Clinical Observation on Treatment of Moderate and Severe Periodical Mastalgia with TCM Hot-wet Compress Therapy

[Objectives] To observe the clinical therapeutic efficacy of local hot-wet compress therapy of digestion ointment prescription on the patients with moderate and severe mastalgia. [Methods] Firstly,60 patients with mastalgia were selected,and divided into the experimental group and control group( 30 cases for each group). The control group was treated with acupuncture at distal point,and the experimental group was treated with TCM local hot-wet compress therapy combined with acupuncture at distal point. Then,the clinical therapeutic efficacy of two groups was compared. [Results]The experimental group was superior to the control group in relieving the breast pain,improving emotional integral,reducing breast lumps,improving lump texture,and improving TCM syndrome integral( P < 0. 05). [Conclusions]The digestion ointment prescription local hot-wet compress therapy has a significant therapeutic effect on treatment of mastalgia and can significantly improve the breast pain symptom of patients.

Clinical Effects of the Qi-acupuncture Therapy of TCM on Portal Hypertension

Objective:To explore the effective prevention and treatment of portal hypertension(PH).Methods:A total of 220 patients who came to our hospital from March 2015 to October 2018 were treated.They were randomly divided into the treatment group and the control group,each with 110 cases.Before treatment,there was no significant differences in age,sex,clinical symptoms,signs,laboratory tests and color Doppler ultrasound related examinations between the 2 groups(P>0.05).Among them,the treatment group on the basis of traditional Chinese and Western medicine treatment in our hospital,the Qi-acupuncture therapy of TCM was added.The extra meridian acupoints along with acupoints were selected.The control group received conventional treatment with traditional Chinese and Western medicine in our hospital.Results:There were significant differences in clinical symptoms,signs and chemistry between groups after treatment(P<0.01).There were significant differences in test,color ultrasound related examination and so on(P<0.01).Those in the treatment group was significantly better than the control group(P<0.01).Conclusion:On the basis of the Qi-acupuncture therapy of TCM,selecting extra meridian acupoint and acupoints can effectively treat PH.

The Comparison of Acute Clinical Outcome between 30 and 40 Sessions of Hyperbaric Oxygen Therapy for Management of Visible Hematuria from Radiation-Induced Hemorrhagic Cystitis

Background: Radiotherapy is one of the most popular treatments for pelvic malignancy, which causes patients suffering from the adverse effect such as cystitis, hematuria, proctitis, hematochezia and distal ureteric stricture. The hematuria condition from radiation-induced hemorrhagic cystitis is the most common adverse event suffering the patients, losing properties, wasting time, and deteriorating quality of life. One of the most effective treatments for radiation-induced hemorrhagic cystitis is the hyperbaric oxygen therapy with no necessity for patients to be hospitalized, no need of anesthesia use, and also non-invasion. However, it requires that patients spend 90 - 120 minutes a day for 40 days administered out-patient treatment session. The transportation cost as well as the accommodation one will greatly burden the self-pay health care patients. In addition, there is still no definite standardized number of HBOT treatment session assignment at present. Objectives: To compare the treatment outcome (bladder mucosal characteristics, red blood cells in urine) between 30 and 40 sessions of HBOT for treatment of radiation-induced hemorrhagic cystitis. Methods: Prospective cohort observational study of patients (n = 15) who were diagnosed with radiation-induced hemorrhagic cystitis that were treated with hyperbaric oxygen therapy in Somdechprapinklao Hospital between October 2020 and September 2021. We compared the parameter about hemoglobin concentration, red blood cell number in urine during the course of HBOT treatment every 10 sessions and cystoscopic finding severity as EORTC/RTOG classification for radiation-induced hemorrhagic cystitis in Table 1 before treatment, and after 30 and 40 sessions of treatment. Results: From 15 of treated patients, 93.3% of patients had evidence of posterior wall lesion. The mean duration from radiotherapy (radiation and brachytherapy) to the first episode gross hematuria is 112 months. This study shows no statistically different cystoscopic findings as EORTC/RTOG classification for radiation-induced hemorrhagic cystitis after 30 and 40 sessions of HBOT (p = 0.653) and statistically significant improvement after the treatment of more than 30 sessions (p = 0.008). No relationship was found with the hemoglobin concentration and red blood cell number in urine during the course of HBOT. Conclusions: Radiation-induced hemorrhagic cystitis can be treated with HBOT. There is no different treatment outcome between 30 and 40 sessions of HBOT.

Non-pharmacological therapy of TCM for the treatment of essential hypertension

Non-pharmacotogicat treatment is an important means to control hypertension, with many advantages such as tow cost, tess medication, stable btood pressure, tess compHcations, and improved prognosis. This article reviews the research progress of non-drug treatment of hypertension in Chinese medicine in the past five years, and evaluates traditional Chinese medicine such as TCM Qigong, Wuhuo opera, Ba Duanjin and Taijiquan, and Chinese medicine acupuncture, moxibustion, massage, apptication, acupoint embedding and other traditional Chinese medicine. The effect of external treatment in hypertension control provides guidance for non-drug therapy to control hypertension.

Systematic review and meta analysis of the TCM therapy of Fuzheng and Kangai combined with chemotherapy in treating advanced NSCLC

Objective:To systematically evaluate TCM of Fuzheng and Kangai combined with chemotherapy in the treatment of Advanced NSCLC,including the efficacy and effect on the quality of life of patients.Methods:Two researchers independently searched the literature of clinical trails from Jan.2010 until Jun.2020 in the Cochrane Library,Pubmed,Embase,CBM,CNKI,WanFang Data and VIP database.Also,they had been evaluated and extracted strictly by REVMAN 5.3.Results:A total of 1303 patients were included in 15 articles.The meta analysis shows that the TCM of Fuzheng and Kangai combined with chemotherapy can improve the objective response rate[OR=2.14,95%CI(1.67,2.74),P<0.00001],disease control rate[OR=2.54,95%CI(1.88,3.42),P<0.00001]and KPS score[OR=3.28,95%CI(1.92,5.60),P<0.0001],decrease the incidence rate of liver injury[OR=0.34,95%CI(0.21,0.54),P=0.003],hemoglobin reduction[OR=0.53,95%CI(0.28,1.01),P=0.05],leukopenia[OR=0.22,95%CI(0.13,0.39),P<0.00001],thrombocytopenia[OR=0.32,95%CI(0.21,0.50),P<0.00001],toxic effects on the digestive systems[OR=0.30,95%CI(0.19,0.46),P<0.00001].Conclusions:the experimental group was better than control one in short-term efficacy and KPS score.Furthermore,the experimental group can reduce the incidence rate of myelosuppression,toxicity of digestive system and liver.

八段锦联合放松功对轻中度抑郁的影响研究

【目的】探究中医行为心理疗法八段锦联合放松功干预轻中度抑郁的效果。【方法】将40例轻中度抑郁患者随机分为干预组和对照组,每组各20例。干预组给予八段锦锻炼联合放松功干预治疗,对照组给予西药氢溴酸西酞普兰片治疗,疗程为6周。观察2组患者干预前后汉密尔顿抑郁量表(HAMD)评分、蒙哥马利抑郁量表(MADRS)评分、匹兹堡睡眠质量指数(PSQI)评分以及生活质量综合评定问卷(GQOL-74)评分的变化情况,并评价2组患者的抑郁改善疗效。【结果】(1)抑郁改善疗效方面,治疗6周后,干预组的总有效率为95.0%(19/20),对照组为90.0%(18/20),组间比较(χ2检验),差异无统计学意义(P>0.05)。(2)抑郁程度方面,治疗后,2组患者的HAMD评分和MADRS评分均较治疗前明显下降(P<0.01),但治疗后组间比较,差异均无统计学意义(P>0.05)。(3)生活质量方面,治疗后,2组患者的GQOL-74的躯体功能、心理功能、社会功能、物质生活等各项评分及总分均较治疗前明显改善(P<0.01),但治疗后组间比较,差异均无统计学意义(P>0.05)。(4)睡眠质量方面,治疗后,2组患者的PSQI的睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物和日间功能等各项评分及总分均较治疗前明显改善(P<0.01),且干预组对PSQI的睡眠质量、入睡时间评分及总分的改善作用明显优于对照组(P<0.05)。【结论】八段锦锻炼联合放松功干预对轻中度抑郁症状的改善有明确的疗效,可以为轻中度抑郁症患者提供更广泛的选择可能,特别是对西药治疗不耐受的患者更具有一定的优势。

中医药治疗特发性肺纤维化研究进展

特发性肺纤维化是原因不明的慢性进行性致纤维化间质性肺炎,主要见于中老年男性,局限于肺,临床上呈渐进性呼吸困难和肺功能恶化,组织病理学和胸部HRCT表现为特征性的寻常型间质性肺炎。特发性肺纤维化属中医学“肺痿、肺痹”范畴,中医对此病的认识历史悠久,优势明显,近年来受到越来越多的重视,通过对近5年多(2018年—至今)中医药在特发性肺纤维化的研究文献进行总结,主要从病机(“肺虚络瘀”论、“热毒滞络”论、“肺寒络凝”论、其他)、临床研究(古方、自拟方、中成药、六字诀呼吸操、热敏灸)2方面进行了综述,以期为此病的治疗提供有益的参考。

血府逐瘀汤治疗冠心病研究进展

冠心病是临床常见的心血管疾病之一,其发病率和病死率呈上升趋势,严重危害居民健康,加重国家经济负担。血府逐瘀汤有活血化瘀、理气止痛的功效,主治胸中血瘀证。临床上根据其功效常用于治疗血瘀证冠心病,并取得良好疗效。此文旨在对血府逐瘀汤治疗冠心病的临床运用、作用机制及研究进展展开探讨,为深入挖掘血府逐瘀汤临床及实验研究提供新思路。

隐性听力损失中医病机及防治研究进展

隐性听力损失是以纯音听阈正常,噪声背景下言语识别能力降低为主要症状的疾病,噪声暴露、药物损伤、年龄老化是主要的致病危险因素,其发病隐匿,容易忽视,危险因素持续暴露可造成不可逆听力损伤,目前临床多无有效的治疗方法,以早期预防为主。根据隐性听力损失的致病因素及发病机制,探讨隐性听力损失的中医病机,认为脾虚湿滞、清窍蒙蔽、肾元不足、邪聚耳窍为致病的内在因素,毒邪犯耳、内毒留滞、毒瘀经络为病理机制,并对近年来隐性听力损失的预防与治疗研究概况做一总结,为中医药治疗隐性听力损失研究提供理论依据和临床经验。

调补脾肾中药复方治疗原发性骨质疏松症临床研究

目的:观察调补脾肾中药复方治疗原发性骨质疏松症(primary osteoporosis,POP)的临床疗效。方法:POP患者共计60例,采用随机数字表法随机分为对照组(30例)和治疗组(30例)。对照组治疗方法为常规综合治疗,治疗组治疗方法为在对照组的基础上加用调补脾肾中药复方。比较2组患者的骨密度、血清碱性磷酸酶(ALP)、血红蛋白(Hb)、白蛋白(ALB)、血钙(Ca)、血磷(P)及临床疗效。结果:治疗组总有效率高于对照组(P<0.05)。治疗后,2组的ALP水平均降低,治疗组低于对照组(P<0.05),Hb、ALB水平及骨密度均提高,三个指标相比较治疗组高于对照组(P<0.05)。结论:POP用调补脾肾中药复方治疗效果明确,能有效调节ALP、Hb、ALB水平,提高骨密度。

中医外治法治疗痛风性关节炎研究文献可视化分析

目的 分析中医外治法治疗痛风性关节炎相关文献,了解该领域研究现状、研究热点和发展趋势,为该领域后续研究提供研究思路。方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)2000年1月1日-2022年11月30日收录的中医外治法治疗痛风性关节炎研究文献,利用NoteExpress3.6.0软件对文献进行人工筛选,借助Excel2019绘制发文趋势图和期刊分布图;采用VOSviewer1.6.18软件绘制核心作者合作网络、机构合作密度视图和关键词共现图谱,使用CiteSpace6.1.R4软件绘制关键词聚类分析图、时间线图及关键词突现图谱,并对以上内容进行分析。结果 共纳入1 304篇文献,发文量总体呈增长态势;纳入文献涉及318本期刊、2 890位作者,发文量最多的是广州中医药大学;分析得出文献关键词1 181个,形成12个有意义的聚类,并展现出了湿热蕴结型、炎性因子、中医药疗法等20个突现词。结论 中医外治法治疗痛风性关节炎的研究热点主要集中于中药内服外敷、临床疗效观察及中药外敷、针刺、刺血疗法、电针、火针、针刀等中医外治法,备受关注的中医证型是湿热蕴结型。

芪葛威灵胶囊治疗糖尿病周围神经病变临床观察

目的:观察芪葛威灵胶囊治疗气阴两虚兼血瘀型糖尿病周围神经病变患者的临床疗效。方法:选取120例气阴两虚兼血瘀型糖尿病神经病变患者,按随机数字表法分为两组各60例。治疗组予芪葛威灵胶囊治疗,对照组予甲钴胺片口服。治疗8周后,比较两组患者临床疗效、中医证候积分、多伦多临床评分系统(TCSS)评分、神经传导速度、不良反应等。结果:治疗组总有效率91.67%,优于对照组的68.33%(P﹤0.05);治疗后,两组患者肢体麻木、疼痛及小腿抽搐证候积分均明显下降(P﹤0.05),两组TCSS评分均明显降低(P﹤0.05),腓总神经、胫后神经运动神经传导速度均明显提高(P﹤0.05),且治疗组改善程度均优于对照组(P﹤0.05)。结论:芪葛威灵胶囊可改善气阴两虚兼血瘀型糖尿病周围神经病变患者的临床症状,提高TCSS评分、改善神经传导速度,临床疗效良好。

七味白术散加味治疗肝硬化腹泻临床观察

目的:观察七味白术散加味治疗肝硬化腹泻的临床疗效。方法:选取确诊的96例肝硬化腹泻患者,随机分为两组各48例。两组均予肝硬化西医常规治疗,对照组在此基础上予双歧杆菌四联活菌口服,治疗组予七味白术散加味治疗,疗程均为2周,比较两组临床疗效以及肠道sIgA水平变化、肠道菌群的改善情况。结果:治疗组总有效率为95.83%,对照组总有效率81.25%,两组比较差异有统计学意义(P﹤0.05);治疗后,治疗组患者的ALT、AST、TBIL改善程度明显优于对照组(P﹤0.05);治疗组肠道sIgA水平、肠道菌群改善水平均明显优于对照组(P﹤0.05)。结论:七味白术散加味治疗肝硬化腹泻疗效较好,可改善患者肝功能水平及肠道有益菌群生长,增加患者肠道sIgA水平。

巴芪除痒止咳方治疗肺肾两虚兼风寒犯肺型咳嗽变异性哮喘疗效观察

目的:观察巴芪除痒止咳方治疗肺肾两虚兼风寒犯肺型咳嗽变异性哮喘的临床疗效。方法:选取门诊60名咳嗽变异性哮喘患者,随机分为两组各30例。对照组予布地奈德/福莫特罗粉吸入剂治疗,治疗组在对照组基础上予巴芪除痒止咳方治疗,疗程2周。比较两组临床疗效,VAS、CET、FeNO评分及中医证候积分变化情况。结果:治疗后,治疗组总有效率96.67%,高于对照组的80.00%,两组比较差异具有统计学意义(P﹤0.05);两组VAS、CET及FeNO评分均得到了改善(P﹤0.05),且治疗组VAS、CET评分较对照组改善更明显;治疗后治疗组咳痰、咽痒、恶风、自汗积分均小于对照组(P﹤0.05)。结论:巴芪除痒止咳方能减轻肺肾两虚兼风寒犯肺型咳嗽变异性哮喘患者气道炎症反应,缓解临床症状。

排卵障碍性不孕中医外治法研究进展

排卵障碍性不孕是妇科临床常见病、多发病,排卵障碍包括持续性不排卵、稀发排卵、不恰当排卵(包括小卵泡排卵)、多囊卵巢综合征、高泌乳素血症、早发性卵巢功能不全、高雄激素血症、黄素化卵泡未破裂综合征、黄体功能不足和卵巢早衰,这些均可导致不孕。近年来,排卵障碍性不孕的发病率有明显上升的趋势,受到广泛关注,西医治疗主要是使用促排卵药物,促排卵药物除了具有排卵率高、妊娠率低的特点,大部分还能发挥替代外源性激素的作用,但不能从根本上调节体内的生殖内分泌紊乱,具有一定的局限性。而长期排卵障碍不仅增加了育龄期女性的受孕难度,而且严重影响怀孕。中医外治法在治疗排卵障碍性不孕方面,在个性化、辨证论治上占据独特优势,有多种治疗手法可供患者选择,患者易于接受,既可减少患者每日服药量,又不易产生依赖性、耐药性等不良反应,还能避免药物对肝肾等脏器的损害,减轻患者的心理负担,存在显著的优势,确有成效。文章主要探讨针刺疗法、艾灸疗法及综合疗法治疗排卵障碍性不孕患者的疗效,也包括中药保留灌肠、穴位注射、耳穴压豆等中医外治法的运用,以期为排卵障碍性不孕的临床研究及相关科研提供参考。

辨证施护联合热敏灸治疗肝硬化腹水临床观察

目的探究中医辨证施护联合热敏灸治疗肝硬化腹水的临床效果。方法选择肝硬化腹水患者60例,分为对照组(予常规治疗)和试验组(予热敏灸联合中药治疗),对比两组临床疗效及不良反应发生率。结果试验组治疗总有效率为96.67%(29/30),高于对照组的83.33%(25/30),差异有统计学意义(P<0.05)。对照组不良反应发生率为6.67%(2/30),而试验组患者未出现不良反应,差异有统计学意义(P<0.05)。结论中医辨证施护联合热敏灸治疗肝硬化腹水效果显著、安全高,值得临床推广应用。

养阴润肠方联合针刺治疗老年慢传输型便秘临床观察

目的:观察养阴润肠方联合针刺治疗老年慢传输型便秘临床疗效。方法:选取老年慢传输型便秘患者84例,根据随机数字表法分为两组各42例。对照组予针刺治疗,治疗组在对照组基础上联合养阴润肠方治疗,疗程均为4周。观察两组患者临床疗效、中医证候评分、血清胃肠激素水平、结肠动力变化、肠道菌群数量检测及便秘患者生活质量量表(PAC-QOL)评分。结果:治疗组总有效率92.86%高于对照组的76.19%(P﹤0.05)。治疗后两组中医证候评分、血清VIP、5-HT水平、右半结肠通过时间、左半结肠通过时间、全结肠通过时间、大肠埃希菌平均数量、PAC-QOL评分均较治疗前明显降低(P﹤0.05),且治疗组各指标水平均低于对照组(P﹤0.05);治疗后两组乳酸杆菌数量、双歧杆菌数量、血清SP水平较治疗前上升(P﹤0.05),且治疗组均高于对照组(P﹤0.05)。结论:养阴润肠方联合针刺治疗老年慢传输型便秘可提高肠道动力,改善肠道菌群和胃肠激素水平,有效缓解临床症状,提高患者生活质量。

中和思想指导下苇茎汤治疗胸腔积液临床观察

目的 在中和医派思想的指导下探讨苇茎汤治疗胸腔积液的临床疗效。方法 选取2022年1月—2023年1月收治的胸腔积液患者60例,随机分为观察组和试验组,每组30例。观察组采用常规西医治疗,试验组在常规西医治疗的同时,联合应用苇茎汤进行治疗,3个疗程后观察2组临床疗效并对患者肺功能进行评价。结果 治疗后,试验组FVC、FEV1、FEV1/FVC、PEER均高于观察组(P<0.05)。结论 苇茎汤能够提高胸腔积液患者的肺功能,改善肺循环及气道阻塞,提高重症患者治愈率及生活质量。

平肝熄风胶囊联合耳穴压豆治疗中青年高血压疗效观察

目的:观察平肝熄风胶囊联合耳穴压豆治疗中青年高血压患者的临床疗效。方法:将100例中青年高血压患者随机分为两组各50例。对照组予生活方式干预及常规降压药物治疗,治疗组在对照组基础上予平肝熄风胶囊联合耳穴压豆治疗。两组均治疗8周。观察两组中医证候总有效率、降压总有效率情况,比较两组治疗前后24 h动态血压、尿微量白蛋白及生活质量评分变化。结果:治疗后,治疗组血压、24 h动态血压、尿微量白蛋白水平均明显低于对照组(P<0.05),治疗组中医证候疗效、降压疗效、生活质量均优于对照组(P<0.05)。结论:平肝熄风胶囊联合耳穴压豆治疗中青年高血压疗效较好,可降低患者血压,改善临床症状,提高生活质量。

中医定向透药疗法和中频脉冲电刺激治疗偏瘫肩痛的疗效差异分析

目的 分析偏瘫肩痛患者实施中医定向透药与中频脉冲电刺激治疗的效果。方法 随机选取潍坊市中医院于2022年11月—2023年11月收治的60例偏瘫肩痛患者为研究对象,掷骰子分组为透药组与刺激组,各30例。透药组行中医定向透药治疗,刺激组行中频脉冲电刺激治疗。比较两组疼痛情况、肩关节活动度、肢体功能情况及有效率。结果 治疗后,透药组疼痛评分低于刺激组,肩关节活动度高于刺激组,上肢功能及上肢自理能力优于刺激组,差异有统计学意义(P均<0.05)。透药组治疗总有效率为96.67%,高于刺激组的76.67%,差异有统计学意义(χ^(2)=5.192,P<0.05)。结论 中医定向透药疗法可大幅减轻肩痛问题,拓展肩关节活动度,提升肩关节功能,有效率高,相比中频脉冲电刺激疗效更好。