Lung cancer has become one of the most common types of cancer,and has the highest morbidity and mortality rates.We herein performed a bioinformatic analysis to explore the gene expression of hexokinase domain containi...Lung cancer has become one of the most common types of cancer,and has the highest morbidity and mortality rates.We herein performed a bioinformatic analysis to explore the gene expression of hexokinase domain containing 1(HKDC1)to further illuminate the molecular mechanisms involved in non-small cell lung cancer(NSCLC).We also examined the relationship between HKDC1 expression and patient survival.The Oncomine and cBioPortal cancer genomics databases were used to investigate the expression of HKDC1 in NSCLC.Then the protein-protein interaction network and protein expression intensity of HKDC1 were examined with the Gene MANIA and The Human Protein Atlas databases.Finally,the prognostic impact of HKDC1 was evaluated via the GEPIA,Oncolnc and Kaplan-Meier Plotter online tools.HKDC1 was significantly up-regulated in NSCLC patients.In addition,the mutation frequency of HKDC1 in NSCLC was high in a large number of studies.Moreover,HKDC1 expression was correlated with a poor prognosis in NSCLC patients.These findings suggest that HKDC1 represents a novel therapeutic target for NSCLC.展开更多
基金the National Natural Science Foundation of China(No.81860494).
文摘Lung cancer has become one of the most common types of cancer,and has the highest morbidity and mortality rates.We herein performed a bioinformatic analysis to explore the gene expression of hexokinase domain containing 1(HKDC1)to further illuminate the molecular mechanisms involved in non-small cell lung cancer(NSCLC).We also examined the relationship between HKDC1 expression and patient survival.The Oncomine and cBioPortal cancer genomics databases were used to investigate the expression of HKDC1 in NSCLC.Then the protein-protein interaction network and protein expression intensity of HKDC1 were examined with the Gene MANIA and The Human Protein Atlas databases.Finally,the prognostic impact of HKDC1 was evaluated via the GEPIA,Oncolnc and Kaplan-Meier Plotter online tools.HKDC1 was significantly up-regulated in NSCLC patients.In addition,the mutation frequency of HKDC1 in NSCLC was high in a large number of studies.Moreover,HKDC1 expression was correlated with a poor prognosis in NSCLC patients.These findings suggest that HKDC1 represents a novel therapeutic target for NSCLC.
