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Co-expression of HBZ,TAX and FOXp3 and HTLV-1-associated myelopathy/tropical spastic paraparesis development in HTLV-1-infected individuals:A systematic review
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作者 Ana Carolina Marinho Monteiro Lima Greice Carolina Santos da Silva +3 位作者 Fernanda Khouri Barreto Filipe Ferreira de Almeida Rego Luana Leandro Gois Luciane Amorim Santos 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2021年第8期333-340,共8页
Human T-cell lymphotropic virus type 1(HTLV-1)is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP).It has been reported that the HTLV-1 proteins(specifically TAX and... Human T-cell lymphotropic virus type 1(HTLV-1)is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP).It has been reported that the HTLV-1 proteins(specifically TAX and HBZ)can modulate FOXp3,resulting in an immune imbalance that can favor the progression of HAM/TSP.This review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 m RNAs and/or viral proteins(TAX and HBZ)with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/TSP development.This systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis.The search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject descriptors.After screening,six articles were included in this review.The studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP,which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy donors.This systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/TSP development. 展开更多
关键词 htlv-1 htlv-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP) FOXP3 HBZ TAX
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Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: Clinical presentation and pathophysiology
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作者 Jean-Pierre Louboutin 《World Journal of Neurology》 2015年第3期68-73,共6页
Human T-cell lymphotropic virus type 1(HTLV-1)-associated myelopathy/tropical spastic paraparesis(HAM/TSP) is a slowly progressive neurodegenerative disorder in which lesions of the central nervous system cause progre... Human T-cell lymphotropic virus type 1(HTLV-1)-associated myelopathy/tropical spastic paraparesis(HAM/TSP) is a slowly progressive neurodegenerative disorder in which lesions of the central nervous system cause progressive weakness, stiffness, and a lower limb spastic paraparesis. In some cases, polymyositis, inclusion bodymyositis, or amyotrophic lateral sclerosis-like syndromes are associated with HTLV-1. TSP was first described in Jamaica in 1888 and known as Jamaican peripheral neuritis before TSP was related to HTLV-1 virus, the first retrovirus being identified, and the disease is since named HAM/TSP. There is no established treatment program for HAM/TSP. Prevention is difficult in lowincome patients(i.e., HTLV-1 infected breast feeding mothers in rural areas, sex workers). Thus, there is a need for new therapeutic avenues. Therapeutic approaches must be based on a better understanding, not only of clinical and clinicopathological data, but also of the pathophysiology of the affection. Consequently, a better understanding of existing or newly developed animal models of HAM/TSP is a prerequisite step in the development of new treatments. 展开更多
关键词 tropical spastic paraparesis HUMAN T-CELL lymphotropic VIRUS type-1 Polymyositis Animal models Retroviruses myelopathy HUMAN T-CELL lymphotropic VIRUS type 1-associated myelopathy Pathogenesis
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Role of post-translational modifications of HTLV-1 Tax in NF-κB activation 被引量:1
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作者 Noula Shembade Edward W Harhaj 《World Journal of Biological Chemistry》 CAS 2010年第1期13-20,共8页
Human T-cell leukemia virus type 1(HTLV-1),the first human retrovirus discovered,is the etiological agent of adult-T-cell leukemia/lymphoma.The HTLV-1 encoded Tax protein is a potent oncoprotein that deregulates gene ... Human T-cell leukemia virus type 1(HTLV-1),the first human retrovirus discovered,is the etiological agent of adult-T-cell leukemia/lymphoma.The HTLV-1 encoded Tax protein is a potent oncoprotein that deregulates gene expression by constitutively activating nuclear factor-κB(NF-κB).Tax activation of NF-κB is critical for the immortalization and survival of HTLV-1-infected T cells.In this review,we summarize the present knowledge on mechanisms underlying Tax-mediated NF-κB activation,with an emphasis on post-translational modifications of Tax. 展开更多
关键词 Adult-T-cell leukemia/lymphoma HUMAN T-CELL LEUKEMIA VIRUS TYPE 1 Nuclear factor-κB HUMAN T-CELL LEUKEMIA VIRUS TYPE 1-associated myelopathy/ tropical spastic paraparesis IKK
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嗜人T淋巴细胞病毒I型(HTLV-I)相关HAM/TSP病(附5例报告) 被引量:3
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作者 郑璇 杨棉华 +4 位作者 杜登青 庄伟端 陈显光 陈国敏 曾毅 《临床神经病学杂志》 CAS 1996年第6期339-341,共3页
本文报道应用间接免疫荧光法,从汕头地区97例神经系统疾病患者血清中,检测出嗜人T淋巴细胞病毒I型(HTLV-I)抗体阳性的HTLV-I相关HAM/TSP病患者5例,阳性率为5.15%。并对HTLV-I相关HAM/TS... 本文报道应用间接免疫荧光法,从汕头地区97例神经系统疾病患者血清中,检测出嗜人T淋巴细胞病毒I型(HTLV-I)抗体阳性的HTLV-I相关HAM/TSP病患者5例,阳性率为5.15%。并对HTLV-I相关HAM/TSP病的临床特点、伴发疾病、病理及发病机制、治疗等进行了讨论,认为国内进一步开展对HTLV-I相关HAM/TSP病的检测和研究是非常必要的。 展开更多
关键词 脊髓疾病 热带痉挛性瘫痪 htlv-I
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Th17细胞及其效应分子IL-17在HAM/TSP患者体内的变化及Tax蛋白对IL-17的影响 被引量:2
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作者 肖颖秀 庄伟端 张俏忻 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2013年第1期34-37,共4页
目的研究Th17细胞及其效应分子IL-17在HTLV-Ι相关性脊髓病/热带痉挛性截瘫(HTLV-Ιassociated myelopsthy/tropical spastic paraparesis,HAM/TSP)患者中的变化及Tax蛋白对IL-17的影响。方法分别应用ELISA法和流式细胞技术检测HAM/TSP... 目的研究Th17细胞及其效应分子IL-17在HTLV-Ι相关性脊髓病/热带痉挛性截瘫(HTLV-Ιassociated myelopsthy/tropical spastic paraparesis,HAM/TSP)患者中的变化及Tax蛋白对IL-17的影响。方法分别应用ELISA法和流式细胞技术检测HAM/TSP患者CSF上清液中的IL-17水平及外周血Th17细胞的百分率。应用RNAi干扰技术抑制Tax蛋白的表达,并用ELISA法检测干扰后细胞培养悬浮液中IL-17的表达。结果HAM/TSP患者脑脊液上清中IL-17含量(4.58±0.70)pg/mL较对照组(0.76±0.17)pg/mL显著升高(P<0.01);HAM/TSP患者外周血中Th17细胞的百分率(2.00%±0.64%)较对照组(0.41%±0.24%)显著升高(P<0.01)。RNAi技术干扰Tax蛋白表达后,IL-17水平(5.04±1.27)pg/mL较未干扰组细胞培养悬浮液中IL-17水平(7.69±2.11)pg/mL显著降低(P<0.05)。结论 Th17细胞及其效应分子IL-17在HAM/TSP患者体内显著提高,提示在其发病机制中发挥一定作用,而且IL-17的表达水平受Tax蛋白调控。 展开更多
关键词 htlv-Ι相关性脊髓病/热带痉挛性截瘫 TH17细胞 白细胞介素17
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HTLV-Ⅰ相关性HAM/TSP患者血浆及脑脊液sFas、sFasL的测定及意义 被引量:1
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作者 肖颖秀 郑璇 《中国神经免疫学和神经病学杂志》 CAS 2005年第3期164-166,共3页
目的探讨人嗜T淋巴细胞病毒Ⅰ型相关性脊髓病/热带痉挛性瘫痪(humanT-lymphotropicvirustypeⅠassociatedmyelopathy/tropicalspasticparaparesis,HAM/TSP)患者血浆及中可溶性Fas(sFas)和Fas配体(sFasL)表达水平及其与HAM/TSP病发病机... 目的探讨人嗜T淋巴细胞病毒Ⅰ型相关性脊髓病/热带痉挛性瘫痪(humanT-lymphotropicvirustypeⅠassociatedmyelopathy/tropicalspasticparaparesis,HAM/TSP)患者血浆及中可溶性Fas(sFas)和Fas配体(sFasL)表达水平及其与HAM/TSP病发病机制的关系。方法应用ELISA方法检测HAM/TSP患者血浆及脑脊液(CSF)中sFas和sFasL水平。结果HAM/TSP患者血浆sFas表达水平[(1.08±0.26)ng/mL]与其他神经系统疾病(otherinflammatoryneurologicdiseases,OIND)[(0.29±0.05)ng/mL]及正常对照组[(0.18±0.07)ng/mL]相比显著增高(P<0.05),血浆sFasL表达水平[(0.26±0.11)ng/mL]与OIND组[(0.22±0.04)ng/mL]及正常对照组[(0.21±0.05)ng/mL]比较差异无显著性(P>0.05);CSFsFas与sFasL表达水平[(0.19±0.07)ng/mL与(0.24±0.08)ng/mL]均高于OIND组[(0.11±0.06)ng/mL与(0.01±0.01)ng/mL](P<0.05)。结论sFas、sFasL蛋白可能在HAM/TSP发病机制中起重要作用。 展开更多
关键词 人嗜T淋巴细胞病毒Ⅰ型相关性脊髓病/热带痉挛性瘫痪 SFAS sFas配体
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细胞凋亡及sFas、sFasL在人嗜T-淋巴细胞病毒Ⅰ型相关性脊髓病/热带痉挛性瘫痪中的表达及其意义 被引量:1
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作者 肖颖秀 郑璇 +1 位作者 庄伟端 吴育彬 《汕头大学医学院学报》 2004年第3期140-142,F003,共4页
目的 :研究人嗜T淋巴细胞病毒Ⅰ型相关性脊髓病 /热带痉挛性瘫痪 (HAM/TSP)外周血淋巴细胞凋亡情况 ,以及患者血浆及脑脊液 (CSF)中sFas、sFasL的表达水平在HAM/TSP发生、发展中的作用。方法 :用单细胞电泳检测HAM /TSP患者外周血淋巴... 目的 :研究人嗜T淋巴细胞病毒Ⅰ型相关性脊髓病 /热带痉挛性瘫痪 (HAM/TSP)外周血淋巴细胞凋亡情况 ,以及患者血浆及脑脊液 (CSF)中sFas、sFasL的表达水平在HAM/TSP发生、发展中的作用。方法 :用单细胞电泳检测HAM /TSP患者外周血淋巴细胞的凋亡情况 ,ELISA方法检测HAM/TSP患者血浆及CSF中存在的sFas、sFasL。结果 :HAM/TSP患者外周血淋巴细胞凋亡率明显增高 ,与正常对照组比较有统计学意义 (P <0 0 5 ) ;患者血浆sFas、sFasL表达水平与其他神经系统感染性疾病 (OIND)及正常对照组相比显著增高 (P <0 0 5 ) ;血浆sFasL表达水平高于OIND及正常对照组 (P >0 0 5 ) ;CSF、sFas、sFasL表达水平均高于OIND组 (P <0 0 5 )。结论 :淋巴细胞凋亡及凋亡相关因子sFas、sFasL可能在HAM/TSP的发生。 展开更多
关键词 患者 血浆 脊髓病 FASL表达 对照组 正常 CSF 水平 情况 结论
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FQ-PCR同步检测HTLV-Ⅰ及HTLV-Ⅱ方法的建立及临床应用
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作者 陈琦 唐景峰 +4 位作者 程鹏飞 张长明 周立 汪晓莉 王业富 《武汉大学学报(医学版)》 CAS 北大核心 2012年第5期667-672,共6页
目的:建立可同时检测HTLV-Ⅰ和HTLV-Ⅱ的双重荧光定量PCR(FQ-PCR)方法,并对所建体系进行方法学评价。方法:根据HTLV-Ⅰpol基因和HTLV-Ⅱtax基因的保守序列设计引物及TaqMan-LNA探针,构建重组质粒作为荧光定量PCR的标准品。优化荧光定量... 目的:建立可同时检测HTLV-Ⅰ和HTLV-Ⅱ的双重荧光定量PCR(FQ-PCR)方法,并对所建体系进行方法学评价。方法:根据HTLV-Ⅰpol基因和HTLV-Ⅱtax基因的保守序列设计引物及TaqMan-LNA探针,构建重组质粒作为荧光定量PCR的标准品。优化荧光定量PCR反应条件,建立起可同时检测HTLV-Ⅰ和HTLV-Ⅱ的双重荧光定量PCR(FQ-PCR)的方法。结果:结果显示该方法对HTLV-Ⅰ及HTLV-Ⅱ的线性范围分别为108-102 copy/μl和107-10copy/μl;检测灵敏度分别为102copy/μl和10copy/μl。对阳性标本检测均呈阳性,对非目标菌检测均呈阴性。应用该方法对175例临床标本进行考核,有HTLV-Ⅰ阳性6例,HTLV-Ⅱ阳性3例,其中HTLV-Ⅰ和HTLV-Ⅱ双阳性2例。结论:本研究建立的双重FQ-PCR方法特异、快速、灵敏,对HTLV的血液筛查有重要意义。 展开更多
关键词 人嗜T淋巴细胞病毒 人嗜T淋巴细胞病素-Ⅰ型相关性脊髓病 热带痉挛性截瘫 荧光定量PCR
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白细胞介素6在HAM/TSP中的表达及意义
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作者 吴育彬 吴映华 +2 位作者 林鑫江 奚宝珊 郑璇 《中国医师杂志》 CAS 2007年第1期34-36,共3页
目的探讨白细胞介素6(IL-6)在人嗜T淋巴细胞病毒I型相关性脊髓病/热带痉挛性瘫痪(HAM/TSP)发病中的意义。方法检测8例HAM/TSP患者血清和脑脊液中IL-6、IgG水平,与10例正常对照组(NC)比较。结果血清IL-6含量在HAM/TSP组、NC... 目的探讨白细胞介素6(IL-6)在人嗜T淋巴细胞病毒I型相关性脊髓病/热带痉挛性瘫痪(HAM/TSP)发病中的意义。方法检测8例HAM/TSP患者血清和脑脊液中IL-6、IgG水平,与10例正常对照组(NC)比较。结果血清IL-6含量在HAM/TSP组、NC组中分别为(194.76±28.68)、(129.13±17.77)pg/ml,HAM/TSP组血清IL-6表达水平明显比正常组高(P〈0.01)。脑脊液IL-6含量在分别为(184.12±36.39)、(125.32±14.01)pg/ml。差异有统计学意义(P〈0.01)。HAM/TSP患者血清IL-6与IgG呈线性正相关。IgG指数均〉0.7。结论IL-6在HAM/TSP发病机制中起重要作用,促进IgG表达上调,HAM/TSP可能是HTLV-1感染后引起的中枢神经系统脱髓鞘病变。 展开更多
关键词 人类嗜T淋巴细胞病毒1 轻截瘫 热带痉挛性 白细胞介素6
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