BACKGROUND Brucellosis is a contagious bacterial disease caused by Brucella species,which is a leading zoonotic disease worldwide.Most patients with brucellosis have a clear infection source;however,our case had a rar...BACKGROUND Brucellosis is a contagious bacterial disease caused by Brucella species,which is a leading zoonotic disease worldwide.Most patients with brucellosis have a clear infection source;however,our case had a rare presentation of secondary haemophagocytic lymphohistiocytosis without any epidemiological history.CASE SUMMARY A 50-year-old man was admitted to our hospital with a fever of unknown origin.After laboratory examinations,such as blood culture and bone marrow biopsy,the patient was diagnosed with brucellosis and secondary haemophagocytic lymphohistiocytosis.After antibiotic therapy,the patient was afebrile,and his haemogram recovered to normal,after which he was discharged.CONCLUSION Brucellosis cannot be excluded in patients with clinically unexplained fever,even in those without epidemiologic history.展开更多
BACKGROUND Haemophagocytic syndrome(HPS)is rarely seen in patients with acute pancreatitis(AP).HPS as a complication of AP in patients without any previous history has not been elucidated.CASE SUMMARY A 46-year-old ma...BACKGROUND Haemophagocytic syndrome(HPS)is rarely seen in patients with acute pancreatitis(AP).HPS as a complication of AP in patients without any previous history has not been elucidated.CASE SUMMARY A 46-year-old man was admitted for symptom of persistent abdominal pain,nausea,and vomiting for 2 d after heavy drinking.During hospital stay,he suddenly developed skin rash and a secondary fever.The laboratory findings revealed progressive pancytopenia,abnormal hepatic tests,and elevation of serum triglyceride,ferritin,and lactate dehydrogenase levels.However,apparent bacterial or viral infections were not detected.He was also possibly related to autoimmune diseases because of positive expression of various autoimmune antibodies and no remarkable past history.Finally,the bone marrow examination showed a histiocytic reactive growth and prominent hemophagocytosis,which resulted in a diagnosis of HPS.Unexpectedly,the patient responded well to the immunosuppressive therapy.CONCLUSION HPS is a very rare extrapancreatic manifestation of AP.The diagnosis relies on bone marrow examination and immunosuppressive therapy is effective.For AP with skin changes,the possibility of HPS should be considered during clinical work.展开更多
基金Xiamen Medical and Health Guidance Project,No.3502Z20199137.
文摘BACKGROUND Brucellosis is a contagious bacterial disease caused by Brucella species,which is a leading zoonotic disease worldwide.Most patients with brucellosis have a clear infection source;however,our case had a rare presentation of secondary haemophagocytic lymphohistiocytosis without any epidemiological history.CASE SUMMARY A 50-year-old man was admitted to our hospital with a fever of unknown origin.After laboratory examinations,such as blood culture and bone marrow biopsy,the patient was diagnosed with brucellosis and secondary haemophagocytic lymphohistiocytosis.After antibiotic therapy,the patient was afebrile,and his haemogram recovered to normal,after which he was discharged.CONCLUSION Brucellosis cannot be excluded in patients with clinically unexplained fever,even in those without epidemiologic history.
基金Supported by the National Natural Science Foundation of China,No.81800467,No.81974062,and No.81770637.
文摘BACKGROUND Haemophagocytic syndrome(HPS)is rarely seen in patients with acute pancreatitis(AP).HPS as a complication of AP in patients without any previous history has not been elucidated.CASE SUMMARY A 46-year-old man was admitted for symptom of persistent abdominal pain,nausea,and vomiting for 2 d after heavy drinking.During hospital stay,he suddenly developed skin rash and a secondary fever.The laboratory findings revealed progressive pancytopenia,abnormal hepatic tests,and elevation of serum triglyceride,ferritin,and lactate dehydrogenase levels.However,apparent bacterial or viral infections were not detected.He was also possibly related to autoimmune diseases because of positive expression of various autoimmune antibodies and no remarkable past history.Finally,the bone marrow examination showed a histiocytic reactive growth and prominent hemophagocytosis,which resulted in a diagnosis of HPS.Unexpectedly,the patient responded well to the immunosuppressive therapy.CONCLUSION HPS is a very rare extrapancreatic manifestation of AP.The diagnosis relies on bone marrow examination and immunosuppressive therapy is effective.For AP with skin changes,the possibility of HPS should be considered during clinical work.
