Background: Workers’ health condition is an important issue. It affects not only the well-being of workers but also the firms and society as a whole through medical costs and productivity losses due to absenteeism an...Background: Workers’ health condition is an important issue. It affects not only the well-being of workers but also the firms and society as a whole through medical costs and productivity losses due to absenteeism and presenteeism. Data and Methods: Data were obtained from 1136 employees at an operational site of a large corporation. The dataset contained both medical checkups and working record information. Health factors affecting long-term absence (over three days in three months) were analyzed. Logistic regression models and the procedure for selecting proper covariates based on likelihood test statistics and the Akaike information criterion were used. Results: Among health factors, high-density lipoprotein cholesterol (HDL-C) and blood sugar levels were important in the selected model. For HDL-C, the odds ratio (OR) based on one standard deviation difference was 0.75 with a 95% confidence interval (CI) of 0.59 - 0.95. For blood sugar, the OR was 1.20 with a 95% CI of 1.01 - 1.42. Improving HDL-C and blood sugar levels would reduce long-term absence by 25% and 20%, respectively. Conclusion: Controlling HDL-C and blood sugar levels is important to reduce long-term absenteeism. These factors can be improved by modifying eating habits. Since the operational site has its own company cafeterias, which most employees use, nutritional intervention is relatively easy with little or no cost. It may be worthwhile to implement nutritional intervention, especially for patients with low HDL-C or high blood sugar levels. Limitations: The results of this study were based on one operational site of a corporation. The employees were mainly operators working inside the building. The results may be different from other types of jobs and working conditions, such as fieldwork. Analyses of different types of jobs and working conditions are necessary.展开更多
目的研究脑卒中患者高密度脂蛋白(high density lipoprotein,HDL)亚类组成及相对百分含量的变化,并探讨脑卒中患者血压与HDL亚类组成的关系。方法采用双向电泳-免疫印迹检测法分析了79例正常对照和98例脑卒中患者HDL亚类组成及相对百分...目的研究脑卒中患者高密度脂蛋白(high density lipoprotein,HDL)亚类组成及相对百分含量的变化,并探讨脑卒中患者血压与HDL亚类组成的关系。方法采用双向电泳-免疫印迹检测法分析了79例正常对照和98例脑卒中患者HDL亚类组成及相对百分含量。结果脑梗死组preβ1-HDL(P<0.05或P<0.001)、HDL3c(P<0.001)水平显著增加,而HDL2a(P<0.05)及HDL2b(P<0.05或P<0.001)水平显著减少。脑出血组preβ1-HDL、HDL3c含量显著增加(P<0.05),而HDL2b含量显著减少(P<0.001)。受试者按收缩压水平分组发现,随着收缩压水平逐渐升高,小颗粒的preβ1-HDL、HDL3c及HDL3a水平均有升高趋势,而大颗粒的HDL2b水平有降低趋势。与正常组比较,收缩压高组(组Ⅳ:160 mmHg≤收缩压<180 mmHg)及收缩压极高组(组V:收缩压≥180 mmHg)preβ1-HDL、HDL3c含量均显著升高(P<0.05),而HDL2b含量显著降低(P<0.05)。且收缩压水平与preβ1-HDL、HDL3c水平呈正相关(r=0.235,r=0.250),而与HDL2b水平呈负相关(r=-0.228)。结论脑卒中患者HDL颗粒直径呈变小趋势,并且随着收缩压水平升高,其HDL颗粒的变小程度更加明显。展开更多
目的:探讨丝胶对2型糖尿病大鼠低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)的调节作用。方法:48只雄性SD大鼠随机分为正常对照组、糖尿病模型组...目的:探讨丝胶对2型糖尿病大鼠低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)的调节作用。方法:48只雄性SD大鼠随机分为正常对照组、糖尿病模型组、丝胶治疗组和阳性对照组,每组12只大鼠。25mg/kg链脲佐菌素腹腔注射3d(1次/d)建立2型糖尿病大鼠模型;模型成功建立后,糖尿病模型组大鼠不再做任何处理,丝胶治疗组大鼠给予丝胶(2.4g/kg/d)灌胃35d,阳性对照组大鼠给予二甲双胍(55.3mg/kg/d)灌胃35d。分别检测各组大鼠的血糖以及血清HLD-C和LDL-C的水平。结果:与正常对照组大鼠比较,模型组大鼠的血糖、LDL-C明显升高,HDL-C明显降低(P<0.01,P<0.05);与模型组大鼠比较,丝胶治疗组、阳性对照组大鼠的血糖、LDL-C明显降低,HDL-C明显升高(P<0.01)。结论:丝胶可通过提高HDL-C水平、降低LDL-C水平改善糖尿病时血脂代谢紊乱。展开更多
文摘Background: Workers’ health condition is an important issue. It affects not only the well-being of workers but also the firms and society as a whole through medical costs and productivity losses due to absenteeism and presenteeism. Data and Methods: Data were obtained from 1136 employees at an operational site of a large corporation. The dataset contained both medical checkups and working record information. Health factors affecting long-term absence (over three days in three months) were analyzed. Logistic regression models and the procedure for selecting proper covariates based on likelihood test statistics and the Akaike information criterion were used. Results: Among health factors, high-density lipoprotein cholesterol (HDL-C) and blood sugar levels were important in the selected model. For HDL-C, the odds ratio (OR) based on one standard deviation difference was 0.75 with a 95% confidence interval (CI) of 0.59 - 0.95. For blood sugar, the OR was 1.20 with a 95% CI of 1.01 - 1.42. Improving HDL-C and blood sugar levels would reduce long-term absence by 25% and 20%, respectively. Conclusion: Controlling HDL-C and blood sugar levels is important to reduce long-term absenteeism. These factors can be improved by modifying eating habits. Since the operational site has its own company cafeterias, which most employees use, nutritional intervention is relatively easy with little or no cost. It may be worthwhile to implement nutritional intervention, especially for patients with low HDL-C or high blood sugar levels. Limitations: The results of this study were based on one operational site of a corporation. The employees were mainly operators working inside the building. The results may be different from other types of jobs and working conditions, such as fieldwork. Analyses of different types of jobs and working conditions are necessary.
文摘目的:探讨丝胶对2型糖尿病大鼠低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)的调节作用。方法:48只雄性SD大鼠随机分为正常对照组、糖尿病模型组、丝胶治疗组和阳性对照组,每组12只大鼠。25mg/kg链脲佐菌素腹腔注射3d(1次/d)建立2型糖尿病大鼠模型;模型成功建立后,糖尿病模型组大鼠不再做任何处理,丝胶治疗组大鼠给予丝胶(2.4g/kg/d)灌胃35d,阳性对照组大鼠给予二甲双胍(55.3mg/kg/d)灌胃35d。分别检测各组大鼠的血糖以及血清HLD-C和LDL-C的水平。结果:与正常对照组大鼠比较,模型组大鼠的血糖、LDL-C明显升高,HDL-C明显降低(P<0.01,P<0.05);与模型组大鼠比较,丝胶治疗组、阳性对照组大鼠的血糖、LDL-C明显降低,HDL-C明显升高(P<0.01)。结论:丝胶可通过提高HDL-C水平、降低LDL-C水平改善糖尿病时血脂代谢紊乱。
