An 83-year-old Japanese man presented with multiple verrucous papules clustering on a plaque located on the frontal aspect of the scrotum. Histologically, there were three distinct epithelial changes compatible with c...An 83-year-old Japanese man presented with multiple verrucous papules clustering on a plaque located on the frontal aspect of the scrotum. Histologically, there were three distinct epithelial changes compatible with condyloma acuminatum , Bowen’s disease, and extramammary Paget’s disease (EMPD). By in situ hybridiza tion, the zone of condyloma acuminatum was positive for HPV 6 and well demarcate d from HPV 31-positive Bowen’s disease. EMPD was negative for targeted HPV 6/11 /16/18/31/33 probes. Immunohistochemically, Paget’s cells expressing cytokeratin 7 were distributed as scattered single cells or clusters mainly in the lower pa rt of theHPV6/31-positive epithelium. To the best of our knowledge, this is the first reported case of the occurrence of condyloma acuminatum, Bowen’s disease , and EMPD within the same lesion.展开更多
文摘An 83-year-old Japanese man presented with multiple verrucous papules clustering on a plaque located on the frontal aspect of the scrotum. Histologically, there were three distinct epithelial changes compatible with condyloma acuminatum , Bowen’s disease, and extramammary Paget’s disease (EMPD). By in situ hybridiza tion, the zone of condyloma acuminatum was positive for HPV 6 and well demarcate d from HPV 31-positive Bowen’s disease. EMPD was negative for targeted HPV 6/11 /16/18/31/33 probes. Immunohistochemically, Paget’s cells expressing cytokeratin 7 were distributed as scattered single cells or clusters mainly in the lower pa rt of theHPV6/31-positive epithelium. To the best of our knowledge, this is the first reported case of the occurrence of condyloma acuminatum, Bowen’s disease , and EMPD within the same lesion.
