2型糖尿病并发脑梗死患者血清高半胱氨酸、致动脉硬化指数和非HDL-C水平分析

目的观察动脉硬化指数(AIP)、血清同型半胱氨酸(Hcy)以及非高密度脂蛋白(non-HDL-C)在2型糖尿病(T2DM)并发脑梗死患者体内的水平变化及其临床作用。方法 40例T2DM并发脑梗死患者和62例非糖尿病并发脑梗死组患者,另设对照组60例健康患者。测定所有患者的Hcy、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG),根据所得测定结果求出AIP及non-HDL-C,分析各组患者AIP及non-HDL-C的水平。结果 T2DM并发脑梗死组的血清TG、TC、LDL-C、non-HDL-C含量明显高于非糖尿病并发脑梗死组和健康人对照组。102例并发脑梗死患者的Hcy、TG、AIP水平均明显升高(P<0.01),HDL-C显著降低(P<0.01),脑梗死患者的Hcy不受患者血脂、血糖的影响。TC、TG、LDL-C、FPG水平越高则non-HDL-C水平也越高,呈正比关系。TG、non-HDL-C、HDL-C与AIP密切相关,HDL-C与AIP负性相关,而TG、non-HDL-C与AIP则为正性相关。结论 T2DM并发脑梗死患者的血清Hcy、AIP和non-HDL-C水平明显升高,这些指标可反映降糖、降脂疗效,为疾病的恶化发展提供参考。

氯吡格雷治疗不稳定型心绞痛的疗效及对HDL-C水平影响观察

目的分析氯吡格雷治疗不稳定型心绞痛的疗效及对HDL-C水平影响观察。方法选取2018年1月~2018年12月本院收治80例不稳定型心绞痛患者,随机将患者分为两组,对照组40例使用常规药物治疗,研究组40例在对照组基础上添加氯吡格雷治疗,对比两组患者临床疗效及各项血脂指标情况。结果研究组患者治疗总有效率为97.50%,明显高于对照组77.50%(P<0.05);研究组患者治疗后TC、TG、HDL-C、LDL-C指标分别为(1.37±0.44)mmol·L-1、(3.28±1.05)mmol·L-1、(1.34±0.15)mmol·L-1、(2.36±0.55)mmol·L-1,各项指标明显优于对照组(P<0.05)。结论临床对不稳定型心绞痛患者使用氯吡格雷治疗,可改善患者血脂指标,有效提高其治疗效果,值得临床推广使用。

黄连素+小剂量阿托伐他汀对高脂血症HDL-C水平的影响

分析高脂血症治疗中黄连素+小剂量阿托伐他汀对患者HDL-C水平的影响。方法 高脂血症患者取样90例,纳入时间2019年06月至2022年03月,随机数表分组,45例/组,给予对照组小剂量阿托伐他汀治疗,联合组则在此基础上加用黄连素治疗,对比GIQL分值、总有效率、血脂水平、血管内皮功能指标。结果 治疗后,联合组GIQL总分(127.87±6.29),比对照组(117.54±7.33)分高,总有效率100.00%,比对照组86.67%高,TC(4.19±0.42),TG(1.01±0.20),LDL-C(2.21±0.30)mmol/L,比对照组低,HDL-C(1.61±0.30)mmol/L,比对照组(1.21±0.34)mmol/L高,同时,联合组血管内皮功能指标优于对照组,P<0.05。结论 在高脂血症治疗中结合应用小剂量阿托伐他汀与黄连素可优化疗效,有效改善患者生活质量、血脂指标与血管内皮功能指标。

氨氯地平阿托伐他汀钙片治疗高血压病合并冠心病的效果观察及TG、TC、HDL-C水平影响评价

目的:为了深入研究对高血压病合并冠心病患者实施联合治疗后,患者TG、TC、LDL-C、HDL-C水平。方法:选取我院2019.06-2020.06这一时间区间收治的患者共130例,将其随机分成2组,给予联合治疗组为观察组,给予单一治疗组为对照组。对比两组患者TG、TC、LDL-C、HDL-C水平。结果:干预期结束后,观察组TG、TC、LDL-C、HDL-C水平显著低于对照组,差异均有统计学意义(P<0.05)。结论:临床对高血压病合并冠心病患者实施联合治疗,可有效降低患者TG、TC、LDL-C、HDL-C水平,故方案值得推广。

阿托伐他汀联合氯吡格雷治疗对冠心病心绞痛患者临床疗效及TC、TG、LDL-C、HDL-C水平的影响

目的探究阿托伐他汀联合氯吡格雷治疗对冠心病心绞痛患者临床疗效及TC、TG、LDL-C、HDL-C水平的影响。方法选取2018年4月至2020年3月我院收治的166例冠心病心绞痛患者,随机分成两组,每组83例,对照组在常规治疗基础上应用氯吡格雷治疗,研究组则在常规治疗基础上应用阿托伐他汀联合氯吡格雷治疗。对比两组患者的治疗效果、炎性因子水平和机体的血脂水平、心功能。结果与对照组相比较,研究组的临床治疗效果更高(P<0.05);与对照组相比较,研究组的CRP(C-反应蛋白)、TNF-α(肿瘤坏死因子)水平更低(P<0.05);治疗前,研究组的三酰甘油(TG)、总胆固醇(TC)水平和低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平与对照组相比较无明显差异(P>0.05),治疗后与对照组相比较,研究组的TG、TC、LDL-C等血脂指标水平更低(P<0.05),而与对照组相比较,研究组的HDL-C水平更高(P<0.05);治疗前,研究组心功能指标水平与对照组比较无明显差异(P>0.05),治疗后与对照组相比较,研究组的各项心功能指标水平更高(P<0.05)。结论在冠心病心绞痛患者的临床治疗中应用阿托伐他汀与氯吡格雷的联合治疗具有理想治疗效果,值得推广应用。

健康体检者血清HDL-C、LDL-C和TG水平检测结果及其血脂异常的发生因素分析

目的分析健康体检人群发生血脂异常的情况和血清中HDL-C、LDL-C、TG的数值意义分析研究。方法将2016年于我院健康管理中心的2766例健康体检者作为本次研究对象,分析其血清HDL-C、LDL-C和TG水平检测结果及血脂异常者中的男女比例和年龄比例。结果在2766例健康体检中血清中HDL-C、LDL-C、TG的数值在两个不同年龄段组之间存在明显差异,两组相比具有统计学意义(P<0.05)。男性发生血脂异常比例小于女性,两组相比具有统计学意义(P<0.05)。结论在健康体检者中,其血清中HDL-C、LDL-C、TG的数值和血脂异常通常和年龄、性别有关。

探究常规血脂检验诊断冠心病的临床意义

目的对冠心病检测工作中展开常规血脂检验的效果进行探究。方法收集我院经诊断明确为冠心病患者纳为本次研究对象,从中挑选86例患者为分析组,选取84例健康体检人员为对照组。均予以常规血脂检验进行相关的诊断工作。客观对比分析组与对照组常规血脂检验结果。结果和对照组相比,分析组患者的HDL-C水平较低,载脂蛋白B水平、脂蛋白A1水平、低密度脂蛋白胆固醇水平以及甘油三酯水平较高,P<0.05。结论血脂出现异常情况为冠心病主要特征之一,通过常规血脂检验结果可有效的诊断出冠心病患者,以便及时对其进行科学的治疗,在冠心病检测工作中具有极高的应用价值。

Correlation between thyroid function and nodular goiter accompanied with gallstone

Objective： The purpose of the study wass to explore the correlation between thyroid function and nodular goiter accompanied with gallstone. Methods： We collected 120 cases about nodular goiter accompanied with gallstone and 128 cases about nodular goiter and establish 50 healthy control groups. Detected t level of hyrotropic hormone （TSH）, total triio- dothyronine （TT3）, total thyroxine in the peripheral venous blood of these cases in the three groups by using electrochemilu- minescenca immunoassay, measure level of total cholesterol （TC）, high-density tipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol （LDL-C） and total bile acid （TBA） levels by using enzymic method, and observed the changes of thyroid function and blood lipid among the three groups. Results： The serum TT3 level in nodular goiter accompanied with gallstone group and the nodular goiter group was significantly lower than that in control group （P 〈 0.01）, and TSH level in the nodular goiter accompanied with gallstone group is significantly higher than that in control group （P 〈 0.01）, There were no statistical significance about difference of TT4 level among the three groups （P 〉 0.05）. Accordingly, TC and LDL-C level in nodular goiter accompanied with gallstone group was significantly higher than that in nodular goiter and control group （P 〈 0.01）, while TBA level in nodular goiter accompanied with gallstone group was significantly lower than that in simple nodular goiter group and control group （P 〈 0.01）. There was no statistical significance about difference of TC and LDL-C level between simple nodular goiter group and control group （P 〉 0.05）. The HDL-C level in nodular goiter accompanied with gallstone group and control group was higher than that in simple nodular goiter group （P 〈 0.01）. Conclusion： The originating etiologic factor of nodular goiter accompanied with gallstone may be related to that the decreased TT3 induced sub-clinical hypothyroidism.

Correlation between tongue manifestations and glucose, total cholesterol, and high-density lipoprotein cholesterol in patients with acute cerebral infarction

OBJECTIVE: To analyze the association between tongue manifestations and the levels of glucose (GLU), total cholesterol(TCH), and high-density lipoprotein cholesterol(HDL-C) in subjects with acute cerebral infarction.METHODS: Hospitalized patients with first unilateral cerebral infarction in the Neurological Department of Xuanwu Hospital were included and the correlation between tongue fur color, fur nature,and the levels of GLU,TCH, HDL-C were analyzed.RESULTS: HDL level in the thin fur group was higher than that in the thick fur group(P=0.02). The difference in the levels of GLU,TCH, and HDL-C among the groups was significant(P<0.05), classified in terms of slippery, moist, and dry fur. Further comparison between the groups by Student-Newman-Keuls test showed that GLU level in the dry fur group was the highest. Moreover, the TCH level in the slippery fur group was higher than the other two groups.CONCLUSION: A correlation between tongue manifestations and GLU, TCH, HDL-C was identified in the patients with acute cerebral infarction.