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生殖器疱疹患者HSV-2和anti-HSV-2检测的临床意义 被引量:1
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作者 张燕 《中国热带医学》 CAS 2008年第1期40-41,共2页
目的探讨生殖器疱疹(GH)患者HSV-2PCR及HSV-2抗体(包括IgG、IgM)检测的临床意义,评价其对GH诊断的重要性和实用性。方法对182例生殖器部位有皮损的现症GH患者检测HSV-2PCR及HSV-2抗体(包括IgG、IgM)。结果HSV-2PCR阳性检测率为90.6%(165... 目的探讨生殖器疱疹(GH)患者HSV-2PCR及HSV-2抗体(包括IgG、IgM)检测的临床意义,评价其对GH诊断的重要性和实用性。方法对182例生殖器部位有皮损的现症GH患者检测HSV-2PCR及HSV-2抗体(包括IgG、IgM)。结果HSV-2PCR阳性检测率为90.6%(165/182),明显高于HSV-2IgG阳性检测率68.7%(125/182)和HSV-2IgM阳性检测率为14.3%(26/128);初发患者HSV-2PCR阳性检测率为89.7%(61/68)明显高于HSV-2IgG阳性检测率39.7%(27/68)和HSV-2IgM阳性检测率25%(17/68);复发患者HSV-2PCR阳性检测率为95.6%(109/114),HSV-2IgG阳性检测率为100%(114/114),两者几无差别,而HSV-2IgM阳性检测率为0;23例皮损不明显患者HSV-2IgG阳性检测率为78.3%(18/23),明显高于HSV-2PCR阳性检测率26%(6/23)和HSV-2IgM阳性检测率13%(3/23)。结论HSV-2PCR检测法对有典型临床症状如水疱和糜烂的GH阳性率高、诊断价值大,对临床症状不典型者阳性率低;HSV-2IgG检测对无皮损和无症状的患者有较大的诊断价值;HSV-2IgM对诊断GH感染的价值不大。 展开更多
关键词 生殖器疱疹 hsv-2 PCR hsv-2IgG hsv-2igm
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性病门诊妇女宫颈糜烂与单纯疱疹病毒2型活动感染关系探讨及临床治疗初探 被引量:2
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作者 王晓霞 皮肖冰 +1 位作者 伍启康 李启欣 《中国艾滋病性病》 CAS 2004年第5期367-368,378,共3页
目的 探讨性病门诊妇女宫颈糜烂与单纯疱疹病毒 2型 (HSV 2 )的活动感染的关系 ,并初步探讨用干扰素栓治疗的临床效果。方法 用酶联免疫吸附试验 (ELISA)对 110例不同程度 (Ⅰ、Ⅱ、Ⅲ度 )宫颈糜烂病人和 2 9例正常对照检测血清HSV 2... 目的 探讨性病门诊妇女宫颈糜烂与单纯疱疹病毒 2型 (HSV 2 )的活动感染的关系 ,并初步探讨用干扰素栓治疗的临床效果。方法 用酶联免疫吸附试验 (ELISA)对 110例不同程度 (Ⅰ、Ⅱ、Ⅲ度 )宫颈糜烂病人和 2 9例正常对照检测血清HSV 2型特异性IgM抗体。同时用ELISA法对病例组和对照组宫颈糜烂面分泌物和宫颈表面分泌物检测HSV 2抗原。HSV 2抗原检测阳性的患者用干扰素栓治疗。结果  110例不同程度宫颈糜烂病人HSV 2型特异性IgM抗体阳性率为 4 0 91% (45 /110 ) ,宫颈糜烂面分泌物HSV 2抗原阳性率为 34 5 5 % (38/110 ) ,抗原抗体同时阳性的感染率为 2 0 0 0 % (2 2 /110 ) ,均显著或非常显著地高于对照组 (P =0 0 12 ,0 0 0 0 3,0 0 0 76 )。在病例组中 ,HSV 2抗原检出率随糜烂程度加重而增高。 38例抗原阳性患者用干扰素栓治疗痊愈显效率为73 6 8% ,病毒抗原转阴率为 71 10 %。结论 性病门诊妇女宫颈糜烂的产生与HSV 2的原发活动感染有关 ,用干扰素栓治疗有效。 展开更多
关键词 单纯疱疹病毒2型抗原与抗体 宫颈糜烂 干扰素
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荧光定量PCR和酶联免疫吸附试验检测生殖器疱疹病毒感染的意义 被引量:2
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作者 朱慧兰 李常兴 +1 位作者 林路洋 张锡宝 《中国麻风皮肤病杂志》 2006年第11期894-895,共2页
目的:探讨荧光定量聚合酶反应(fluorescent quantitative PCR,FQ-PCR)和酶联免疫吸附法(ELISA)检测生殖器疱疹病毒感染的临床意义。方法:对性病门诊140例有现症生殖器疱疹(GH)患者用FQ-PCR检测生殖器疱疹病毒II型(HSV-2)和ELISA方法进行... 目的:探讨荧光定量聚合酶反应(fluorescent quantitative PCR,FQ-PCR)和酶联免疫吸附法(ELISA)检测生殖器疱疹病毒感染的临床意义。方法:对性病门诊140例有现症生殖器疱疹(GH)患者用FQ-PCR检测生殖器疱疹病毒II型(HSV-2)和ELISA方法进行HSV-2抗原和抗体(包括IgG和IgM)检测。结果:FQ-PCR和HSV-2抗原法检测140例GH患者的阳性率分别为92.14%和89.29%,均明显高于HSV-2 IgG(66.43%)和IgM(14.29%)(P<0.01);125例具有典型临床症状如水疱、溃疡和宫颈糜烂等患者中:FQ-PCR和HSV-2抗原分别为100%和97.60%,均明显高于HSV-2IgG(65.60%)和HSV-2 IgM(14.40%)(P<0.01);15例表现为结痂的患者中:FQ-PCR、HSV-2抗原和HSV-2 IgM阳性率分别为26.67%、20.0%和13.33%,均明显低于HSV-2 IgG阳性率(P<0.01)。结论:FQ-PCR法和ELISA HSV-2抗原法均能快速准确检测GH感染;ELISA HSV-2 IgM抗体诊断GH感染的价值不大;ELISA HSV-2 IgG法对诊断临床症状不典型的GH有较大的价值。 展开更多
关键词 生殖器疱疹 hsv-2抗原 hsv-2IgG hsv-2 igm
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Human immunodeficiency virus p24 antigen and antibody,herpes simplex virus-2 IgM and tumor necrosis factor alpha plasma levels in adult female children living in sing le-parent households:a case-control observational study
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作者 Mathew Folaranmi Olaniyan Tolulope Busayo Olaniyan 《Journal of Bio-X Research》 2022年第1期42-46,共5页
Objective: Human immunodeficiency virus (HIV) p24 antigen and antibody and herpes simplex virus 2 IgM are seromarkers indicating infection with HIV and herpes simplex virus-2 (HSV-2), respectively, whereas tumor necro... Objective: Human immunodeficiency virus (HIV) p24 antigen and antibody and herpes simplex virus 2 IgM are seromarkers indicating infection with HIV and herpes simplex virus-2 (HSV-2), respectively, whereas tumor necrosis factor α is an inflammatory biomarker that can be triggered by infections. Female children of single parents are faced with many socio-economic challenges that make them vulnerable to sexual influences and prone to sexually transmitted infections. The goal of this work was to determine HIV p24 antigen/antibody, HSV-2 IgM and tumor necrosis factor-α plasma levels in adult female children living in single-parent households.Methods: In this case-control observational study, 100 adult female children living with a single parent (50 living with a single mother and 50 living with a single father;age: 18-22 years) and 100 age-matched women living with both parents were recruited to serve as the test and control groups, respectively. All subjects were negative for acid-fast bacilli, plasmodium, hepatitis C virus, and hepatitis B virus. Human tumor necrosis factor α, HSV-2 IgM, antibody to hepatitis C virus, hepatitis B surface antigen and human immunodeficiency virus p24 antigen and antibody (HIV p24 Ag/Ab) levels were determined by ELISA, while the detection of acid-fast bacilli in sputum andPlasmodium in blood was carried out by optical microscopy. This work was carried out in the Owo/Ose Federal Constituency in Ondo State that shares boundaries with Edo State. The study protocol was approved by the Research and Ethical Committee of the Department of Medical Laboratory Science, Achievers University, Owo, Nigeria (AUO/MLS/2020/127) on August 27, 2020.Results: HIV p24 Ag/Ab was detected in 0 adult female children living with a single mother, 1 (2%) adult female child living with a single father and 1 (1 %) adult female child living with both parents. HSV-2 IgM was detected in 9 (18%) adult female children living with a single mother, 13 (26%) adult female children living with a single father, and 5 (10%) adult female children living with both parents.Conclusion: This work shows that adult female children of single parents are vulnerable to sexual influences, and thereby more prone to HSV-2 and possibly HIV, especially adult female children of single fathers. 展开更多
关键词 adult female children HIV p24 Ag/Ab hsv-2 igm single parent household tumor necrosis factorα
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