In the present study, the safety of Hoemophilus influenza type b conjugate vaccines inoculated in the upper arm deltoid and vastus lateralis muscle was evaluated. 680 infants aged 2-5 months and 6-12 months were selec...In the present study, the safety of Hoemophilus influenza type b conjugate vaccines inoculated in the upper arm deltoid and vastus lateralis muscle was evaluated. 680 infants aged 2-5 months and 6-12 months were selected to be the research subjects in whom the Hib conjugate vaccines were inoculated by injection in the upper arm deltoid and vastus lateralis muscle, respectively. The safety analysis indicated that there were no statistic differences in the incidence rates of adverse reactions when the Hib conjugate vaccines were inoculated at different sites. So we concluded that the safety of inoculation injection of Hib conjugate vaccines in vastus lateralis muscle was the same as that inoculated in the upper arm deltoid.展开更多
目的探讨不同部位接种b型流感嗜血杆菌结合疫苗(haemophilus type b conjugate vaccine,Act-Hib)不良反应情况。方法将500例预防接种Act-Hib的2～8月龄婴幼儿随机分为实验组与对照组,每组各250例,分别于大腿前外侧肌和上臂三角肌进行疫...目的探讨不同部位接种b型流感嗜血杆菌结合疫苗(haemophilus type b conjugate vaccine,Act-Hib)不良反应情况。方法将500例预防接种Act-Hib的2～8月龄婴幼儿随机分为实验组与对照组,每组各250例,分别于大腿前外侧肌和上臂三角肌进行疫苗接种。比较两组婴幼儿接种后局部及全身反应情况。结果实验组婴幼儿局部反应程度明显轻于对照组,两组比较,差异具有统计学意义(P<0.05)。结论婴幼儿预防接种Act-Hib,在大腿前外侧肌注射接种局部反应程度明显轻于在上臂三角肌注射。展开更多
目的建立A群C群脑膜炎球菌多糖疫苗和b型流感嗜血杆菌结合疫苗中丙酮残留量的检测方法并加以验证。方法参照《中华人民共和国药典》三部（2010年版）中＂毛细管柱顶空进样等温法＂,优化色谱条件,建立A群C群脑膜炎球菌多糖疫苗和b型流感...目的建立A群C群脑膜炎球菌多糖疫苗和b型流感嗜血杆菌结合疫苗中丙酮残留量的检测方法并加以验证。方法参照《中华人民共和国药典》三部（2010年版）中＂毛细管柱顶空进样等温法＂,优化色谱条件,建立A群C群脑膜炎球菌多糖疫苗和b型流感嗜血杆菌结合疫苗中丙酮残留量的检测方法并对该方法进行验证及初步应用。结果色谱条件为顶空平衡温度70℃,顶空平衡时间40 min,汽化室温度200℃,柱箱温度40℃,检测器温度250℃,进样量为1.0 m L,载气（高纯氮气）流量1.3 m L/min,尾吹气（高纯氮气）流量5 m L/min,分流比1∶1。丙酮质量分数在2×10^-6-5×10^-5范围内具有良好的线性关系（r〉0.99）。丙酮的平均回收率及相对标准偏差（RSD）分别为86.05%-105.11%及2.1%-9.5%,检测限为2×10^-6,定量限为3×10^-6。结论本方法的线性、特异性、准确性、重复性等均符合规定,方法准确、稳定,可用于A群C群脑膜炎球菌多糖疫苗和b型流感嗜血杆菌结合疫苗中丙酮残留量的检测。展开更多
Introduction:Haemophilus influenzae(Hi)is subdivided into typeable(a-f)and non-typeable groups.Hi serotype b(Hib)has historically been one of the important pathogens responsible for invasive infection.However,after wi...Introduction:Haemophilus influenzae(Hi)is subdivided into typeable(a-f)and non-typeable groups.Hi serotype b(Hib)has historically been one of the important pathogens responsible for invasive infection.However,after widespread Hib vaccination,the emergence of other Hi serotypes,specifically Hi serotype a(Hia),was noted during the last few decades,mostly in children younger than 5 years of age.Case presentation:We present two cases of severe intracranial infections with detected Hia in patients>5 years of age within a short time frame and within the same geographic area.Conclusion:Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia.This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.展开更多
文摘In the present study, the safety of Hoemophilus influenza type b conjugate vaccines inoculated in the upper arm deltoid and vastus lateralis muscle was evaluated. 680 infants aged 2-5 months and 6-12 months were selected to be the research subjects in whom the Hib conjugate vaccines were inoculated by injection in the upper arm deltoid and vastus lateralis muscle, respectively. The safety analysis indicated that there were no statistic differences in the incidence rates of adverse reactions when the Hib conjugate vaccines were inoculated at different sites. So we concluded that the safety of inoculation injection of Hib conjugate vaccines in vastus lateralis muscle was the same as that inoculated in the upper arm deltoid.
文摘目的探讨不同部位接种b型流感嗜血杆菌结合疫苗(haemophilus type b conjugate vaccine,Act-Hib)不良反应情况。方法将500例预防接种Act-Hib的2～8月龄婴幼儿随机分为实验组与对照组,每组各250例,分别于大腿前外侧肌和上臂三角肌进行疫苗接种。比较两组婴幼儿接种后局部及全身反应情况。结果实验组婴幼儿局部反应程度明显轻于对照组,两组比较,差异具有统计学意义(P<0.05)。结论婴幼儿预防接种Act-Hib,在大腿前外侧肌注射接种局部反应程度明显轻于在上臂三角肌注射。
文摘目的建立A群C群脑膜炎球菌多糖疫苗和b型流感嗜血杆菌结合疫苗中丙酮残留量的检测方法并加以验证。方法参照《中华人民共和国药典》三部（2010年版）中＂毛细管柱顶空进样等温法＂,优化色谱条件,建立A群C群脑膜炎球菌多糖疫苗和b型流感嗜血杆菌结合疫苗中丙酮残留量的检测方法并对该方法进行验证及初步应用。结果色谱条件为顶空平衡温度70℃,顶空平衡时间40 min,汽化室温度200℃,柱箱温度40℃,检测器温度250℃,进样量为1.0 m L,载气（高纯氮气）流量1.3 m L/min,尾吹气（高纯氮气）流量5 m L/min,分流比1∶1。丙酮质量分数在2×10^-6-5×10^-5范围内具有良好的线性关系（r〉0.99）。丙酮的平均回收率及相对标准偏差（RSD）分别为86.05%-105.11%及2.1%-9.5%,检测限为2×10^-6,定量限为3×10^-6。结论本方法的线性、特异性、准确性、重复性等均符合规定,方法准确、稳定,可用于A群C群脑膜炎球菌多糖疫苗和b型流感嗜血杆菌结合疫苗中丙酮残留量的检测。
文摘Introduction:Haemophilus influenzae(Hi)is subdivided into typeable(a-f)and non-typeable groups.Hi serotype b(Hib)has historically been one of the important pathogens responsible for invasive infection.However,after widespread Hib vaccination,the emergence of other Hi serotypes,specifically Hi serotype a(Hia),was noted during the last few decades,mostly in children younger than 5 years of age.Case presentation:We present two cases of severe intracranial infections with detected Hia in patients>5 years of age within a short time frame and within the same geographic area.Conclusion:Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia.This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.
