Tropical spastic paraparesis/HTLV I associated myelopathy (TSP/HAM) is the classical neurological manifestation of HTLV I. Only a few studies have described isolated peripheral neuropathy (PN) among HTLV I infected in...Tropical spastic paraparesis/HTLV I associated myelopathy (TSP/HAM) is the classical neurological manifestation of HTLV I. Only a few studies have described isolated peripheral neuropathy (PN) among HTLV I infected individuals. 335 infected individuals without TSP/HAM were evaluated for the presence of PN and 45 of them showed evidences of peripheral nervous system involvement. Of these 21 patients had isolated PN, defined by clinical and/or electrophysiological criteria. Sural nerve biopsies revealed inflammatory infiltrates in 2, axonal degeneration in 2 and segmental demyelination in 1. Therefore, peripheral neuropathy can be found as an isolated manifestation of HTLV I infection. We conclude that HTLV I infection should be investigated in patients with PN of unknown origin.展开更多
Urinary tract infection (UTI) is a frequent pathology among HTLV-I+ individuals being capable of severely compromising the kidneys and bladder. Molecular characteristics of uropathogenic Escherichia coli (UPEC) from H...Urinary tract infection (UTI) is a frequent pathology among HTLV-I+ individuals being capable of severely compromising the kidneys and bladder. Molecular characteristics of uropathogenic Escherichia coli (UPEC) from HTLV-I+ infected individuals are unknown. UPEC isolates from HTVL-I+ individuals, with and without clinical symptoms of myelopathy, were submitted to genetic typing seeking to infer bacterial diversity and potential virulence. 71 bacterial isolates were characterized according to random amplified polymorphic DNA and phylotypes. Phylotyping classified E. coli into four phylogenetic groups: A (18.3%), B1 (16.9%), B2 (39.4%), and D (25.3%) and 8 phylotypes according to the presence of the genetic sequences chuA, yjaA and the DNA fragment TSPE4.C2: ﹣﹣﹣ (5.6%) and ﹣+﹣ (12.6%) in phylogroup A, ﹣﹣+ (7.0%) and ﹣++ (9.8%) in B1, +++ (32.3%) and ++﹣ (7.0%) in B2, +﹣﹣ (15.4%) and +﹣+ (9.8%) in D. The B2 phylogroup was the most prevalent among HTLV﹣ associated myelopathy and asymptomatic individuals. RAPD-PCR typing revealed a high degree of bacterial polymorphism indicating a non-clonal origin. Genotypes were not found to be distributed according to clinical status or epidemiological features. Our results lead us to suggest that the neurological impairment in HTLV-I+ individuals can be a risk factor for urinary infections due E. coli which are caused by distinct bacterial lineages.展开更多
Objective: To investigate the role of human T lymphotrophic virus type I (HTL V I) infection in four patients who developed slowly progressive myelopathy wit h abnormal MRI lesions in the cervical cord levels. Methods...Objective: To investigate the role of human T lymphotrophic virus type I (HTL V I) infection in four patients who developed slowly progressive myelopathy wit h abnormal MRI lesions in the cervical cord levels. Methods: Clinical and neuror adiologic examinations were performed, and the odds that an HTLV I infected in dividual of specified genotype, age, and provirus load had HTLV I associated m yelopathy (HAM)/tropical spastic paraparesis (TSP) were calculated. Results: Ant i HTLV I antibodies were positive in both the serum and the CSF in all of the patients. Biopsied sample from spinal cord lesions showed inflammatory changes i n Patient 1. Patient 2 had a demyelinating type of sensorimotor polyneuropathy. Two of the three patients examined showed high risk of developing HAM/TSP in vir ologic and immunologic aspects. Conclusion: These four cases may belong to a var iant form of HAM/TSP, predominantly involving the cervical cord levels.展开更多
In this paper, a mathematical model for HTLV-I infection of CD4+ T cells that incorporates the CD8+ cytotoxic T-cell(CTL) response is studied. We establish two threshold parameters R0 and R1, the basic reproduction nu...In this paper, a mathematical model for HTLV-I infection of CD4+ T cells that incorporates the CD8+ cytotoxic T-cell(CTL) response is studied. We establish two threshold parameters R0 and R1, the basic reproduction numbers for viral persistence and for CTL response, respectively. We also show that the parameter R1 can be used to distinguish asymptomatic carriers from HAM/TSP patients and as an important control parameter for preventing the development of HAM/TSP.展开更多
It is beyond dispute that cytotoxic T-lymphocytes(CTLs)exert a vital function in the host's antiviral defense mechanism.With the idea of the above factor and the logistic proliferation of CD4+T-cells,we establish ...It is beyond dispute that cytotoxic T-lymphocytes(CTLs)exert a vital function in the host's antiviral defense mechanism.With the idea of the above factor and the logistic proliferation of CD4+T-cells,we establish a HTLV-I(human T-cell leukemia virus type-I)mathematical model.First,two threshold parameters Ro and Re(the basic reproduction numbers for viral infection and CTL immune response,respectively)are obtained.Second,sufficient criteria for local and global asymptotic stabilities of the feasible equilibria of the model are deduced,respectively.Third,the sensitivity analyses of Ro and Rc are performed to better understand the effective strategies for HTLV-I infection.Finally,not only numerical simulations are given to illustrate the stability conclusions,but also the biological significance is stated.展开更多
文摘Tropical spastic paraparesis/HTLV I associated myelopathy (TSP/HAM) is the classical neurological manifestation of HTLV I. Only a few studies have described isolated peripheral neuropathy (PN) among HTLV I infected individuals. 335 infected individuals without TSP/HAM were evaluated for the presence of PN and 45 of them showed evidences of peripheral nervous system involvement. Of these 21 patients had isolated PN, defined by clinical and/or electrophysiological criteria. Sural nerve biopsies revealed inflammatory infiltrates in 2, axonal degeneration in 2 and segmental demyelination in 1. Therefore, peripheral neuropathy can be found as an isolated manifestation of HTLV I infection. We conclude that HTLV I infection should be investigated in patients with PN of unknown origin.
文摘Urinary tract infection (UTI) is a frequent pathology among HTLV-I+ individuals being capable of severely compromising the kidneys and bladder. Molecular characteristics of uropathogenic Escherichia coli (UPEC) from HTLV-I+ infected individuals are unknown. UPEC isolates from HTVL-I+ individuals, with and without clinical symptoms of myelopathy, were submitted to genetic typing seeking to infer bacterial diversity and potential virulence. 71 bacterial isolates were characterized according to random amplified polymorphic DNA and phylotypes. Phylotyping classified E. coli into four phylogenetic groups: A (18.3%), B1 (16.9%), B2 (39.4%), and D (25.3%) and 8 phylotypes according to the presence of the genetic sequences chuA, yjaA and the DNA fragment TSPE4.C2: ﹣﹣﹣ (5.6%) and ﹣+﹣ (12.6%) in phylogroup A, ﹣﹣+ (7.0%) and ﹣++ (9.8%) in B1, +++ (32.3%) and ++﹣ (7.0%) in B2, +﹣﹣ (15.4%) and +﹣+ (9.8%) in D. The B2 phylogroup was the most prevalent among HTLV﹣ associated myelopathy and asymptomatic individuals. RAPD-PCR typing revealed a high degree of bacterial polymorphism indicating a non-clonal origin. Genotypes were not found to be distributed according to clinical status or epidemiological features. Our results lead us to suggest that the neurological impairment in HTLV-I+ individuals can be a risk factor for urinary infections due E. coli which are caused by distinct bacterial lineages.
文摘Objective: To investigate the role of human T lymphotrophic virus type I (HTL V I) infection in four patients who developed slowly progressive myelopathy wit h abnormal MRI lesions in the cervical cord levels. Methods: Clinical and neuror adiologic examinations were performed, and the odds that an HTLV I infected in dividual of specified genotype, age, and provirus load had HTLV I associated m yelopathy (HAM)/tropical spastic paraparesis (TSP) were calculated. Results: Ant i HTLV I antibodies were positive in both the serum and the CSF in all of the patients. Biopsied sample from spinal cord lesions showed inflammatory changes i n Patient 1. Patient 2 had a demyelinating type of sensorimotor polyneuropathy. Two of the three patients examined showed high risk of developing HAM/TSP in vir ologic and immunologic aspects. Conclusion: These four cases may belong to a var iant form of HAM/TSP, predominantly involving the cervical cord levels.
基金Supported by the Scientic and Technological Project of Henan Province(122300410034,132300410344)Supported by the the Universities Young Teachers Program of Henan Province(2010GGJS-104)
文摘In this paper, a mathematical model for HTLV-I infection of CD4+ T cells that incorporates the CD8+ cytotoxic T-cell(CTL) response is studied. We establish two threshold parameters R0 and R1, the basic reproduction numbers for viral persistence and for CTL response, respectively. We also show that the parameter R1 can be used to distinguish asymptomatic carriers from HAM/TSP patients and as an important control parameter for preventing the development of HAM/TSP.
基金supported by the National Natural Science Foundation(NNSF)of China(Nos.11871201,11871238 and 12001178)。
文摘It is beyond dispute that cytotoxic T-lymphocytes(CTLs)exert a vital function in the host's antiviral defense mechanism.With the idea of the above factor and the logistic proliferation of CD4+T-cells,we establish a HTLV-I(human T-cell leukemia virus type-I)mathematical model.First,two threshold parameters Ro and Re(the basic reproduction numbers for viral infection and CTL immune response,respectively)are obtained.Second,sufficient criteria for local and global asymptotic stabilities of the feasible equilibria of the model are deduced,respectively.Third,the sensitivity analyses of Ro and Rc are performed to better understand the effective strategies for HTLV-I infection.Finally,not only numerical simulations are given to illustrate the stability conclusions,but also the biological significance is stated.
