Evaluation of Effectiveness of Diode Laser System (808 nm) versus Intense Pulse Light (IPL) in the Management of Unwanted Hair: A Split Face Comparative Study

We have evaluated and compared the effectiveness of diode laser system (808 nm) and Intense Pulse Light (IPL) system (690 - 1200 nm) by studying the change in hair density, and the time of regrowth the hair. A total of 26 have completed three months’ treatment, aged 16 - 50 years. Patients were treated by diode laser 808 nm and IPL 690 - 1200 nm devices. Pulse repetition rate for both was 1 Hz and short pulse width for diode laser and the IPL pulse width was 15 ms. The fluence was (33 - 41 and 30 - 41) J/cm2 respectively. A split face treatment method was used. The treatment was carried out on monthly bases for three months. Hair density and regrowth duration were recorded before and after each session. After the third session, the hair density was decreased by (58%) for diode laser versus (49%) for IPL p = 0.366. The time of hair regrowth was increased to (327%) for diode laser versus IPL (339%) p = 0.821. Pain appeared more during the treatment with IPL than with diode laser. Post treatment side effects such as erythema, hyper pigmentation, and burn appeared on patients treated with diode laser more than those treated with IPL. In conclusion both diode laser and IPL were effective in reduction of hair density, and prolongation of the time of hair regrowth.

Study on the repairing effect of poly(N-vinylpyrrolidone-co-methacrylic acid)on permed or bleached damaged hair

The repairing effect of poly(N-vinylpyrrolidone-co-methacrylic acid)on permed or bleached damaged hair was studied.The combing and tensile strength of permed and bleached hair before and after treatment with the copolymer solution were tested,and the effects of the mass fraction of copolymer solution and immerseing time on the combing and tensile strength for permed or bleached damaged hair were investigated.The repair mechanism of permed or bleached damaged hair was also explored.The results show that when the immersing time is 3 hours,the tensile strength of the permed hair increases with the mass fraction of the copolymer solution Tensile strength within 0%-0.3%,but no obvious change is observed when250 Yield strength the mass fraction is over 0.3%.Therefore,the optimal mass 200 fraction of the copolymer solution for repairing the permed hair(cN/dtex)is 0.3%.Similarly,the optimal mass fraction of the copolymer 150strength/solution for repairing the bleached hair is 0.5%.Furthermore,the effects of immersing time on the tensile strength of the100Tensile damaged hair fibers were compared between the permed and90 bleached hair before and after treatment with the copolymer500.40.30.500.10.2 solution.Coincidentally,the optimal immersion time for permedw(P(NVP-co-MAA))/%or bleached damaged hair is both 2 hours.The tensile strength of the permed and bleached hair soaked in 0.3%and 0.5%copolymer solutions for 2 hours increases by 15.55%and 18.12%,respectively,compared to untreated hair.Through infrared spectroscopy analysis,it is found that the amide II band in hair fibers shifted to the blue after repair,with the wave number shift of 11.12 and 11.09 cm^(-1),which confirm the formation of hydrogen bonds in the hair samples.Additionally,the urea hydrogen bond disruption experiment demonstrates that urea does not disrupt the hydrogen bonds in untreated hair fibers,but prevents the formation of new hydrogen bonds in damaged hair fibers.It further validates that the improvement of the tensile strength of the copolymer treated damaged hair fibers is mainly due to the formation of hydrogen bonds.After treatment with the copolymer,the dry and wet combing friction decrease by 30.73%and 28.55%for the permed hair,and decrease by 28.55%and 24.83%for the bleached hairs,respectively.The scanning electron microscope shows that the copolymer can flatten the cuticle and fill the space between the raised cuticles.

Recent progress in hair follicle stem cell markers and their regulatory roles

Hair follicle stem cells(HFSCs)in the bulge are a multipotent adult stem cell population.They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing.An increasing number of biomarkers have been used to isolate,label,and trace HFSCs in recent years.Considering more detailed data from single-cell transcriptomics technology,we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.

Peptide Cy_(RL-QN15)accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor

Individuals with diabetes frequently face serious challenges,including delayed wound healing and increased risk of infection.Notably,the regeneration of hair follicles plays a crucial role in accelerating diabetic skin damage repair,reducing the risk of infection,and enhancing overall skin health.Research has predominantly emphasized the re-epithelialization of diabetic wounds,with a paucity of in-depth studies on hair follicle regeneration.In the current study,we explored the effects of a bioactive amphibian-derived peptide,Cy_(RL-QN15),on promoting hair regeneration in a diabetic skin model.In vivo experiments demonstrated that local treatment with Cy_(RL-QN15)not only accelerated wound healing of scalded skin on the backs of diabetic Kunming(KM)mice but also improved growth of damaged hair follicles.Additionally,back-shaved diabetic C57BL/6 mice showed a significant increase in the growth of newly formed hair after 28 days of continuous Cy_(RL-QN15)treatment.Further analysis indicated that the hairregenerating effects of Cy_(RL-QN15)were closely associated with the proliferation and migration of hair follicle stem cells(HFSCs).Cy_(RL-QN15)enhanced intracellularβ-catenin expression by binding to the Frizzled-7 receptor on the surface of HFSCs.The up-regulation inβ-catenin modulated the levels of downstream proteins,such as cMYC,Cyclin D1,and Lef1,ultimately inducing hair regeneration.This study not only reveals the robust effects of the bioactive peptide Cy_(RL-QN15)in hair follicle regeneration but also provides novel avenues for the development of more targeted and effective therapeutics for diabetic wound healing in the future.

A review of methods for evaluating effectiveness of cosmetic products and ingredients based on mechanisms of the human hair growth cycle

With the increasing incidence of hair loss and especially among younger population in recent years,the demand for diversified products on anti-hair loss solutions is growing and the market of cosmetic products expanding accordingly.Worldwide attention is being paid to the research and development of anti-hair loss actives,while there is no unified standard for the efficacy evaluation and testing methods of anti-hair loss cosmetics.Therefore,it is critical to establish standardized methodology for assessing the effectiveness of anti-hair loss actives and their cosmetic products.In this review,an overview of the human hair follicle structure,the hair follicle cycle,and the biological pathways and signaling mechanisms involved in hair growth are summarized.This provides the fundamental understanding of human hair growth for reviewing anti-hair loss actives and cosmetic hair loss products,and respective methods and techniques applied for evaluating their efficacy.Additionally,changes in the normal hair cycle,and corresponding cosmetic strategies to slow down and reduce hair loss have been provided.This review aims to provide recommendations for evaluating the effectiveness of anti-hair loss actives on the mechanisms involved in the hair follicle growth cycle,and so provide criteria for new technology development and scientific research for cosmetic products.

Bhlhe40 protects cochlear hair cell-like HEI-OC1 cells against H_(2)O_(2) ‑triggered oxidative injury

Background:Cochlear hair cell injury is a common pathological feature of hearing loss.The basic helix-loop-helix family,member e40(Bhlhe40),a gene belonging to the basic helix-loop-helix(bHLH)family,exhibits strong transcriptional repression activity.Methods:Oxidative damage,in House Ear Institute-Organ of Corti 1(HEI-OC1)cells,was caused using hydrogen peroxide(H2O2).The Ad-Bhlhe40 particles were constructed to overexpress Bhlhe40 in HEI-OC1 cells.Various assays including cell counting kit-8(CCK-8),terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay(TUNEL),flow cytometry,immunofluorescence,and corresponding commercial kits were employed to investigate the impacts of Bhlhe40 on cell viability,apoptosis,oxidative stress levels,mitochondrial membrane potential and cellular senescence.Additionally,a dual-luciferase reporter assay was performed to confirm the targeting of the histone deacetylases 2(Hdac2)by Bhlhe40.Results:The results revealed that Bhlhe40 was downregulated in H_(2)O_(2)-treated HEI-OC1 cells,but its overexpression improved cell viability and mitigated H_(2)O_(2)-induced oxidative injury in HEI-OC1 cells with increase of superoxide dismutase(SOD),catalase(CAT)and glutathione peroxidase(GPx)activities and decrease of reactive oxygen species(ROS)levels.Besides,overexpression of Bhlhe40 suppressed H_(2)O_(2)-triggered cell senescence,as evidenced by the fact that the upregulation of P53,P21,and P16 in HEI-OC1 cells treated with H2O2 were all alleviated by Bhlhe40 overexpression.And we further verified that overexpression of Bhlhe40 could inhibit the expression of Hdac2,which may be related to the repression of Hdac2 transcription.Conclusion:This study suggests that Bhlhe40 plays a protective role against senescence and oxidative damage in cochlear hair cells exposed to H2O2.

Efficacy Evaluation Method of Hair Removal Cream

To explore the efficacy evaluation method of depilatory cream.60 subjects were selected as subjects,and statistical analysis was carried out on the depilation effect of large samples.The hair was removed with a razor in the control area and with depilation cream in the sample area,Antera 3D skin imaging analyzer was used to image the experimental area before and after the experiment,and the hair growth was dynamically monitored at 7,14,21 and 28 days,measure the length of hair with instrument and measure the number of people.The hair length change rate and hair inhibition rate were dynamically monitored in 28 days.The hair length change rate was-10.5%and hair inhibition rate was 93.3%after 28 days,more intuitive display of the product depilation effect,so as to determine the efficacy of depilation products evaluation method.

Determinants of Occipital Involvement in Males and Females with Pattern Hair Loss: A Retrospective Study

Background: Pattern hair loss (PHL) is the most common form of hair loss affecting both men and women. The occipital region, located at the back of the scalp, has been considered resistant to hair loss in PHL. It is often used as a donor site for hair transplantation procedures. However, evidence suggests that the occipital region may also be affected by PHL, although to a lesser extent compared to the frontal and vertex regions. Objective: To assess the levels and determinants of occipital involvement in PHL, focusing on gender and disease severity. Such data would enhance the comprehensive understanding of PHL progression and inform development of improved treatment strategies. Methods: This retrospective study involved 1993 adults (1000 males, 993 females) following for PHL at a specialized hair clinic in Jeddah, Saudi Arabia. Any patient who had hair transplantation in the past and any male who had balding areas (Hamilton-Norwood scales 4 to 7) at the initial consultation was excluded. The primary outcome was occipital involvement, defined as >10% thin hairs in the trichometry assessments of the occipital region. Additional data included patients age, treatment status, disease severity, and other trichometry parameters. Results: The prevalence of occipital involvement was found to be 23.8% overall, significantly more frequent in females (35.6%) than males with early PHL (Hamilton-Norwood scales 2 and 3) (12.1%) (p Conclusion: This study underscored the relevance of gender and disease severity in occipital involvement in PHL. Females had significantly higher rates of occipital involvement, suggesting that gender differences are critical in understanding PHL progression. Future research should aim to validate these findings, with an aim to refine therapeutic and surgical approaches to improve patient outcomes.

Comparison between the Medullary Indexes of Hairs from Apodemus orestes and A.draco,with Discussion about the Taxonomic Status of A.orestes

The taxonomic status of long-tailed field mouse (Apodemus orestes) is still uncertain up to now.Some scholars regarded it as a subspecies or a synonym of dragon field mouse (A.draco),while other scholars considered it a valid species.In the study,five specimens of adult long-tailed field mouse,dragon field mouse and Chevrier's field mouse (A.chevrieri) (as a contrast) were chosen respectively.After treated,with the eyepiece micrometer in the inverted microscope,we made measurements of the widths of hairs and medullas and then calculated the medullary indexes of straight guard hairs from around the mouth,head,back,abdomen and forelimb of each species.The results indicate that,viewing at each of the five parts and the mixture of the five parts,there are no significant differences between A.orestes and A.draco,Significant differences can be found between A.orestes & A.chevrieri and A.draco & A.chevrieri though.The standpoint that A.orestes was listed as a valid species is not supported by this study.

Effects of Different Culture Condition in vitro on Growth of Cashmere Goat Primary Hair Follicles

[Objective] The aim of this study is to lay a foundation for illustrating the biological characteristics and growth regulation mechanism of hair follicles.[Method]Cashmere goat primary hair follicles were separated under aseptic condition and cultured in serum-free DMEM and serum-free Williams E media respectively;subsequently,the growth rate and morphological changes were observed under the inverted microscope.[Result]Hair follicles cultured in serum-free DMEM media showed a growth rate of 0.034 mm/d during the first 3 days,whose structure and morphological characteristics could maintian a stable status for a long time in the growth process.Hair follicles grew much faster in the serum-free Williams E media with a growth rate of 0.077 mm/d during the first 3 days.[Conclusion]There were significant differences(P<0.05)between the growth of cashmere goat hair follicles cultured in the 2 kinds of media.Serum-free Williams E medium was superior to serum-free DMEM medium.

Effects of Estradiol on Cashmere Goat Primary Hair Follicles Cultured in vitro

[Objective] The aim of this study was to preliminarily explore the effects of estradiol on morphology and growth of cashmere goat primary hair follicles. [Method] Cashmere goat primary hair follicles were cultured in serum-free Williams E media supplemented with different doses of 17 β-E2 (0, 0.1, 1.0, 10.0, 100.0 nmol/L), and their growth rates and morphological changes were observed. [Result] The growth rate of 0.1 nmol/L 17 β-E2 group was quite comparable with that of the control group(0 nmol/L), but the 17 β-E2 with concentrations of 1.0, 10.0 and 100.0 nmol/L displayed different degrees of inhibition on the growth of hair follicles. Different morphological changes of hair follicles could also be discovered in different concentration treatments. [Conclusion] The study laid a certain foundation for exploring the regulation mechanism of estrogen on growth of cashmere goat hair follicles.

Comparison on Several Methods for Extracting DNA from Raccoon Dog Hair Follicle

[Objective] This study aimed to investigate a reliable method for DNA ex- traction from Wusuli raccoon dog＇s hair. [Method] Several DNA extraction methods were used to extract DNA from Wusuli raccoon dog hair, including Chelex-100 method, PCR buffer method, organic phenol-chloroform method and centrifugal col- umn type kit method. The extracted DNA was analyzed by using PCR amplification and electrophoresis to compare these four DNA extraction methods. [Result] Accord- ing to the results of spectrophotometer detection and gel electrophoresis, nucleic acid extracted by Chetex-100 method had proteins and other impurities; nucleic acid ex- tracted by PCR buffer method was low in concentration; however, DNA extracted by organic phenol-chloroform method and centrifugal column type kit was high in con- centration with no impurity band. [Conclusion] This study had laid the strong founda- tion of scientific theory to further explore the efficient and simple method for extracting DNA from Wusuli raccoon dog hair follicle.

Microscopic Structure of Rabbit Hair

[Objective] The paper was to explore the microscopic structure of rabbit hair. [Method] Single rabbit hair with typical features was selected to observe its mi- croscopic structure from tip to root, and its fiber diameter was also measured. [Result] The rabbit hair tip was constituted by scale layer and cortical layer, without medullary layer; the middle part was generally constituted by scale layer, cortical layer and medullary layer; the root had no medullary layer, and the scale layer was wheatear-shaped. This was the property of rabbit hair, which could be used for comparative studies with other animal fiber and species identification. Rabbit hair had developed medullary layer, and fiber diameter was positively related to column number of medullary cavity. The hair generally was single column, and coarse hair was multi-column. Single rabbit hair was the finest in the tip, coarse in the middle and tapering in the root. The diameter difference of various parts was large, and the ex- ternal growth characteristics was spindle-shaped. [Conclusion] Using biological micro- scope method to identify different animal fur and product species is more objective and simple.

Hair and Villus Production Performance of Tianzhu White Yak

[ Objective ] To analyze the hair and villus production performance of Tianzhu white yak and thus provide conditions for the genetic breed ing and product development. [Method] The hair and villus yield as well as villus rate of male and female Tianzhu white yaks from one year to six years old was detected and the villus yield was also determined. And these indexes of hair and villus were analyzed to evaluate the production per formance. [ Result] In Tianzhu white yaks from one year to two years old, the hair and villus yield was lower, but the villus rate and yield were high er. The hair and villus yield, villus rate, and villus yield were all higher in Tianzhu white yaks from three years to six years old but significantly de creased in 7yearold Tianzhu white yaks. In addition, the hair and villus yield was significantly （ P 〈 0.05） or very significantly （ P 〈 0.01 ） higher in male yaks than in female yaks. The villus rate was very significantly （ P 〈0.01 ） higher than in female yaks from five years to seven years old than in male yaks at the same age. [ Conclusion] Tianzhu white yaks from one year to two years old have the best hair and villus production perform ance; Tianzhu white yaks from three years to six years old are in the main phase of hair and villus production; Tianzhu white yaks older than seven years old should not be used for hair and villus production.

HAIR-AN综合征、白癜风、甲状腺功能减退并发1例

患者女，18岁。颈部、腋窝、腹股沟皮肤肥厚、色素沉着8年，颈部皮肤色素沉着表面白色斑片2年。皮肤科情况：颈部、腋窝、腹股沟皮肤肥厚、色素沉着，呈绒毛样增生。颈部皮肤色素沉着表面见约4．5em×3．0cm大小的色素脱失斑，周边见色素沉着晕。实验室检查：空腹和餐后2h血胰岛素水平分别为38．59μIU／mL（正常值2．0—30．5iμIU／mL）和1361μIU／mL（正常值11．5—99．65μIU／mL）。血睾酮水平113．5ng/dL（正常值10．0～75．0ng／dL）。3T功能：血清促甲状腺激素（TSH）〉100μIU／mL（正常值0．34～5．60DxlU／mL），FT32．9pmolZL（正常值3．8～6．0pmol／L），FT42．8pmol／L（正常值7．9～14．4pmol／L）。诊断：HAIR—AN综合征、白癜风、甲状腺功能减退并发。

Comparative Study on the Infrared Spectra of Straight Guard Hairs of Leopard Cat and Golden Cat

[Objective] The paper was to compare the infrared spectra of straight guard hairs of leopard cat and golden cat. [Method] The straight guard hairs of leopard cat and golden cat were detected and analyzed by FTIR （Fourier Transform Infrared Spectroscopy）. [Result] There was significant interspecific difference in the infrared spectra and second derivative spectra for the middle part of guard hair. An evident M-shaped bimodal absorption peak appeared in golden cat at 648 and 654 cm-1, respectively, while did not appear in leopard cat. The second derivative spec-tra of golden cat at wave numbers from 709 to 763 cm -1 were mainly unimodal peaks with strong peak intensity, while that of leopard cat mainly was M-shaped bi-modal absorption peak with weak peak intensity. It indicated that there was obvious difference in the structure of protein side chain in guard hairs of these two animals. [Conclusion] The FTIR analysis showed great application foreground in the study of animal hairs for interspecific identification.

隐喻和转喻视角下人体词“发”和“hair”的对比分析

基于认知语言学中的隐喻和转喻概念,对人体词汉语“发”和英语“hair”进行了对比分析。分析结果表明,“发”和“hair”均可映射到情感域和抽象域;“发”和“hair”均可代指人,均可代指人的内心状态,均可代指某种社会关系,而“发”还可以代指政治立场和年龄;“发”和“hair”在隐喻和转喻方面具有较高的相似性,但由于语言和文化差异,这两个词在隐喻和转喻方面也存在差异。该研究在一定程度上证明了隐喻和转喻作为基本的认知模式具有一定的普遍性。

John's Hair

John liked to wear his hairvery long.Some of his friendsthought that he looked_1_agirl,but they_2_made jokesabout it,because John was abig,strong young man.John al-ways went to the barber's(理发店)_3_a month to have his_4_cut and washed.And

Sulfur-encapsulated in heteroatom-doped hierarchical porous carbon derived from goat hair for high performance lithium–sulfur batteries

Biomass-derived carbon materials have aroused widespread concern as host material of sulfur to enhance electrochemical performances for lithium–sulfur batteries. Herein, goat hair, as a low-cost and eco-friendly precursor, is employed to fabricate cauliflower-like in-situ nitrogen, oxygen and phosphorus tri-doped porous biomass carbon(NOPC) by a facile activation with H_3PO_4 and carbonization process.The morphology and microstructure of NOPC can be readily tuned by altering pyrolysis temperature. The as-prepared NOPC matrix material carbonized at 600 °C possesses 3D hierarchical porous structure, high specific surface area(535.352 m^2 g^(-1)), and appropriate pore size and pore size distribution. Encapsulating sulfur into the NOPC depends on a stem-melting technology as cathode materials of Li–S batteries. Due to the synergistic effect of special physical structure and inherent tri-doping of N, O and P, electrons and ions transfer and utilization of active sulfur in the materials are improved, and the shuttle behaviors of soluble lithium polysulfides are also mitigated. Consequently, the S/NOPC-600 composite exhibits excellent electrochemical performance, giving a high initial discharge capacity of 1185 mA h g^(-1) at 0.05 C and maintaining a relatively considerable capacity of 489 m A h g^(-1) at 0.2 C after 300 cycles. Our work shows that a promising candidate for cathode material of Li–S batteries can be synthesized using low-cost and renewable biomass materials by a facile process.

Mercury concentration in hair samples from Chinese people in coastal cities

This investigation was made to estimate current normal concentrations of total mercury in the hair of Chinese coastal people. Hair samples were collected from 659 healthy inhabitants in the areas along the coast and the rivers (such as Shanghai, Ningbo, Dalian, Xiamen, and Zhoushan) of China from Feb. 2005 to June 2006. Total mercury concentrations in the samples were analyzed by the cold vapor atomic adsorption spectrometry method (CVAAS). The results showed the geometric mean concentration of total mercur...