Rationale:Haemophagocytic lymphohistiocytosis is a rare complication of malaria,which is often misdiagnosed.Patient concerns:A 30-year-old male was admitted to our department for persistent fever,which began after ret...Rationale:Haemophagocytic lymphohistiocytosis is a rare complication of malaria,which is often misdiagnosed.Patient concerns:A 30-year-old male was admitted to our department for persistent fever,which began after returning from a stay in Guinea-Conakry.The laboratory investigations revealed a pancytopenia and an elevated C-reactive protein.Peripheral smear examination showed Plasmodium falciparum,therefore confirming the diagnosis of malaria.The laboratory tests showed a worsening pancytopenia.Bone marrow aspiration and biopsy revealed images of hemophagocytosis.Diagnosis:The diagnosis of haemophagocytic lymphohistiocytosis complicating malaria infection was established.Interventions:The patient was treated with artemether-lumefantrine.No immunosuppressant treatment was delivered to the patient.He received antipyretic and antimalarial treatment only.Outcomes and lessons:We report a case of haemophagocytic lymphohistiocytosis trigged by malaria infection and we review all reported cases secondary to Plasmodium falciparum malaria by searching PubMed publications till October 2019.Haemophagocytic lymphohistiocytos secondary to malaria should be suspected even in non-severe cases of malaria.展开更多
BACKGROUND Brucellosis is a contagious bacterial disease caused by Brucella species,which is a leading zoonotic disease worldwide.Most patients with brucellosis have a clear infection source;however,our case had a rar...BACKGROUND Brucellosis is a contagious bacterial disease caused by Brucella species,which is a leading zoonotic disease worldwide.Most patients with brucellosis have a clear infection source;however,our case had a rare presentation of secondary haemophagocytic lymphohistiocytosis without any epidemiological history.CASE SUMMARY A 50-year-old man was admitted to our hospital with a fever of unknown origin.After laboratory examinations,such as blood culture and bone marrow biopsy,the patient was diagnosed with brucellosis and secondary haemophagocytic lymphohistiocytosis.After antibiotic therapy,the patient was afebrile,and his haemogram recovered to normal,after which he was discharged.CONCLUSION Brucellosis cannot be excluded in patients with clinically unexplained fever,even in those without epidemiologic history.展开更多
文摘Rationale:Haemophagocytic lymphohistiocytosis is a rare complication of malaria,which is often misdiagnosed.Patient concerns:A 30-year-old male was admitted to our department for persistent fever,which began after returning from a stay in Guinea-Conakry.The laboratory investigations revealed a pancytopenia and an elevated C-reactive protein.Peripheral smear examination showed Plasmodium falciparum,therefore confirming the diagnosis of malaria.The laboratory tests showed a worsening pancytopenia.Bone marrow aspiration and biopsy revealed images of hemophagocytosis.Diagnosis:The diagnosis of haemophagocytic lymphohistiocytosis complicating malaria infection was established.Interventions:The patient was treated with artemether-lumefantrine.No immunosuppressant treatment was delivered to the patient.He received antipyretic and antimalarial treatment only.Outcomes and lessons:We report a case of haemophagocytic lymphohistiocytosis trigged by malaria infection and we review all reported cases secondary to Plasmodium falciparum malaria by searching PubMed publications till October 2019.Haemophagocytic lymphohistiocytos secondary to malaria should be suspected even in non-severe cases of malaria.
基金Xiamen Medical and Health Guidance Project,No.3502Z20199137.
文摘BACKGROUND Brucellosis is a contagious bacterial disease caused by Brucella species,which is a leading zoonotic disease worldwide.Most patients with brucellosis have a clear infection source;however,our case had a rare presentation of secondary haemophagocytic lymphohistiocytosis without any epidemiological history.CASE SUMMARY A 50-year-old man was admitted to our hospital with a fever of unknown origin.After laboratory examinations,such as blood culture and bone marrow biopsy,the patient was diagnosed with brucellosis and secondary haemophagocytic lymphohistiocytosis.After antibiotic therapy,the patient was afebrile,and his haemogram recovered to normal,after which he was discharged.CONCLUSION Brucellosis cannot be excluded in patients with clinically unexplained fever,even in those without epidemiologic history.
