取2016年1月至2017年8月,就诊于我院的18~35岁不同近视程度的患者共95例(190只眼)。记录患者性别、年龄,采集其眼轴、医学验光屈光度(等效球镜)、视...目的采用Cirrus HD OCT测量近视人群的青光眼诊断参数差异性及近视人群的特征。方法选取2016年1月至2017年8月,就诊于我院的18~35岁不同近视程度的患者共95例(190只眼)。记录患者性别、年龄,采集其眼轴、医学验光屈光度(等效球镜)、视盘周围视网膜神经纤维层厚度(cpRNFL)包括平均、上下方,颞鼻侧5个参数、黄斑部神经节细胞和内丛状层(GCIPL)厚度包括平均、最小、上下方、鼻颞侧6个参数。根据屈光度分为A组(-0.25~3.0D);B组(-3.25^-6.0D);C组(>-6.0D),采用单因素方差分析进行所有参数的组间比较。采用Pear-son相关性分析不同屈光度与眼轴、GCIPL厚度、cpRNFL厚度的相关性及GCIPL厚度与cpRNFL厚度之间相关性。结果各组的性别及年龄无统计学差异。但各组间平均屈光度差异有统计学意义(F=521.963,P=0.000),眼轴和屈光度之间呈显著负相关(相关系数-0.706,P=0.000)。根据屈光度分组,所有参数各组之间均有显著差异(F=3.396~16.305,P<0.05)。cpRNFL厚度除颞侧外均与屈光度呈负相关(相关系数-0.316^-0.212,P<0.05),GCLIP厚度各参数均与屈光度呈负相关(相关系数-0.205^-0.384,P<0.05)。两种参数之间除颞侧外,其余参数均具呈正相关性(相关系数0.222~0.559),GCIPL与cpRNFL厚度在近视人群中均随屈光度发生一定的改变。结论近视眼cpRNFL厚度上下方及鼻侧象限均随屈光度增大逐渐变薄,颞侧变厚。GCIPL厚度各参数均随屈光度增大逐渐变薄,二者具有很好的一致性。近视人群采用此两种方法评估青光眼损害时,均需要考虑近视程度对参数的影响。展开更多
Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was...Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period. LTMH, CTFT, and CCET of the operated eyes and the unoperated fellow eyes were measured using high-definition optical coherence tomography（HD-OCT）. Correlations between three OCT assessments and age, time following surgery, graft size, bed size, and the number of residual sutures were analyzed. Results： Compared to patients with keratoconus, patients with other corneal conditions had significantly higher CCET in the fellow eye（P=0.024）. For all patients, CCET in the operated eye was significantly negatively correlated with the number of residual sutures（R=-0.579, P=0.008）, and was significantly positively correlated with time following surgery（R=0.636, P=0.003）. In the fellow eye, a significant positive correlation was found between age and CCET（R=0.551, P=0.012）, and a significant negative correlation between age and CTFT（R=-0.491, P=0.028）. LTMH was found to be significantly correlated between operated and fellow eyes（R=0.554, P=0.011）. There was no significant correlation between LTMH and age, bed/graft size, time following surgery, or residual sutures（all possible correlations, P0.05）. Conclusions： Patients with keratoconus tend to have a thinner central corneal epithelium. Corneal epithelium keeps regenerating over time after DALK. DALK did not induce a significant change in tear volume compared with the fellow eye. Postoperative tear function might depend on an individual＇s general condition, rather than on age, gender, bed/graft size, time following surgery, or residual sutures.展开更多
文摘AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) parameters.METHODS: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL parameters discriminated early glaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma patients.CONCLUSION: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere glaucoma). Further, the discriminating performance of GC-IPL thicknesses is comparable to that.
文摘目的采用Cirrus HD OCT测量近视人群的青光眼诊断参数差异性及近视人群的特征。方法选取2016年1月至2017年8月,就诊于我院的18~35岁不同近视程度的患者共95例(190只眼)。记录患者性别、年龄,采集其眼轴、医学验光屈光度(等效球镜)、视盘周围视网膜神经纤维层厚度(cpRNFL)包括平均、上下方,颞鼻侧5个参数、黄斑部神经节细胞和内丛状层(GCIPL)厚度包括平均、最小、上下方、鼻颞侧6个参数。根据屈光度分为A组(-0.25~3.0D);B组(-3.25^-6.0D);C组(>-6.0D),采用单因素方差分析进行所有参数的组间比较。采用Pear-son相关性分析不同屈光度与眼轴、GCIPL厚度、cpRNFL厚度的相关性及GCIPL厚度与cpRNFL厚度之间相关性。结果各组的性别及年龄无统计学差异。但各组间平均屈光度差异有统计学意义(F=521.963,P=0.000),眼轴和屈光度之间呈显著负相关(相关系数-0.706,P=0.000)。根据屈光度分组,所有参数各组之间均有显著差异(F=3.396~16.305,P<0.05)。cpRNFL厚度除颞侧外均与屈光度呈负相关(相关系数-0.316^-0.212,P<0.05),GCLIP厚度各参数均与屈光度呈负相关(相关系数-0.205^-0.384,P<0.05)。两种参数之间除颞侧外,其余参数均具呈正相关性(相关系数0.222~0.559),GCIPL与cpRNFL厚度在近视人群中均随屈光度发生一定的改变。结论近视眼cpRNFL厚度上下方及鼻侧象限均随屈光度增大逐渐变薄,颞侧变厚。GCIPL厚度各参数均随屈光度增大逐渐变薄,二者具有很好的一致性。近视人群采用此两种方法评估青光眼损害时,均需要考虑近视程度对参数的影响。
基金Project supported by the Zhejiang Provincial Natural Science Foundation of China(No.LQ16H120002)
文摘Objective： To assess the lower tear meniscus height（LTMH）, central tear film thickness（CTFT）, and central corneal epithelial thickness（CCET） after deep anterior lamellar keratoplasty（DALK）. Methods： This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period. LTMH, CTFT, and CCET of the operated eyes and the unoperated fellow eyes were measured using high-definition optical coherence tomography（HD-OCT）. Correlations between three OCT assessments and age, time following surgery, graft size, bed size, and the number of residual sutures were analyzed. Results： Compared to patients with keratoconus, patients with other corneal conditions had significantly higher CCET in the fellow eye（P=0.024）. For all patients, CCET in the operated eye was significantly negatively correlated with the number of residual sutures（R=-0.579, P=0.008）, and was significantly positively correlated with time following surgery（R=0.636, P=0.003）. In the fellow eye, a significant positive correlation was found between age and CCET（R=0.551, P=0.012）, and a significant negative correlation between age and CTFT（R=-0.491, P=0.028）. LTMH was found to be significantly correlated between operated and fellow eyes（R=0.554, P=0.011）. There was no significant correlation between LTMH and age, bed/graft size, time following surgery, or residual sutures（all possible correlations, P0.05）. Conclusions： Patients with keratoconus tend to have a thinner central corneal epithelium. Corneal epithelium keeps regenerating over time after DALK. DALK did not induce a significant change in tear volume compared with the fellow eye. Postoperative tear function might depend on an individual＇s general condition, rather than on age, gender, bed/graft size, time following surgery, or residual sutures.
