目的研究我国不同汉族人群血小板同地区种抗原HPA-3、HPA-9w多态性。方法采用聚合酶链反应．序列特异性引物（polymerase chain reaction-sequence specific primers，PCR-SSP）技术对1000名来自不同省份汉族无关献血者进行HPA-3、HPA-9...目的研究我国不同汉族人群血小板同地区种抗原HPA-3、HPA-9w多态性。方法采用聚合酶链反应．序列特异性引物（polymerase chain reaction-sequence specific primers，PCR-SSP）技术对1000名来自不同省份汉族无关献血者进行HPA-3、HPA-9w抗原基因分型。结果在调查的1000名汉族人群中11PA-3a、1-1PA-3b基因频率分别为0．5935和0．4065，HPA-9全为a／a纯合子。经X^2检测，符合Hardy-Weinberg平衡。不同地区汉族人群之间比较，广东省与陕西、黑龙江、浙江、云南、江苏5省的HPA-3多态性分布差异有统计学意义，其余省份之间多态性分布差异无统计学意义。中国汉族人群与越南人、澳大利亚人HPA-3的多态性分布差异有统计学意义。结论在随机输血中供受者HPA-3抗原不配合比例达0．3661，这为研究同种免疫血小板减少症、开展血小板同型输注提供了理论基础。展开更多
As an important intermediate substance in the process of producing 1,3-propanediol （1, 3-PD） by bio-dissimilation of glycerol, the concentration of 3-hydroxypropionaldehyde （3-HPA） has inhibitory action on glycero...As an important intermediate substance in the process of producing 1,3-propanediol （1, 3-PD） by bio-dissimilation of glycerol, the concentration of 3-hydroxypropionaldehyde （3-HPA） has inhibitory action on glycerol dehydratase （GDHt） and 1, 3-propanediol oxi- doreductase （PDOR）. Considering the transmission of glycerol and 1,3-PD across cell membrane by both passive diffusion and active transmission as well as the inhibitory action of 3-HPA on the specific rate of growth, this paper aims to establish and dis- cuss a nonlinear hybrid dynamical system model to ascertain the concentration range of 3-HPA where it does exhibit an inhibitory action on GDHt and PDOR. A quantita- tive definition of biological robustness is presented and an identification model is estab- lished based on biological robustness. An algorithm procedure is constructed to solve the identification problem. Numerical results show that only within a proper concentration range 3-HPA can have inhibitory action on the two enzymes mentioned above.展开更多
文摘目的研究我国不同汉族人群血小板同地区种抗原HPA-3、HPA-9w多态性。方法采用聚合酶链反应．序列特异性引物（polymerase chain reaction-sequence specific primers，PCR-SSP）技术对1000名来自不同省份汉族无关献血者进行HPA-3、HPA-9w抗原基因分型。结果在调查的1000名汉族人群中11PA-3a、1-1PA-3b基因频率分别为0．5935和0．4065，HPA-9全为a／a纯合子。经X^2检测，符合Hardy-Weinberg平衡。不同地区汉族人群之间比较，广东省与陕西、黑龙江、浙江、云南、江苏5省的HPA-3多态性分布差异有统计学意义，其余省份之间多态性分布差异无统计学意义。中国汉族人群与越南人、澳大利亚人HPA-3的多态性分布差异有统计学意义。结论在随机输血中供受者HPA-3抗原不配合比例达0．3661，这为研究同种免疫血小板减少症、开展血小板同型输注提供了理论基础。
文摘As an important intermediate substance in the process of producing 1,3-propanediol （1, 3-PD） by bio-dissimilation of glycerol, the concentration of 3-hydroxypropionaldehyde （3-HPA） has inhibitory action on glycerol dehydratase （GDHt） and 1, 3-propanediol oxi- doreductase （PDOR）. Considering the transmission of glycerol and 1,3-PD across cell membrane by both passive diffusion and active transmission as well as the inhibitory action of 3-HPA on the specific rate of growth, this paper aims to establish and dis- cuss a nonlinear hybrid dynamical system model to ascertain the concentration range of 3-HPA where it does exhibit an inhibitory action on GDHt and PDOR. A quantita- tive definition of biological robustness is presented and an identification model is estab- lished based on biological robustness. An algorithm procedure is constructed to solve the identification problem. Numerical results show that only within a proper concentration range 3-HPA can have inhibitory action on the two enzymes mentioned above.
