Ex vivo 3D osteocyte network construction with primary murine bone cells

Osteocytes reside as three-dimensionally（3D） networked cells in the lacunocanalicular structure of bones and regulate bone and mineral homeostasis. Despite of their important regulatory roles, in vitro studies of osteocytes have been challenging because：（1） current cell lines do not sufficiently represent the phenotypic features of mature osteocytes and（2） primary cells rapidly differentiate to osteoblasts upon isolation. In this study, we used a 3D perfusion culture approach to：（1） construct the 3D cellular network of primary murine osteocytes by biomimetic assembly with microbeads and（2） reproduce ex vivo the phenotype of primary murine osteocytes, for the first time to our best knowledge. In order to enable 3D construction with a sufficient number of viable cells, we used a proliferated osteoblastic population of healthy cells outgrown from digested bone chips. The diameter of microbeads was controlled to：（1） distribute and entrap cells within the interstitial spaces between the microbeads and（2） maintain average cell-to-cell distance to be about 19 mm. The entrapped cells formed a 3D cellular network by extending and connecting their processes through openings between the microbeads. Also, with increasing culture time, the entrapped cells exhibited the characteristic gene expressions（SOST and FGF23） and nonproliferative behavior of mature osteocytes. In contrast, 2D-cultured cells continued their osteoblastic differentiation and proliferation. This 3D biomimetic approach is expected to provide a new means of：（1） studying flow-induced shear stress on the mechanotransduction function of primary osteocytes,（2） studying physiological functions of 3D-networked osteocytes with in vitro convenience,and（3） developing clinically relevant human bone disease models.

The Budget Constrained Multi-product Newsboy Problem with Reactive Production:A Problem from Entrepreneurial Network Construction

This paper develops an extended newsboy model and presents a formula- tion for this model. This new model has solved the budget contained multi-product newsboy problem with the reactive production. This model can be used to describe the status of entrepreneurial network construction. We use the Lagrange multiplier procedure to deal with our problem, but it is too complicated to get the exact solu-tion. So we introduce the homotopy method to deal with it. We give the flow chart to describe how to get the solution via the homotopy method. We also illustrate our model in both the classical procedure and the homotopy method. Comparing the two methods, we can see that the homotopy method is more exact and efficient.

Safety Risk Assessment Analysis of Bridge Construction Using Backpropagation Neural Network

The evaluation of construction safety risks has become a crucial task with the increasing development of bridge construction.This paper aims to provide an overview of the application of backpropagation neural networks in assessing safety risks during bridge construction.It introduces the situation,principles,methods,and advantages,as well as the current status and future development directions of backpropagation-related research.

Efficacy and safety of perioperative therapy for locally resectable gastric cancer:A network meta-analysis of randomized clinical trials

BACKGROUND Gastric cancer(GC)is the fifth most commonly diagnosed malignancy worldwide,with over 1 million new cases per year,and the third leading cause of cancer-related death.AIM To determine the optimal perioperative treatment regimen for patients with locally resectable GC.METHODS A comprehensive literature search was conducted,focusing on phase II/III randomized controlled trials(RCTs)assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable GC.The R0 resection rate,overall survival(OS),disease-free survival(DFS),and incidence of grade 3 or higher nonsurgical severe adverse events(SAEs)associated with various perioperative regimens were analyzed.A Bayesian network meta-analysis was performed to compare treatment regimens and rank their efficacy.RESULTS Thirty RCTs involving 8346 patients were included in this study.Neoadjuvant XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared with surgery alone,and the former had the highest probability of being the most effective option in this context.Neoadjuvant plus adjuvant FLOT was associated with the highest probability of being the best regimen for improving OS.Owing to limited data,no definitive ranking could be determined for DFS.Considering nonsurgical SAEs,FLO has emerged as the safest treatment regimen.CONCLUSION This study provides valuable insights for clinicians when selecting perioperative treatment regimens for patients with locally resectable GC.Further studies are required to validate these findings.

A Multilayer Perceptron Artificial Neural Network Study of Fatal Road Traffic Crashes

This paper examines the relationship between fatal road traffic accidents and potential predictors using multilayer perceptron artificial neural network (MLANN) models. The initial analysis employed twelve potential predictors, including traffic volume, prevailing weather conditions, roadway characteristics and features, drivers’ age and gender, and number of lanes. Based on the output of the model and the variables’ importance factors, seven significant variables are identified and used for further analysis to improve the performance of models. The model is optimized by systematically changing the parameters, including the number of hidden layers and the activation function of both the hidden and output layers. The performances of the MLANN models are evaluated using the percentage of the achieved accuracy, R-squared, and Sum of Square Error (SSE) functions.

Effectiveness and safety of seven oral Chinese patent medicines as adjuvant therapy for cancer-related anemia: A systematic review and network meta-analysis of randomized controlled trials

Objective:To evaluate the effectiveness and safety of seven oral Chinese patent medicines(CPMs)as adjuvant therapy for cancer-related anemia(CRA)by network meta-analysis(NMA).Methods:A literature search to obtain randomized controlled trials(RCTs)of seven oral CPMs in the adjuvant treatment of CRA was conducted in multiple databases from the inception to April 2022.The RevMan5.3 and R 4.1.1 software were used for NMA.Results:We ultimately included 29 RCTs with 2140 patients.Traditional meta-analysis showed that Fufang E'jiao syrup(FFEJS),Shengxuebao mixture(SXBM),Shengxuening tablets(SXNT),Jianpi Shengxue granules(JPSXG),and Yixuesheng capsule(YXSC)combined with basic Western treatment(BWT)could improve the hemoglobin(HGB)level.JPSXG combined with BWT could improve the red blood cell(RBC).FFEJS combined with BWT improved the Karnofsky performance status(KPS).NMA showed that FFEJS,JPSXG,SXBM,and SXNT plus BWT improved HGB better than Shengxue tablets(SXT)plus BWT,with top three ranking results being JPSXG plus BWT>SXNT plus BWT>FFEJS plus BWT.FFEJS plus BWT,JPSXG plus BWT,SXBM plus BWT,SXNT plus BWT,and SXT plus BWT improved RBC better than BWT,with top three ranking results being SXNT plus BWT>JPSXG plus BWT>FFEJS plus BWT.In terms of the KPS score,compared with SXT plus BWT,FFEJS,JPSXG,SXBM,SXNT,and Yizhong Shengxue capsule(YZSXC)plus BWT had higher KPS,with top three ranking results being SXBM plus BWT>JPSXG plus BWT>FFEJS plus BWT.Conclusions:Our NMA demonstrated that seven oral CPMs used as adjuvant treatment of CRA had a definite clinical effect.JPSXG not only increases the levels of HGB and RBC to enhance the clinical effect but also improves patients'quality of life.More accurate conclusions need to be verified by more high-quality RCTs.

基于Browser/Server的医院HIS的设计与实现

介绍了医院HIS系统的设计与实现，系统采用WinNT Server4 .0作为网络服务器，实现了网上医院，从八个方面阐述了其软件设计，并加上系统安全性设 计。

Design of Aided Decision-Making Program for Prioritizing Construction Projects in Urban Road Network Planning

The importance and complexity of prioritizing construction projects (PCP) in urban road network planning lead to the necessity to develop an aided decision making program (ADMP). Cost benefit ratio model and stage rolled method are chosen as the theoretical foundations of the program, and then benefit model is improved to accord with the actuality of urban traffic in China. Consequently, program flows, module functions and data structures are designed, and particularly an original data structure of road ...

Attention-based long short-term memory fully convolutional network for chemical process fault diagnosis

A correct and timely fault diagnosis is important for improving the safety and reliability of chemical processes. With the advancement of big data technology, data-driven fault diagnosis methods are being extensively used and still have considerable potential. In recent years, methods based on deep neural networks have made significant breakthroughs, and fault diagnosis methods for industrial processes based on deep learning have attracted considerable research attention. Therefore, we propose a fusion deeplearning algorithm based on a fully convolutional neural network(FCN) to extract features and build models to correctly diagnose all types of faults. We use long short-term memory(LSTM) units to expand our proposed FCN so that our proposed deep learning model can better extract the time-domain features of chemical process data. We also introduce the attention mechanism into the model, aimed at highlighting the importance of features, which is significant for the fault diagnosis of chemical processes with many features. When applied to the benchmark Tennessee Eastman process, our proposed model exhibits impressive performance, demonstrating the effectiveness of the attention-based LSTM FCN in chemical process fault diagnosis.

FOUR-PARAMETER AUTOMATIC TRANSMISSION TECHNOLOGY FOR CONSTRUCTION VEHICLE BASED ON ELMAN RECURSIVE NEURAL NETWORK

From the viewpoint of energy saving and improving transmission efficiency, the ZL50E wheel loader is taken as the study object. And the system model is analyzed based on the transmission system of the construction vehicle. A new four-parameter shift schedule is presented, which can keep the torque converter working in the high efficiency area. The control algorithm based on the Elman recursive neural network is applied, and four-parameter control system is developed which is based on industrial computer. The system is used to collect data accurately and control 4D180 power-shift gearbox of ZL50E wheel loader shift timely. An experiment is done on automatic transmission test-bed, and the result indicates that the control system could reliably and safely work and improve the efficiency of hydraulic torque converter. Four-parameter shift strategy that takes into account the power consuming of the working pump has important operating significance and reflects the actual working status of construction vehicle.

Application of extension neural network to safety status pattern recognition of coalmines

In order to accurately and quickly identify the safety status pattern of coalmines,a new safety status pattern recognition method based on the extension neural network (ENN) was proposed,and the design of structure of network,the rationale of recognition algorithm and the performance of proposed method were discussed in detail.The safety status pattern recognition problem of coalmines can be regard as a classification problem whose features are defined in a range,so using the ENN is most appropriate for this problem.The ENN-based recognition method can use a novel extension distance to measure the similarity between the object to be recognized and the class centers.To demonstrate the effectiveness of the proposed method,a real-world application on the geological safety status pattern recognition of coalmines was tested.Comparative experiments with existing method and other traditional ANN-based methods were conducted.The experimental results show that the proposed ENN-based recognition method can identify the safety status pattern of coalmines accurately with shorter learning time and simpler structure.The experimental results also confirm that the proposed method has a better performance in recognition accuracy,generalization ability and fault-tolerant ability,which are very useful in recognizing the safety status pattern in the process of coal production.

Using analytic network process to analyze problems for implementing turn-key construction projects in Taiwan

The turn-key construction project is implemented in Taiwan not by a single company but by a make-shift group of several companies. Hence,problems to coordinate the professional construction management (PCM) and the supervising architectural company often occur for the lack of long-term experience to work together. The various factors that affect the implementation of turn-key projects currently practiced in Taiwan are analyzed using the analytic network process (ANP). The objective is to study how the twelve key factors in the four layers of "Role assignment","Signing contract","Operational procedures" and "Losing capital investment" affect the progress of implementing the turn-key project in Taiwan. The results reveal that "Delay in payment" has the most negative influence with 15.62% weighing factor; "Latent risk" comes next with 11.14% weighing factor,and "Responsibility of construction company for project quality" is the third with 10.79% weighing factor.

Performance of beacon safety message dissemination in Vehicular Ad hoc NETworks (VANETs)

Currently, there is a growing belief that putting an IEEE 802.11-like radio into road vehicles can help the drivers to travel more safely. Message dissemination protocols are primordial for safety vehicular applications. There are two types of safety messages which may be exchanged between vehicles: alarm and beacon. In this paper we investigate the feasibility of deploying safety applications based on beacon message dissemination through extensive simulation study and pay special attention to the safety requirements. Vehicles are supposed to issue these messages periodically to announce to other vehicles their current situation and use received messages for preventing possible unsafe situations. We evaluate the performance of a single-hop dissemination protocol while taking into account the quality of service (QoS) metrics like delivery rate and delay. We realize that reliability is the main concern in beacon message dissemination. Thus, a new metric named effective range is defined which gives us more accurate facility for evaluating QoS in safety applications specifically. Then, in order to improve the performance, the effects of three parameters including vehicle's transmission range, message transmission's interval time and message payload size are studied. Due to special characteristics of the safety applications, we model the relationship between communication-level QoS and application-level QoS and evaluate them for different classes of safety applications. As a conclusion, the current technology of IEEE 802.11 MAC layer has still some challenges for automatic safety applications but it can provide acceptable QoS to driver assistance safety applications.

BARN:Behavior-Aware Relation Network for multi-label behavior detection in socially housed macaques

Quantification of behaviors in macaques provides crucial support for various scientific disciplines,including pharmacology,neuroscience,and ethology.Despite recent advancements in the analysis of macaque behavior,research on multi-label behavior detection in socially housed macaques,including consideration of interactions among them,remains scarce.Given the lack of relevant approaches and datasets,we developed the Behavior-Aware Relation Network(BARN)for multi-label behavior detection of socially housed macaques.Our approach models the relationship of behavioral similarity between macaques,guided by a behavior-aware module and novel behavior classifier,which is suitable for multi-label classification.We also constructed a behavior dataset of rhesus macaques using ordinary RGB cameras mounted outside their cages.The dataset included 65?913 labels for19 behaviors and 60?367 proposals,including identities and locations of the macaques.Experimental results showed that BARN significantly improved the baseline SlowFast network and outperformed existing relation networks.In conclusion,we successfully achieved multilabel behavior detection of socially housed macaques with both economic efficiency and high accuracy.

Coal mine safety production forewarning based on improved BP neural network

Firstly, the early warning index system of coal mine safety production was given from four aspects as per- sonnel, environment, equipment and management. Then, improvement measures which are additional momentum method, adaptive learning rate, particle swarm optimization algorithm, variable weight method and asynchronous learning factor, are used to optimize BP neural network models. Further, the models are applied to a comparative study on coal mine safety warning instance. Results show that the identification precision of MPSO-BP network model is higher than GBP and PSO-BP model, and MPSO- BP model can not only effectively reduce the possibility of the network falling into a local minimum point, but also has fast convergence and high precision, which will provide the scientific basis for the forewarnin~ management of coal mine safetv production.

Relational graph location network for multi-view image localization

In multi-view image localization task,the features of the images captured from different views should be fused properly.This paper considers the classification-based image localization problem.We propose the relational graph location network(RGLN)to perform this task.In this network,we propose a heterogeneous graph construction approach for graph classification tasks,which aims to describe the location in a more appropriate way,thereby improving the expression ability of the location representation module.Experiments show that the expression ability of the proposed graph construction approach outperforms the compared methods by a large margin.In addition,the proposed localization method outperforms the compared localization methods by around 1.7%in terms of meter-level accuracy.

Analysis on evaluation ability of nonlinear safety assessment model of coal mines based on artificial neural network

Based on the integration analysis of goods and shortcomings of various methods used in safety assessment of coal mines, combining nonlinear feature of mine safety sub-system, this paper establishes the neural network assessment model of mine safety, analyzes the ability of artificial neural network to evaluate mine safety state, and lays the theoretical foundation of artificial neural network using in the systematic optimi- zation of mine safety assessment and getting reasonable accurate safety assessment result.

Comparison of School Building Construction Costs Estimation Methods Using Regression Analysis, Neural Network, and Support Vector Machine

Accurate cost estimation at the early stage of a construction project is key factor in a project’s success. But it is difficult to quickly and accurately estimate construction costs at the planning stage, when drawings, documentation and the like are still incomplete. As such, various techniques have been applied to accurately estimate construction costs at an early stage, when project information is limited. While the various techniques have their pros and cons, there has been little effort made to determine the best technique in terms of cost estimating performance. The objective of this research is to compare the accuracy of three estimating techniques (regression analysis (RA), neural network (NN), and support vector machine techniques (SVM)) by performing estimations of construction costs. By comparing the accuracy of these techniques using historical cost data, it was found that NN model showed more accurate estimation results than the RA and SVM models. Consequently, it is determined that NN model is most suitable for estimating the cost of school building projects.

A Novel Network Screening Methodology for Rural Low-Volume Roads

Low-volume roads (LVRs) are an integral part of the rural transportation network providing access to remote rural areas and facilitating the movement of goods from farms to markets. These roads pose unique challenges for highway agencies including those related to safety management on the highway network. Specifically, traditional network screening methods using crash history can be effective in screening rural highways with higher traffic volumes and more frequent crashes. However, these traditional methods are often ineffective in screening LVR networks due to low traffic volumes and the sporadic nature of crash occurrence. Further, many of the LVRs are owned and operated by local agencies that may lack access to detailed crash, traffic and roadway data and the technical expertise within their staff. Therefore, there is a need for more efficient and practical network screening approaches to facilitate safety management programs on these roads. This study proposes one such approach which utilizes a heuristic scoring scheme in assessing the level of risk/safety for the purpose of network screening. The proposed scheme is developed based on the principles of US Highway Safety Manual (HSM) analysis procedures for rural highways and the fundamentals in safety science. The primary application of the proposed scheme is for ranking sites in network screening applications or for comparing multiple improvement alternatives at a specific site. The proposed approach does not require access to detailed databases, technical expertise, or exact information, making it an invaluable tool for small agencies and local governments (e.g. counties, townships, tribal governments, etc.).